The risk of lymph node metastasis in the new FIGO 2018 stage IA cervical cancer with >7 mm diameter

Laure Nicolai,Refika Yigit,Maaike C.G. Bleeker,Joost Bart,Jacobus van der Velden,Jacobus van der Velden,Constantijne H. Mom 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.6

Objective: In the 2018 FIGO staging system, cervical cancers with ≤5 mm depth of invasion (DOI) and a diameter of >7 mm, first classified as stage IB, are classified as stage IA. In this group, it is unclear what the risk of lymph node metastasis (LNM) is. This retrospective cohort study aims to determine the incidence of LNM and to study the association between disease-related characteristics and LNM. Methods: Women diagnosed with FIGO 2009 IB cervical cancer, with ≤5 mm DOI and a diameter >7 mm, treated with a radical hysterectomy and pelvic lymphadenectomy between 1985 and 2020 were selected from the databases of the Amsterdam University Medical Center and the University Medical Center Groningen. The specimens of patients with LNM were revised by expert pathologists. The incidence of LNM was calculated. The associations between LNM and DOI, diameter, histological type, clinical visibility and lymphovascular space invasion (LVSI) were evaluated by calculating odds ratios using logistic regression. Results: Of the 389 patients included, 10 had pathologically confirmed LNM (2.6%, 95% confidence interval=1.3%–4.5%). In case of LVSI, univariate analysis showed an increased risk of LNM (p=0.003 and p=0.012, respectively). No difference in LNM was found between lesions diagnosed by microscopy and clinically visible lesions. No LNM were found in patients without LVSI and a DOI of ≤3 mm. Conclusion: For patients with stage IA cervical cancer with a diameter >7 mm, we recommend considering a pelvic lymph node assessment in case of DOI >3 mm and/or presence of LVSI.

혐기성 소화액 시용 방법에 따른 토양 중 질소의 거동 분석

치미로리젯 ( Laure L. Chimi ),홍성구 ( Hong Seong-gu ) 한국농공학회 2019 한국농공학회 학술대회초록집 Vol.2019 No.-

Anaerobic digestion has been considered as one of the most environmentally beneficial technologies for the production of bioenergy. The agronomic and environmental effect of the use of digestates for crop fertilization depends mostly on the dynamics of nutrients on both its characteristics and the biotic and abiotic conditions of the soil. The main concerns regarding the application of digestate and other compost or fertilizer to agricultural land are emissions of N to the environment with associated impacts on air and water quality, ecosystem functioning and human health. Considering the N cycle occurring in the soil, the proper management needs to be taken into account. The objective of this study is to assess the nitrogen losses from the soil by different application methods of digestate. The majors’ practices of digestate application field are led to nitrogen losses via leaching and volatilization. Therefore, novel strategies can be constructed to preserve these unused N resources. High organic carbon soil addition like sawdust can regulate soil carbon and C: N ratio which could reduce those losses and the improvement of some N precision application method. Therefore, we assumed that combine sawdust and biogas digestate may be useful for sustainable crop production since it reduces nitrate losses from agricultural soils and improves nitrogen utilization efficiency. In order to test the suitability of this, we will conduct a pot and field experiments to determine the effects on its performance on the dynamics inorganic form from the soil. Treatments applied were as follow soil + sawdust + digestate; two application methods (injection and hole) with the same dose of digestate (170kg N/ha); irrigation digestate in the field. Therefore, to follow the nitrogen fate, three soil samples will removed from the surface and the depth (0-26cm) at day 0, 2, 3, 7, 14, 28, 36, 72, 90 days for the analysis of inorganic form (NH4-N and (NO3-N). Additionally, pH, soil organic, electrical conductivity will be measured. The samples without the addition of digestate will treat as control. In total 108 samples were prepared. So, the results expected are showed that the sawdust treatment have retained more nitrogen in the soil compared to the conventional method of application. However, this improvement of digestate treated and precision N application method were counterbalanced by advantage like N immobilization and mitigation of nitrogen losses. This study can help improve digestate management to meet crop N demands, nitrogen use efficiency while reducing nitrogen losses concerns regarding groundwater and atmosphere pollution.

Zipper-like molecular packing of donor–acceptor conjugated co-oligomers based on perylenediimide

Biniek, Laure,Schwartz, Pierre-Olivier,Zaborova, Elena,Heinrich, Benoî,t,Leclerc, Nicolas,Mé,ry, Sté,phane,Brinkmann, Martin The Royal Society of Chemistry 2015 Journal of Materials Chemistry C Vol.3 No.14

<▼1><P>The structure of perylene diimide co-oligomers used in organic photovoltaics is uncovered by TEM and GIXD on highly oriented films.</P></▼1><▼2><P>The molecular packing of a new class of perylene diimide-based acceptor–donor (A–D) co-oligomers has been investigated by combining electron diffraction and X-ray scattering methods for AD dyads and an ADA triad structure. The AD and ADA compounds form highly ordered lamellar mesophases with well-defined donor and acceptor domains. To determine the structure of the co-oligomers, highly oriented films with different orientations were prepared. Both flat-on and edge-on orientations of the lamellae were obtained by using two different alignment methods. High temperature rubbing leads to edge-on oriented lamellae with the long molecular axis of the co-oligomer oriented almost parallel to the rubbing direction. Instead, on oriented substrates of poly(tetrafluoroethylene) (PTFE), flat-on lying lamellae with the π-stacking direction oriented parallel to the PTFE chains are obtained. The structural data gathered by low dose selected area electron diffraction and high resolution transmission electron microscopy are used to establish a structural model of an AD dyad. Driven by the strong π-stacking of the PDI core, both AD and ADA co-oligomers form two similar self-assembled lamellar structures with an original zipper-like organization of the PDI blocks.</P></▼2>

혐기성 소화액 시용 방법에 따른 토양 중 질소의 거동 분석

시미로리셋 ( Laure L. Chimi ),홍성구 ( Seonggu Hong ) 한국농공학회 2019 한국농공학회 학술대회초록집 Vol.2019 No.-

Anaerobic digestion has been considered as one of the most environmentally beneficial technologies for the production of bioenergy. The agronomic and environmental effect of the use of digestates for crop fertilization depends mostly on the dynamics of nutrients on both its characteristics and the biotic and abiotic conditions of the soil. The main concerns regarding the application of digestate and other compost or fertilizer to agricultural land are emissions of N to the environment with associated impacts on air and water quality, ecosystem functioning and human health. Considering the N cycle occurring in the soil, the proper management needs to be taken into account. The objective of this study is to assess the nitrogen losses from the soil by different application methods of digestate. The majors’ practices of digestate application field are led to nitrogen losses via leaching and volatilization. Therefore, novel strategies can be constructed to preserve these unused N resources. High organic carbon soil addition like sawdust can regulate soil carbon and C: N ratio which could reduce those losses and the improvement of some N precision application method. Therefore, we assumed that combine sawdust and biogas digestate may be useful for sustainable crop production since it reduces nitrate losses from agricultural soils and improves nitrogen utilization efficiency. In order to test the suitability of this, we will conduct a pot and field experiments to determine the effects on its performance on the dynamics inorganic form from the soil. Treatments applied were as follow soil + sawdust + digestate; two application methods (injection and hole) with the same dose of digestate (170kg N/ha); irrigation digestate in the field. Therefore, to follow the nitrogen fate, three soil samples will removed from the surface and the depth (0-26cm) at day 0, 2, 3, 7, 14, 28, 36, 72, 90 days for the analysis of inorganic form (NH4-N and (NO3-N). Additionally, pH, soil organic, electrical conductivity will be measured. The samples without the addition of digestate will treat as control. In total 108 samples were prepared. So, the results expected are showed that the sawdust treatment have retained more nitrogen in the soil compared to the conventional method of application. However, this improvement of digestate treated and precision N application method were counterbalanced by advantage like N immobilization and mitigation of nitrogen losses. This study can help improve digestate management to meet crop N demands, nitrogen use efficiency while reducing nitrogen losses concerns regarding groundwater and atmosphere pollution

Electrochemical skin conductance is sensitive and has clinical utility in patients with untreated or poorly controlled diabetes

Marie-Laure Névoret 대한의용생체공학회 2019 Biomedical Engineering Letters (BMEL) Vol.9 No.4

We read with interest and disappointment the article by Kim et al. [ 1 ], testing the Sudoscan device for diff erentiating between a group of diabetic patients and controls. Unfortunately, it appears that the authors have failed to understand the intended uses of ESC, in particular in diabetes.

Laryngeal silicone stent as a treatment option for laryngeal paralysis in dogs: a preliminary study of 6 cases

Marie-Laure Théron,Tomas Lahuerta-Smith 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.4

Background: Laryngeal paralysis is a common idiopathic degenerative neurological disease in older medium-to-large breed dogs, with surgical correction of the obstruction being the treatment of choice. Objectives: This study evaluated the use of laryngeal silicone stents to treat canine laryngeal paralysis in dogs where classic surgical treatment was not accepted by the owners. Methods: Dogs diagnosed with laryngeal paralysis, for which the owners refused arytenoid lateralization surgery as a first-line treatment, were treated with laryngeal silicone stents. Results: Six dogs with bilateral laryngeal paralysis were included in the study. All dogs showed improvement in clinical signs immediately after the procedure. No clinical signs or radiographic changes were noted in four out of six dogs in the follow-up visit performed 1 wk later. One dog was suspected of aspirating water while drinking, but the signs disappeared after repositioning the stent. Another dog had a relapse of stridor due to caudal migration of the stent. This dog underwent arytenoid lateralization surgery because larger stents are not commercially available. At the time of writing, between seven and 13 mon after stent placement, no significant incidents have occurred in four dogs, and all owners report a satisfactory quality of life. Conclusions: Laryngeal silicone stenting is an interesting alternative for treating dogs with acquired laryngeal paralysis when the owners refuse classic arytenoid lateralization surgery. Furthermore, stent placement can be a temporary solution to stabilize these dogs until a permanent surgical treatment can be performed.

Vulnerability of Fishing Communities to Environmental Changes on Lake Lagdo, Cameroon

Yaka Laure-Ephigenie 한국수산과학회 양식분과 2020 한국수산과학회 양식분과 학술대회 Vol.2020 No.7

Vulnerability of fishing communities to environmental changes on Lake Lagdo, Cameroon

Yaka Laure-Ephigenie,Andrew Baio 한국수산과학회 양식분과 2021 한국수산과학회 양식분과 학술대회 Vol.2021 No.4

IFN-γ: A Crucial Player in the Fight Against HBV Infection?

Marine Laure Bettina Hillaire,Philip Lawrence,Brice Lagrange 대한면역학회 2023 Immune Network Vol.23 No.4

About 0.8 million people die because of hepatitis B virus (HBV) infection each year. In around 5% of infected adults, the immune system is ineffective in countering HBV infection, leading to chronic hepatitis B (CHB). CHB is associated with hepatocellular carcinoma, which can lead to patient death. Unfortunately, although current treatments against CHB allow control of HBV infection, they are unable to achieve complete eradication of the virus. Cytokines of the IFN family represent part of the innate immune system and are key players in virus elimination. IFN secretion induces the expression of interferon stimulated genes, producing proteins that have antiviral properties and that are essential to cell-autonomous immunity. IFN-α is commonly used as a therapeutic approach for CHB. In addition, IFN-γ has been identified as the main IFN family member responsible for HBV eradication during acute infection. In this review, we summarize the key evidence gained from cellular or animal models of HBV replication or infection concerning the potential anti-HBV roles of IFN-γ with a particular focus on some IFN-γ-inducible genes.

La Crise Constitutionnelle de l'UE : Les Moyens de S'en Sortir

Basilien, Marie-Laure 이화여자대학교 사회과학연구소 2007 이화-솔본느 누벨 (파리3대학) 학술세미나 : 21세기 아시아와 유럽연합: 한국과 프랑스간 Vol.2007 No.