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Asymmetric Synthesis of 12-epi-PGF₂α by a Palladium-Mediated, Three-Component Coupling Reaction
Larock, Rlchard C.,Lee, Nam Ho 濟州大學校 基礎科學硏究所 1995 基礎科學硏究 Vol.8 No.1
The prostaglandin analogue 12-epi-PGF₂α(2) has been synthesized from optically active cis-4-t-butyldimethylsilyloxy-2-cyclopenten-1-ol(4b) in 4 steps in an overall yield of 21%. An extremely efficient Pb(Ⅱ)-mediated, three-component coupling reaction is employed to obtain the key intermediate 9.
Lee, Nam-Ho,Larock, Richard C. Korean Chemical Society 2002 Bulletin of the Korean Chemical Society Vol.23 No.1
A short synthesis of novel prostanoids, 12-epi-carbacyclins 3 and 24, has been accomplished using palladium chemistry as a key step. The silyl enol ether 10a prepared through organopalladium chemistry has been allowed to react with 1-octen-3-one in the presence of $Pd(OAc)_2$ to give compound 12 in a single step. The unusual chemo- and stereoselective reduction of the ${\alpha},{\beta}$-unsaturated ketone in 12 has been effected with (S)-BINALH. Subsequent desilylation and Wittig reaction have provided the Subsequent desilylation and Wittig reaction have provided the $PGI_2$ analogues 3 and 24.
A Review on the Radioisotopic Methods for Measuring Bacterial Production in Aquatic Environments
Hyun, Jung-Ho,Larock, Paul A. The Korean Society of Oceanography 1996 Journal of the Korean Society of Oceanography Vol.31 No.2
Advantages and disadvantages of four radioisotopic methods, $^{3}H$-thymidine, $^{3}H$-adenine, $^{3}H$-leucine, and $^{35}S$-sulfate, for measuring bacterial production were reviewed. The maior issues discussed in production methods were: (1) whether all the actively growing bacteria take up the radiolabeled (organic) tracers; (2) how each target molecule should be purified (nonspecific labeling); and (3) how important the determination of the precursor pool specific activity is (internal isotope dilution). Since all the radioisotoic methods have their own advantages and disadvantages, careful consideration must be paid in choosing the radioisotope according to the conditions of each environment investigated.
이남호,Lee, Nam Ho,Richard C. Larock Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.8
Efficient syntheses of PGI2 analogue 2a and its epimer 3 have been accomplished. Using aryl iodide 6 as the common intermediate, either radical or palladium-assisted tandem alkene insertion strategies have been employed for construction of the benzoprostacyclin framework.