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Kyungsu Kang,Saet Byoul Lee,Sang Hoon Jung,Kwang Hyun Cha,Woo Dong Park,Young Chang Sohn,Chu Won Nho 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.3
Phytoestrogens are the natural compounds isolated from plants, which are structurally similar to animal estrogen, 17β-estradiol. Tectoridin, a major isoflavone isolated from the rhizome of Belamcanda chinesis. Tectoridin is known as a phytoestrogen, however, the molecular mechanisms underlying its estrogenic effect are remained unclear. In this study we investigated the estrogenic signaling triggered by tectoridin as compared to a famous phytoestrogen, genistein in MCF-7 human breast cancer cells. Tectoridin scarcely binds to ER α as compared to 17β- estradiol and genistein. Despite poor binding to ER α, tectoridin induced potent estrogenic effects, namely recovery of the population of cells in the S-phase after serum starvation, transactivation of the estrogen response element, and induction of MCF-7 cell proliferation. The tectoridininduced estrogenic effect was severely abrogated by treatment with U0126, a specific MEK1/2 inhibitor. Tectoridin promoted phosphorylation of ERK1/2, but did not affect phosphorylation of ER α at Ser118. It also increased cellular accumulation of cAMP, a hallmark of GPR30- mediated estrogen signaling. These data imply that tectoridin exerts its estrogenic effect mainly via the GPR30 and ERK-mediated rapid nongenomic estrogen signaling pathway. This property of tectoridin sets it aside from genistein where it exerts the estrogenic effects via both an ERdependent genomic pathway and a GPR30-dependent nongenomic pathway.
Temperature-Aware Integrated DVFS and Power Gating for Executing Tasks With Runtime Distribution
Kyungsu Kang,Jungsoo Kim,Sungjoo Yoo,Chong-Min Kyung IEEE 2010 IEEE transactions on computer-aided design of inte Vol.29 No.9
<P>At high-operating temperature, chip cooling is crucial due to the exponential temperature dependence of leakage current. However, traditional cooling methods, e.g., power/clock gating applied when a temperature threshold is reached, often cause excessive performance degradation. In this paper, we propose a method for delivering lower energy consumption by integrating the cooling and running in a temperature-aware manner without incurring performance penalty. In order to further reduce the energy consumption, we exploited the runtime distribution of each sub-segment of a task called “bin” in an analytical manner such that time budget for cooling in each bin is allocated in proportion to the probability of the occurrence of the bin. We apply the proposed method to two realistic software programs, H.264 decoder and ray tracing and a benchmark program, equake. The experimental results show that the proposed method yields additional 19.4%-27.2% reduction in energy consumption compared with existing methods.</P>
Kyungsu Ha,Sangchul Lee 한국재난정보학회 2014 한국재난정보학회 논문집 Vol.10 No.2
이 연구에서는 ‘기계경비 112신고 기준’인 감독명령 제2013-1호를 분석하고 정책적 과제를 제시하였다. 이 감독명령은 기계경비업체의 출동대응의무 등 독자적인 범죄예방 능력 확보 와 통계기반 구축을 위해 확인신고를 원칙으로 하고 긴급신고의 대상을 특정하는 선별신고 제도의 시행을 규정하고 있다. 선별신고제도의 목적을 달성하기 위한 정책적 과제로 첫째, 통계기반의 구축을 위한 오경보와 오신고, 비상버튼과 감지신호에 대한 용어의 정립과 기 계경비원을 대체할 적절한 용어의 개발이 필요하다. 둘째, 기계경비업체는 이 감독명령의 112신고 기준을 준수하기 위한 대응체제를 구축하여야 한다. 셋째, 경찰은 선별신고제도의 긴급신고 대상 설정에 대한 재검토가 있어야 한다. 넷째, 이 감독명령을 엄정하게 시행하기 위한 행정규제와 감독의 강화가 요구된다.
A Discussion on the Deep Horizontal Drillhole Disposal Concept of Spent Nuclear Fuel in Korea
Kyungsu Kim,Sung-Hoon Ji 한국방사성폐기물학회 2019 방사성폐기물학회지 Vol.17 No.3
본 논문에서는 최근 새롭게 제안된 심부수평시추공처분 개념을 소개하고, 우리나라 여건에서는 어떻게 적용될 수 있을지에 대하여 고려해 보았다. 이 개념은 방향제어시추기술로 심부수평시추공을 설치하고 고준위방사성폐기물을 처분하는 개념으로, 경제성과 안전성에서 기존의 동굴식 처분개념에 비해 큰 장점을 가지고 있는 것으로 평가된다. 그러나, 아직까지 아이디어 수준이므로 국제사회에서 처분 안전성과 성능을 실증하기까지 시간이 꽤 걸릴 것이고, 규제기관의 지침 개발도 뒷받침되어야 하는 문제가 있다. 우리나라는 국토가 좁고 인구밀도가 높아 NIMBY (Not In My Back Yard) 현상이 강할 수 밖에 없고, 더불어 사용후핵연료 발생량도 적지 않아 매우 어려운 입지여건을 가지고 있다. 이러한 여건에서 연안 육지부보다는 대륙붕의 안정된 환경의 장점을 살려 연안 해저암반을 심부수평시추공처분 개념의 처분영역으로 활용한다면 해당 지역사회의 심리적인 불안감을 획기적으로 완화시킬 수 있고 처분 안전성도 향상시킬 수 있을 것으로 기대한다. 더불어, 중앙집중식심부 동굴처분시설을 건설하는 경우에도 대륙붕을 활용하여 동일한 장점을 살리는 것을 고려해볼 필요가 있다. This technical note introduces a newly-proposed concept of deep horizontal drillhole disposal of spent nuclear fuel, and considers how it can be applied in the Korean environment. This disposal concept, in which high-level radioactive waste is disposed in deep horizontal drillholes installed with directional drilling technique, is expected to have great advantages over the existing deep mined repository concept in economics and safety. Since this concept is still at the idea level, however, it is necessary for worldwide expert groups to demonstrate its safety and performance. In addition, the development of guidelines by the regulatory body should be supported. The Korean circumstances, which include a narrow territory and a high population density, as well as the amount of spent nuclear fuel, make the NIMBY (Not In My Back Yard) phenomenon very strong and the siting conditions difficult. Under these conditions, if the disposal section of deep horizontal drillhole concept can be located at the continental shelf, with a stable environment, rather than in a coastal land area, it is expected to alleviate the psychological anxiety of the local community and stakeholders. Moreover, even when constructing a centralized deep mined repository in the future, it is necessary to consider locating the repository in the continental shelf.
Kyungsu Oh,Seungho Park,Ohmyoung Kwon,Young Ki Choi,Joon Sik Lee 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.6
The proton exchange membrane plays a critical role as an electrolyte for proton transports in the PEMFC. Generally, the membrane, such as Nafion 117, consists of a polytetrafluoroethylene(PTFE) backbone and side-chains terminated with a sulfonate group(SO₃<SUP>-</SUP>).<br/> Operating the fuel cell, the membrane preferentially becomes hydrated by absorbing water. Then the hydrogen atom on the SO₃<SUP>-</SUP> part of the side-chain can detach from its own position and hop to the next SO₃<SUP>-</SUP> site.<br/> The water management is the key to the efficient operation of the fuel cell, since the water content is the one of decisive factors for membrane's lifetime and efficient operations of fuel cells as well.<br/> In this report, we made the molecule based model for hydrated Nafion 117 and simulated for various temperature and monomer numbers. Here, we analyzed the movement of water molecules and determinated the self-diffusion coefficients of water in the Nafion 117 using the mean-square displacement.