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Suggestive Evidence for Linkage of Schizophrenia to Chromosome 8p21-12 in Multiplex Korean Families
EunYoung Cho,YuSang Lee,KyeongSook Choi,YongLee Jang,SeungHee Cho,HyunOk Jeun,JongWon Kim,KyungSue Hong 대한신경정신의학회 2004 PSYCHIATRY INVESTIGATION Vol.1 No.1
Objectives-Chromosome 8p21-12 has been identified as a susceptibility locus for schizophrenia based on several genomewide linkage scans with Caucasian families. The purpose of this study is to investigate the linkage of this locus to schizophrenia in Korean families. Materials and Methods-We recruited ninety-one family members from twenty-seven multiplex schizophrenia families. Fifty-nine of them were affected individuals. Seven microsatellite markers of this region with 3cM intervals were genotyped. Non-parametric linkage analysis was performed by evaluating the levels of allele sharing between the affected relative pairs. Results-In the multi-point analysis, all the points tested within this area showed positive but non-significant non-parametric lod (NPL) scores with the peak occurring between D8S1820 and D8S1769. In the single point analysis, statistically significant allele sharing was observed at D8S1769 (NPL=1.65, p=0.049). Higher levels of NPL scores (the highest single point NPL=1.98, p=0.025) were observed when the same analyses were applied to a subgroup of families in which all of the affected individuals showed auditory hallucination. Conclusions-These findings support the previous evidence from Caucasian families for a locus predisposing to schizophrenia at 8p21-12. Further studies designed to screen positional candidate genes and their SNPs at this locus are warranted, in order to identify the specific causative genetic variation of schizophrenia.
Temperature-Aware Integrated DVFS and Power Gating for Executing Tasks With Runtime Distribution
Kyungsu Kang,Jungsoo Kim,Sungjoo Yoo,Chong-Min Kyung IEEE 2010 IEEE transactions on computer-aided design of inte Vol.29 No.9
<P>At high-operating temperature, chip cooling is crucial due to the exponential temperature dependence of leakage current. However, traditional cooling methods, e.g., power/clock gating applied when a temperature threshold is reached, often cause excessive performance degradation. In this paper, we propose a method for delivering lower energy consumption by integrating the cooling and running in a temperature-aware manner without incurring performance penalty. In order to further reduce the energy consumption, we exploited the runtime distribution of each sub-segment of a task called “bin” in an analytical manner such that time budget for cooling in each bin is allocated in proportion to the probability of the occurrence of the bin. We apply the proposed method to two realistic software programs, H.264 decoder and ray tracing and a benchmark program, equake. The experimental results show that the proposed method yields additional 19.4%-27.2% reduction in energy consumption compared with existing methods.</P>
A Discussion on the Deep Horizontal Drillhole Disposal Concept of Spent Nuclear Fuel in Korea
Kyungsu Kim,Sung-Hoon Ji 한국방사성폐기물학회 2019 방사성폐기물학회지 Vol.17 No.3
본 논문에서는 최근 새롭게 제안된 심부수평시추공처분 개념을 소개하고, 우리나라 여건에서는 어떻게 적용될 수 있을지에 대하여 고려해 보았다. 이 개념은 방향제어시추기술로 심부수평시추공을 설치하고 고준위방사성폐기물을 처분하는 개념으로, 경제성과 안전성에서 기존의 동굴식 처분개념에 비해 큰 장점을 가지고 있는 것으로 평가된다. 그러나, 아직까지 아이디어 수준이므로 국제사회에서 처분 안전성과 성능을 실증하기까지 시간이 꽤 걸릴 것이고, 규제기관의 지침 개발도 뒷받침되어야 하는 문제가 있다. 우리나라는 국토가 좁고 인구밀도가 높아 NIMBY (Not In My Back Yard) 현상이 강할 수 밖에 없고, 더불어 사용후핵연료 발생량도 적지 않아 매우 어려운 입지여건을 가지고 있다. 이러한 여건에서 연안 육지부보다는 대륙붕의 안정된 환경의 장점을 살려 연안 해저암반을 심부수평시추공처분 개념의 처분영역으로 활용한다면 해당 지역사회의 심리적인 불안감을 획기적으로 완화시킬 수 있고 처분 안전성도 향상시킬 수 있을 것으로 기대한다. 더불어, 중앙집중식심부 동굴처분시설을 건설하는 경우에도 대륙붕을 활용하여 동일한 장점을 살리는 것을 고려해볼 필요가 있다. This technical note introduces a newly-proposed concept of deep horizontal drillhole disposal of spent nuclear fuel, and considers how it can be applied in the Korean environment. This disposal concept, in which high-level radioactive waste is disposed in deep horizontal drillholes installed with directional drilling technique, is expected to have great advantages over the existing deep mined repository concept in economics and safety. Since this concept is still at the idea level, however, it is necessary for worldwide expert groups to demonstrate its safety and performance. In addition, the development of guidelines by the regulatory body should be supported. The Korean circumstances, which include a narrow territory and a high population density, as well as the amount of spent nuclear fuel, make the NIMBY (Not In My Back Yard) phenomenon very strong and the siting conditions difficult. Under these conditions, if the disposal section of deep horizontal drillhole concept can be located at the continental shelf, with a stable environment, rather than in a coastal land area, it is expected to alleviate the psychological anxiety of the local community and stakeholders. Moreover, even when constructing a centralized deep mined repository in the future, it is necessary to consider locating the repository in the continental shelf.
Kyungsu Ha,Sangchul Lee 한국재난정보학회 2014 한국재난정보학회 논문집 Vol.10 No.2
이 연구에서는 ‘기계경비 112신고 기준’인 감독명령 제2013-1호를 분석하고 정책적 과제를 제시하였다. 이 감독명령은 기계경비업체의 출동대응의무 등 독자적인 범죄예방 능력 확보 와 통계기반 구축을 위해 확인신고를 원칙으로 하고 긴급신고의 대상을 특정하는 선별신고 제도의 시행을 규정하고 있다. 선별신고제도의 목적을 달성하기 위한 정책적 과제로 첫째, 통계기반의 구축을 위한 오경보와 오신고, 비상버튼과 감지신호에 대한 용어의 정립과 기 계경비원을 대체할 적절한 용어의 개발이 필요하다. 둘째, 기계경비업체는 이 감독명령의 112신고 기준을 준수하기 위한 대응체제를 구축하여야 한다. 셋째, 경찰은 선별신고제도의 긴급신고 대상 설정에 대한 재검토가 있어야 한다. 넷째, 이 감독명령을 엄정하게 시행하기 위한 행정규제와 감독의 강화가 요구된다.