Analysis of KAP1 expression patterns and human endogenous retrovirus Env proteins in ovarian cancer

Kyung‑Yoon Jeon,Eun‑Ji Ko,Young Lim Oh,Hongbae Kim,Wan Kyu Eo,김아리,Han Gyu Sun,Meesun Ock,Ki Hyung Kim,Hee‑Jae Cha 한국유전학회 2020 Genes & Genomics Vol.42 No.10

Background Human endogenous retroviruses (HERVs) constitute around 8% of the human genome and have important roles in human health and disease, including cancers. Previous studies showed that HERV envelope (Env) proteins are highly expressed in cancer tissues and co-related with cancer progression. KAP1 has been reported to play a key role in regulating retrotransposons, including HERV-K, through epigenetic silencing. Objective The relationship between KAP-1 and HERV Envs expressions was analyzed only in tumor cell lines and has not yet been studied in cancer tissues. In this study, we analyzed the expression patterns and relationship between KAP1 and HERV Env proteins in ovarian cancer tissues. Method The expression patterns of KAP-1 and HERV Env proteins, including HERV-K and HERV-R, were analyzed in ovarian cancer tissue microarrays that contained 80 surgical specimens, including normal ovary and malignant ovarian cancers. Results The expression of HERV-R Env and KAP1 proteins is signifcantly higher in ovarian cancer compared with normal ovary tissues. However, the expression of HERV-K Env did not change signifcantly in cancer tissues. The expression patterns of HERV-K Env and HERV-R Env signifcantly increased in early stages of cancer and KAP1 expression was higher in certain stage and types of cancers. However, the expression of HERV-K Env, HERV-R Env, and KAP1 did not change in diferent age groups. The correlation between the expression of KAP1 and HERV-Env, including HERV-K and HERV-R, was not signifcantly correlated. Conclusions The results of this study showed that there was no signifcant correlation between the expression of KAP1 and HERV Env proteins in ovarian cancer tissues, unlike studies with cell lines in vitro. These results suggest that the actual expression of HERV Env proteins in ovarian cancer tissues may be regulated through various complex factors as well as KAP1.

MBTI 성격분석을 통한 체육전공학생과 일반전공학생의 차이점 연구비교

전매희,오경록 한국학교체육학회 2002 한국학교 체육학회지 Vol.12 No.1

본 연구는 체육전공학생과 일반전공학생의 성격 유형적인 차이점과 묵성을 비교하여 어떤 관계가 형성되는 지를 밝히는데 그 목적이 있다. 연구대상은 2001년 현재 경기도에 소재하고 있는 K대학교에 재학중인 대학생을 모집단으로 설정한 후, 집락무선표집법(cluster ramdom sampling)으로 표본을 추출하여 (MBTI)성격유형 검사도구를 사용하여 분석하였으며, 남자 299명(69%), 여자 100명(31%), 총 300명이었다. 이러한 실험과 실험에 따른 분석절차를 통해서 규명된 결론은 아래와 같다. 첫째 체육전공학생과 일반전공학생과의 성격유형의 차이를 경종한 결과 체육전공학생과 일반전공학생과는 성격유형의 차이가 있었다. 구체적으로 체육전공은 ESTJ(외향적 감각형)형이 높고, 일반 전공학생들은 ISTJ(내향성 감각형)형이 높게 나타났다. 둘째 체육전공학생과 일반전공학생과의 선호지표의 차이를 검증한 결과 E-I(외향형, 내향형) 성향은 차이가 있었다. 구체적으로 체육전공학생은 E(외향형)성향이 높고, 일반전공학생들은 I(내향형)성향이 높게 나타났다. 셋째 체육전공학생과 일반전공학생과의 선호지표의 차이를 검증한 결과 S-N(감각형, 직관형) 성향은 차이가 있었다. 구체적으로 체육전공학생은 S(감각형)성향이 높고, 일반전공학생은 N(직관형)성향이 높게 나타났다. 넷째, 체육전공학생과 일반전공학생과의 선호지표의 차이를 점증한 결과 T-F(사고형, 감정형) 성향은 차이가 있었다. 구체적으로 체육전공학생은 T(사고형)성향이 높고, 일만 전공학생은 F(감정형)성향이 높은 것으로 나타났다. The aim of this study is to specify the dissimilarity in character between athletes and non-athletes, and look at the nature of their relationships of personality traits. The population of this study are students from university "K", in the year 2002, located in Kyung-Gi province. After establishing I selected 300 students(31%) from using cluster random sampling method. The final step of the study involves actual analysis using MBTI psychological type indicator. As a result of such a analysis, f come to the following conclusion ; · When I study on the difference of the personality traits between the athletes and non-athletes, I find that there is a personality traits difference between two groups, Concretely, the indicator shows that the athletes can be defined as ESTJ pattern (Extraverted Sensing). · In my study of the preferences between two groups, the difference of the E-I(Extraversion, Intraversion) pattern shows. In a concrete way, the athletes are more consistent with the Extraversion trait, while the general group frequently keep the 1(Introversion) trait. · MBTI results on the difference of the preferences indicate that the difference of(T-F) traits exists. · The athletes are common to the T(thinking) traits, to the contrary, the general students are common to the F(Feeling) Traits. · There is no difference of J-P(Judging, Perceiving) traits between them. · After examining the difference of the preference, I learn to know that the athletes and the general students share the same traits(S-N, I-F, J-P).

공압을 이용한 수중운동체의 수압시뮬레이터 설계 연구

전우선,정원지,김원제,남경원 國立 昌原大學校 産業技術硏究所 2000 産技硏論文集 Vol.14 No.-

HILS(Hardware In Loop Simulation) is an effective means of testing unmanned underwater vehicle under extreme operational conditions and a variety of operational environments. In order to verify the vehicle performance under time-varying pressure conditions, a reliable pressure simulator is vital to an integrated system for the HILS. This paper presents the results of design research for the pressure simulator using pneumatic pressure (nitrogen), a high speed solenoid valve and a PWM control method. The test and evaluation results of the pressure simulator show that the simulator can generate an appropriate level of desired pressure with an average error below 1m depth for time-varying pressure change conditions corresponding to vehicle dynamics. In addition, the levels of overshoot and vibration have been shown to be under the requirements of design specifications.

한국 집배원 유니폼의 개선요소 분석

전경애 東義大學校 生活科學硏究所 2003 生活科學論集 Vol.7 No.-

본 연구는 한국전자통신 연구원에서 주관하는 2002년도 위탁연구과제인 『인간공학기반 집배환경연구』의 일환으로 한국집배원 유니폼의 문제점을 다각도로 고찰하고 분석하였다. 집배원들의 좀 더 나은 작업환경을 위하여 가장 시급하고 당면한 과제인 유니폼의 개선을 통하여 집배원들의 직무만족도를 높이고 집배 업무의 효율성을 높이고자 함이다. This study evaluates the problems with various aspects of Korean mail carrier uniforms. It is sponsored by the <Korean Electronics and Telecommunications Research Institute> as part of a 2002 research project. This research project is ‘A study on mail collection and delivery environment based on ergonomics.' One of the most urgent tasks to create a better work environment is improvement of mail carrier uniforms. Improved uniforms will result in improved job performance and satisfaction.

아프리칸 방염기법을 이용한 섬유디자인 연구

전경애 東義大學校 生活科學硏究所 2001 生活科學論集 Vol.5 No.-

The study consists of combining traditional Resist-Dyeing techniques, which are utilized extensively by the Yoruba people of West Africa, and fabric design created by using these techniques. This approach not only enhances the aesthetic expression of fine textiles but also developes fabric design through another medium and methodology. The goal is explore and exploit combining new materials and designs with ancient tradition, therefore, such an ancient tradition as Yoruba adire cloth could also progress and develop.

林道의 開設效果에 關한 硏究

田璟秀,李種樂,柳澤圭 경희대학교 부설 식량자원개발연구소 1991 硏究論文集 Vol.12 No.-

The objectives of forest management is in a state of equilibrium between economic timber production and the indirect utility of forest. But establishment conditions for forest management is to maintain the poor equilibrium, in korea. In order to accomplish of these objective, forest road is prerequisite. So the purpose of this study is to analyse the economic efficiency on constructed forest road, in CheonBuk province. The results were as follows : 1. As the growing stock is expected to increase in the future, it is suggested that the enlargement of forest road networks and mechanization of forest works should be excellerated in order to retrench a large amount of labor required. 2. The average of density, vertical gradient and curve radius in investigated forest road were 5.61m/ha, 8.13% and 23.8m, respectively. 3. In the constructed forest road, not only forest management but also multiple use are gradually increasing.

부부간 의사소통 유형이 결혼만족도에 미치는 영향

전귀연,구순주,박경란 인제대학교 아동ㆍ가족복지연구소 1998 아동ㆍ가족복지연구 Vol.2 No.-

The purpose of this study was to identify the influence of marital communication style on marital satisfaction. For this purpose, two instruments were administrated to 352 couples who were mothers and fathers of the students attending five middle shcholols in Taegu. The instruments of measurement were Martal Satisfaction Scale and Marital Communication Scale. Factor Analysis. Cronbach' a and multiple regression were conducted for the data analysis. Major findings of this study were as follows: 1) In the case of wives, the style of marital communication influencing on marital satisfaction were rational attitude and reproachful attitude of hushand. 2) In the case of husbands, the style of marital communication influencing on marital satisfaction were rational attitude, concessive attitude, and unconcerned attitude of wife.

체질량지수에 따른 여고생의 영양 섭취에 관한 연구

전재영,김태운,백영호,최문기,이경희 釜山大學校 附設 體育科學硏究所 2006 體育科學硏究所 論文集 Vol.22 No.2

The purpose of this study was to investigate the daily nutrition intake of high school girl students according to the BMI. The subjects of this study were classified into under weight group; UG(<14.9percentile; n=9), normal weight group; NG(15.0~84.9percentile; n=12), and obese group; OG(>85percentile; n=12) by BMI.......

Aerobic Training이 女學生들의 肺機能 및 PWC170에 미치는 影響

全廷祐,金耕知 慶熙大學校 體育科學大學 1990 體育科學論叢 Vol.- No.3

The purpose of this study was to determine one effect of ten week of aerobic training on pulmonary function and physical work capacity The subject all female were collected from the K university The results of the study were as follow ; in the FVC the subjects improved from 3.29 ±0.22ml to 3.46 ±0.18ml after training with 5.2% increase. The subjects also improved from 2.48 ±0.21 to 2.67 ±0.2 in the FEV 1.0, from 5.86 ±0.42 to 6.28 ±0.58 in the PF. However all the values were statistically not significant in the PWC170 by kpm/min the subjects improved from 673.2 ±54 to 691.6 ±49, with 2.73% increase. In the PWC170 by kpm/kg/min the subject improved from 11.75 ±1.11 to 12.34 ±1.26, with 5.02% increase. The subjects also improved from 16.40 ±1.29 to 16.60 ±1.25 in PWC170 expressed by kpm/kg(L.B.M)/min all the values were however statistically no significant.

자가골 이식과 골유착상 임프란트를 이용한 하악골 개선

전주홍,박기광,조경엽,이상대,송정록 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1

Bony defects of mandible caused by trauma, infection, or tumor resection have been reconstructed by autologous bone graftings. These reconstruction can restore facial contour and integrity of the oral cavity. However, it is often necessary to reduce the bulk of bone to allow soft tissue coverage of the graft. Therefore, the construction of removable dentures in this situation is fraught with frustation. The use of osseointegrated implants is a method to allow improved anchorage and support for the successful fabrication of dental protheses. We report two cases of the use of osseointegrated implants of the Branemark type(3i), in conjunction with bone grafting to the lower jaw.