제2형 당뇨병 환자의 치료에서 복약순응도가 혈당 조절에 미치는 영향

김경선,김민정,박소현,박영주,허정순,이은경,김선영,이수형,김상수,강양호,손석만,김인주,김용기 한국병원약사회 2009 병원약사회지 Vol.26 No.2

Abstract: As known in clinical trial like DCCT, UKPDS, tight glycemic control is essential to prevent complications from diabetes mellitus(DM). In type 2 diabetes taking multiple medication, nonadherence to medications is common problem. The aim of our study is to investigate adher-ence rate of patients with type 2 DM and to evaluate association between many factors including adherence rate and HbA_(1C). 441 patients with type 2 DM who visited Busan National University Hospital endocrine internal department from Aug 13 to Sep 2, 2008(3weeks) were enrolled. We conducted a man-to-man questionnaire survey about general knowledge about diabetes mellitus, medicine and adherence, and measured HbA_(1C). Among them, 305 patients taking oral hypo-glycemic agent(OHA) were analyzed to investigate correlation between adherence rate and glycemic control. We studied 305 patients(male 126, female 179, average age 61.2±9.8 years, DM duration 8.6±6.4 years, average adherence 88.8±16.2%, average HbA_(1C) 7.03± 1.18%). HbA_(1C) showed significant relation with DM duration(r=0.137, p=0.017), number of aHA in regimen (r=0.135, p=0.018), dosage frequency(r=0.132, p=0.026), Medication Refill Adherence(MRA)(r=-0.124, p=0.030) and adherence(r=-0.168, p=0.003). Adherence had significant relation with MRA(r=0.148, p=0.010) but didn't have statical corelationship with DM duration, number of aHA and dosage frequency. Patients that their adherence rate exceed 90% took fewer OHA(p=0.011) and went on a better dietary treatment(p=0.007). In patients controlling diabetes mellitus with aHA, when adherence rate and MRA was higher, HbA_(1C) was lower. As a result, to improve adher-ence rate, it is necessary to enhance patient education, do careful consideration about prescrip-tion medicine number and dosage frequency

약물사용 고위험군 선별척도의 표준화 연구(Ⅰ)

김만희(Man-Hee Kim),김경빈(Kyung-Bin Kim),전현민(Hyun-Min Jun) 한국중독정신의학회 1998 중독정신의학 Vol.2 No.1

One of the screening tests used for identifying the high risk group of adolescent drug users is High Risk Group of Adolescent Drug Users Screening Test (HIRIGADUST) developed by Kyung-Bin Kim (1977) that consist of six subscales and 70 items. The Purpose of this study was to examine the reliability and construct validity of HIRIGADUST. HIRIGADUST was administered to 370 third grade middle school students. In the reliability test, the Cronbach’s α coefficients were 0.70-0.89 in five subscales, but the Cronbach’s α coefficient was 0.53 in ‘Personal experience and general environment’ subscale. The resulting of testing the construct validity of five subscales of HIRIGADUST by factor analysis provided evidence for the validity of the each subscales. We used T score 65 as a cut-off point. The cutting scores were 12 for ‘Peer relationships and school performance’ subscale, 14 for ‘Personality and value system’ subscale, 14 for ‘Psychological problems and health concerns’ subscale, 8 for ‘Family history and characteristics of parents’ subscale, and 14 for ‘Conserns about parents’ drinking subscale.

Distribution and Potential Toxicological Effects of 2,2',4,4'-tetrabromodiphenyl Ether (BDE-47) as a Endocrine Disrupting Chemical in Human and Animals

Jung, Eui-Man,Yang, Hyun,An, Beum-Soo,Lee, Geun-Shik,Hyun, Sang-Hwan,Choi, Kyung-Chul,Jeung, Eui-Bae 韓國受精卵移植學會 2011 한국동물생명공학회지 Vol.26 No.4

Polybrominated diphenyl ethers (PBDEs) are a class of "brominated" (bromine containing) man-made chemicals used as flame retardant additives in plastics, foams, and textiles. PBDEs are found in various environmental contaminants in air, soil, sediment, and water, and 209 individual forms (congeners) of PBDE exist. Among these, 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) is the dominant congener found in the environment. Exposure to BDE-47 is now worldwide, and levels of BDE-47 have been detected in the blood of animals, including humans. BDE-47 can adversely affect the developmental system in both humans and animals. BDEs have structural similarities to polychlorinated biphenyls and thyroid hormones. However, recent studies have shown that BDEs may act as hormonal disrupting chemicals with detrimental effects. Therefore, a reliable assessment of BDE-47 toxicological action is required to understand the detrimental impacts of BDE-47 on human health. In this review, we overview recent studies on the distribution and potential toxicological effects of BDE-47 in humans and animals.

포도씨 추출물 섭취가 경계성 고혈압자의 안정 시와 운동 중 심혈관반응과 혈관내피세포기능에 미치는 영향

전승민(Joen, Seung-Min),김경애(Kim, Kyung-Ae),이만균(Lee, Man-Gyoon) 한국체육과학회 2018 한국체육과학회지 Vol.27 No.2

The aim of this study was to investigate the effects of a 2-week ingestion of grape seed extract(300 mg/day) on cardiovascular response and vascular endothelial cell function at rest and during handgrip exercise in prehypertensive individuals. Nine prehypertensive men, aged 24.6±3.1 yrs, repeatedly participated in both grape seed extract trial and placebo trial in a randomized, double-blind, crossover manner. While the subjects ingested grape seed extract or placebo in a 2-week trial, their cardiovascular response, blood vessel diameter, blood flow volume, and vascular endothelial cell function at rest and during handgrip exercise were measured. Each variable was compared between two trials as well as between two tests simultaneously using a repeated two-way ANOVA. Main result of the present study were as follows: 1) Systolic blood pressure decreased significantly at rest after the 2-week ingestion of grape seed extract. 2) Systolic blood pressure and mean blood pressure decreased significantly during handgrip exercise after the 2-week ingestion of grape seed extract. 3) Flow-mediated dilation volume and % flow-mediated dilation increased significantly after the 2-week ingestion of grape seed extract. It was concluded that 2 weeks of ingestion of grape seed extract would have an positive effect on cardiovascular response and vascular endothelial cell function at rest and during handgrip exercise in prehypertensive men. Future research investigating the effects of various period and amount of ingestion of grape seed extract during aerobic exercise including large muscle group would be warranted.

在美 韓國 老人의 健康 및 生活 實態에 關한 硏究

金應翊,朴祥華,韓允愚,徐敬萬 대한보건협회 1992 대한보건연구 Vol.18 No.1

This study was perfomed to figure out the health status and life style of aged population in Korean-Americans living in Los Angeles in the United States. The number of subjects in this study were 283 persons aged 65 and over (male 141. female 142) drawn from Los Angeles Country in U.S.A. The data were collected by trained interviewers from July to August. 1991. The questionaire consisted of 1) general characteristics, 2) health status and medical health services, 3) 24 questions of CMI, and 4) the level of adaptations and difficulties to immigrant society. The results of this study are as followings: 1. In age distribution, 33.2 percent of total subjects was 65-69 age group, and 33.1 percent was 70-75 age group. The average duration of immigration were 7.89 years in male and 10.18 years in female, and percent distribution by duration of migration were 33.3 percent in 1-4 years, 30.5 percent in 5-9 years, 23.7 percent in 10-14 years, and 13.5 percent in 15 years and over. Of total subjects. 84.7 percent had permanent residence and only 13.8 percent had citizenship. In the reason of immigration of the elderly, 76.4 percent of them responded as reason for helping and joining to family, and only 8.5 percent of subjects were economic reason. The educational level of the subjects were generally high. Only 9.0 percent of the subjects recevied no or little education in the modern day education system. Primary graduates were 35.7 percent, middle and high school graduates were 37.8 percent and university(college) and over graduates constituted 16.6 percent. The educational level of the male were generally higher than that of female. A large proportion of the subjects(94.3 percent) responded as having religion, and 67.8 percent were protestant, 16.7 percent were catholic and 7.4 percent were buddhist. In the family structure. 75.6 percent of the elderly lived alone and with their spouses and 22.1 percent live in a family with 2 generation living together. The marital status of male showed that 80.7 percent of them lived with their spouses, 14.3 percent of men were widowed, and only 26.3 percent of female lived with their spouses and 71.5 percent of female were widowed. 2. One out ten of the elderly was presently smoking. Of the smokers, there were 4 times as many male smokers as female smokers. In response to a question about their drinking habits, 82.0 percent of the aged replied that they did not consume alcohol. Those who consumed alcohol 'daily' constituted 3.6 percent, 'frequently' were 4.3 percent 'sometimes' were 7.9 percent and 'scarcely' constituted 2.2 percent. Among the exercises and sports which the elderly were doing for the fitness and preservation of health. A walking was the most popular at 32.1 percent of the population. More rigorous sports such as hiking, jogging, physical cardiovascular exercises and ball games were being enjoyed by only a very few. 37.2 percent of the elderly replied that they did not exercise regularly. In the major pastime of daily life activities. 40.9 percent of the subjects responded 'none', 14.7 percent of them were domestic duty for family, about 10 percent of them were hobby, religion activities, social work and participating in social education program respectively. In the problems and difficulties of immigration, 78.1 percent of them responded 'yes' in the early times of immigration and 30.4 percent in the present time of immigration. Six major problems were identified by respondent. They were, in the rank order of their language; homesickness: transportation; income and economic and custom. 3. Most of the respondents considered themselves healthy. The proportion of the question to their health at the time of study, 36.2 percent in male and 23.2 percent in female replied that they seemed to be 'excellent healthy', 34.7 percent in male and 32.4 percent in female be 'good', and 4.3 percent in male and 2.1 percent in female be 'Very poor'. In considering specific parts of their body as having problems, many of the ederly pointed out the disease of circulatory system(17.7 percent in male and 23.2 percent in female). Comparatively few of the elderly thought that they had something wrong with their musculoskeletal system(5.7 percent in male and 16.1 percent in female), digestive system(9.2 percent in male and 5.6 percent in female) and endocrine and metabolic disease(6.4 percent in made and 9.9 percent in female). Of those elderly who perceived of some problems with their circulatory and musculoskeletal systems, there were more elderly women compared to elderly men. The largest percentage of the elderly(20.7 percent in male and 26.5 percent in female) indicated palsy as the disease they fear most. Thereafter, the order of diseases feared by the elderly was diabets. hypertension, neuralgia, cancer, and dotage. A majority of the elderly, 54.6 percent of men and 44.4 percent of women, replied that they did not visit a medical institution or a pharmacy to treat their diseases during the one month prior to the survey. Of the total survey subjects who did visit a medical facilities, those complaining of circulatory system disease constituted 13.5 percent in male and 14.8 percent in female, and digestive system diseases were 7.8 percent in male and 8.5 percent in female. For the endocrine and metablic disease, disease of nervous and sens organs and musculoskeletal system were all each less than 7 percent of all the study subjects. Of the total elderly, 49.0 percent utilized medical facilities such as hospitals, herbal clincics, pharmacies and others to treat illness within one month prior to the time of survey; the utilization of clinicl and hospital were 86.0 percent, herb clinic were 8.4 percent and pharmacy were 4.2 percent. 34.8 percent of men and 11.3 percent of female did not take a medicine for treatment and promoting nutrition at the time of the survey. 55.4 percent of total elderly used the drug for treatment of diseases, and 16.6 percent for promoting nutrition. 4. Except for group of questions concerning urinary system more women than men generally complained of problems and discomforts in each groups. More elderly suffered from problems associated with musculoskeletal system than any others, and the decreasing order of the groups of problems with which most complaints were indicated are the problems associated with mental condition, urinary system, circulatory system, nervous system, visual and auditory organs, respiratory system and digestive system.

육아종성 균상 식육종

이경신,김영옥,허만하,서기석,김상태 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.5

동통성 안근마비를 나타낸 양측성 자발성 경동맥해면정맥동루 2례

전성만,박경원,차재관,김상호,김재우,최순섭 대한신경과학회 1997 대한신경과학회지 Vol.15 No.5

병기 ⅠB-ⅡB 자궁경부암에서의 CD44v4/5, CD44v6, α-Smooth Muscle Actin과 nm23의 발현

장희경,허만하,김동휘,박은동 대한병리학회 1997 Journal of Pathology and Translational Medicine Vol.31 No.6

창녕 교동 제89호분 출토 금동제 안교장식 : 보존처리와 제작기법 조사

김경희,한만성,안병찬 국립중앙박물관 1999 박물관보존과학 Vol.1 No.-

국립김해박물관 개관전시를 위해 일제시대 창녕 교동 제89호분에서 출토된 금동제안교장식(金銅製鞍橋裝飾 이하 “안교장식”)을 보존처리하였다. 안교장식은 수많은 편으로 파손된 채 다른 유물과 뒤섞여 보관되어 왔다. 보존처리는 유물의 원형을 되찾고 재질을 안정화시키는 점에 두고 과학적인 조사와 처리를 실행하는 한편 유물의 제작기법도 상세히 조사할 수 있었다. 그 결과 안교장식의 두꺼운 부식생성물을 벗기고 파편을 접착하여 원래 모습으로 복원하게 되었고 전시와 관리도 가능하게 조치하였다. 또한 다양한 고대 제작기법이 적용된 안교장식임을 확인할 수 있었다. Conservation treatments were done for the gilt bronze saddle accessory excavated from Tomb No. 89 in Kyo-dong, Changnyong in Japanese rule period. The saddle accessory, broken into numerous pieces, was mixed with other remains. Principal aims of conservation treatments were to recover original shape of object and stabilize its material. In the process of treatments manufacturing technique of the remain was examined minutely. Thick layers of corrosion substances were peeled off and numerous pieces were pasted together to restore the original shape. And then the saddle accessory was mounted on an acrylic board to be handled and exhibited safely. In this process, it was confirmed that various ancient techniques of metalic crafts such as amalgam gilding, riveting, piercing, line engraving, stamping, chasing etc. had been used to make the saddle accessory.

간경변 환자에서 Oro-cecal Transit Time의 측정

원경준,이준,변유미,조민근,조주연,서정균,김영대,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Background: Neurotransmitter like substances in the gut have been proposed to contribute to the overall portal systemic encephalopathy (PSE). The source of the ammonia in patients with PSE is mainly the small bowel, as a result of the conversion of glutamine in the diet to glutamate and ammonia. PSE is highly responsive to changes in diet, to antibiotic therapy and to ingestion of nondigestible disaccharides such as lactulose. This study was performed to evaluate the relationship between PSE and oro-cecal transit time. In addition, performed to evaluate the effect of severity, cause, complications of liver cirrhosis on oro-cecal transit time. Methods: Between August 2006 and February 2007, 48 cirrhotic patients consecutively was enrolled in study their oro-cecal transit time after informed consent was obtained. A non-invasive hydrogen breath test was used to study oro-cecal transit time (OCTT). Result: The OCTT were delayed in cirrhotic patients with PSE compared without PSE (123.3 ± 42.7 min vs 170.0 ± 58.3 min, p<0.05). OCTT tended to prolongate further as the damage in the liver got worse, nevertheless the result was statistically meaningless (p<0.111). Neither presence of ascites or cause of PSE had any influence on gastrointestinal transit. Conclusions: Cirrhotic patients with PSE have more delayed OCTT than without PSE. Further research is needed to find out the relationship between OCTT and severity of liver cirrhosis.