Bloodstream Infections and Clinical Significance of Healthcare-associated Bacteremia: A Multicenter Surveillance Study in Korean Hospitals

Son, Jun Seong,Song, Jae-Hoon,Ko, Kwan Soo,Yeom, Joon Sup,Ki, Hyun Kyun,Kim, Shin-Woo,Chang, Hyun-Ha,Ryu, Seong Yeol,Kim, Yeon-Sook,Jung, Sook-In,Shin, Sang Yop,Oh, Hee Bok,Lee, Yeong Seon,Chung, Doo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.7

<P>Recent changes in healthcare systems have changed the epidemiologic paradigms in many infectious fields including bloodstream infection (BSI). We compared clinical characteristics of community-acquired (CA), hospital-acquired (HA), and healthcare-associated (HCA) BSI. We performed a prospective nationwide multicenter surveillance study from 9 university hospitals in Korea. Total 1,605 blood isolates were collected from 2006 to 2007, and 1,144 isolates were considered true pathogens. HA-BSI accounted for 48.8%, CA-BSI for 33.2%, and HCA-BSI for 18.0%. HA-BSI and HCA-BSI were more likely to have severe comorbidities. <I>Escherichia coli</I> was the most common isolate in CA-BSI (47.1%) and HCA-BSI (27.2%). In contrast, <I>Staphylococcus aureus</I> (15.2%), coagulase-negative <I>Staphylococcus</I> (15.1%) were the common isolates in HA-BSI. The rate of appropriate empiric antimicrobial therapy was the highest in CA-BSI (89.0%) followed by HCA-BSI (76.4%), and HA-BSI (75.0%). The 30-day mortality rate was the highest in HA-BSI (23.0%) followed by HCA-BSI (18.4%), and CA-BSI (10.2%). High Pitt score and inappropriate empirical antibiotic therapy were the independent risk factors for mortality by multivariate analysis. In conclusion, the present data suggest that clinical features, outcome, and microbiologic features of causative pathogens vary by origin of BSI. Especially, HCA-BSI shows unique clinical characteristics, which should be considered a distinct category for more appropriate antibiotic treatment.</P>

Suppression of lung inflammation by the methanol extract of <i>Spilanthes acmella</i> Murray is related to differential regulation of NF-κB and Nrf2

Kim, Kyun Ha,Kim, Eun Jung,Kwun, Min Jung,Lee, Ji Yeon,Bach, Tran The,Eum, Sang Mi,Choi, Jun Yong,Cho, Sayeon,Kim, Sang-Jun,Jeong, Seung-Il,Joo, Myungsoo Elsevier 2018 Journal of Ethnopharmacology Vol.217 No.-

<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P>Although <I>Spilanthes acmella</I> has been used to relieve inflammation, fever, pain, or infection in traditional Asian medicine, experimental evidence supporting these functions is scarce. Here, we examined an anti-inflammatory function and a possible underlying mechanism of <I>S. acmella</I> Murray (SAM).</P> <P><B>Materials and method</B></P> <P>The methanol extract of SAM was fingerprinted by HPLC. C57BL/6 mice were administered with a single intratracheal (i.t.) LPS and 2 h later with a single i.t. SAM. The effect of SAM on lung inflammation was assessed by histology, semi-quantitative RT-PCR, and MPO assay of lung tissue. The effects of SAM on a pro-inflammatory factor NF-κB and an anti-inflammatory factor Nrf2 were analyzed by immunoblotting of nuclear proteins and by semi-quantitative RT-PCR analysis of mRNA of the genes governed by these transcription factors. V5-Nrf2 was precipitated by an anti-V5 antibody and the ubiquitinated V5-Nrf2 was revealed by immunoblotting of HA-tagged ubiquitin.</P> <P><B>Results</B></P> <P>The i.t. SAM robustly diminished a neutrophilic lung inflammation induced by i.t. LPS treatment of mice. In RAW 264.7 cells, SAM suppressed the nuclear localization of NF-κB and the expression of NF-κB-dependent cytokine genes. SAM increased the level of Nrf2 in the nucleus and the expression of Nrf2-dependent genes while suppressing ubiquitination of Nrf2.</P> <P><B>Conclusion</B></P> <P>Our results suggest that SAM can suppress a neutrophilic inflammation in mouse lungs, which is associated with suppressed NF-κB and activated Nrf2. Our results provide experimental evidence supporting the anti-inflammatory function of <I>S. acmella</I>.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

이해관계자중심 경영패러다임의 실천을 위한 전략적 인적자원관리 시스템 모형 탐색 연구

하상균(Ha, Sang-Kyun),박용승(Park, Young-Sung) 한국경영교육학회 2020 경영교육연구 Vol.35 No.5

[연구목적] 본 연구의 목적은 이해관계자중심 경영패러다임의 실천 위한 인적자원관리 시스템의 이론적 모형을 정립하는 것이다. 이를 위해 본 연구에서는 새로운 이해관계자 중심 경영패러다임의 경영 원리를 전략적으로 지원하는 인적자원관리 시스템 모형의 도입 필요성과 전략적 운영 기조 그리고 주요 구성요소를 설명한다. 주주중심 경영패러다임에서 이해관계자중심 경영패러다임으로의 전환을 실질적으로 이루어내기 위해 종업원들의 태도와 가치체계의 변화 그리고 그 제도를 실천할 종업원의 역량이 개발되도록 하고, 패러다임의 전환이 상징적 구호와 레토릭으로 전락하지 않도록 하는 새로운 전략적 인적자원관리의 이론적 모형을 제시한다. [연구방법] 이해관계자중심전략경영, 전략적 인적자원관리, 지속가능 경영 및 깨어있는 자본주의, 학습조직, 시스템이론 등 기업경영의 새로운 패러다임에 관한 광범위한 문헌연구를 수행하고 이를 종합하는 탐색적 수준의 질적 연구를 통해 이해관계자 중심 경영패러다임 실천에 기여하는 새로운 전략적 인적자원관리 시스템 모형을 도출한다. [연구결과] 본 연구에서는 이해관계자중심 경영패러다임을 조직에 내재화하여 실천에 기여하는 생태적 인적자원관리 시스템(Eco-HRM System)을 제안한다. 주주중심 경영패러다임의 가치와 원리에 갇혀 있는 전략적 인적자원관리 시스템의 한계를 넘어 이해관계자 중심 경영패러다임을 전략적으로 지원하는 인적자원관리 시스템의 비전과 실천모형을 제시하였다. [연구의 시사점] 이론적 시사점은 기존연구에서는 거의 논의가 없었던 이해관계자중심 경영패러다임 실천에 기여하는 인적자원관리시스템(Eco-HRM System)의 이론적 모형을 제안하였다는 점이다. 또한 실무적으로는 새로운 이해관계자 경영패러다임의 현장 실천을 위한 인적자원관리 시스템의 재설계를 위한 아이디어를 제공한다는 점이다. [Purpose] The purpose of this paper is to explore a Conceptual Model of Eco-HRM System. For this purpose, this paper is to explain a new human resource management system model that strategically supports the stakeholder-centered management paradigm. In order to change from a shareholder-centered management paradigm to a stakeholder-centered management paradigm, the attitudes of employees in the enterprise must change. [Methodology] This paper carried out extensive literature research on the new paradigm of corporate management, including stakeholder-centered strategic management, strategic human resource management, sustainable management and conscious capitalism, learning organization and system theory. And this study was conducted on qualitative methodology this paper proposes a new strategic human resource management system model that contributes to the practice of stakeholder -centered management paradigm. [Findings] In this study, we propose an Eco-HRM system that contributes to the practice of the stakeholder-centered management paradigm. The Eco-HRM system is an evolutionary model that complements the limitations of strategic human resource management system. [Implications] Theoretical implications are that the conceptual model of the Eco-HRM System, which contributes to the implementation of the stakeholder-centered management paradigm. The practical implications are that it provides ideas for redesigning the human resource management system.

Toxic Goiter 환자에서 골다공증 발생에 따른 대퇴골 간부 골절 : 1례 보고 A Case Report

김태균,송하현 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1

In thyroid problems, thyroid acropachy that having clubbing fingers on distal phalanges, periosteonic new bone formation, swelling of soft tissues in bony changes can be developed, exopthalmos and pretibial myxedema is a part of this syndrome, in addition, osteoporosis can be accompanied in maltreated hyperthyroidism. It was happened fracture of femur shaft in a 30year-old man treated under the diagnosis of toxic goiter. He has severe osteoporosis but no clubbing finger and soft tissue swelling. The femur fracture treated by closed reduction and internal fixation with metal nail. We report one case of femur fracture due to osteoporosis developed from the toxic goiter with a review of the literature.

XBC(XML Based Catalog)의 설계에 관한 연구

김하균 한국정보시스템학회 2004 情報시스템硏究 Vol.13 No.1

In the catalogs that have presently been under research, the product information cannot be represented in a classified form but it also fails to be well defined, lacking the description of detail information for various products on a systematic fashion. And the product information is duplicated on its representation. In this study, an implementing model is to be proposed to analyze and classify the information that can be in use of describing various products, and to describe an integrated products information for various types of products while making up for the weak points of presently available researches. Also, this study shows that it is possible for the proposed model to represent various units of product information with presently proposed model applied to computers and book products in high demand of transaction, and by implementing electronic catalogues in the existing researches to prove its efficiency.

공무원 사이버 교육효과에 미치는 영향요인 탐색연구 : 지방공무원을 중심으로 Focusing on Local officials

김하균,박명주,장창진 한국정보시스템학회 2004 情報시스템硏究 Vol.13 No.1

Along with the advance of information technology and the introduction of the information era, cyber education through the internet has been activated in universities and private educational organization. However, most cyber education is not being practically applied in government employ. This study looks at the influential factors of cyber education in order to create a cyberspace where the public official can obtain information at a place and time convenient to them. This will provide a chance to activate cyber education effectively. The hypothesis was approved through multiple regression analysis was executed in order to explain and predict the relationship between influential factors and cyber education effects. The results of the study show the influential factors of education effect as follows: the instruction design and contents factors such as interesting educational contents, interaction between learners and teacher, and positive instruction, all had an important influence. the learner factors, such as a desire to learn, motivation, and interest in the lesson, also had a significant influence. the environmental factors such as systematical basis and support, atmosphere, and consideration of others had a large effect on the education effect.

한국인 신생아 황달과 UGT1A1 유전자의 2056G>C 단일염기다형성에 관한 연구

하상균 외 중앙대학교 의과대학 의학연구소 2006 中央醫大誌 Vol.31 No.1·2·3

The incidence of neonatal hyperbilirubinemia is twice as high in East Asians as in Caucasians. Although it has not been clearly defined, the UDP-glucuronosyltransferase gene (UGT1A1) mutation was found to be a risk factor of neonatal hyperbilirubinemia. We studied whether neonatal hyperbilirubinemia is associated with the 2056G>C (rs8330) polymorphism of the UGT1A1 gene. The genomic DNA was isolated from 80 Korean full term neonates who had greater than a 12 mg/dl level of serum bilirubin with no obvious cause, and also isolated from 164 Korean neonates of the control population. We studied a single nucleotide polymorphism (SNP) of 2056G>C in the untranslated region of the UGT1A1 gene by direct sequencing. Three of the 80 neonates with a serum bilirubin level above 12 mg/dl had homozygous mutations and 10 of the 80 neonates had heterozygous mutation. Thirteen of the 164 neonates of the control group had homozygous mutation and 16 neonates of the control group had heterozygous mutation. The allele frequency of 2056G>C polymorphism of UGT1A1 in the hyperbilirubinemia group was 0.1, which was not significantly different from 0.128 in the control group. In this study, our results indicated that this SNP is not associated to the hyperbilirubinemia in Korean neonates.

절삭공구 팁의 TiCN코팅 특성

황경층,윤종호,최재하,김성청 충북대학교 산업과학기술연구소 2002 산업과학기술연구 논문집 Vol.16 No.2

As the machine tool industry progresses, the performance of cutting tools also needs to be of good quality and specialized. If the existing metal cutting tool tip is coated properly, its life would be longer and the machining of a difficult-to-cut material also could be possible. For the development of the high quality cutting tool, the applicabilities of TiCN coating deposited by PVD on the cutting insert were experimentally investigated. The various analyses such as SEM micrograph, XRD pattern, AFM surface morphology, and hardness were performed to cross-check the possibility and availability of TiCN coated tool in the field.

當歸類가 혈관신생에 미치는 영향에 대한 비교연구

吳霞植,金亨煥,安德均,崔湖榮 대한본초학회 2001 大韓本草學會誌 Vol.16 No.2

A rat sponge implant model was used to examine the angiogenic effect of water extract of Angelica Gigantis Radix (EAG). Angelica Sinensis Radix (EAS) and Angelica Radix (EAA). It was based on subcutaneous implantation of sterile polyester sponges in the Sprague Dawley (SD) rat and we have characterized a dye method that incorporates 5% carmine red in 10% gelatin. Vascularity index (V.I.) expressed as ㎍ dye/㎎ dry tissue. The result of study is as follows; 1. Subcutaneous implantation of sterile polyester sponges in SD rats enhanced the angiogenesis over 14 days, as determined by measurements of relative angiogenic effects by a vascularity index. 2. Daily oral administration (100 ㎎/㎏ for 14 days) of EAS and EAA produced weak effect on sponge-induced angiogenesis but EAG caused intense neovasculalization. 3. PBS (50 μ1) and EAG (100 ㎎/㎏) - induced angiogenesis represents a special form of angiogenesis. 4. The vasoconstrictor peptidem, angiotensin Ⅱ(AⅡ), in daily doses of 100 nmol, caused an intense neovascularization and coadministration of the AⅡ (100 nmol) and EAG (100 ㎎/㎏), AⅡ and EAS (100 ㎎/㎏) and AⅡ and EAA (100 ㎎/㎏) produced angiogenic effect. Especially, AⅡ (100 nmol) and EAG (100 ㎎/㎏) caused very potent angiogenesis. We have shown that oral administration of EAG (100 ㎎/㎏) induced angiogenesis. Thus the sponge model offers a new means for continuous and reproducible studies on the controlling mechanisms of angiogenesis.

신이식환자에서 Thiopurine Methyltransferase의 활성이 Azathioprine 치료에 미치는 영향

조주연,배균섭,유경상,이소영,장인진,신상구,김상준,하종원,안규리 大韓臨床藥理學會 2000 臨床藥理學會誌 Vol.8 No.1