알코올중독 환자의 예후 예측에 관한 연구(Ⅱ) : 가족력 및 DRD₂와의 관계를 중심으로

성상경,차성조,이규항,이정균 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

알코올중독 환자의 예후인자를 알아보기 위해 나이와 성별을 통제하여 음주군과 단주군 남자환자 각각 30명을 대상으로 비교 연구하였다. 양군간의 인구통계학적 특성, 음주력, 가족력, 자아강도 등의 차이 및 도파민 D2수용체 유전자 분포를 비교하였으며, 질병경과, 가족력 및 도파민 D2수용체 유전자와의 관련성을 알아보았다. 그 결과는 다음과 같다. 1) 단주군은 음주군에 비해 기혼율이 높았으며, 높은 경제상태, 높은 학력 등이 중요한 요소였으나 직업의 종류 및 종교에 있어서는 차이가 없었다. 2) 단주군은 음주군에 비해 과거 음주력상 최대 단주기간이 길었으나 평균 음주량이 더 많았다. 또한 음주군은 단주군에 비해 사회경제적 스트레스 및 정신적 불안정이 주된 음주 이유인 경우가 많았으나 음주기간, 음주양상, 음주시기, 음주시작 연령, 술의 종류에 있어서는 차이가 없었다. 3) 알코올중독의 가족력에 따른 비교에서 단주군과 음주군 사이에 유의한 차이는 없었다. 4) 단주군은 음주군에 비해 자아강도의 평균점수가 더 높았다. 5) 도파민 D2수용체 유전자의 A1 대립유전자 비교에서 단주군에서 A1 대립유전자의 이환율은 70%, 음주군에서는 60%였다. A1 대립유전자의 빈도는 각각 0.38과 0.42로 양군간에 차이는 없었다. 6) 알코올중독 가족력에 따른 도파민 D2 수용체 유전자분포 비교에서 가족력이 있는 군에 A1 대립유전자의 이환율은 70%, 빈도는 0.43이었고, 가족력이 없는 군에서는 이환율이 61%, 빈도는 0.38로 양군간에 유의한 차이는 없었다. 가족력이 있는 경우에 음주시작의 연령이 더 낮았으며 문제음주도 보다 일찍 나타났다. 그러나 평균 음주기간은 가족력이 없는 경우에 더 길었으며, 평균 음주량, 최고 단주기간 및 NAST 비교에서는 차이가 없었다. 결론적으로 알코올중독 환자의 긍정적 예후인자로 기혼, 높은 학력 및 경제상태, 과거 음주력상 보다 긴 단주 기간 및 강한 자아강도를 들 수 있었다. 반면에 직업, 종교, 알코올중독 가족력 유무, 음주기간, 음주양상, 음주시작 연령, 술의 종류 및 도파민 D2수용체 유전자 A1 대립유전자 분포 등에서는 알코올중독의 예후의 의미 있는 상관관계가 없었다. Objectives : The purpose of the study was to identify the prognosis-predicting indicators is alcoholics by the correlation between prognosis and demographic characteristics, ego strength, family history and distribution of dopamine D2 receptor gene A1 allele. Methods : The subjects were composed of 60 alcoholics including 30 psychiatric inpatients(drinking group) and 30 alcoholics abstinent for 6 months or more after discharge(abstinent group). They were investigated with interview, questionnaire, blood sample and review of their charts. Results : The results were as follows ; 1) The abstinent group had higher rate of married state, higher economic status and longer education years than the drinking group. There were no differences in occupation and religion between the two groups. 2) There were no differences between the abstinent group and drinking group according to alcoholic family history. 3) The abstinent group had higher mean score in ego strength scale than the drinking group. 4) In comparision of dopamine D2 receptor gene A1 allele, the prevalence of A1 allele was seventy percent and the frequency was 0.38 in the abstinent group. The prevalence of A1 allele was sixty percent and the frequency was 0.42 in the drinking group. Both groups were not significantly different in A1 allele prevalence and frequency. 5) In comparision of dopamine D2 receptor gene A1 allele according to alcoholic family history, the prevalence of A1 allele was seventy percent and the frequency was 0.43 in the family history positive group. The prevalence of A1 allele was sixty-one percent and the frequency was 0.38 in the family history negative group. Both groups were not significantly different in A1 allele prevalence and frequency. Conclusions : With the above results, the authors think that successful prognostic indicators of alcoholics are married state, higher economic status, longer education years, longer abstinenence period in past history, and strong ego strength. But family history and distribution of dopamine D2 receptor A1 allele were not significantly related to the prognositc indicators of alcoholics.

세 종류의 측두엽 간질증후군 ; 내측두엽, 전외측두엽 및 후외측두엽 간질의 임상양상 및 전기생리학적 특징

이상건,김주용,김병건,이광우,노재규,명호진 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

유연구조물의 진동제어를 위한 압전작동기의 응용

성윤경,이규태 朝鮮大學校 機械技術硏究所 2004 機械技術硏究 Vol.7 No.1

The paper presents the modeling and optimal control for the reduction of transverse vibration of simply supported beam under a moving mass. The equations of motion are derived by using assumed mode method. The coriolis and centripetal accelerations are accommodated in the equations of motion to account for the dynamic effect of the traveling mass. In order to reduce the transverse vibration of the beam, an optimal controller with full state feedback is designed based on the linearized equations of motion. The optimal actuator locations are determined with the evaluation of an optimal cost functional defined by the worst initial condition with the trade-off of controlled mode performance. Numerical simulations are performed with respect to various velocities and different traveling masses. Even if the velocity of the traveling mass reaches to the critical speed which can cause the resonance of the beam, the controller with two piezoelectric actuators shows the excellent performance under severe time-varying disturbances of the system.

법랑아세포종의 임상병리학적 연구

성일용,류성호,신상훈,김욱규,김종렬,정인교,변기정 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.1

The authors analyzed retrospectively the 60 patients with ameloblastoma who were treated at Department of Oral and Maxillofacial Surgery, Pusan National University Hospital from MArch, 1990 to December, 1995. The results obtained were as follows: There were 26 males (43.3%) and 34 females (56.7%). The peak age of patients was the third decade (41.7%). The majority of cases occurred in the mandible 93.3%, especially in the angle region (91.1%). Eighteen of 60 patients (30.0%) were associated with an impacted tooth, by impacted 3rd molar teeth (16.6%), molar (10.0%), and premolar and canine (3.4%) in order., Fifteen of 60 patients (25%) were associated with an odontogenic cyst, by dentigenous cyst(13.3%), odontogenic keratocyst(8.4%), and radicular cyst(3.3%) in order. Radiographically, there were 32 unilocular types(54.2%) with average age of 24.9±10.8 years, 14 multilocular types(23.7%) with average age of 35.7±17.7 and 13 mixed types(22.0%) with average age of 41.4±15.8. Histopathologically, there were 42 follicular types(70.0%) with average age of 33.7±15.1 years and 18 plexiform types(30.0%) with average age of 26±14.6. Conservertive treatment was performed in the 33 patients(55.0%) and their average age was 25.2±13.9 years and radical treatment in the 27 patients(45.0%) and their average age was 39.3±41.8. Overall recurrence rate was 10%. A consistent correlation between the age of the patient and the radiographic or histologic type of mandibular ameloblastoma was observed. There was a tendency for ameloblastomas of the follicular type to show a multilocular or mixed appearance and for those of the plexiform type to show a unilocular appearance.

분자유전학적방법에 의해 확진된 Leber씨 유전성 시신경병증 2예

김응규,김종환,김상진,예종수,김성은,허경,원인건,황정민 대한신경과학회 1998 대한신경과학회지 Vol.16 No.1

트랙터의 로터리 驅動을 위한 PTO 시스템과 油壓驅動 시스템의 性能 試驗에 關한 硏究

成始興,崔圭洪 建國大學校 附設 自然科學硏究所 1993 建國自然科學硏究誌 Vol.4 No.-

엔진 회전속도 변동에 따른 PTO 회전수, PTO 토크, PTO 출력 및 연료 소비율을 측정하여 기계식과 유압식의 동력 특성을 비교, 분석한 결과는 다음과 같다. 1) 기계식, 유압식 모두 엔진의 회전 속도가 증가할수록 PTO 회전수는 증가하는 경향으로 나타났으며, 기계식이 변속단수 변동에 따른 엔진의 회전속도 폭이 안정적으로 나타난 대 반하여 유압식은 다소 크게 나타났다. 2) 엔진의 회전속도가 증가할수록 기계식, 유압식의 토크는 반비례 관계로 나타났다. 3) 최대 출력은 기계식의 경우 PTO 1, 2, 3단 순으로 나타난 데 비하여 유압식은 PTO 3, 2, 1단 순으로 나타나 PTO 변속 단수가 증가될수록 출력도 증가하는 것으로 나타났다. 4) 연료 소비율은 기계식, 유압식 모두 엔진의 회전수가 증가됨에 따라 연료 소비율은 어느 일정한 회전수 부근에서 최소가 된 후 다시 증가하는 경향으로 나타났다. 5) 유압구동 로터리의 효과적인 이용을 위해서는 유압펌프가 항상 고속으로 회전할 수 있도록 로터리는 어느 일정 회전속도를 유지시켜 작업하는 것이 필요할 것으로 판단되었다. 6) 유압식의 경우 유압펌프의 회전속도가 증가함에 따라 출력 및 연료 소비율이 향상되는 성으로 나타나 기계식에 비하여 효율이 크게 뒤떨어지지 않아 실용화의 가능성이 큰 것으로 생각되었다. The speed of revolution, the PTO torque, the PTO output power, and the specific fuel consumption caused by the variation in the revolution of an engine speed were measured. Therefore, the overall dynamic performance of the hydraulic PTO system was compared and analyzed with that of mechanical PTO system. The results are summarized as follows : 1) Both RPM of the hydraulic PTO and that of the mechanical one increased linearly as the engine speed increased. The engine speed from the variation of a mechanical type was saftly and small changed, but that of a hydraulic type was high changed. 2) Both torques of the hydraulic PTO system and those of the mechanical one decreased linearly as the engine speed increased. 3) The maximum power of the mechanical PTO system was the highest at the first gear of the mechanical one followed by the second one and the third one. However, that of the hydraulic PTO system was at the third gear followed by the second one and the first one. It means that the output power of a hydraulic PTO system increased as the variable PTO gear was increased. 4) After the specific fuel consumption decreased gradually to the specific point, which was required the lowest fuel consumption, then it increased as the engine speed increased. 5) To utilize effectively the hydraulic drive system, this system needs always to be kept revoluting constantly at an engine speed for hydraulic pump to rotate at the high speed. 6) The output power and the specific fuel consumption were improved by using the hydraulic system as the revolution of the engine speed was increased. The performance of hydraulic system was not significant of that of mechanical system. Therefore a hydraulic PTO system, which is convenient for a machine attached it to control automatically, would be utilized in future.

비글개에서 신원방우황청심원의 급성 및 아급성독성시험

성하정,권오경,방명주,곽형일,이진영,신대희,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of New wonbangwoohwangchungsimwon (NSCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs (3 males and 3 females) in acute experiments were administered orally with sinlge dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NSCH, 160 ㎎/㎏/day (low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NSCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NSCH in beagle dogs is considered to be safe.

골반통증을 동반한 폐쇄신경 기원의 퇴행성 신경초종

이상욱,김두상,조현득,이창호,전윤수,이남규 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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韓國的 家族福祉의 方向 : 保護扶養機能을 中心으로 한 詩論 With Specific Regard to the Family Welfare Function

成圭鐸 연세대학교 신과대학 1987 신학논단 Vol.17 No.-

여성 알코올 의존 환자의 임상적 특성에 관한 연구 : - 일 정신병원 입원환자를 중심으로 -

성상경,신동환,송종호,이규항 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 남. 여 알코올의존 환자의 인구통계학적 특성, 음주력, 가족력, 음주양상, 음주동기, 공유질병 등을 포함하는 임상적 특성의 차이 및 여성 알코올의존에 대한 질병양상과 그 가족의 태도를 파악함으로써 향후 여성 알코올의존 환자의 치료 대책수립을 위한 기초자료를 제공하는데 그 목적이 있다. 방 법: 1991년 1월1일부터 1996년 5월31일까지 일 정신병원에 입원 치료한 남. 여 각각 51명의 알코올의존 환자를 연구대상으로 하였으며, 연구방법으로 병력기록지 및 설문지 조사를 통한 자료 수집을 이용하였다. 양군간의 비교를 위해 남. 여 인원 및 나이를 통제하였고, 여성 알코올의존자의 평균 연령은 44.45±11.02세였고 남성 환자군의 평균 연령은 44.17±10.08이었다. 진단은 DSM-Ⅲ-R에 의해 이루어졌으며 대상자 모두는 알코올 의존의 진단기준을 만족하였다. 결 과: 여성 알코올의존자는 남성 알코올의존자에 비해 음주시작 연령이 늦었고 과거 음주기간은 짧았으며 일 음주량이 적었다. 그리고 여성 알코올의존자는 남성 알코올의존자에 비해 자발적 입원이 많았으며 입원후 금단증상, 알코올성 간염, 당뇨등 신체적 합병증이 적었다. 또한, 입원후 가족의 태도에서 가족의 이혼위협 등 치료에 비협조적인 경우가 남성 알코올의존자에 비해 많았으며, 과거력상 사별, 이혼, 남편의 구타 등 상실의 경험이 많았다. 결 론: 남. 여 알코올의존자간에 인구통계학적 특성, 임상 특성, 가족의 태도 등 여러가지 면에서 차이가 나는 것으로 나타났다. 여성 알코올의존자 집단은 가족의 죽음, 부부생활의 갈등과 같은 심리 사회적 좌절 경험이 더 많고 가족들이 더 비협조적이었다. 그러므로 치료자는 이러한 여성알코올의존자의 특성을 치료와 예방에 반영하고 이들에 대한 세심한 배려를 해야할 것이다. Objectives: This study aimed to provide a basic data of female alcoholics by understanding the gender differences of the clinical characteristics including demographic characteristics, alcoholic history, family history, drinking patterns, reasons for drinking, and comorbidity in male and female alcoholics. It also ained to establish the therapeutic plans through understanding the patterns of disease and the patterns of family cooperation in female alcoholics. Methods: The study subjects consisted of 51 male and female alcoholics admitted to a mental hospital from January 1, 1991 to May 31, 1996. Subjects were age-and sex-matched. We reviewed patients charts and administered questionaires. Mean age of female alcoholics was 44.45±11.02 years and that of male alcoholics was 44.17±10.08 years. All male and female patients met with the DSM-Ⅲ-R criteria of alcohol dependence. Results: Female alcoholics were later in drinking-onset age, and to had shorter duration of previous drinking history and less average amount of daily drinking than male alcoholics. And female alcoholics were found to seek treatment more voluntarily, and to have less frequent delirium tremens after admission and less medical complications such as hepatitis and diabetes mellitus. Also female alcoholics had more frustration experiences of separation such as death of family member, divorce, and husband`s physical abuse. Female alcoholic`s families had more uncooperative attitude toward treatment such as threat to divorce after admission. Conclusions: There were many differences between male and female alcoholics of demographic characteristics, clinical characteristics, and patterns of family cooperation. Female alcoholics were found to have more experiences of psychosocial frustration including death of family member and marital conflicts, and more uncooperative attitude of her family members. Therefore, it is required that therapists consider the characteristics of female alcoholics upon treatment and prevention, and have more concern about female alcoholics.