폐슬러지 감량화 및 재활용을 위한 오존 처리시 하수슬러지내의 미생물 군집구조의 변화

홍준석,임병란,안규홍,맹승규 대한상하수도학회 2004 상하수도학회지 Vol.18 No.1

The change of the microbial community structure in excess sludge of different sewage treatment plants by ozone treatment was investigated by quinone profiles. The resulting ozone dosage ranged from 0.1 to 0.4 gO₃/gTS. In terms of overall sludge reduction, more than 50% reduction of the total sludge mass could be achieved by ozone treatment at 0.4 gO₃/gTS. Quinone concentration and type in sludge of different treatment plants were remarkably decreases with increasing ozone dose. Ubiquinones(UQs)-8, -10 and MK-8 were still remained in the ozonized sludge at 0.4 gO₃/gTS. The results of this study showed that the remaining microorganisms belong to UQs-8, -10 and MK-8 were difficult to destruct cell membrane or wall by ozonation. Fecal Streptococci and Salmonella were not detected at ozone dose of 0.2 gO₃/gTS, but Fecal Colifom was not detected at ozone dose of 0.4 gO₃/gTS.

하수 2차 처리수 재이용을 위한 저압 및 중압 고도산화시스템의 성능평가

안규홍,안석,맹승규,김기팔,홍준석,정민우,권지향,Ahmed, Zubair 대한상하수도학회 2003 상하수도학회지 Vol.17 No.4

In the present study, the feasibility of UV/H₂O₂ systems was investigated using low and medium-pres sure lamps on biologically treated wastewater effluents for secondary effluent reclamation. Two types of UV lamps were used as the light sources (a 33W lowpressure mercury lamp and a 350-W mediumpressure mercury lamp). The results from these UV systems showed that the removal of organic compounds could be achieved in the contact time of longer than 30min (i.e., low UV doses). Efficiencies of color removal and disinfection were far better than those of organic matters measured as TOC, DOC and TCOD_(cr). In the low pressure lamp UV system, it has been found that DOC and color removals were 60.9 and 86.2% with 50㎎/L of H₂O₂ and contact times of 30 minute, respectively. Whereas, with the mediumpressure lamp UV system, TOC, DOC and color removal were 27.1, 5.6 and 95% with 14.3㎎/L of H₂O₂ and 14 minute of contact times, respectively. Both systems could be applied for the reclamation of secondary effluent treated with biological treatment processes.

위발성 위장관 악성림프종 환자에서 항암치료의 효과

김찬규,신영록,김현정,배상병,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Purpose: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin's lymphoma (NHL), which is increasing in incidence, but there is no established optimal treatment modality. Thus, this study was investigated the clinicohistologic feature, the therapeutic modalities, and the prognosis for GI-NHL, as well as the factors affecting it. Methods: We retrospectively analyzed 45 patients who had been diagnosed as having GI-NHL and had been followed up from July 1994 to February 2005 at Soonchunhyang University Hospital. The patients were divided into groups according to the site of origin and to various other features, and the survivals of the various groups were compared. The modified Ann Arbor system and WHO classification were adopted for staging and histopathologic classification, respectively. Results: GI-NHL of the stomach, small bowel, ileocecal region, and colon occurred in 28 patients (62.2%), 5 patients (11.1%), 3 patients (6.7%), and 8 patients (17.8%), respectively, In one patient, the entire gastrointestinal tract was diffusely involved. The median age of patients was b5 years (25~78 years), and male-to-female ratio was 1:1.1. Fourteen patients were in stage Ⅰ, 24 in stage Ⅱ, 4 in stage Ⅲ, and 3 in stage Ⅳ. Surgical resection was performed in 19 patients, and combination chemotherapy was performed in 43 patients. Surgical resection only was performed in 4 patients, Chemotherapy only was performed in 26 patients. The expected overall 5 year survival of 45 patients was 39.6%, and there was a significant survival difference between the stages, but between sites of origin (p=0.842). The most important factors influencing the survival was the stage and other factors were not significant. Conclusion: The stomach was the most common site of GI-NHL. Most GI-NHL were localized Stage was the most important prognostic factor. However, Prospective randomized studies are needed to approve the therapeutic modality.

전통 사상 및 교육 방법의 현대 도덕 교육과정에서의 활용 가능성 연구

함규진 ( Kyu-jin Ham ),신창호 ( Chang Ho Shin ),임홍태 ( Hong Tae Lim ),지준호 ( Chun-ho Chi ) 한국철학사연구회 2016 한국 철학논집 Vol.0 No.50

도덕은 하나의 철학적, 심리적 상념으로서도 존재하지만, 실천으로 이어져야만 비로소 도덕으로서 역할을 할 수 있게 된다. 기본적으로 도덕이란 타자가 자신과 공존할 때, 그 타자와의 관계에서 좋음(goodness) 또는 옳음(righteousness)을 추구하는 것이기 때문이다. 그런 도덕이란 대부분 본능적으로 체득할 수 없기에 도덕교육이 있게 되는데, 한국인의 경우 서구와 다른 도덕적 전통을 갖고 있으며 따라서 서구적 도덕교육으로 충분하지 않거나, 전통적 도덕교육을 활용함으로써 더 나은 교육이 이루어질 수 있는 가능성을 찾을 수 있다. 그런 견지에서 전통의 실천적 의미를 재해석하고 활용하는 일은 한편의 논문으로는 너무 방대한 과제이다. 그래서 이 글에서는 비교와 범주화, 그리고 활용의 편의를 위해 전통을 ‘근세 유교(조선왕조 이후의 유교) 전통’으로 한정짓고, 다시 도덕교육 가운데 현행 도덕과 교육의 교육과정을 전통 교육과정과 비교함으로써 일정한 성과를 얻고자 하였다. 전통 교육과정은 기(氣)의 발달에 근거하여 연령별로 단계별 학습을 시도했으며, 그 핵심 이념은 인(仁)과 의(義), 실천적 덕목은 효(孝), 제(弟), 자(慈), 직(直), 근(勤), 검(儉)이라고 정리해볼 수 있다. 여기서는 그러한 전통 교육 이념이 ‘자신과의 관계’, ‘타인과의 관계’, ‘사회 공동체와의 관계’, ‘자연·초월과의 관계’로 영역을 나누고 각기 지향할 가치, 실천할 덕목을 배정한 현 도덕과 교육의 체계와 상통할 수 있다고 보고, 그에 따라 교육 현장에서 실천할 몇 가지 전통-현대 융합적 교육 방안들을 제안하였다. Any moral ideas get integrity upon their practices. Because in human society systems, morality have capability among human interactions, for it gives moral standards(good or bad/ right or wrong) to them. And when the society system is Korean, Koreans surely have developed unique styles of moral practice and moral education in their traditional ages. So reinterpretating and categorizing the moral tradition for taking advantage of it in contemporary context, make sense. In this study, Korean moral tradition is focused in its scope, as ``Confucian moral tradition in semi-modern era``. For convenience of study and the potentials of effective revision, Korean tradition have been resized. In Confucian moral tradition, semi-modern Korean moral ideas could be presented as ren(仁) and yi(義). Furthermore, ren and yi could be practiced with several moral virtues, like xiao(孝), di(弟), ci(慈), zhi(直) qin(勤) gian(儉). When compared with contemporary moral education idea systems, the traditional system can have affinity with the systems in moral ideas division(``with-self morality``, ``with-others morality``, ``with-universe and transcendence morality``). And several fusion-style, integration-based education practices can be developed and applied at contemporary school moral education.

A. 高校 科學 (生物·地球科學) 및 數學科 探究學習의 評價模型 定立과 評價紙 開發

李相協,權炳奎,林在圭,孫文求,吳岱燮,楊洪準,梁承榮,姜用熙,林成圭,金正遠,金吉民,兪正在 경북대학교 과학교육연구소 1982 科學敎育硏究誌 Vol.6 No.-

Currently the evaluation of high school science and mathematics learning has been too much knowledge-centered without concerning the inquiring ability or scientific attitude. This study, therefore, was made for the purpose of establishing of evaluation model for high school science (biology and earth science) and mathematics learning and its evaluation items. In this paper, the research was done about three fields, biology, earth science and mathematics. 1. For the biology, the evaluation methods of inquiry learning were studied with the foreign references, and proper evaluation items were suggested. 2. For the earth science, after analizing 5 kinds of earth science textbook of current using in high school, essential 19 items were selected. 5 of them were tested in test group and control group, then, the results were analized. 3. For the mathematice, the teaching elements of「Set」and「Flow chart」in mathematics (Ⅰ) were selected and structured. Detailed teaching objects were established and evaluation items were introduced.

거리의 도상성원리와 영어여격교체현상

김광현,황규홍 새한영어영문학회 2001 새한영어영문학 Vol.43 No.2

An Iconicity-theoretic Approach to the English Dative Alternation Construction Kim, Kwang-Hyun · Hwang, Kyu-Hong This paper aims to examine the semantic and structural differences between the double-object construction and its prepositional counterpart based on Haiman's (1980, 1983, 1985) iconicity theory. The alternation phenomena have attracted a great deal of attention, and a range of proposals have been put forward to account for them. In particular, an attempt has been made among the majority of scholars to differentiate the double-object construction and its corresponding dative construction by resorting to the differences in verb meaning and those in relation between arguments. To achieve the above goal, in this paper, we attempt to identify the subtle meaning differences between the two constructions by way of the distance principle of the iconicity theory: "the linguistic distance between expressions corresponds to the conceptual distance between them." Namely, we argue that the double-object construction is used when the agent and the recipient are conceptually close, while the dative counterpart is used when the conceptual distance between the two is remote. This line of approach seems to be appealing in that it can explain the differences between the constructions more explicitly and systematically and in that it can also account for other alternation phenomena such as locative and conative constructions in a similar context.

재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

흉선종 제거후에 발생한 재생 불량성 빈혈 : 증례보고

전원선,이상철,김현정,배상병,김찬규,이남수,박노진,이규택,박성규,홍대식,박희숙,원종호 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

Thymoma is associated with myasthenia gravis, Pure red cell aplasia, and autoimmune diseases such as autoimmune hemolytic anemia, aplastic anemia, and hypogammaglobulinemia. It's association with aplastic anemia is rare and aplastic anemia appearing after surgical removal of thymoma is especially rare. The authors hereby report a case of aplastic anemia occuring in a patient who was diagnosed with thymoma and myasthenia gravis and had the tumor surgically removed. The patient was treated with anti-thymocyte globulin, cyclosporin, and prednisolone, and showed partial remission with hematologic improvements after 12 months.

은행잎박을 이용한 큰느타리버섯 배지 개발

김홍규 외 한국버섯학회 2009 한국버섯학회지 Vol.7 No.3

Ten to thirty percent of ginko leaf pomace(GLP) were added to pine sawdust to investigate mycelial growth. Mycelial growth on the medium with GLP was 86~101(mm/28 days) and was slower than that of the control without GLP as, 102(mm/28 days). Mycelial growth time on medium of sawdust with 10 to 20% GLP was similar to the control without GLP as 29 days but that on medium with 30% GLP was delayed for 2 days. The time of pinhead formations of sawdust with 10 to 20% GLP was 7 days, the growth time to harvest was 11 days. These results were similar to those of the control without GLP. The sizes of pileus of treatments with 10 to 30% GLP were tend to be smaller compared with the control. The length of stipe of 10% GLP treatment was 98mm which was longer than that of the control with 91mm. The thickness of stipes of 10 to 30% GLP treatments were 45 to 48mm which were tend to be thicker than that of the control with 45mm. The hardness of stipe were 35,062(g/㎠) to 4,1065(g/㎠)) which were harder than that of the control with 32,156(g/㎠)). GLP treatments seem to be favorable to store or distribute. Yields per volume of GLP added treatments were 88.7g to 95.6g, which was increased 3 to 12% compare to 85.8g of the control without GLP. 최근 국제원자재가 상승에 따라 버섯 배지 가격이 50% 이상 상승하여 톱밥 대체 배지의 개발이 절실한 실정으로 충남 도내에서 생산되는 은행잎부산물을 이용하여 버섯 배지로 개발하여 생산비 절감 및 경제적 이익 창출을 도모하기 위해 수행한 결과를 요약하면 다음과 같다. 은행잎박을 10~30% 첨가량에 따른 균사생장은 대조구 102 mm/28일에 비해 은행잎박 10~30% 첨가시 86~101mm/28일로 균사생장이 느린 경향이었으며, 균배양일수는 은행잎박 10~20% 첨가시 29일로 대조구와 같았다. 초발이 소요일수는 은행잎박 10~20% 첨가시 7일, 생육 일수는 11일로 대조구와 같았지만, 은행잎박 30% 첨가시 초발이소요일수는 1일정도 늦었다. 갓의 크기는 은행잎박 첨가시 대조구에 비해 작은 경향이 있었고, 대의 길이는 은행잎박 10% 첨가시 98mm로 대조구 91mm에 비해 길었다. 대의 두께는 대조구 45mm에 비해 은행잎박 10~30% 첨가시 45~48mm로 두꺼운 경향이었다. 대의 경도는 대조구 32,156(g/㎠)에 비해 은행잎박 10~30% 첨가시 35,062g/㎠~41,065g/㎠로 높아 저장 및 유통에 유리하였고, 병당 수량은 대조구 85.8g/병에 비해 은행잎박 10~30% 첨가시 88.7~95.6g/병으로 3~11% 증수되었다. 따라서 큰느타리 병재배시 은행잎박 10%를 첨가하는 것이 수량 증수 효과가 있는 것으로 사료된다.

5HT 2A/T102C 다형성과 정신분열병 및 임상아형과의 관련연구

홍현상,백인호,김정진,이창욱,이 철,도규영 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.4

목 적 : 가계연구, 입양연구, 쌍생아연구들은 정신분열병의 원인으로 유전학적 요소가 매우 중요하다는 것을 지적해 주고 있다. 그러나 정신분열병의 유전적인 복잡성으로 인하여 많은 연구들이 시행되었음에도 유전방식이나 원인 유전자를 밝히지는 못하였다. 최근에는 5HT₂a수용체가 비정형항정신병약물의 주된 작용부위하는 것이 밝혀지면서 5HT₂a 수용체의 유전자가 정신분열병의 원인과 관련이 있을 것이라는 관심이 늘어나게 되었다. 따라서 저자들은 한국인 정신분열병환자들을 대상으로 5HT₂a 수용체 T102C 다형성과의 association study를 시행하였다. 방 법 : 환자군은 강남성모병원에 입원했던 DSM-Ⅲ-R의 진단기준에 의한 정신분열병환자로 250명이었으며 평균연령은 30.1±9.3세 이었다. 정신분열병환자를 위한 양성증상과 음성증상척도의 종합척도를 기준으로 점수가 1이상인 경우를 양성군, -1이하인 경우를 음성군으로 하였다. 대조군은 정신과나 신경과 질환의 과거력이나 가족력이 없는 236명의 지원자로 구성하였으며 평균연령은 23.6±3.7세이었다. 다형성과 정신분열병 및 임상양상과 임상아형 사이의 유전적인 관련성의 분석에는 로지스틱 회귀분석과 일원 변량분석을 시행하였으며 통계 프로그램으로는 SPSS 7.5를 사용하였다. 말초혈액에서 DNA를 분리한후 중합효소 연쇄반응으로 증폭하였으며, 증폭산물을 제한효소인 MspI으로 처리하여 유전자형을 판별하였다. 결 과 : 5HT₂a 수용체 T102C 다형성의 대립유전자 빈도와 유전자형 분포는 환자군과 대조군 사이에 유의한 차이를 보여주지 못하였으며, 임상아형과도 유의한 관련이 없는 것으로 나타났다. 그러나 정신분열병환자를 위한 양성증상과 음성증상척도중 음성증상척도는 유전자형에 따른 유의한 차이를 나타내었다(F=3.828, df=2, p=0.023). 결 론 : 본 연구의 결과는 한국인에서 5HT₂a 수용체의 T102C 다형성이 정신분열병의 발생과 임상아형의 결정에는 관련이 없으나 음성증상의 발현에는 관련이 있음을 시사해 준다고 하겠다. Objectives : Family, twin and adoption studies indicate that genetic factors play a crucial role in the etiology of schizophrenia. However, mode of inheritance of schizophrenia is uncertain, and genes for schizophrenia have not yet been identified despite extensive studies due to the complexity of the genetics of schizophrenia. Currently, 5HT₂a receptor gene has attracted considerable interest as a susceptibility gene of schizophrenia since the 5HT₂a receptor has been known as one of the major target sites of atypical neuroleptics. We conducted an association study of T102C polymorphism in the 5HT₂a receptor gene in Korean schizophrenic patients using PCR-RELP method. Methods : Two hundred and fifty biologically unrelated schizophrenic patients meeting DSM-Ⅲ-R criteria from Kangnam St. Mary's Hospital affiliated with Catholic University of Korea were recruited for our study. The patient group consisted of 123 male and 127 female subjects, aged 30.1±9.3years. The controls were volunteers for DNA library of Kangnam St. Mary's Hospital without family history of psychiatric or neurologic illness. The control group consisted of 124 males and 112 females, aged 23.6±3.7years. Amplified genomic DNA was digested by MspI. The significance of genetic association of the polymorphism was estimated by the logistic regression analysis and ANOVA using SPSS 7.5. Results : The allele frequencies and the genotypic distribution of 5HT₂a receptor gene were not significantly different between the patient and control group. In addition the allele frequencies and the genotypes of 5HT₂a receptor gene were not significantly associated with subtype of schizophrenia. However, negative symptom score according to genotype show significant difference(F=3.828 df=2 p=0.023). Conclusion : It is suggested that even if the development and subtype of schizophrenia may not be associated with T102C polymorphism of 5HT₂a receptor in Korean population, T102C polymorphism may be associated with the severity of negative symptom.