위발성 위장관 악성림프종 환자에서 항암치료의 효과

김찬규,신영록,김현정,배상병,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Purpose: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin's lymphoma (NHL), which is increasing in incidence, but there is no established optimal treatment modality. Thus, this study was investigated the clinicohistologic feature, the therapeutic modalities, and the prognosis for GI-NHL, as well as the factors affecting it. Methods: We retrospectively analyzed 45 patients who had been diagnosed as having GI-NHL and had been followed up from July 1994 to February 2005 at Soonchunhyang University Hospital. The patients were divided into groups according to the site of origin and to various other features, and the survivals of the various groups were compared. The modified Ann Arbor system and WHO classification were adopted for staging and histopathologic classification, respectively. Results: GI-NHL of the stomach, small bowel, ileocecal region, and colon occurred in 28 patients (62.2%), 5 patients (11.1%), 3 patients (6.7%), and 8 patients (17.8%), respectively, In one patient, the entire gastrointestinal tract was diffusely involved. The median age of patients was b5 years (25~78 years), and male-to-female ratio was 1:1.1. Fourteen patients were in stage Ⅰ, 24 in stage Ⅱ, 4 in stage Ⅲ, and 3 in stage Ⅳ. Surgical resection was performed in 19 patients, and combination chemotherapy was performed in 43 patients. Surgical resection only was performed in 4 patients, Chemotherapy only was performed in 26 patients. The expected overall 5 year survival of 45 patients was 39.6%, and there was a significant survival difference between the stages, but between sites of origin (p=0.842). The most important factors influencing the survival was the stage and other factors were not significant. Conclusion: The stomach was the most common site of GI-NHL. Most GI-NHL were localized Stage was the most important prognostic factor. However, Prospective randomized studies are needed to approve the therapeutic modality.

재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

흉선종 제거후에 발생한 재생 불량성 빈혈 : 증례보고

전원선,이상철,김현정,배상병,김찬규,이남수,박노진,이규택,박성규,홍대식,박희숙,원종호 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

Thymoma is associated with myasthenia gravis, Pure red cell aplasia, and autoimmune diseases such as autoimmune hemolytic anemia, aplastic anemia, and hypogammaglobulinemia. It's association with aplastic anemia is rare and aplastic anemia appearing after surgical removal of thymoma is especially rare. The authors hereby report a case of aplastic anemia occuring in a patient who was diagnosed with thymoma and myasthenia gravis and had the tumor surgically removed. The patient was treated with anti-thymocyte globulin, cyclosporin, and prednisolone, and showed partial remission with hematologic improvements after 12 months.

The Generalization and Application of Hadamard and CNOT Operators for n-dimensional Quantum States

배규찬 대구대학교 사범대학 부설 교육연구소 2007 敎育硏究 Vol.2 No.2

We generalize the Hadamard and CNOT operators for n-dimensional quantum states. Using these generalizations, we propose the generalized scheme of quantum teleportation and quantum secure direct communication (QSDC) for arbitrary n-dimensional system.

불가한시(佛家漢詩)의 동양 미학적 표현 기법 : 거리와 농담을 중심으로 mainly on 'distance' and 'Jest'

배규범 경희대학교 인문학연구소 2002 인문학연구 Vol.6 No.-

The purpose of this treatise is to read a chinese poem centering around a expression technique based of the orient esthetics. There are several esthetic expression techniques such as distance[距離], a jest[濃淡], a blank[餘白]. And also, an object of study is restricted to Chinese poetry in a Buddhist. A precondition of This treatise is that an expression of landscape painting is the same as eukyung[意境] of Chinese poetry in a Buddhist. That is, landscape painting uses the way of looking far-off to see an object esthetically. This has a similar pattern with keeping a distance in Chinese poetry in a Buddhist. And this is described concretely such like rearrangement of natural things, delivering of sense image and expression of paradox. Also, gradation used in landscape is deeply related to a thinking system of Zen expressed in Chinese poetry in a Buddhist.

필러의 종류가 UTMA 계 광중합형 복합레진의 강도에 미치는 영향

배태성,최진용,최규형,채민수 大韓齒科器材學會 2000 대한치과재료학회지 Vol.27 No.3

This study was performed to evaluate the effect of resin and filler type on the strength of light-activated composites. Experimental composites were prepared using the four types of urethane tetramethacrylate monomers(HM-4M, TM-4M, XY-4M and DC-4M) and three different shapes of silica fillers. Cylindrical specimens of 3㎜ in diameter and 6㎜ in length and rectangular specimens of 2×2×24㎜ were prepared for the compressive test and 3-point bend test, respectively. All specimens were immersed in distilled water at 37℃ for 24 hours. Compressive and 3-point bend tests were carried out at a crosshead speed of 0.5 ㎜/min and fracture surfaces were observed with scanning electron microscope. The results obtained were summarized as follows : 1. When the size distribution of fillers was same, composites containing the spherical fillers showed the relatively higher loading rate of fillers and compressive strength than those containing the crushed fillers. 2. Compressive strength values of the composites based on UTMA monomers containing the aliphatic UTMA monomers (HM-4M and TM-4M) showed the relatively higher strength values than those of the composites based on UTMA monomers containing the aromatic or cyclohexane ring in their chemical structure(XY-4M and DC-4M). 3. The compressive and transverse strength values of UTMA-based composites were higher than those of Bis-GMA-based composites. 4. According to the microscopic observation of fracture surfaces, composite failure developed along the matrix resin and resin/filler interface region.

한국의 공업화와 근로자 의식의 변천

배규한 서울대학교 사회과학연구소 1985 社會科學과政策硏究 Vol.7 No.3

三相誘導電壓調整器의 極性에 對한 實驗的 考察

裵圭渙 釜山工業大學校 1969 論文集 Vol.8 No.-

直流機의 整流에 對한 實驗的 考察

裵圭渙 釜山工業大學校 1969 論文集 Vol.9 No.-

Pefloxacin이 난치성 외과적 감염에 미치는 영향

배재문,박규주,윤여규,김진복 대한화학요법학회 1990 대한화학요법학회지 Vol.8 No.2

Resistance of bacterial pathogens to antibiotics is a problem that increases from year to year often resulting from indiscriminate use of β-lactam antibiotics and aminoglycosides. Pefloxacine, a new quinolone derivative, has been shown to have a broad spectrum of antibacterial activity with less resistance. In order to evaluate their efficacy and safety in surgical patients, 30 patients (24 patients with postoperative wound infection, 6 patients with postoperative sepsis) were given pefloxacin 400㎎ bid i.v. for 5 days. The results of treatments are as follows: 1. Overall efficacy of pefloxacine was 96.6% 2. In all but 3 of 19 patients with documented initial pathogen, bacteriologic eradication of the pathogen were achieved(84.2%) 3. Hematologic and biochemical assays performed before, during, and 5 days after pefloxacin did not reveal any adverse effects. 4. Side effects of pefloxacine were observed in 5 (16.6%) patients. 4 patients had nausea, and 1 patients had urticaria, The side effects were usually mild except in 1 patients who had to discontinue pefloxacine due to severe hausea. It can be concluded that pefloxacine is a safe and effective antibiotics that can be used in surgical patients with complicated infections.