Targeting Multiple Myeloma Cell Death with Polyphenol EGCG

Tae‐Hoon Lee,Hee‐Young Yang,Hoon‐In Choi,Ung Yang,Kyoung‐Jin Chung,Lina Ren 한국동물생명공학회(구 한국동물번식학회) 2011 발생공학 국제심포지엄 및 학술대회 Vol.2011 No.1

(‐)‐Epigallocatechin 3‐gallate (EGCG) is a potent antioxidant polyphenol in green tea that acts as an anticancer agent via both direct and indirect pathways. Although the relationship between EGCG’s anticancer effects and its antioxidant activity is not fully understood, it is known that EGCG stimulates production of reactive oxygen species (ROS), which induce oxidative stress leading to cell death. In IM9 multiple myeloma cells, EGCG acted in a dose‐ and time‐dependent manner to induce apoptotic cell death. Among the antioxidant enzymes expressed in IM9 cells, levels of peroxiredoxin (Prdx) V were selectively and significantly reduced by EGCG. Moreover, the ROS scavenger NAC completely inhibited EGCG‐induced apoptosis and PrdxV reduction, while overexpression of PrdxV, but not a PrdxVC48S mutant, protected IM9 cells from EGCG‐induced apoptosis. EGCG‐induced reductions in cell viability and PrdxV levels were also observed in primary CD138+ multiple myeloma cells from patients. These results suggest that PrdxV is a key target via which EGCG mediates its anticancer effects.

강력범죄 피해자의 외상 후 스트레스 증상 및예측요인에 대한 탐색적 연구

김태경(Kim, Tae­Kyoung),윤성우(Yun, Sung­Woo),이영은(Lee, Young­Eun),이새롬(Lee, Saerom) 한국피해자학회 2018 被害者學硏究 Vol.26 No.1

The aim of this study was to investigate the posttraumatic stress symptoms of violent crime and predictors to the symptoms. For this, we analyzed data of 473 victims registered to the integrated supporting center for violent crime victims who agreed to participate in the study. The results showed that more than 90% of victims experience significant PTSD symptoms, 30% of them were in extreme mental confusion that required medication or hospitalization. There was a significant difference in the severity of sequela according to gender, time since visiting to the center, pre-event adaptation level, and event type. Although the victim experienced more avoidance and hypervigilance symptoms than the family, the psychological distress experienced by the family was not less than that of the victim. Psychological sequela of the events were found to be more severe with more experiences of childhood trauma, lack of ego resilience, low level of perceived social support, strong dissociation tendency, and avoiding coping styles. A result of the stepwise regression analysis, avoidant coping style explained 10.6% of the total variance. Limitations and implications of this study were discussed.

공동 주택별 주차면수 확보기준의 합리화 방안에 관한 연구

김태경(Tae-Kyoung Kim),이주아,이훈 한국도시부동산학회(구.도시정책학회) 2019 도시정책학회 학술대회 Vol.2019 No.-

Looking at the trend of the nation's housing market and housing policy, one can see that apartments are taking up a very large share from some point on. The number of motor vehicle registrations has also been on a steady rise as social trends that value the quality of life are shaping up, as are the rise of living standards, the rise of double-income households and the word ‘Work-life balance’. This implies an increase in the number of households with more than one vehicle, which in turn is one of the main factors that exacerbate the problem of parking in apartments along with the increase in urban density. However, some parks in certain areas require realistic parking demand forecasts and rationalization of actual parking plan standards to address these problems, as problems such as double parking and illegal parking have become a serious residents' dispute due to a lack of parking spaces, while apartment complexes and small-scale, customized public rental houses in small cities in the provinces have been left empty due to low demand for parking. At a time when various problems caused by the popularization of apartment housing culture are increasingly becoming social problems, and various complementary measures and policies are being developed, the question of securing a reasonable parking area for apartment houses will be of great significance. Therefore, this study aims to summarize and analyze the effects of the convenience of public transportation, especially urban railroads, on the parking demand of apartment units by region, by noting the relationship between the demand for parking of parking lots of apartments under the present reality of parking lots, and to present the need and direction of realistic and reasonable standards for installing parking lots for apartment apartments in each area.

체육교사의 리더십 유형과 고등학생의 체육수업 만족에 관한 연구

김흥태(Heung-Tae Kim),신진원(Jin-Won Shin),최경호(Kyoung-Ho Choi) 한국엔터테인먼트산업학회 2011 한국엔터테인먼트산업학회논문지 Vol.5 No.4

본 연구는 체육교사의 리더십 유형에 따른 고등학생의 체육수업 만족을 규명하는데 목적이 있다. 이 연구의 목적을 규명하기 위하여 경기도 성남시에 소재하고 있는 5개 고등학교 1, 2학년생 500명을 대상으로 편의추출법(convenience sampling)으로 총 487부를 회수하였고, 그 중 442부가 분석에 사용되었으며, SPSS 13.0 Windows 프로그램을 이용하여 타당도와 신뢰도 검증, 빈도분석, t-검증, 그리고 표준중다회귀분석을 실시하여 다음과 같은 결론은 얻었다. 첫째, 일반적 특성에 따른 고등학생의 체육수업 만족은 성별에 따라 교사만족, 사회성함양, 수업용이는 남자가 여자보다 높았고, 수업만족, 수업평가는 여자가 남자 보다 높게 나타났으며, 학년별에 따른 고등학생의 체육수업 만족은 모두 1학년이 2학년보다 높게 나타났다. 둘째, 체육교사의 리더십 유형과 고등학생의 체육수업 만족과의 영향 관계는 긍정적 보상형으로 수업을 할수록 고등학생의 체육수업 만족은 높아지는 것으로 나타났다. 이와 같이 고등학교 체육교사의 리더십과 학생간의 체육수업 만족에 대한 결과를 바탕으로 향후 바람직한 학교체육의 방향을 논의하는 기초적인 자료로써 활용되기를 바란다. This study is aim to define high school students" satisfaction based on the type of leadership in a physical education teacher in high school physical education classes. To investigate this study, we used "convenient sampling" to 500 high school students who are in 1st and 2nd grade in Kyoung-gi-do and recollected 487 copies, and SPSS 13.0 windows program was used for verifying a frequency analysis and reliability analysis, t-test and a standard multiple regression analysis. And they were conducted by all of the following conclusion was obtained. First, in terms of satisfaction on teachers, social propensity and class satisfaction, there is statistical significance that male students have more positive attitude than female students. Female students showed higher satisfaction on the class satisfaction and test method in the physical education class. It showed that the first grade students have higher satisfaction than the second graders according to the grade survey. Second, students" satisfaction became higher and higher when physical education teachers gave more positively reward to them related on their satisfaction and effect in the physical education class. Thus, we hope that this data will be used as a basic data to discuss the direction on the right school physical education between teachers" leadership and students" satisfaction in physical education class.

전기저항식 로드셀을 이용한 균등긴장시스템 개발 및 성능실험

박원태(Park Weon-Tae),천경식(Chun, Kyoung-Sik) 한국산학기술학회 2016 한국산학기술학회논문지 Vol.17 No.2

MS(Multi-Strand) 케이블은 여러 개의 강연선으로 이루어져있어, 케이블 시공시 각 강연선을 차례대로 개별적으로 긴장한다. 그리고 마지막 강연선이 정착되었을 때, 모든 강연선에 동일한 장력이 도입되어야하며, 이것이 MS 균등긴장의 핵심기술이다. 본 연구에서는 엑스트라도즈(Extradosed)교 및 사장교의 사재케이블(Stay Cable)에 적용되는 2,200MPa 초고강 도 강연선들을 균등하게 긴장, 제어할 수 있는 MS 케이블 균등긴장시스템을 개발하였다. 개발한 균등긴장시스템은 전기저항 식 로드셀, 유압잭, 유압펌프 그리고 통합제어기로 구성되며, Master 강연선과 Slave 강연선의 장력변화를 실시간으로 예측하 며 제어하는 알고리즘을 탑재하였다. 개발시스템의 기능과 성능을 검증하기 위해 균등긴장 실험을 수행한 후, 광양 태인2교 (ED교)의 사재케이블 가설긴장에 성공적으로 적용하였다. Because MS(Multi-Strand) cables consist of many strands, a jacking force is applied to each strand one by one for cable construction. All strands should have an equal tensile force when the last one is wedged. This is the core technology for MS iso-tensioning. In this study, a new MS cable iso-tensioning system was developed for controlling and jacking the high-strength strands, with an ultimate tensile strength of 2,200MPa, for a stay cable of extra-dosed/cable-stayed bridges. The newly developed iso-tensioning system consists of electrical resistance load cells, hydraulic jacking devices, hydraulic pumps, and integrated controllers. Moreover, it is embedded with an algorithm that can control and predict the variations in tensile forces of the Master and Slave strands in real time. Actual experiments were carried out to verify the function and performance of the newly developed system. This system was applied successfully to the stay cable construction of 2nd Tae-in extra-dosed bridge in Gwangyang.

21가지 장미꽃 품종의 페놀성 화합물 함량 및 항산화 활성

조연재(Yeon Jae Jo),서정현(Jeong Hyun Seo),홍채영(Chae Young Hong),김성태(Seung Tae Kim),최은경(Ehn-Kyoung Choi),김윤배(Yun-Bae Kim),이준수(Junsoo Lee),정헌상(Heon Sang Jeong) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.4

본 연구는 21품종의 장미꽃에 대한 식품 및 화장품 원료로 사용 가능성을 살펴보기 위해 페놀성 화합물과 항산화 활성을 평가하였다. 총 폴리페놀, 총 플라보노이드 및 타닌 함량은 러버샤이 품종에서 각각 379.70 mg GAE/extract g, 50.10 mg CE/extract g 및 339.44 mg TAE/extract g으로 높게 나타났으며, 칠백리 품종에서 각각 107.25 mg GAE/extract g, 9.46 mg CE/extract g 및 36.31 mg TAE/extract g으로 낮았다. 페놀산 함량은 총 폴리페놀 함량과 유사한 결과를 보였으며, 러버샤이 품종에서 27.40 mg/extract g으로 높았다. 안토시아닌은 대부분 cyanidin-3,5-diglucoside로 확인되었으며 총 안토시아닌 함량은 유니나 품종에서 8.80 mg/extract g으로 가장 높았다. ABTS 및 DPPH 라디칼 소거 활성은 각각 428.10 및 419.59 mg AAE/extract g로 러버샤이 품종에서 가장 높았으며, 항산화 활성과 페놀 화합물의 함량과 높은 양의 상관관계를 보였다. 이러한 결과는 러버샤이와 같은 항산화 활성이 뛰어난 품종들이 관상 목적뿐만 아니라 높은 기능성을 가진 식품 및 화장품의 원료로 사용 가능성이 있다고 판단된다. This study evaluated the functional components and antioxidant activities of 21 different rose flower extracts, to confirm their value as a food and cosmetics ingredient. The highest values of total polyphenol, flavonoid and tannin contents (379.70±1.64 mg GAE/extract g, 50.10±0.76 mg CE/extract g, and 339.44±1.20 mg TAE/extract g, respectively) were obtained in Lover Shy. The proanthocyanidin content ranged from 61.88 mg CE/extract g in the Unina cultivar to 5.34±0.13 mg CE/extract g in the Aileen cultivar. The phenolic acid content obtained was highest in the Lover Shy cultivar (27.40±0.26 mg/extract g), whereas highest levels of anthocyanin (8.83±0.03 mg/extract g) were obtained in the Unina cultivar. High ABTS and DPPH radical scavenging activities were determined in the Lover Shy cultivar (428.10±0.29 and 419.59±3.12 mg AAE/extract g, respectively). Taken together, these results indicate that the antioxidant activity and functional components of Lover Shy cultivar are superior, and this extract can potentially be applied as a food and cosmetic ingredient.

사업장(事業場) 근로자(勤勞者)의 사상체질(四象體質)에 따른 생활습관(生活習慣), 자각증상(自覺症狀), 건강인식(健康認識)에 관(關)한 연구(硏究)

서명효,강홍구,장두섭,왕명자,차남현,김삼태,권소희,정해경,송용선,이기남,Seo Muoung-Hoy,Kang Hong-Goo,Jahng Doo-Sub,Wang Myoung-Ja,Cha Nam-Hyun,Kim Sam-Tae,Kwon So-Hee,Jung Hae-Kyoung,Song Yung-Sun,Lee Ki-Nam 대한예방한의학회 2003 대한예방한의학회지 Vol.7 No.2

The study was conducted to evaluate the difference of life style, subjective symptoms and health cognition depending on the Sasang Constitution in the industrial workers. The results were as follows ; Constitutional distribution among exposed group were Tae-eum In(38.4%), So-eum In(35.2%), and So-yang In(26.4%) and it was turned out that Tae-eum In took a higher portion of Sasang constitution than other constitutions in technician workers. 'Exercise' and 'Obesity' were found most in Tae-eum In, In So-eum In there were many 'Normal' weight and 'Having digestive disorders' were found most in So-eum In. There were no significant difference in the health cognition among the constitutions. The closer to 'normal' weight, the higher prevalence in 'having' concern about health condition and the more 'normal' condition in sleeping, the higher prevalence of 'having' self-confident in present health.

사무직 근로자들의 직무 스트레스와 피로

차경태,김일희,고상백,현숙정,박준호,박종구,차봉석,장세진 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.3

목적: 이 연구는 전국 규모의 조사 연구에서 수집된 자료 중 사무직 근로자들을 대상으로,사회인구학적 특성,직업 특성,건강행태,직무 스트레스와 피로수준 간의 관련성을 분석하는 데 있다. 방법:‘한국인 직무스트레스 측정도구의 표준화 전국 조사연구National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002∼2004)’를 위해 2002년 5월 1일부터 2003년 5윌 30일 까지 수행되었으며,전국의 사업장에 근무하는 근로자 30,146명(남자: 84%,여자: 16%) 중 사무직 근로자 4,457명(남자: 68.9%,여자 31.1%)을 연구 대상으로 하였다. 자료수집방법은 사업장을 방문하여 보건 및 안전관리자 등에게 연구의 취지를 알린 후 설문조사에 대한 협조를 구하고 응답자 직접 기입법을 이용 하였으며,사회인구학적 특성,직업적 특성,건강관련 요인,KOSS-SF를 이용한 7개의 직무 스트레스 요인,그리고 MFS를 이용하여 피로 수준에 영향을 주는 요인에 대해 분석하였다. 결과: 일반적 특성,작업관련 특성,건강행태관련 특성 및 직무 스트레스 요인이 근로자들의 피로와 강한 관련성이 있음이 입증되었으며,특히 직무 스트레스의 하부 요인 중에서도 피로와 관련성을 보이는 요인이 남녀별로 다소 상이 하게 관련된다는 것을 발견할 수 있었다. 남자의 경우는 직무 스트레스의 하부 영역 중 직무 요구도,직무 불안정성,보상부적절 등이 영향력이 높은 주요 직무 스트레스 요인이었던 반면,여자는 직무 요구도,보상부적절,직장문화가 주요한 직무 스트레스 요인이었다. 결론: 직장인 피로가 갖는 보건학적 의학적 경제학적 중요성을 감안할 때,조직의 생산성 향상과 근로자 개개인의 삶의 질 향상 및 건강증진을 위해선 직무 스트레스 관리 프로그램이 절실히 요청된다고 볼 수 있다. Background & Objectives: A growing body of research has documented that occupational stress is closely associated with increased risk of fatigue. This study was conducted in an effort to assess the relationship of occupational stress to self-perceived fatigue among Korean white collar employees. Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project, 2002-2004). Among them, a total of 4,502 white collar employees were recruited. A structured questionnaire was employed to evaluate the participants' sociodemographics, job-related factors, health-related behaviors, occupational stress, and self-perceived fatigue. Occupational stress and self-perceived fatigue were assessed using the Korean Occupational Stress ScaleShort form (KOSS-SF) and the Multidimensional Fatigue Scale (MFS), respectively. Results: In logistic regression analyses, occupational stress was associated with an increased risk of fatigue, and some domains of occupational stress had different effects on fatigue by gender (job demand, job insecurity, and lack of reward for men, job demand, lack of reward, and discomfort in occupational climate for women), which indicates that occupational stress may perform a slightly different role in increasing the risk of fatigue by gender. Conclusion: The results of this study suggest that occupational stress is a determinant predictor of self-perceived fatigue. Thus, a stress management program for the reduction of occupational stress, and the promotion of white collar worker's health and quality of life is strongly recommended. Some limitations of this study and considerations for future studies were also discussed.

무기고화제를 이용한 중금속 오염 광미의 안정화 처리를 위한 기초연구

민경원,김태풍,이현철,서의영 江原大學校 産業技術硏究所 2009 産業技術硏究 Vol.29 No.A

Stabilization treatment is one of processes for wastes and their components to reduce their toxicity and migration rates to surroundings. Inorganic binders such as calcium hydroxide, blast furnace slag and red mud were tested for their potential applicability to in-situ stabilization of heavy metal contaminated tailings in the abandoned metal mines. Columns(150mm dia. x 450mm length) filled with mixtures of inorganic binders and tailing from the Geumjang mine with various mixing ratios of binders to tailings, 5%, 7% and 9% were applied artificial rainfall tests for 28 days. Effluents from columns filled with calcium hydroxide and tailing showed high pH's of ~12.5 and a increasing trend of concentration in Pb and Zn with a significant decrease in permeability in terms of elapsed days. Those with burning slag and tailing showed pH's of ~8.5 and significantly low concentrations in heavy metals with a stable permeability. In case of red mud, effluents showed significantly low concentrations in heavy metals but a decreased permeability with pH's of ~10.5. Conclusively, this basic study suggests burning furnace slag be a potential stabilizer for effective treatment of heavy metal contaminated mine tailings.

신선초가 수은중독된 mouse의 간장에 미치는 영향

정영태,정경아 광주보건대학 2000 論文集 Vol.25 No.-

To investigate the defensive effect of Angelica keiskei koidz against the mercury toxicity, ICR mouse(30g) were divided into 3groups: the control group, the mercury treated group, and the Angelica keiskei koidz-mercury treated group. 1. The result of mercury treated group was as follows. The nucleus was observed irregularly. Rough endoplasmic reticulum(rER) and mitochondria were modificated. Many lysosome observed. 2. The result of Angelica keiskei koidz-mercury treated group was as follows. The mucleus was observed normally. rER showed slightly dilated. Many lysosome and modificated mitochondria were observed. 3. As result, the Angelica keiskei koidz has positive effect on reducing toxicity of mercury on the mouse liver.