임신부 체중증가와 신생아 체중과의 관계

정효지,김은정,최봉순,최경호,신정자,윤성도 동아시아식생활학회 2000 동아시아식생활학회지 Vol.10 No.6

This study was carried out to find the factors which are related to the weight gain during pregnancy of women and infant birth weight. The information of the general characteristics and pregnancy outcomes of the 506 women who had a delivery during Jan to Dec. 1997 in a hospital at Taegu area were collected from the medical records. The results are as follows. The mean age of the subjects was 29 years old and the average prepregnancy weight was 52.75㎏. They gained 13.51㎏ of weight during the pregnancy. The weight gain during pregnancy was higher in prepregnancy BMI <20kg/m^(2), the infant weight was heavier in groups that had over 14kg of weight gain during the pregnancy than other groups. The prepregnancy BMI was negatively correlated to weight gain during pregnancy (r=0.2825), and positively correlated to number of pregnancy (r=0.2146), number of living delivery (r=0.1409), and infant weight (r=0.1250). The baby weight was positively correlated to weight gain during pregnancy (r=0.1392) and Apgar score(r=0.1627). The results showed that the prepregnancy BMI and weight gain during pregnancy may be the influential factors on the infant weight, thus we need to develop the specific nutritional management program according to the status of prepregnancy weight.

학술지 출판비용출처의 분야별 차이에 대한 고찰

정경희 한성대학교 인문과학연구원 2012 소통과 인문학 Vol.15 No.-

This paper's goal is to analyze the disciplinary differences between article processing charges(APC), advertising income and dues that were the sources of cost for open access publishing in Korean journals. As a result, humanities and social sciences areas that had a very low gratis open access journal ratio in Korean journals had a relatively low APC. The additional APC was very often, and often without advertising revenue. Full member dues for societies were also proportionally less than other areas, not only to executive dues. Natural sciences and engineering sciences that had a high percentage of gratis open access journals had a relatively high APC and low additional APC. In addition, these academic departments had a greater advertising income than other departments. Engineering also had higher dues than humanities and social sciences fields.

ONO 적층절연막의 전기전도 특성에 관한 연구

정양희,김경민 여수대학교 1998 論文集 Vol.12 No.2

In this paper, the stacked-dielectric layer oxide/nitride/oxide(ONO) is studied to scale down the memory device. Studying the change of composition in ONO layer due to the process condition and the conduction mechanism are investigated. The composition of the oxide film grown through the oxidation of nitride film is analyzed using auger electron spectroscopy(AES). AES results show that oxygen concentration increases at the interface between oxide and nitride layers as the thickness of the top oxide layer increases. When the top oxide film is thicker than 35Å, the concentration of oxygen increases both at the surface of nitride and in the nitride film. As the thickness of the top oxide and nitride increases, the electrical breakdown field increases. Optimum film thickness for scaled stacked-layer dielectric(ONO) is 63Å for nitride and 28Å for top oxide. In this case, maximum electrical breakdown field and leakage current is 18.5[MV/cm] and 8×10??[A], respectively.

Thioacetamide에 의한 BALB/c 마우스 간의 시간별 약물대사효소 억제 양상 : A Time-Course Study

이정운,고우석,김갑호,배연경,하현정,한상섭,천영진,정태천 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-

Thioacetamide is a potent hepatotoxicant which requires metabolic activation by cytochrome P450s (P450s) for toxicity. In the present study, the elevation kinetic of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities by thioacetamide treatment was investigated in male BALB/c mice. Inaddition, the inhibitory effects of thioacetamide on liver microsomal P450 enzymes were further investigated. Thioacetamide at 100 mg/kg/ was treated intraperitoneally for 6, 12, 24, 36, 48 and 72 hr. The blood was collected at the designated time for assaying the serum enzyme activities. To determine the P450 isozyme-specific activities. ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), and benzyloxyresorufin O-debenzylase (BROD) activities were determined for P450 1A1, 1A2 and 2B1, respectively, in liver microsomal fractions. The activities of ALT and AST were started to be elevated 6 hr after thioacetamide treatment andreached the maximun at 36 hr after the treatment. The elevated activities were dramatically recovered at 72 hr. The microscopic exmination of the liver specimen also showed a similar profile of hepatotoxicity. All P450-associated enzyme activities were time-dependently inhibited by the treatiment with thioacetamide. The maximum inhibition of P450 enzymes was observed 36 hr after the treatment. Because the inhibition of P450 enzymes by thioacetamide was time-dependent, our present results suggest that thioacetamide might inhibit P450 enzymes in mechanism-based inactivation.

불측정 상태변수를 갖는 이산치 다변수계통에 대한 슬라이딩 모드 제어기의 설계

김경민,정양희 여수대학교 1998 論文集 Vol.12 No.2

In this paper, we degined sliding mode controller for discrete-time multivariable systems with unmeasurable state variables. Practical control systems are usually realized by digital computer. And there has existed a gap between the continuously designed VSCS (Variable Structure Control System) and the realized control systems. So, we propose the sliding mode control theory which are extended from continuous VSCS theory for controlling the discrete systems. And the previous sliding mode control theory assumed that the systems have all of measurable state variables. However, in practical systems, all state variables are not measurable. Thus, in this paper, we also investigate the discrete system there not all states are available for switching function synthesis or control. In all the case, computer simulation results are presented to demonstrate the effects of theories.

여성 아나운서의 메이크업 스타일 변화에 관한연구 : 1990년대와 2000년대를 비교중심으로

김보경,이정민 한국메이크업디자인학회 2008 한국메이크업디자인학회지 Vol.4 No.1

The following paper cross-examines the change and reason in the announcer's makeup styles following the change in broadcasting programs. The announcers of the 90's were more of an information carrier as an announcer and a broadcaster than a female, and hence their makeup was restricted to express reliability and professionalism. However, as the role of female announcers became more diverse with program changes and as they became more involved in programs other than news, their makeup styles changed and became more diverse. The announcers of the 21st century are involved in many areas of activities and roles as to be called 'annatainers'. The demand for broadcasters is increasing to meet the need for diversity, and this in turn calls for diverse talent on the part of the announcer, not just on celebrities. Starting with this paper, there should be consistent research on announcers and female broadcasters in diverse fields and changes in their makeup styles following changes in fashion and trend.

Berberine의 항생제 내성 황색포도구균에 대한 항미생물 효과

김해경,차정단,유용욱,김강주,이동근 원광대학교 생체재료·매식연구소 2000 원광생체재료·매식 Vol.9 No.1

Antibiotic-resistant Staphylococcus aureus (S. aureus) emerged in many parts of the world and increased complex clinical problems. Therefore, new agents are needed to treat to antibiotic-resistant S. aureus. Some natural products are candidates of new antibotic substances. Previous reports showed that the extract of Coptidis Rhizoma and Phellodendri Cortex have antimicrobial effects. The main antibacterial substance of Coptidis Rhizoma and Phellodendri Cortex is berberine. In this study, we examined the antimicrobial activity of berberine to antibiotic-resistant S. aureus. We isolated the 13 strains of antibiotic-resistant S. aureus from the oral cavity of healthy children in a preschool, and investigated the antimicrobial activity of berberine. We examined the effects of berberine on the level of resistance to antibiotic-resistant S. aureus. We observed that the invasion of S. aureus into human gingival fibroblasts was blocked by berberine. Berberine inhibited the growth of antibiotic-resistant. S. aureus as a dose dependent maner. Minimum inhibition concentration (MIC) of berberine against antibiotic-resistant S. aureus was 50-100 ㎍/ml. The inhibition of S. aureus invasion was depended on the concentration of berberine in human gingival fibroblasts. The MIC of ampicillin against antibiotic-resistant S. aureus was 32 ㎍/ml. However, the MIC of ampicillin against antibiotic-resitant S. aureus in the presence of 50 ㎍/ml berberine was 1 ㎍/ml. These data indicate that the combination with berberine and β-lactam antibiotics resulted in the synergistic reaction. These results suggest that the berberine may have the antimicrobial activities to antibiotic-resistant. S. aureus, and the mechanism may be the inhibition of growth and intracellular invasion. and alteration of antibiotic-resistance level of antibiotic-resistant S. aureus.

산화전세정에 따른 표면 Microroughness 및 불량분석에 관한 연구

김경민,유일현,정양희 麗水大學校 産業基術硏究所 1999 産業基術硏究所 論文集 Vol.8 No.-

The purity of wafer surface is an essential requisite for the successful fabrication of VLSI silicon circuits. In the cleaning step, the precleaning(NH₄OH/H₂O₂/H₂O) method has been used. The precleaning process for bare wafer can affect the state of wafer surfaces. It can cause the degeneration of gate oxide layer. For the investigation of this problem, we measured the microroughness of silicon wafer surface using the atomic force microscope(AFM). The microroughness is in the range of 1.1∼1.6Å. The result is increased proportionally to the number of cleaning times. This problem by additional precleaning distributed to edge in the wafer. To avoid th yield drop due to the microroughness, we suggest that the content ratio of precleaning solution is to be at 0.2:1:10 and the cool DI water rinsing should be followed after cleaning step. However, additional cleaning process should be applied carefully to avoid failure even in the optimized precleaning process.

Porphyromonas endodontalis의 침투에 따른 혈관 내피세포의 유전자 발현

공희정,최경규,박상혁,이진용,최기운 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.6

During the last two decades, there has been an increasing interest in the impact of oral health on atherosclerosis and subsequent cardiovascular disease (CVD). To date, some periodontal pathogens including Porphyromonas gingivalis (P. gingivalis) have been reported to be relevant to CVD. Porphyromonas endodontalis (P. endodontalis), which shares approximately 87% sequence homology with P. gingivalis, is mostly found within infected root canals. However, recent studies reveal that this pathogen also resides in the dental plaque or periodontal pocket in patients with periodontitis. It has been shown that P. endodontalis invades human coronary artery endothelial cells (HCAEC) and coronary artery smooth muscle cells (CASMC). To evaluate whether P. endodontalis can participate in the progression of atherosclerosis and CVD, we examined the changes in transcriptional gene expression profiles of HCAEC responding to invaion by P. endodontalis in this study. The following results were obtained. 1. Porphyromonas endodontalis was invasive of HCAEC. 2. According to the microarray analysis, there were 625 genes upregulated more than two-folds, while there were 154 genes downregulated by half. 3. Upregulated genes were relevant to inflammatory cytokines, apoptosis, coagulation and immune response. Enhanced expression of MMP-1 was also noticeable. 4. The transcription profiles of the 10 selected genes examined by real-time PCR agreed well with those observed in the microarray analysis. Thus, these results show that P. endodontalis presents the potential to trigger and augment atherosclerosis leading to CVD. 본 연구에서는 Porphyromonas endodontalis와 죽상경화증 및 심혈관질환과의 관계를 알아보기 위해, P. endodontalis가 사람의 관상동맥 내피세포에 침투했을 때 나타나는 유전자 발현의 변화를 microarray와 real-time PCR로 측정하였고, 발현이 증가된 유전자 중에서 죽상경화증과 연관된 유전자들이 관련 KEGG pathway 상에서 유의성 있는 영향을 미치는지를 분석하여 다음과 같은 결과를 얻었다. 1. Porphyromonas endodontalis는 사람의 관상동맥 내피세포에 침투하였다. 2. Microarray 분석결과, 대조군보다 발현이 2배 이상 증가된 유전자는 625개였고, 1/2이하로 감소된 유전자는 154개였다. 3. 발현이 2배 이상 증가된 유전자 중에는 염증성 cytokine 및 chemokine, 세포자멸사, 혈액응고와 면역반응 관련 유전자들이 포함되었다. 4. Microarray 분석결과를 확인하기 위해 발현이 2배 이상 증가된 유전자 중에서 10개의 유전자를 선택하여 real-time PCR을 시행하였고, 그 결과 microarray에서와 마찬가지로 발현 정도가 대조군보다 모두 높게 나타났다. 따라서 P. endodontalis가 사람의 관상동맥 내피세포에 만성적으로 작용했을 때, 심혈관질환에서 중요한 부분을 차지하는 죽상경화증을 유발하는 위험 요소 중의 하나로 작용할 수 있을 것으로 판단된다. 이와 관련된 자세한 기전을 이해하기 위해서는 앞으로 더 많은 연구가 필요할 것으로 보인다.

Berberine의 항생제 내성 확색포도구균에 대한 항미생물 효과

김강주,차정단,김해경,유현희,유용욱,이동근 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.2

Antibiotic-resistant Staphylococcus aureus (S. aureus) emerged in many parts of the world and increased complex clinical problems. Therefore, new agents are needed to treat the antibiotic-resistant S. aureus. Some natural products are candidates of new antibiotic substances. Previous reports showed that the extract of Coptidis Rhizoma and Phellodendri Cortex have antimicrobial effects. The main antibacterial substance of Coptidis Rhizoma and Phellodendri Cortex is berberine. In this study, we examined the antimicrobial activity of berberine to antibiotic-resistant S. aureus. We isolated the 13 strains of antibiotic-resistant S. aureus from the oral cavity of healthy children in a preschool, and investigated the antimicrobial activity of berberine. We examined the effects of berberine on the level of resistance to antibiotic-resistant S. aureus. We observed that the invasion of S. aureus into human gingival fibroblasts was blocked by berberine. Berberine inhibited the growth of antibiotic-resistant S. aureus as a dosw dependent maner. Minimum inhibitory concentration (MIC) of berberine against antibiotic-resistant S. aureus was 50∼100㎍/㎖. The inhibition of S. aureus invasion was depended on the concentration of berberine in human gingival fibroblasts. The MIC of ampicillin against antibiotic-resistant S. aureus was 32㎍/㎖. However, the MIC of ampicillin against antibiotic-resistant S. aureus in the presence of 50㎍/㎖ berberine was 1㎍/㎖. These data indicate that the combination with berberine and β-lactam antibiotics resulted in the synergistic reaction. These results suggest that the berberine may have the antimicrobial activities to antibiotic-resistnat S. aureus, and the mechanism may be the inhibition of growth and intracellular invasion, and alteration of antibiotic-resistance level of antibiotic-resistant S. aureus.