Astromicin sulfate의 약동학 및 안전성 평가

정숙인,김연숙,오원섭,복혜숙,김명민,최경업,김연화,김성민,백경란,송재훈 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.3

목적 : Astromicin은 aminoglycoside계 항생제와 유사한 화학구조와 특성을 지니고, 기존의 aminoglycoside와 유사하거나 향상된 임상효과 및 부작용을 지닌 것으로 알려져 있다. 저자들은 astromicin의 약동학적 특성을 분석하고, astromicin 투여 환자를 대상으로 한국인에서 그 임상적 및 세균학적 효과와 안전성을 평가하고자 하였다. 대상 및 방법 : 약동학적 지표는 정상성인 남자를 대상으로 astromicin 200㎎을 30분간 정주한 후 24시간까지 혈장 및 뇨 검체를 수집하여 one-compartment open model에 따라 분석하였다. 중증으 세균감염이 있는 18세 이상의 환자를 대상으로 병용 또는 단독 투여한 후 임상적 효과와 세균학적 효과를 판정하였고, 치료전과 후의 순음청력검사와 혈청 크레아티닌으로 이독성과 신독성을 평가하였다. 결과 : 정상 성인 남자 12명을 대상으로 약동학적 지표를 평가하였고, 최고혈장농도는 투여 종료시점(C_(0))에서 16.87±1.68㎍/mL였으며, 반감기는 1.86±0.43 시간 이었고, AUC_(0-12h)은 38.12±10.57㎍ㆍhr/mL, Vd는 0.18±0.02L/㎏, CL은 5.25±2.07L/hr였다. 이러한 약동학적 지표는 다른 aminoglycoside와 유사한 결과를 보였다. 59명의 환자를 대상으로 시행한 임상적 효과 분석에서는 단독요법을 시행한 50명 중 임상적 치유율 94%, 세균학적 치유율 100%를 보였고, 순음청력검사를 시행한 48례의 환자중 의미있는 청력감소 소견은 관찰되지 않았으며, 신독성 또한 전혀 나타나지 않았다. 결론 : Astromicin의 약동학적 지표는 다른 aminoglycoside의 약동학적 지표와 비슷한 양상을 보이므로 향후 astromicin의 약물농도 감시에 있어서 다른 aminoglycoside의 치료적 약물 농도 감시 방법과 유사한 방법을 적용할 수 있으리라 기대된다. 또한 임상적 치유율이 우수하면서 신독성이나 이독성이 적어 세균 감염 환자의 치료에 있어서 단독 또는 병합 요법으로 비교적 안전하게 사용할 수 있으리라 생각된다. Astromicin(Fortimicin®) has some characteristics in common with other aminioglycoside antibiotics, although it has a unique chemical structure, which is different from them. This study was performed to elucidate the pharmacokinetic (PK) parameters of astromicin following single-dose intravenous infusion of 200 mg and to evaluate clinical efficacy and safety of astromicin in Korean populations. PK parameters of astromicin were determined in 12 healthy volunteers (65.5±5.2㎏). The plasma and urine samples were collected up to 24hrs. PK variables were calculated by fitting individual concentration-time curves to a one-compartment open model. Plasma level at the end of infusion was 16.87?1.68 ㎍/mL and declined to 1.05±0.35 (㎍/mL 8hr later. The half-life was 1.86±0.43 hr. Apparent volume of distribution was 0.18±0.02 L/㎏g, and total body clearance was 5.25±2.07 L/hr. These values were similar to those of other aminioglycosides. Clinical efficacy and safety were eviuated in 59 patients with moderate to severe bacterial infections who needed parenteral antibiotics. Among 50 patients who recieved astromicin monotherapy, 49 (98%) had favorable clinical reponse and 28 (100%) had favorable bacteriological response. Serial audiograms revealed no change in all of 48 patients. No nephrotoxicity was observed in all patients. Conclusively, our data suggest that therapeutic drug monitoring of astromicin can be conducted in a similar fashion as other aminioglycosides and astromicin is a useful and safe antibiotic in the treatment of severe bacterial infections.

아프리카계 미국인 영어의 특징

송경숙 동의대학교 2005 인간과 문화 연구 Vol.- No.10

대구보건대학 학생들의 흡연 실태 및 니코틴 의존도

윤인숙,김경희 대구보건대학 2001 대구보건대학 論文集 Vol.21 No.-

This study was surveyed to ask smoking status and nicotine dependency of Taegu health college students : male 420, female 954 for one month of June, 2000. The survey asked 19 questions : students' general characteristics(three questions), smoking status and smoking habit(ten questions), nicotine dependency(six questions). The students were divided into two, such as public health group(public health section and nurse section) and non-public health group(engineering section and section of social practical affairs). The present ratio of smoking was turned out 70.5% of male, 3.3% of female(p<0.01). In terms of age, the ratio of males was shown : 83.3% of age 25 and the older, and 67.6% of age 20-24(p<0.01), while the female ratio was done : 8.7% of age 25 and the older, and 3.1% of age 20-24. The ratio of non-public health group is higher than that of public health group. Specially, in males, the ratio of non-public health group is also higher : 78.4% of non-public health group and 53.8% of public health group, while in females, the ratio of non-public health group is also higher : 8.8% of non-public health group and 2.2% of public health group(p<0.01). According to the major of the students, in males, the ratio of health administration department of public health group is the highest(83.3%) and in females, the ratio of radio-technology department of public health group is the highest(7.9%), while financial technology information department of non-public health group of both male and female is the highest : 100.0%, 14.6% respectively. The motivation of smoking was all curiosity : 40.2% of male and 45.2% of female. The males answered that they have started to smoke since high school first or second year(33.1% which is the highest). However, the females have started since middle school(38.7%, the highest). In terms of the place of smoking, 35.7% of male smokes every where, while 38.7% female do at bars or entertaining places(p<0.01). The sexual distribution of nicotine dependency is 57.1% of male and 61.3% of female which are highly nicotine dependency. Throughout the survey analysis, the survey of Taegu health college students is considerable and they got bad damages against the physically and psychologically optimal status. So, the study showed that the education of self health maintenance would be needed to the students for prevent planning.

일종합병원 입원환자의 불안에 관한 연구

오경옥,강문희,박영희,심희숙 충남대학교 간호과학연구소 2003 충남대 간호학술지 Vol.6 No.1

The purpose of this study was to evaluate the anxiety of inpatients in a general hospital in Daejeon. Data were collected through self-reported questionaires from January, 2003 to February, 2003, The anxiety was measured by Zung's Self-Rating Anxiety Scale. Analysis of data was done was descriptive statistics, t-test ANOVA and factor analysis. The results of the study were as follows : (1) The average score for the level of anxiety was 37.75±8.44 point (2) The anxiety items, such as sweating. apprehension, dyspnea, insomnia and restlessness showed the high score in inpatient. (3) Anxiety showed significant difference by education level(p<0.01), duration of hospitasization (p<0.01), prognosis(p(0.05), ward(medical/surgical) (p{0.05), experienc of admission (p<0.05). (4) According to the factor analysis, four factors of sweating, apprehension, dyspnea and restlessness showed high score in inpatient. Inpatient's anxiety characteristically showed more somatic symptoms than affective symptoms.

대유행 인플루엔자(H1N1 2009) 급성호흡곤란증후군에 대한 체외막 산소화 장치의 조기적용 1예

이경학,이길수,오원섭,유숙원,천성빈,이승준 대한감염학회 2010 감염과 화학요법 Vol.42 No.2

Despite advanced technologies in intensive care, pandemic influenza (H1N1 2009) can rapidly progress to acute respiratory distress syndrome (ARDS) and cause death in a small subset of patients. Extracorporeal membrane oxygenation (ECMO) is expected to provide adequate gas exchange, to reduce ventilator-induced lung injury and, eventually, to improve outcome in these patients. A previously healthy, young female received mechanically ventilatory support because of rapidly progressive respiratory failure caused by 2009 H1N1 influenza. As she failed to respond to high ventilatory support, ECMO was instituted at 6 hours after admission. We describe detailed course of case and literature review on ECMO, helping physicians make a decision to initiate ECMO in patients with influenza-related ARDS.

식품표시에 관한 소비자 교육의 효과

이경애,김향숙 한국조리과학회 2002 한국식품조리과학회지 Vol.18 No.5

The effect of consumer education on food label was investigated by conducting a survey. The questionnaire had been collected from university students in Choongnam and Chungbuk province, and total 462 answers were collected and analyzed. Awareness and understanding of food label appeared to be improved by consumer education. Especially, the respondents showed a good understanding on food additive labeling after consumer education. However, most respondents misrecognize ‘sell by date’as ‘expiration date’. The results suggested the necessity of consumer education on the shelf life of foods.

비동기식 적응형 파이프라인 구조 설계

이승숙,이제훈,조경록 충북대학교 컴퓨터정보통신 연구소 2006 컴퓨터정보통신연구 Vol.14 No.2

본 논문은 비동기식 프로세서에서 동작 상황에 따라 파이프라인 구조가 변경 가능하고 명령어 종류에 따라 병렬처리를 지원하는 적응형 파이프라인 구조를 제안하였다. 제안된 구조는 스테이지 스키핑(stage-skipping)과 스테이지 통합(stage-combining) 기법을 지원한다. 이 기법들은 명령어 종류에 따라 서로 다른 데이터패스를 사용하는 명령어들을 병렬로 처리하여 머신 사이클을 단축시켜 프로세서의 동작 속도를 증가시킨다. 본 논문에서는 제안된 파이프라인 구조를 적용한 ARM 명령어 호환 프로세서를 설계하였다. SPEC2000 벤치마크를 사용하여 성능을 평가한 결과, 타겟 프로세서는 평균 365 MIPS의 속도로 동작하여 영국 맨체스터 대학에서 개발한 비동기 프로세서인 AMULET3i에 비해 2.3배 높은 성능을 보였다. This paper presented an adaptive pipeline architecture for a high-performance and low-power asynchronous processor. The proposed pipeline architecture employs a stage-skipping and a stage-combining scheme. By using these schemes, the proposed pipeline architecture can reduce the processing time and power consumption. Also, the proposed architecture supports multi-processing in the EX stage that executes parallel 4 instructions. We designed an asynchronous ARM processor to prove the efficiency of the proposed pipeline architecture. We used SPEC2000 benchmark programs for evaluating the performance of the target processor. As a result, the proposed architecture showed about 2.3 times higher speed than the asynchronous counterpart, AMULET3i.

일부 종합병원 간호원의 이직의사 요인에 대한 조사 연구

강현숙,오경옥 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.1

This study was attempted to determine the main factors on the turnover intention of the nurses in Taejeon area. The questionaires were given to 170 nurses were working at hospital in Taejeon from 2 to 8 June, 1984. The scales used for this study were the job satisfaction scale and the turnover intention scale developed. by the investigator. The results of the study were as follows : 1. The relationships between turnover intention and general characteristics-age, marital status, and level of education showed no statistical significance(P>0.05). The length of service, a˙ptitude to the job, concern of supporting family and the kind of hospital(i, e. , public or private) were proved to be significantly related to the turnover intention (P<0.05). 2. The relationships between turnover intention and job factors-pay, promotion, the type of supervision, co-worker, hospital administration, recognition, benefits, work itself were significant statistically(P<0.05). 3. Factors including job factors and general characteristics seem to be responsible to the turnover intention by 33.54%(R^2=0.3354). Among them hospital administration was the most significant .

정신질환자의 사회적 지지와 자아존중감에 관한 연구

김태숙,오경옥 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.1

This study was conducted to determine the relationship between social support and self-esteem of the psychiatric patients. One hundred ninety subjects( 95 psychiatric patients and 95 normals) between the ages of 18 and 65 were included in the study. The psychiatric patients were recruited from outpatient clinic of C university hospital in Taejon city. The normal subjects were residents of Taejon, who have been matched with the psychiatric patients according to age, sex and spouse status. The instruments used for this study were Norbeck Social Support Questionnaire developed by Norbeck, Lindsey and Carrieri, and Rosenberg's Self-esteem Scale. The collected data were analyzed using percentage, x^2-test, t-test, ANOVA, Pearson Correlation Coefficient by SPSS-X. The results of this study were as follows; 1. The score of psychiatric patients was lower than that of normals on social support(total functional support : t==-8.22, p<.001 ; total social support network : t=-7.82, p<.001). 2. The score of psychiatric patients was lower than that of normals on self-esteem (t = -6.55, p<.001). 3. The relative variables influencing the degree of social support of psychiatric patients were birth order(F=2.66, p<.07), normals were sex(F=4.99, p<.05), birth order(F=4.06, p<.05). 4. The relative variables influencing the degree of self-esteem of psychiatric patients were sex(F=6.21, p<.01), age(F=5.07, p<.008), spouse status(F=7.32, p<.008), birth order(F=3.51, p<.03), normals were sex(F=-9.86, p<.002), age(F-4.4, p<.01) 5. The relationship between the degree of social support and self-esteem of psychiatric patients was found to be a positive correlation that was not statistically significant (r =.054, p>.05). 6. The relationship between the degree of social support and self-esteem of normals was found to be a positive correlation (r=.206, p<.02).

노인의 자아존중감에 관한 연구

오경옥,박인숙,김종임,성은옥 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

This study was performed to investigate the level of self-esteem in the home residents and institution residents. We used a structured questionnaire in interviewing the elderly. The interviewees were composed of 200 persons in homes and 93 persons in institutions aged more than 60 and they were selected by systemic stratified random sampling. The data collecting period was from June 2, 1988. to August 10, 1988. Data were analyzed by the SPSS computer program mean, percentage, t-test, ANOVA. The results of the study were as follows: 1. The level of self-esteem of the elderly in home was very higher than that of the institutionalized elderly(p<0.000) 2. According to whether they have the monthly income(p<0.05), the level of present life satisfaction(p<0.001), the level of relationship with spouse(p<0.001) and sexual life or not(p<0.001), the level of self-esteem of the home resident group showed differences statistically. 3. According to they have the number of offsprings(p<0.05), the level of present life satisfaction (p<,0.001) and the level of present health status(p<0.01), the level of self-esteem of the institution residents group showed difference statistically.