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USER EXPERIENCE STUDY OF SMALL PORTABLE HOME APPLIANCES
Kyo-hwe Goo,Marian Adusei,Kido Chang,James Andrew Self,Jae-hyuk Chae 한국디자인학회 2015 한국디자인학회 학술발표대회 논문집 Vol.2015 No.10
The project is about developing the user experience of an existing sterilizer aimed at the domestic market. This paper attempts to find the insights and the needs of a small portable household appliance that is relevant to the home context. The results found from the user study suggest criteria for home appliance units in general and 3 main keywords were developed using the results. The paper shows how the results found in the user study are used to generate appropriate concepts for small portable home appliances.
Kim, Hyungkuen,Yi, Sun Shin,Lee, Hak-Kyo,Heo, Tae-Hwe,Park, Sang-Kyu,Jun, Hyun Sik,Song, Ki Duk,Kim, Sung-Jo Taylor Francis 2018 Nutrition and cancer Vol.70 No.4
<P>The vine stem of Spatholobus suberectus Dunn (SS) is used as a traditional herbal medicine in China. Chinese herbal medicines are well known as natural bioactive compounds that can be used as new medicines, and their antioxidant and anticancer effects have also been reported. This study aimed to examine the anticancer effect of a high-pressure hot-water SS extract on rat C6 glioma cells. The SS extract effectively suppressed the viability and proliferation of C6 glioma cells through an antioxidant effect. Reactive oxygen species (ROS) levels in cancer cells are higher than that in normal cells. If the ROS level falls below that required for the growth of cancer cells, their rapid proliferation and growth can be suppressed. We also measured the induction of mitochondrial membrane depolarization and cell cycle arrest effect caused by the SS extract in C6 glioma cells through a FACS analysis. In addition, we observed an increase in STAT3, p53, E2F1, and p21 mRNA expression and a decrease in Bcl-2 mRNA expression by quantitative PCR. An increase in p21 protein expression of over 83% was observed through western blot analysis. All these data support the fact that the high-pressure hot-water SS extract has the potential to be used for glioma treatment.</P>
Kim, Sung-Jo,Hong, Minho,Song, Ki Duk,Lee, Hak-Kyo,Ryoo, Sungweon,Heo, Tae-Hwe BioMed Central 2014 BIOLOGICAL RESEARCH Vol.47 No.1
<P><B>Background</B></P><P>Tuberculosis (TB) is a respiratory tract disease caused by <I>Mycobacterium tuberculosis</I> infection. <I>M. tuberculosis</I> exploits immune privilege to grow and divide in pleural macrophages. Fibrates are associated with the immune response and control lipid metabolism through glycolysis with β-oxidation of fatty acids.</P><P><B>Results</B></P><P>In this study, we investigated the effect of fibrate pretreatment on the immune response during <I>M. smegmatis</I> infection in U937 cells, a human leukemic monocyte lymphoma cell line. The protein expression of tumor necrosis factor α (TNF-α), an inflammatory marker, and myeloid differentiation primary response gene 88 (MyD88), a toll like receptor adaptor molecule, in the infected group increased at 1 and 6 h after <I>M. smegmatis</I> infection of U937 cells. Acetyl coenzyme A acetyl transferase-1 (ACAT-1), peroxisome proliferator-activated receptor-α (PPAR-α), TNF-α, and MyD88 decreased in U937 cells treated with fibrates at 12 and 24 h after treatment. More than a 24 h pretreatment with fibrate resulted in similar expression levels of ACAT-1 and PPAR-α between infected vehicle control and infected groups which were pretreated with fibrate for 24 h. However, upon exposure to <I>M. smegmatis,</I> the cellular expression of the TNF-α and MyD88 in the infected groups pretreated with fibrate for 24 h decreased significantly compared to that in the infected vehicle group.</P><P><B>Conclusion</B></P><P>These results suggest that fibrate pretreatment normalized the levels of inflammatory molecules in <I>Mycobacterium smegmatis</I>-infected U937 cells. Further studies are needed to confirm the findings on pathophysiology and immune defense mechanism of U937 by fibrates during <I>M. tuberculosis</I> infection.</P>
Hwang, Eunmi,Sim, Sangwan,Park, Sang Hyuk,Song, Ki Duk,Lee, Hak-Kyo,Heo, Tae-Hwe,Jun, Hyun Sik,Kim, Sung-Jo Elsevier 2018 BIOMEDICINE AND PHARMACOTHERAPY Vol.98 No.-
<P><B>Abstract</B></P> <P>Gliomas are one of the most common types of primary brain tumors, characterized by rapid proliferation and infiltration into normal brain tissue. Corncob is the most plentiful byproducts of <I>Zea mays</I> L., of which anti-cancer effect has not been reported. Therefore, we aimed to examine the anti-proliferative effect of a high-pressure hot-water extract of corncob on glioma cells and elucidated the underlying mechanism. The high-pressure hot-water corncob extract contained approximately 94.8 mg/g and 1.82 μg/g of total phenol and catechin, respectively. Glioma cell treated with different concentrations of high-pressure hot-water corncob extract was shown to be suppressed in growth during three days of culture. In parallel, corncob extract reduced the glioma cell viability and induced cell cycle arrest in G0/G1 phase by upregulating the expression level of cyclin-dependent kinase inhibitor p21. Decreased proliferation and viability in glioma cells treated with corncob extract can be attributed to reduced reactive oxygen species (ROS), antiapoptotic Bcl-2 protein, and a lactate transporter monocarboxylate transporter 1 of which levels are higher than those in normal cells. Based on its inhibitory effects on proliferation and viability of C6 glioma cells, a high-pressure hot-water corncob extract has the potential to be used for glioma treatment.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>