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말기 신부전 환자에서 동맥경화증의 임상적 지표와 고해상도 B모드 경동맥 초음파 소견의 상관성
이승우(Seoung Woo Lee),김문재(Moon Jae Kim),송준호(Joon Ho Song),김경아(Gyeong A Kim),이창근(Chang Keun Lee),박경수(Kyeong Soo Park) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.2
N/A Atherosclerotic cardiovascular disease(AVD) is a major cause of the mortality and morbidity in end-stage renal disease(ESRD) patients undergoing chronic dialysis therapy. The factors such as lipopretein metabolism abnormality, diabetes, hypertension, hyperhomocysteinemia and oxidative stress have been implicated as underlying causes related AVD. Malnutrition, chronic inflammation, increased oxidative stress, hyperparathyroidism and its related lipoprotein abnormalities are suggested to accelerate AVD in ESRD patients. High-resolution B-mode ultrasono-graphy has been used to evaluate atherosclerotic change in carotid artery in a number of epidemiologic or clinical studies because of its non-invasive advantage and proven effects in predicting AVD or cardiovascular mortality. Using high-resolution B-mode sonography, we evaluated the presence of plaque and carotid intima-media area(cIM area), which is known to be a good predictor of athero-sclerosis. We compared and analyzed those sono-graphic findings according to a number of selected clinical and laboratory factors. Study subjects were 27 stable ESRD patient re-ceiving hemodialysis(HD) or chronic ambulatory pe-ritoneal dialysis(CAPD) at least over 24 months. The patients with present or past coronary, cerebral or peripheral vascular disease, history of anti-platelet agents or age over 70 years were excluded. Nine HD and 18 CAPD patients were included and mean age was 52.1±2.6 years and number of male and female patients were sixteen and eleven. Among many factors, sex, age, dialysis duration, diabetes, smoking history, blood pressure, body mass index, albumin, creatinine, high-density lipoprotein, trigly-ceride, C-reactive protein, total calcium, phosphorus, intact-parathyroidid hormone were selected and analyzed for their correlation with carotid sonograpic findings. 1) Mean cIM area of all patients was 15.4±0.7 mm². cIM area was significantly increased in CAPD patients compared to HD patients(16.5±1.2 vs 14.9± 0.9mm², p<0.05). Atherosclerotic plaques were found in 48.1% and bilateral lesion was found in 18.5% of all patients. The incidence of the plaque was 42.1% in HD and 55.6% in CAPD patients. 2) cIM area was more significantly increased in male than female(16.7±0.8 vs 13.6±1.2mm²), in dia- betes than non-diabetes(16.4±0.8 vs 14.7±l.lmm²) and in smoker than non-smoker(18.8±0.7 vs 12.8±0.7mm², p<0.05). It was also significantly inereased in patients with body mass index more than 2.3kg/ m(18.3±1.1 vs 14.6±0.8mm), systolic blood pres-sure more than 14mmHg(16.6±0.7 vs 13.0+1.2mm) and C-reactive pretein more than 0.5 mg/dL(18.9±1.5 vs 14.2±0.77mm²p<0.05). Among those factors, age, systolic blood pressure, body mass index and C-reactive protein were proven to positively correlate to cIM area with statistical significance(p<0.05). Even though cIM area was increased in pa-tients with high serum parathyroid hormone, high total cholesterol and triglyceride and low high-den-sity lipoprotein level, no statistical significances were found in these factors. 3) In comparison of each factor according to the presence of the plaque, age and the presence of dia-betes were proven to be significantly different bet-ween patients without the plaque and with the plaque(45.7±2.7 vs 59.5±3.8 year, 33.3% vs 53.8%, respectively, p<0.05). Systolic blood pressure and C- reactive protein were increased in patients with the plaque but no statistical significance was shown. In conclusions, we found that old age, male sex, presence of diabetes, smoking history, high systolic blood pressure, increased body mass index and increased C-reactive protein were significantly re-lated to increased cIM area and the plaque was more frequent in old age and diabetes patients using high resolution B-mode ultrasonography. It can be assumed that inflammatory state as reflected by C-reactive protein would be more related with atherosclerosis in ESRD patients than such as nu-tritional state, parathyro
관광형 도시재생에 의한 장소성 형성이 지역사회 애착과 태도에 미치는 영향 - 서울시 용산구 해방촌을 중심으로 -
김경아 ( Kyeong-a Kim ),김현정 ( Hyoun Jeong Kim ) 경기대학교 관광종합연구소 2021 여가관광연구 Vol.35 No.-
본 연구는 서울시 용산구 용산가2동 해방촌을 대상으로 도시재생사업의 진행 중간시점에서 지역 주민의 지지도와 참여를 적극 유도 할 수 있는 애착과 장소성간의 관계를 규명하였다. 2018년 10월 6일부터 10월 14일까지 2주간의 주말을 이용하여 지역주민 대상의 설문조사를 실시하였으며 설문지 139부를 배포하여 유효표본 113부를 획득하였다. 설문조사 결과를 바탕으로 각 문항별 탐색적 요인분석을 실시하여 측정 문항의 적합도를 검증하였으며 신뢰도 확보 이후 단계적 회기분석(stepwise regression analysis)을 사용하여 연구를 진행하였다. 그 결과, 장소성 형성 요인은 지지도에 영향을 미치지 않으나 참여의사에는 일부 영향을 미치는 것을 알 수 있었다. This study, targeting Yongsan 2-dong, Yongsan-gu, Seoul, identifies the relationship between attachment and placeness which can actively encourage local residents to support and participate in middle of urban regeneration project. During 2 weeks, from October 6, 2018 to October 14, the survey was conducted on local residents. A total of 139 questionnaires were distributed and 113 effective samples were obtained. Based on the survey results, the study was conducted by the exploratory factor analysis for each question and stepwise regression analysis after gaining credibility. As a result, the factors of placeness formation do not affect the degree of support, but have some influence on the willingness to participate.
NF-κB 신호전달과정의 음성적 조절 -배아줄기세포에서의 조절을 포함하여
이충일 ( Choong Il Lee ),심상형 ( Sang Hhyung Sim ),김영은 ( Young Eun Kim ),황유원 ( Yoo Weon Hwang ),하양화 ( Yang Hwa Ha ),한재민 ( Jae Min Han ),김경아 ( Kyeong A Kim ),황보은 ( Eun Hwang Bo ),이영희 ( Young Hee Lee ) 한국조직공학과 재생의학회 2010 조직공학과 재생의학 Vol.7 No.3
NF-κB is a transcriptional factor which is involved in many biological processes including immunity, inflammation, and cell survival. Many investigators studied on the mechanism involved in activation of NF-κB signalling pathway via ubiquitination and degradation of IkB. Recently, termination of NF-κB signaling after activation is regarded as another essential regulating step. In addition to the negative feedback by IkB protein, ubiquitination and degradation of nuclear p65/RelA, a crucial subunit of NF-κB, is considered another mechanism to terminate the NF-κB signaling. COMMD1, PDLIM2, GCN5 and NMRAL1 are recently reported as proteins related with p65/ RelA ubiquitination. Interestingly, ubiquitination and degradation of p65/RelA through viral protein was also found in the process of viral infection to escape from host defence mechanism. In contrast with somatic cells, expression of NF-κB is relatively low in undifferentiated embryonic stem (ES) cells, and activity of NF-κB is down-regulated by Nanog via direct interaction. Furthermore, enforced expression of NF-κB resulted in differentiation suggesting that down regulation of NF-κB contributes to the maintenance of ES cells. Therefore, better understanding on the negative regulation of NF-κB signaling in somatic cells as well as in ES cells might give more insights into therapeutics targeting NF-κB signaling.
문정범 ( Jeong Beom Moon ),박수진 ( Su Jin Park ),이영호 ( Yong Ho Lee ),김경아 ( Kyeong A Kim ),홍상기 ( Sang Ki Hong ),백수경 ( Su Kyung Baek ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.11
목적: 자궁내막증 환자의 임상적 특징을 파악하여 향후 진단과 치료 및 연구에 도움이 될 기초 연구 자료를 마련하고자 하였다. 연구 방법: 2000년 1월부터 2004년 12월까지 5년 동안 본원 산부인과에서 개복수술, 제왕절개수술, 골반경 수술로 자궁내막증으로 진단된 163예를 대상으로 이들의 임상양상에 대해 후향적으로 조사분석 하였다. 결과: 자궁내막증의 빈도는 4.38%였고, 미산부 및 임신회수가 적은 젊은 여성에서 호발하였다. 주증상은 월경통, 하복부 통증이었으며, 증상이 없는 경우가 35%였다. 병기는 III, IV기가 82.3%였으며, 호발병소는 난소, 더글라스와, 자궁, 나팔관, 복막, 직장 순이었다. 자궁근종과 양성 난소낭종이 흔히 동반되는 부인과 질환이었으며, 혈청 CA125치는 I, II기 보다 III, IV기에서 평균수치가 증가하였고, 비정상적으로 높은 수치를 보이는 경우도 많았다. 결론: 젊은 여성에서 자궁내막증에 대한 조기 진단과 적절한 치료로 가임력 보존 및 여성의 삶의질 향상을 도모하여야 한다. Objective: We studied clinical characteristics of patients have endometriosis to provide basic knowledge for diagnosis, treatment, and futher study of endometriosis. Methods: We have performed a retrospective clinical study on 163 patients diagnosed with endometriosis during laparotomy, cesarean section, laparoscopic surgery at our medical center from January, 2000 to December, 2004. Results: Incidence of endometriosis was 4.38%. The more frequent occurrence was noted in the young women with low parity and in the nulliparous women. Most frequent symptom comprised dysmenorrhea and lower abdominal pain. 33.7% of patients were asymptomatic. And 82.3% of the patients were in stage III and IV. The frequent sites involved were ovaries, Cul-de sac, uterus, tubes, peritoneum and rectum in order. Frequently combind gynecologic disease were uterine myoma, benign ovarian tumor. In Stage III & IV, there are more patients, who had abnormal elevated serum CA 125 level than patients of stage I & II. Conclusion: Early diagnose and appropriate management of Endometriosis for young women can lowered the development of hihger stage case and it is important for fertility and better life quality.