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      • AHCISCOPUSKCI등재
      • KCI등재
      • AHCISCOPUSKCI등재
      • Illudins C_2 and C_3, New Illudin C Derivatives from Coprinus atramentarius ASI20013

        LEE, IN-KY0UNG,JEONG, CHEOL-YOUN,CHO, SOO-MUK,YUN, BONG-SIK,KIM, YANG-SUP,YU, SEUNG-HUN,KOSHINO, HIROYUKI,YOO, ICK-DONG 충남대학교 생물공학연구소 1997 생물공학연구지 Vol.5 No.-

        Ganoderma lucidum 균주는 인공 배지 상에서 광에 의하여 자실체 원기가 형성되었으며, 광질이 자실체 원기 형성에 미치는 영향을 조사한 결과, 자실체 원기 형성능을 가지고 있는 5균주중 3균주는 공시한 모든 형광등의 아래에서 즉, BLB, 순청색, 순녹색, 순황색, 순적색 형광등의 아래에서 자실체 원기가 형성되었고, 2균주는 BLB 형광등을 제외한 가시광선 영역에서 형성되었다. 그러나 암상태에서는 공시한 모든 균주가 자실체를 형성하지 않았다. 자실체 원기는 광도 0.05에서 10.0 μmol m^-2 s^-1의 범위에서 형성되었고, 광도가 0.5 μmol m^-2 s^-1 이상에서는 자실체 원기의 수가 감소하였다. 주기적인 광조사가 자실체 원기의 형성에 미치는 영향을 조사한 결과, G1-009 균주는 자실체 원기의 수와 무게가 연속광을 조사한 경우보다 증가하였다. 자실체 원기를 형성하기 위해서는 최소 4일간의 광조사가 필요하였다. 단색광의 조사가 자실체 원기의 형성에 미치는 영향을 조사한 결과 G1-003 균주는 400에서 800 nm의 모든 단색광 처리구에서 자실체 원기가 형성되었고, 그 외의 4균주는 400에서 500 nm, 그리고 700에서 750 nm 범위에서 형성되었다. The objective of this research was to determine the effect of light quality on formation of fruit body primordia (FBPs) of Ganoderma lucidum. To achieve this 5 isolates of the fungus that develops fruit body primordia on nutrient agar media were incubated with or without continuous irradiation. The fluorescent lamps used different colors such as black light blue (BLB), pure blue (P-B), pure green (P-G), pure yellow (P-Y) and pure red (P-R). Effect of periodic light and dark exposures on FBP formation of isolate G1-009 was investigated. The FBP formation in G. lucidum isolates was also tested under nomochromatic light produced by the combination of interference filters and colored glass filters. Three isolates produced FBPs under all kinds of fluorescent lamps, whereas two induced FBPs only under visible light except for BLB fluorescent lamp. However, these isolated did not form FBPs in the dark. The FBP was formed at light intensity from 0.05 to 10.0 μmol m^-2 s^-1, and begun to reduce its number as light intensity increase over 0.5 μmol m^-2 s^-1. When the isolate was incubated under periodic light and dark exposures, the number and weight of FBP increased as compared with those under continuous light. Initiation of FBP requires at least 4 days of light illumination. Although isolate G1-003 produced FBPs in a wide range of 400 to 800 nm, other four isolates had two effective regions 400 to 500 nm and 700 to 750 nm in FBP formation.

      • 치아이동 후 고정방법이 성견 치주인대섬유의 재배열에 미치는 영향

        이기헌,황현식 전남대학교 치과대학 1996 전남치대논문집 Vol.8 No.1

        The purpose of this study was to evaluate the effect of splinting methods on the rearrangement of periodontal fibers after experimental tooth movement. Orthodontic force was applied by placing closed coil spring between upper third incisor and canine in seven dogs, weighing 20 kg or more. After 3 weeks of force application, 0.0215 inch multistrand wire and polyethylene ribbon were bonded to each side, as a flexible and rigid splinting respectively in 6 experimental animals. The remaining 1 served as the control group. Each 2 animals were sacrificed at 4, 8 and 12 weeks after splinting respectively and prepared histologically for hematoxyline-eosin and Masson's trichrome staining. The results of this study were obtained as follows : 1. After tooth movement, periodontal space was narrowed and periodontal fibers were thick on pressure side, while elongated fibers were observed on tension side. 2. After 4 weeks of retention, the rearrangement of periodontal fibers was observed in the flexible splinting group but not in the rigid splinting group. 3. After 8 weeks of retention, the rearrangement of periodontal fibers was observed in both groups but the difference could not detected between two groups. 4. During the retention period, the rearrangement of periodontal fibers was faster in tension side than in pressure side. These results show that the rearrangement of periodontal fibers is also obtained by rigid splinting after tooth movement. It is suggested that the rigid splinting by polyethylene ribbon can be used as a way of postorthodontic retention.

      • KCI등재

        Flurazepam이 가토 혈중 주정농도에 미치는 영향에 관한 실험적 연구

        이기연 大韓神經精神醫學會 1981 신경정신의학 Vol.20 No.4

        Flurazepam is one of several 1,4-benzodiazepine derivatives widely used in clinical practice. Chemically, it is 7-chloro-1-(2-diethylaminoethyl)-5-(o-flurophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one dihydrochloride. The sedative, anticonvulsant, and muscle relaxant effects of flurazepam on experimental animals resemble those of other benzodiazepines. But, it is used as a safe and potent hypnotic rather than as an anti anxiety agent. Investigators suggested that any new psycho-tropic drug should be tested for their interaction with alcohol, because it might precipitate risk situation in cases of consuming alcohol concurrently. In view of these facts, the author conducted an animal experiment to investigate the effects of flurazepam on blood alcohol level in rabbits. Material and method 1. The experimental work was done on mature rabbits of both sexes, weighing about 2kg. 2. The experimental animals were divided into two groups: the control and the experimental group. 3. The control group was given alcohol alone. 4. The experimental group was divided into 4 subgroups: a) Alcohol plus flurazepam, 15mg/kg of body weight daily for 5 days. b) Alcohol plus flurazepam, 15mg/kg of body weight daily for 10 days. c) Alcohol plus flurazepam, 30mg/kg of body weight daily for 5 days. d) Alcohol plus flurazepam, 30mg/kg of body weight daily for 10 days. 5. Flurazepam was given orally in a single daily dose at a fixed time. The last dose was given one hour and a half before alcohol administration. 6. In all groups, 20% ethanol solution was slowly given in a dose of 5.0ml/kg of body weight for 5 minutes by intravenous route. 7. All of the blood specimens were obtained by cardiac puncture at both 15 and 45 minutes after alcohol administration. 8. The blood alcohol level was determined by Cavett's method. Results 1. Alcohol plus flurazepam, 15mg/kg of body weight daily for 5 days. Flurazepam did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. )respectively, p>0.1) 2. Alcohol plus flurazepam, 15mg/kg of body weight daily for 10 days. In this group, flurazepam elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. (respectively, p<0.05) 3. Alcohol plus flurazepam, 30mg/kg of body weight daily for 5 days. In this group, there was also no significant change in the blood level at both 15 and 45 minutes after alcohol administration. (respectively, p>0.1) 4. Alcohol plus flurazepam, 30mg/kg of body weight daily for 10 days. In this group, flurazepam elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. (respectively, p<0.01) Conclusion 1. Flurazepam, when administered orally in a dose of 15mg/kg of body weight daily for 5 days did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. But, flurazepam, when administered orally in the same dose daily for 10 days, elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. 2. Flurazepam when administered orally in a dose of 30mg/kg of body weight daily for 5 days did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. But, flurazepam, when administered orally in the same dose daily for 10 days, elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration.

      • SCOPUSSCIEKCI등재

        치아이동 후 고정방법이 성견 치주인대 섬유의 재배열에 미치는 영향

        이기헌,황현식 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.5

        실험적 치이아동 후 보정기간 동안 고정방법이 치주인대 섬유의 재배열에 미치는 영향을 알아보기 위하여, 체중 20kg내외의 성견에서 상악 제2절치와 견치 사이에 견인 스프링을 이용하여 120gm의 교정력을 3주간 가한후 좌측에는 유연성 고정장치로 0.0215 인치 multistrand wire를 우측에는 견고성 고정장치로 폴리에틸렌 리본을 레진 접착제로 각각 장착한 다음 4주, 8주, 또는 12주 후 희생시켜 치주조직의 변화를 방사선 사진, 광학 현미경 관찰을 통하여 분석한 바 다음과 같은 결과를 얻었다. 1. 치아이동 후 압박측에서는 치주인대 공간의 압축과 함께 치주인대섬유가 굵어진 소견을 보였으며 인장측의 치주인대섬유는 신장되어 보였다. 2. 보정 4주 후 유연성 고정군에서는 치주인대섬유의 재배열이 관찰되었으나 견고성 고정군에서는 관찰되지 않았다. 3. 보정 8주 후부터는 두 군 모두에서 치주인대섬유의 재배열 소견이 관찰되었으며, 두 군간 치주인대섬유의 재배열차이는 보이지 않았다. 4. 보정기간 동안 치주인대섬유의 재배열은 압박측보다 인장측에서 빠른 소견을 보였다. 이상의 결과는 치아이동 후 견고하게 고정한 보정방법에서도 치주인대섬유의 재배열이 일어남을 보여주었고, 치아 보정시 폴리에틸렌 리본으로 고정한 보정장치도 유용하게 사용될 수 있음을 시사하였다. The purpose of this study was to evaluate the effect of splinting methods on the rearragement of periodontal fibers after experimental tooth movement. Orthodontic force was applied by placing closed coil spring between upper third incisor and canine in seven dogs, weighing 20kg or more. After 3 weeks of force application, 0.0215 inch multistrand wire and polyethylene ribbon were bonded to each side, as a flexible and rigid splinting respectively in 6 experimental animals. The remaining one served as a control. Each two animals were sacrificed at 4, 8 and 12 weeks after splinting respectively and prepared histologically for hematoxylin-eosin and Masson's trichrome staining. The results of this study were obtained as follows: 1. After tooth movement, periodontal space was narrowed and periodontal fibers were thick on pressure side while elongated fibers were observed on tension side. 2. After 4 weeks of retention, the rearrangement of periodontal fibers was observed in the flexible splinting group, but not in the rigid splinting group. 3. After 8 weeks of retention, the rearrangement of periodontal fibers was observed in both groups, but the difference could not be detected between two groups. 4. During the retention, the rearrangement of periodontal fibers was faster i tension side than in pressure side. These results show that the rearrangement of periodontal fibers is also obtained by rigid splinting after tooth movement. It is suggested that the rigid splinting by polyethylene ribbon can be used as a way of postorthodonitc retention.

      • KCI등재
      • KCI등재

        칸막이 공조 시스템의 급기구 위치와 급기 방향 조절에 따른 열환경 특성

        정기범,최상곤 대한건축학회 2004 대한건축학회논문집 Vol.20 No.4

        A partition supply system can provide highly personalized environmental control. The supply air is brought up through raised floors and supplied to outlets located on the partition panels. This paper aims to find out the best location of outlets for the personalized environmental control within a personal task area. Real scale experiments were conducted to allow comparison of outlet designs within a personal task area. Experimental results indicate that two way outlet is better than upper only or lower only case to improve the supply air distribution efficiency of the personal task area. Thermal characteristic comparisons were made among variable cases by the redirection of the supply air. Experimental results suggest that outlets should have operable directional grills that the occupant can control to avoid draft. Such a system can allow an occupant to personally control their immediate environment, resulting in higher productivity.

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