활주형선의 고속어선 적용에 관한 연구

이귀주,이광일,이조원 朝鮮大學校 機械技術硏究所 1999 機械技術硏究 Vol.2 No.2

본 연구는 25노트급 활주형 어선의 기본선형을 도출하기 위해 수행되었다. 대상선형은 총톤수 10톤급으로 자료조사 결과로부터 길이 15m, 폭 3.5m, 깊이 1.32m로 정하였다. 총 5척의 선형에 대하여 저항 및 트림, 침하량 계측시험을 수행하였다. 15노트까지와 저속역에 대한 모형시험은 조선대학교 회류수조에서 수행되었고, 이로부터 3척의 선형에 대하여 서일본유체기술연구소 고속회류수조에서 고속역에 대한 모형시험을 수행하였다. 연구결과 볼록-오목 단면형 선형의 선수를 DeeP V 형으로 개선한 P-4선형이 저항 및 기타 성능 면에서 가장 우수한 결과가 나왔다. This study was carried out to get a basic hull form planning fishing boat. Some principal characteristics of the object hull form of G/T 10ton class are selected as length 15m, breadth 3.5m, depth 1.32m from a result of data research. For 5 models, resistance, trim and sinkage were tested. The model tests at low speed zone were performed in Chosun University, and at high speed zone were performed in CWC at WJFEL. From test results, P-4 which inverted-bell type modified to deep V type was the most excellent with respect to resistance and the other performance

Arachidonic acid 대사산물이 배양골조직의 골흡수에 미치는 영향에 관한 연구

오귀옥,김세원 대한구강생물학회 1989 International Journal of Oral Biology Vol.13 No.2

This experiment was performed to study the arachidonic acid metabolites (prostaglandin E_2, leukotriene B_4 and HETE) and indomethacin of the bone resorption and the effect of indomethacin on the PGE_2-stimulated bone resorption in the organ culture. Ulnae and radii or calvaria were removed from 19-day fetal rats prelabelled by subcutaneous injection of 200 μCi ^45CaCl_2 into mother rats at the 17th day of gestation. The control groups were cultured in fresh BGJb media, while experimental groups were cultured in media containing PGE_2 (10^-6M), indomethacin (10^-5M), leukotriene B_4 (0.1pM, 1pM, 10pM, 100pM and 1nM) or HETE (0.1pM, 1pM, 10pM, 100pM and 1nM) for 48 or 72 hours. Radioactivities of ^45Ca released into media and remained in bone after culture were respectively determined. The effects of each drugs were observed by the ratios of %-release of ^45Ca between control and experimental group. The observed results were as follows. 1. PGE_2, at concentration of 10^-6M, increased ^45Ca release significantly after 24 and 48 hours of culture. 2. Indomethacin, at concentration of 10^-5M, decreased ^45Ca release after 24 and 48 hours of culture, but there was no significant difference. 3. LT and HETE, at all concentrations, had no effect on the bone resorption after 72 hours of culture. 4. Indomethacin, at concentration of 10^-5M, had no effect on the PGE_2-stimulated bone resorption after 72 hours of culture.

산후 정신장애

한귀원 日新基督病院 2000 日新基督病院論文集 Vol.15 No.-

알콜의존 환자에서 음주욕구를 유발하는 조건화자극에 대한 연구

한귀원,김명정,김성곤,변원탄 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

DSM-IV에 의하여 알콜 의존으로 진단되어 입원 중인 18세에서 65세 사이의 남자로서 과거 3주이상의 단주 경험이 있는 환자 110명을 대상으로 음주 욕구를 유발하는 조건화 자극의 종류와 빈도를 조사하였다. 먼저 예비조사를 통하여 환자들로부터 수집한 알콜연관자극들 중에서 흔한 내적 및 외적 자극 각각 25가지씩, 모두 50가지를 선정한 후, 대상 환자로 하여금 50가지의 알콜연관자극 중에서 자신에게 해당하는 자극을 모두 선택하게 하였다. 그 후 각 알콜연관자극의 빈도와 유형별 빈도를 조사하고 환자의 인구학적 특성, 음주력, 불안 및 우울 척도 등과 관련하여 검토하였다. 그 결과는 다음과 같다. 1) 조건화 자극을 내적 및 외적 알콜연관자극으로 분류하였을 때, 내적 자극은 신체 상태, 긍정적 기분 상태 그리고 부정적 기분 상태로, 외적 자극은 즐거운 상황, 불쾌한 상황, 알콜과 연관된 상황 및 기타 상황으로 분류되었다. 2) 1인당 선택한 문항의 평균 수는 14.1±8.6개로 내적 자극이 7.5±4.8개, 외적 자극이 6.5±4.4개이었으며 각 자극을 하나라도 선택한 사람은, 내적 자극은 대상군 모두가 선택하였고 외적 자극은 대상군의 99.1%가 선택하였다. 부정적 기분 상태와 불쾌한 상황은 각각 97.3%, 88.2%로서 가장 높은 빈도를 보였고 긍정적 기분 상태와 즐거운 상황도 각각 42.7%, 71.8%로서 높은 빈도를 보였다. 신체 상태에 관한 자극은 대상군의 68.2%가, 알콜과 연관된 상황에 관한 자극은 68.2%가, 그리고 기타 상황에 관한 자극은 49.1%가 선택하였다. 3) 음주 욕구를 증가사켰던 내적 자극 중 높은 빈도로 선택된 문항들은 화가 날 때(71%), 외로울 때(47%),고민이 될 때(45%), 시장기가 돌 때(45%), 잠이 안올 때(45%) 등이었고, 외적 자극 중에서 높은 빈도로 선택된 문항들은 가족이나 친척들과 갈등이 있거나 다투는 경우(53%), 잔치, 초상, 계 등 사회적인 모임이 있을 경우(52%), 하는 일이 잘 되지 않을 때(49%), 직장에서 혹은 친구와 갈등이 있거나 다투는 경우(42%)등이었다. 4) 환자의 나이와 신체 상태의 알콜연관자극 간에는 유의한 정상관관계가 있었고, 문제 음주로 인해 처음 정신과에 입원한 나이와 신체 상태의 알콜연관자극 간에도 유의한 정상관관계가 있었으며, 교육 수준과 신체 상태의 알콜연관자극 사이에는 유의한 역상관관계가 있었다. 그리고 입원횟수와 부정적 기분 상태의 알콜연관자극 사이에는 유의한 정상관관계가 있었다. 그러나 첫 음주 시작 나이, 문제 음주 시작 나이, 문제 음주 지속 기간, 최대 단주 기간, 병원 치료 후 평균 단주 기간, 개인의 특성 불안과 우울 점수 등과 알콜연관 자극의 유형 간에는 유의한 상관관계가 없었다. 또한 직업 유무별, 사회경제 상태별, 음주가족력 유무별, 결혼 상태별, 종교별 및 음주 양상별로 본 알콜연관자극의 유형별 선택 문항 수에 있어서도 통계적으로 의미있는 차이는 없었다. Conditioned stimuli provoking alcohlol craving in the alcoholics were surveyed in 110 hospitalized male patients with the diagnosis of alcohol dependence according to DSM-IV who had had 3 weeks or more of successful periods of alcohol abstinence after the onset of alcohol dependence. A preliminary study of preparing a list of 50 alcohol related cues(ARCs) was performed by collecting ARCs from 50 alcoholic patients, choosing the more frequent stimuli and rearranging those into 25 internal and 25 external ARCs. And then, each of the 110 subjects was asked to choose all the ARCs which provoked alcohol craving in the past to survey the frequency of the ARCs and their relevance with regards to a number of variables such as certain demographic data, alcohol history and anxiety and depression. The results were as follows ; 1) The ARCs were divided into internal and external ARCs ; the internal ARCs were categorized into positive affects, negative affects and somatic conditions and the external ARCs into pleasant situations, unpleasant situations, alcohlol-related situations and other situations. 2) Total mean number of ARCs per person was 14.1±8.6, that of internal ARCs being 7.5±4.8 and that of external ARSc being 6.5±4.4. All the subjects chose at least one of the internal ARCs and 99.1% chose one or more external ARCs. ARCs of negative affects and unpleasant situations were chosen by 97.3% and 88.2% of the subjects respectively, whereas, those of positive affects and pleasant situations were chosen by 42.7% and 71.8% respectively, showing unexpectedly high frequency. ARCs pertaining to somatic conditions were chosen by 68.2% of the subjects, those of alcohol-related situations were chosen by 68.2% and those of other situations by 49.1%. 3) Frequently chosen items of internal ARCs were when I was angry (71%),' when I was lonely'(47%), 'when I was distressed'(45%), 'when I was hungry'(45%) and 'when I had trouble sleeping' (45%). Those of external ARCs were 'when I had an argument or conflict with a relative' (53%), 'when I was at a social meeting such as party or funeral ceremony'(52%), when the things were not going to work out' (49%), 'when I met a friend whom I liked'(49%) and 'when I had an argument with a friend or people at work' (42%). 4) Positive correlations were seen between age and ARCs of somatic conditions and between age at the first psychiatric hospitalization and ARCs of somatic conditions. However, negative correlation was found between educational level and ARCs of somatic conditions. Number of psychiatric hospitalization was positively correlated with ARCs of negative affects. But there were no significant correlations in age at the first drink, age of onset of alcohol related problems, duration of alcohol related problem drinking, maximal length of abstinence, usual duration of abstinence after hospital treatment and score of trait anxiety and BDI. No significant difference was noted in the mean number of ARC subtypes between different groups divided by other demographic or clinical variables such as status of job, social class, family history of alcohol dependence, status of marriage, religion and drinking patterns.

만성 골수성 백혈병(Chronic Myelogenous Leukemia) 치료 중 인터페론-알파(Interferon-α)에 의한 용혈성 요독 증후군 1예

장재원,김유미,서장원,최귀숙,유수진,지현숙,유종우,박수길 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2

Interferon-alpha is an established therapy for the patients with myeloproliferative disease. Unusual immune- mediated side effects have been reported during treatment. Among them, renal and cardiac toxicities are rare complications. Recently we experienced a case of hemolytic uremic syndome found in a 40-year old male undergoing interferon-alpha therapy for chronic myelogenous leukemia, chronic phase. On admission, his chief complaints were generalized edema and azotemia. Bone marrow biopsy revealed transformation into accelerated phase. bcl/abl gene was positive. Peripheral blood smear showed hemolytic anemia. Despite prompt diagnosis, institution of plasmapheresis, and steroid, his renal function did not recover, as expected. Hemolytic uremic syndrome was a chronic form of renal toxicity due to interferon- alpha. In this case, renal function did not recovered to normal level. However, early detection of renal toxicity such as proteinuria or acute tubular necrosis, and the discontinuation of interferon-alpha could achieve the recovery of normal renal function. Therefore, periodic examination of renal function should be performed in the patients with the use of long-term interferon-alpha. (Korean J Nephrol 2002; 21(2):341-347)

市販 菓子中의 着色料 檢査

곽옥찬,김수자,김옥원,박귀진,홍연표 梨花女子大學校 藥學硏究所 1961 梨花藥學硏究 Vol.- No.2

주산기 백서에서 혈중 에스트로겐 농도와 공간 기억력과의 상관관계

박민성,박제민,신성현,한귀원,김명정,김성곤 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.5

Objectives : This study was designed to find possible effect of pregnancy and parturition on spatial memory, especially in relation to levels of estrogen during the third trimester and postpartal period in rats. Methods : 25 female Sprague Dawley rats were divided into pregnant group (N= 14) and control group (N= 11). Changes in spatial memory during 6 weeks including third trimester and postpartal period were measured using Morris water maze. Time to reach the platform in the maze was indicator of spatial memory. Serum estrogen level was measured on 1 week before delivery, postpartal day 1, and day 14. Results : Both groups showed gradual improvement in performance by trial days and weeks, but no significant difference was found between the two groups. However in the third trimester, pregnant group showed a trend of less achievement on 3 days of learning than control group. Serum estrogen levels did not differ significantly between groups over the 6 weeks of period. However there was positive correlation between serum estrogen level on postpartum day 1 and time to reach platform on postpartum week 2, and negative correlation between estrogen level on postpartum day 14 and latency to the platform on postpartum week 5. Conclusion : These results imply that changes in the serum estrogen level may have dual effects on the spatial learning in peripartal period. It is suggested that decline in cognitive function might occur either by failure of rapid decrease of estrogen, immediately after parturition, or retarded restoration of estrogen in later postpartal period.

Influence of preparation depths on the fracture load of customized zirconia abutments with titanium insert

Kwi-Dug Yun,Min-Kyung Ji,Hyun-Pil Lim,Hyun-Seung Kim,Sang-Won Park,Hong-So Yang,Han-Sung Joo 대한치과보철학회 2015 The Journal of Advanced Prosthodontics Vol.7 No.3

PURPOSE This study evaluated the fracture load of customized zirconia abutments with titanium insert according to preparation depths, with or without 5-year artificial aging. MATERIALS AND METHODS Thirty-six identical lithium disilicate crowns (IPS e.max press) were fabricated to replace a maxillary right central incisor and cemented to the customized zirconia abutment with titanium insert on a 4.5×10 mm titanium fixture. Abutments were fabricated with 3 preparation depths (0.5 mm, 0.7 mm, and 0.9 mm). Half of the samples were then processed using thermocycling (temperature: 5-55℃, dwelling time: 120s) and chewing simulation (1,200,000 cycles, 49 N load). All specimens were classified into 6 groups depending on the preparation depth and artificial aging (non-artificial aging groups: N5, N7, N9; artificial aging groups: A5, A7, A9). Static load was applied at 135 degrees to the implant axis in a universal testing machine. Statistical analyses of the results were performed using 1-way ANOVA, 2-way ANOVA, independent t-test and multiple linear regression. RESULTS The fracture loads were 539.28 ± 63.11 N (N5), 406.56 ± 28.94 N (N7), 366.66 ± 30.19 N (N9), 392.61 ± 50.57 N (A5), 317.94 ± 30.05 N (A7), and 292.74 ± 37.15 N (A9). The fracture load of group N5 was significantly higher than those of group N7 and N9 (P<.017). Consequently, the fracture load of group A5 was also significantly higher than those of group A7 and A9 (P<.05). After artificial aging, the fracture load was significantly decreased in all groups with various preparation depths (P<.05). CONCLUSION The fracture load of a single anterior implant restored with lithium disilicate crown on zirconia abutment with titanium insert differed depending on the preparation depths. After 5-year artificial aging, the fracture loads of all preparation groups decreased significantly.

REVIEW : S100A8/A9 as a biomarker for synovial inflammation and joint damage in patients with rheumatoid arthritis

( Kwi Young Kang ),( Jung Won Woo ),( Sung Hwan Park ) 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.1

S100A8 and S100A9 are major leukocyte proteins, known as damage-associated molecular patterns, found at high concentrations in the synovial fluid of patients with rheumatoid arthritis (RA). A heterodimeric complex of S100A8/A9 is secreted by activated leukocytes and binds to Toll-like receptor 4, which mediates down-stream signaling and promotes inflammation and autoimmunity. Serum and sy-novial fluid levels of S100A8/A9 are markedly higher in patients with RA than in patients with osteoarthritis or miscellaneous inflammatory arthritis. Serum lev-els of S100A8/A9 are significantly correlated with clinical and laboratory markers of inf lammation, such as C-reactive protein, erythrocyte sedimentation rate, rheumatoid factor, and the Disease Activity Score for 28 joints. Significant cor-relations have also been found between S100A8/A9 and radiographic and clinical assessments of joint damage, such as hand radiographs and the Rheumatoid Ar-thritis Articular Damage score. In addition, among known inflammatory mark-ers, S100A8/A9 has the strongest correlation with total sum scores of ultrasonog-raphy assessment. Furthermore, baseline levels of S100A8/A9 are independently associated with progression of joint destruction in longitudinal studies and are responsive to change during conventional and biologic treatments. These find-ings suggest S100A8/A9 to be a valuable diagnostic and prognostic biomarker for RA.

Reigeluth의 정교화 방략요소를 도입한 탐구능력학습을 위한 탐구프로그램의 효과 : 물질의 상태변화에 대한 탐구활동

원귀연, 김동욱 대구교육대학교 과학교육연구소 2004 과학·수학교육연구 Vol.27 No.-