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조복현,오광식,오제직 공주대학교 사범대학 과학교육연구소 1998 과학교육연구 Vol.29 No.1
내용 체계는 제 6 차 교육 과정의 독특한 체계로서 전체적으로 지식에 관련된 영역과 탐구에 관련된 영역으로 나누어져 있는데 지식 영역은 물질, 생명, 지구, 운동과 에너지 등의 4개 영역으로 구분되어 지식 내용 요소들을 학년별로 제시하고 있으며, 탐구 영역은 관찰, 분류, 측정, 실험, 자료해석, 조사, 토의 등 7개 탐구 활동 내용 요소가 학년별로 제시되어 있다. As a unique system of the 6th curriculum it divides in two - one is related to knowledge, and the other to science process skill. Especially in science process skill field, it presents seven factors - observation, division, measurement, experiment, understanding the data, investigation, and discussion. This means conversion to living science emphasized sociological, technical, and scientific side through science process skill based on the 6th curriculum.
Post-market surveillance assay of veterinary medicines in Korea during 2009∼2012
( Kwang Jick Lee ),( Jeong Woo Kang ),( Sung Won Park ),( Jae Jo Kim ),( Seong Joon Joh ),( Heui Jin Kim ),( Meung Ju Chae ),( Soon Ok Jee ),( Seon Jong Yun ),( Byung Jae So ) 한국예방수의학회 2013 예방수의학회지 Vol.37 No.3
As veterinary medicine industry has grown up steadily, the government quality control of veterinary medicine in market has been performed since 1964. The result of post-market surveillance assay from 2009 to 2012 was analyzed in this study. The average violation rate of all veterinary medicines, was 3.2%, 2.8%, 2.8% and 1.4% in 2009, 2010, 2011 and 2012, respectively. The total average violation rate in the category of antibiotics, other drugs except antibiotics, biologics were 1.2%, 4.4% and 0.8%, respectively. The violations due to insufficiency of major active ingredient content occupied 76.7% among the total violations. The most frequent violated in antibiotics were ampicillin and tylosin, followed by sulfonamides, penicillins etc. In case of other drugs except antibiotics, vitamin A and glucocorticoids (dexamethasone and prednisolone) were violated frequently. The overall trend of violation rates gradually decreased from 2009 to 2012, suggesting that quality of veterinary medicines has improved according to Korea Veterinary Good Manufacturing Practice (KVGMP) system settled down in 1988.
Vibrio vulnificus의 병원성 및 철이 병원성에 미치는 영향에 관한 연구
Kwang Jick LE(李光稙),Tae Jong KIM(金泰鍾) 한국예방수의학회 1989 예방수의학회지 Vol.13 No.1
The septicemia associated with Vibro vulificus has been recentyly recognized in the medical field, Therefore, these studies were proposed and carried out to determine the pathogenicity and effect of iron on pathogenicity of V. vulnificus. The results obtained were summarized as follow: 1. The LD₅₀ value of V. vulnificus injected with O.1 ml dose to 8-10 week old ICR-JCL female mice by subcutaneous route was 3.44×10⁷ in ATCC27562 strain, 2.08×10⁶ in C7184 strain, 1.35×10⁹ in KNIH-85-22 strain isolated and 4.23×10⁷ in KNIH-85-B-27 strain isolated, but by intraperitoneal route the virulence seemed to be slightly higher showing 1.09×10⁶ in ATCC 2762 strain, 6.57×10⁵ in C7184, 4.27×10⁶ in KNIH-85-22 strain isolated and 3.29×10⁶ in KNIH-85-B-27 strain isolated. The haematocrit value injected with C7184 strain, KNIH-85-22 strain isolated and KNIH-85-B-27 strain isolated to 5-6 week old female mice injected by intraperitoneal route had increased up to value of 67-68% after 3 to 6 hours from the value of 44-46% in the normal mice. The bacteremia was observed within 10 to 15 minutes in the blood stream of the mice and it was 10³ to 10⁵ cells per ml of the mice blood just before died. 2. Infection with V. vulnificus resulting in septicemia and high mortality have been correlated with pre-existing liver disease. As these conditions are associated with impaired metabolism and as iron availability in the host has been implicated in the pathogenicity of a number of bacterial infections, the role of iron as a possible factor in the pathogenesis of V. vulnificus was examined. Injection of mice with iron resulted in a lowering of the LD₅₀ from 1.09×10⁶/0.1㎖ to 2.3×10³/0.1㎖. By damaging livers with minjections of CCl₄, the LD₅₀ was 0.32×10¹/0.1㎖. The effects of adding iron on the growth of V. vulnificus in human sera was also examined. Iron appeared to be the limiting factor in the ability of this organism to survive or grow in various condition. These results, both in vito and in vivo, provided strong evidence that may play a role in the pathogenesis of V. vulnificus.
Prediction of skin penetration of Bifenthrin using in vitro micro-pig skin model
Ji-Hyun Bang(Ji-Hyun Bang),Hyun-Ok Ku(Hyun-Ok Ku),Byung-Suk Jeon(Byung-Suk Jeon),Hyobi Kim(Hyobi Kim),Kwang-Jick Lee(Kwang-Jick Lee),Yong-Sang Kim(Yong-Sang Kim),Hee Yi(Hee Yi) 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-
Tae Haeng Cho(趙太行),Kwang Jick Lee(李光稙),Jong Myung Park(朴鍾鳴),Sun Namgoong(南宮琁),Keun Sik Park(朴根植) 한국예방수의학회 1993 예방수의학회지 Vol.17 No.1
This report was results to be analyzed for quality control to animal using antibiotics of 28, 741 lots during the periods of 1963 to 1992. Among them, 28, 574 lots are passed and 167 lots rejected through national assay. The preparation forms of animal using antibiotics of total 14, 071 lots examined for 6 years(1987-1992) were classified as feed additives 4, 781 (34.0%), injectables 3, 871 (27.5%) and soluble powders including oral suspensions 3,426(24.3%), respectively. Of the antibiotics of 14,071 lots, 1,182 lots(8.4%) were applied for raw materials, 733(5.2%) as implantations for therapy of bovine mastitis and 78 lots (0.6%) as the other antibiotics. In 1992, 2, 282 lots of animal using antibiotics were examined by regulations of national assay. Among them, mono-antimicrobial drugs were 1, 697 lots (74%) and combined antibiotics 585 lots (26%), respectively. The nomo-antibiotics and combined antibiotics were constituted with 58 kinds of chemical components. During the periods of 1985 to 1992, 18, 230 lots of antibiotics were tested by regulations of national assay. Among them, 167 lots were rejected by results of national assay. By the preparation forms, the soluble powders including the oral suspensions were highly rejected as 54 lots, and injectables, feed additives, implantations and the others were orderly rejected 49, 45, 17 and 2 lots, respectively. By reason of the rejection, 129 of 167 lots were insufficiently potency, 24 excessively humidity, 11 highly pH and 3 adequately characteristic tests, respectively.