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권광일,윤민혁,윤희열,박희찬,권준택,심희옥,김동출 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-
A reversed phase HPLC method was developed and validated for the determination of primidone in human plasma. Propylthiouracil was used as an internal standard. Calibration curves were linear in the concentration range of 10-120 ng/㎖. The coefficient of variation of the intra- and inter-day precision were below 15%. The coefficient of variation of the accuracy were below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Twenty four healthy human male volunteers were orally administered 20 mg of primidone. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(LAST) was 85.0±17.7 ㎍ hr/㎖, C_(max) was 4.22±1.04 ㎍/㎖, T_(max) was 1.85±1.13 hr, t_(1/2) was 17.7±2.4 hr. The pharmacokinetic parameters and the HPLC method can be used for the desigm of bioequivalence study of primidone.
ATM 망에서 우선순위 제어 및 실시간 처리가 가능한 호 수락 제어
이혁진,오민웅,박광채 조선대학교 동력자원연구소 1996 動力資源硏究所誌 Vol.18 No.1
When a new call requests a call set-up, call admission control determines whether to accept a call set-up or not, in order to maintain the QOS of existing and new calls. In this paper, the VP bandwidth is separated to eliminate interference between traffics. We can class CBR and VBR traffic and fulfill call admission control applied to each traffic. The call admission control method of CBR traffic is peak bandwidth allocation and that of VBR traffic is performed to guarantee QOS. Proposed method is suitable for real time processing because the amount of calculation is reduced remarkably by using recursive equations in estimating cell loss probability. Also, proposed method can be applied to prioity control.
( Kwang Jin Woo ),( Hyek Yung Jung ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Xanthogranuloma of the stomach is an extremely rare disease, and only a few cases have been reported. Case presentation: A 71-years-old male was referred to our hospital because of subepithelial tumor of the stomach on health medical examination. On endoscopic examination, there was an about 2. 0cm sized subepithelial lesion at greater curvature of prepyloric antrum. Endoscopic ultrasound revealed that 2cm sized heterogenous mass from third layer of stomach wall, including anechoic, cystic degeneration, suggestive of bleeding or necrosis. In the cystic portion, the mural nodule was detected, suggestive of malignant potential of submucosal mass. During the laparoscopic wedge resection, the submucosal lesion was shrinked and after the resection, brownish fi uidwas squeezed from the cystic portion. Histopathologic examination of the resected specimen demonstrated submucosal nodular xanthogranuloma with central fi brinoid necrosis and cystic change. Conclusions: We report an extremely rare case of gastric submucosal xanthogranuloma which was initially malignant subepithelial lesion because of internal echogeneity with cystic degenetation. Further accumulation and investigation of this entity is necessary.
박광채,이혁진,서순석 조선대학교 동력자원연구소 1995 動力資源硏究所誌 Vol.17 No.2
One of the challenges in the interconnection of LAN and MAN to ATM is the support of connectionless traffic in the ATM network. A commonly proposed strategy consists of maintaining a low bandwidth VP(virtual path) between each pair of gateway and of requesting more bandwidth whenever a burst comes in from the LAN or MAN. Unfortunately this stratege places a heavy burden on the ATM control processor. Therefore we proposed BA(Bandwidth Advertising) scheme, which know available bandwidth and On-the-fly transmission, which transfer bursts without prior bandwidth reservation. The BA scheme and On-the-fly transmission for connectionless traffic is described and is compared with a bandwidth renegotiation strategy.
최소수리를 갖는 정기 정비 정책하에서의 고장률 추정 및 정비주기 산정 : K 제철소 사례 A Case of K Steelworks
전치혁,박광수,황욱연,주민보 대한설비관리학회 1998 대한설비관리학회지 Vol.3 No.1
This paper considers some periodic preventive maintenance policies with minimal repair at failure under the assumption that the time to failures follows a Weibull distribution. The maximum likelihood estimation of Weibull parameters incorporating the censored data is proposed under perfect as well as imperfect preventive maintenance models. The proposed estimation procedure is applied to a real data from the K steelworks.
분산공유 메모리 시스템을 위한 동적 제한 디렉터리 기법
이동광(Lee Dong Kwang),권혁성(Kweon Hyek Seong),최성민(Choi Seong Min),안병철(Ahn Byoung Chul) 한국정보처리학회 1999 정보처리학회논문지 Vol.6 No.4
The caches in distributed shared memory systems enhance the performance by reducing memory access latency and communication overhead, but they must solve the cache coherence problem. This paper proposes a new directory protocol to solve the cache coherence problem and to improve the system performance in distributed shared memory systems. To maintain the cache coherence of shared data, processors within a limited distance reduce the communication overhead by using a bit-vector like the full directory scheme. Processors over a limited distance store pointers in a directory pool. Since the bit-vector and the directory pool remove the unnecessary cache invalidations, the proposed scheme reduces the communication traffic and improves the system performance. The dynamic limited directory scheme reduces the communication traffic up to 66 percents compared with the limited directory scheme and the number of directory access up to 27 percents compared with the dynamic pointer allocation scheme.
축출 우선순위 트래픽 제어 메카니즘의 성능 분석에 관한 연구
이수영,이혁진,오민웅,박광채 조선대학교 동력자원연구소 1994 動力資源硏究所誌 Vol.16 No.2
본 논문에서는 다중의 우선순위를 지원하는 통신망에 확장시켜 적용할 수 있는 Markov chain을 이용한 축출 우선순위 트래픽 제어 메카니즘의 해석방법을 제안하였다. 제안한 해석방법을 전체 버퍼의 크기, 트래픽 세기, 우선순위 트래픽의 혼합비 등을 가변하면서 두개의 우선순위를 지원하는 ATM 망에 적용한 결과 트래픽 세기가 0.5∼0.8일 때 전체 버퍼의 크기가 25정도이면 서비스 품질을 만족하였다. 그러나 다중 우선순위 제어에서는 할당된 우선순위의 수와 우선순위 트래픽의 혼합비 등이 손실에 많은 영향을 미친다는 것을 알 수 있었다. 또한 기존의 해석방법에 비하여 간단하면서도, 비교적 정확한 결과를 얻었으며 임의의 우선순위를 지원하는 통신망에 신축성있게 적용할 수 있음을 알았다. 제안한 해석방법은 시뮬레이션 전용언어인 SIMSCRIPT II.5로 시뮬레이션을 수행하여 결과의 타당성을 강조하였다. In this paper, we propose the analysis method of extended push-out priority traffic control mechanism which can be applied to the network supporting multiple priorities, using Markov chain. When proposed analysis methods are applied to ATM networks with two priorities as varying buffer size, traffic intensity and mixing ratio of priority traffics, as a result, it satifies the quality of service when the buffer size is 25 in traffic intensity 0.5∼0.8. But, in the case of multiple priority control mechanism, the number of assigned priorities and the mixing ratio of traffic affect the loss probability. Also we get very simple and more exact results compared with conventional analysis method and know that the proposed analysis method is flexibly applied to the network with multiple priorities. To verify the proposed analysis method, we perform the simulation using the SIMSCRIPT II.5 simulation package.