시각유발전위 반응의 임상적 응용

옥광휘,정흥섭,서중근,이훈갑,주정화 대한신경외과학회 1987 Journal of Korean neurosurgical society Vol.16 No.4

Visual evoked potentials were elicited by flash in 29 patients with a variety of cerebral lesions and in 10 normal controls. In 12 patients with focal brain lesions, no wave form could be recorded in one side. Of the remaining 23 sides, the average P₁ latency showed no difference from that of the normal controls. In 17 patients with diffuse brain lesions no wave form could be elicited in 12 sides. Average P₁ latency of remaining 22 sides showed statistically significant difference from that of normal controls. In this study it appears that delayed P₁ latencies are associated with diffuse cerebral lesions rather than with localized lesions.

고성능 유도 전동기를 위한 퍼지 속도 제어기

권병휘,全光鎬,崔秉淑,鄭雨均 홍익대학교 산업기술연구소 1997 産業技術 Vol.7 No.-

In this dissertation a novel speed control system that implements the fuzzy logic controller(FLC) is proposed. The proposed FLC used the speed error its rate of change, and the drive current as three fuzzy variables. The real command output current is chosen by the defuzzification of fuzzy output extracted from the fuzzy control rules. The flex and the torque of the induction motor are estimated using the dynamic model with an excellent dynamic response over a wide speed range and with the rotor flux field-oriented scheme of the decoupling characteristics The performance of this control system is substantiated by computer simulations.

퍼지논리를 이용한 자기 주도적 학습 능력과 시험 능력 평가 방법

정회인,양황규,김광백 한국컴퓨터교육학회 2004 컴퓨터교육학회 논문지 Vol.7 No.2

본 논문에서는 학습자 스스로가 학습 능력을 조절하고 학습 능력과 시험 능력을 객관적으로 판단할 수 있는 자기 주도적 학습 능력 및 시험 능력 평가 방법을 제안하였다. 제안된 자기 주도적 학습 능력 및 시험 능력 평가 방법은 삼각형 타입의 소속 함수와 퍼지 논리를 이용하여 학습 능력과 시험 능력의 소속도를 계산하고 각각에 대해 퍼지 등급도를 부여하였다. 학습 능력의 소속도와 시험 능력의 소속도에 대해서 퍼지 관계의 연산 및 합성에 의해 최종 소속도를 계산하고 퍼지 등급도를 결정하여 삭습자가 학습 능력의 소속도와 시험 능력의 소속도 및 최종 퍼지 등급도를 분석하여 스스로 학습을 조정할 수 있도록 하였다. 그리고 제안된 연구 내용을 인터넷 정보 검색사 필기 과목에 적용하여 구현하였다. In this thesis, We propose the self-directed learning and test-performing abilities assessment method to evaluate the learning and the test-performing abilities in which learners can not only control their own learning abilities for themselves, but also judge objectively learning and test-performing abilities. This method shows the membership degree of learning and test-performing abilities by using both the triangle-type membership function and the fuzzy logic. In addition, it gives the fuzzy grades to each item. The final membership degrees are calculated and the fuzzy grades are decided by the operation and composition of fuzzy relations on the membership degrees of learning and test-performing abilities. In this method, which is applicable to a writing subject for information searchers, learners are asked to analyse the membership degrees of the learning and test-performing abilities and the final fuzzy grades and to adjust a learning process for themselves.

韓國의 벤처기업의 발전방안과 벤처캐피탈의 역할에 관한 연구

고광선,양희재 여수대학교 1997 論文集 Vol.11 No.1

Some Venture businesses have come into being as a result of the recent structural change of Korean society, even though the number is yet quite small. those venture businesses are expected to make a contribution to the promotion of korea's economy by taking a part to reform the industrial structrue of Korea into a flexible one, as shown in the American instance. Venture capital should give not only financial support to venture businesses at the start-up stage, but managerial advices after the investment. To activate the venture capital, some supportive polices such as the improvement of legal basis and taxational benefits should be prepared.

한국의 관광자원 개발을 위한 정책 방안에 관한 연구

양희재,고광선 여수대학교 1998 論文集 Vol.13 No.1

For many years some efforts have been made to develop native tour resources and characterized commodities. The efforts have been focused mainly on domestic tours, and preserving native culture has been paid little attention. Tour resources should meet foreign tourists' needs as well as domestic tourists'. And developing tour resources should run parallel with preservation of them.

희귀한 청신경 초종 : 증례보고 Case Report

옥광휘,정용구,박윤관,정흥섭,이훈갑,이기찬,주정화 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.6

A case of cystic acoustic Neurinoma is reported. The Patient was 41 year old man with temporal lobe epilepsy. Computerized tomography disclosed a low density cystic mass at left cerebellopontine angle that extended to suprasellar cistern through tentorium. At operation, multiloculated cysts were found that looked like cysticercosis. Pathological examination revealed a typical neurilemmoma with Antoni A and B area that formed cyst wall.

등방성 이종재료 내의 Ⅴ-노치 균열에 대한 응력강도계수 결정에 관한 연구

조상봉,정휘원,김진광 경남대학교 신소재연구소 1999 論文集 Vol.11 No.-

접합계면 V-노치 균열 문제는 고유치와 고유벡터 문제로 수식화할 수 있다. V-노치 균열첨단에서 응력특이성을 가지는 고유치가 존재한다. 상반일 등고선 적분법(RWCIM)은 고유치와 관련된 고유벡터의 계수를 구하는 한 가지의 방법이다. 상반일 등고선 적분법을 이용하여 접합계면 균열의 응력확대계수를 구하도록 시도하였다. 상반일 등고선 적분법으로 구한 응력확대계수와 경계요소법과 변위외삽법을 이용하여 구한 결과를 비교하였다. An inteiface 17-notched crack problem can be formulated as a eigenvalue problem. there are the eigenvalues which give stress singularities at the V-notched crack tip. The RWCIM is a method of calculating the eigenvector coefficients associated with eigenvalues. Obtaining the stress intensity factors for an interface crack in dissimilar materials was examined by the RWCIM. The results obtained for stress intensity factors using RWCIM were compared with those obtained by using the displacement extrapolation method and the BEM.

자폐아동의 기본운동교육프로그램 참가가 지각운동능력발달에 미치는 영향

이창섭,이명휘,현광석,이창규,조병준 한국특수체육학회 2003 한국특수체육학회지 Vol.11 No.1

The purpose of this study was to examine how the program of basic movement can influence and change the capability of perceptive movement among the children with autism. Four subjects (age3-5) participated in the specially designed program, three times a week for four weeks. For the purpose of this study, Oseretsky's Motor Development Test and PMDT(perception-Movement development Diagnosis Test) were used. The results were as follows; First, the upper limb performance of the children with autism showed significant changes by the movement education program. Second, along with the development of upper limb performance, the motor development index of the children with autism showed significant changes. Third, the Oseretsky spectrum of movement, of the children with autism responded to the order of mono-movement capability, hand-movement and co-operative movement. Fourth, the movement education program was more effective for the children with autism than for the retarded children in view of motor development capability. Fifth, the movement education program was more effective for the child with autism of multi-movement characteristics.

임상검체에서 분리된 Acinetobacter의 항균제 내성(1991-1997)

송호연,조성란,김휘준,고광균 대한화학요법학회 1998 대한화학요법학회지 Vol.16 No.2

목적 : 최근 원내감염의 중요 원인균으로 대두되고 있는 A. baumannii의 발생 양상 및 병동 별 항균제 내성의 변화 추이를 조사하여 치료시 적절한 항균제를 선택하는데 도움이 되는 자료를 제공하고자 하였다. 방법 : 1991년 1월부터 1997년 12월까지 7년간 한 대학병원의 입원환자로부터 분리 동정된 Acinetobacter의 균종별, 계절별, 임상검체별 분리양상을 조사하고 디스코 확산법에 의한 항균제 내성의 변화 추이 및 중환자실과 일반 병실에서의 항균제 내성 차이를 분석하였다. 결과 : 분리 동정된 Acinetobacter 4,128균주 중 91.5%가 A. baumannii로 연도에 따라 발생율이 증가하는 양상을 보였고 여름철이 호흡기계 검체로부터 가장 많이 분리되었다. A. baumannii로 imipenem과 ciprofloxacin을 제외한 대부분의 항균제에 높은 내성을 나타내었고 많은 항균제에서 내성율이 연도에 따라 점차 증가하였다. 3,777균주의 A. baumannii 중 45.2%가 중환자실 및 신생아실에서 분리되었는데 이는 중환자실 입원 환자수가 일반병동보다 훨씬 적은 것을 고려할 때 매우 높은 발병율임을 알 수 있었다. 또한 중환자실에서 분리된 균주의 다제내성율은 일반병동에서 분리된 균주보다 훨씬 높았다. 결론 : 중환자실에는 일반병동에 비해 다제내성율이 훨씬 높아 감염에 대한 저항력이 저하된 중증환자들의 생명을 끊임없이 위협하고 있는데 이런 다제내성균의 출현 및 원내감염을 줄이기 우한 중환자실만의 집중적인 대책이 수립되어야 할 것으로 사료된다. Background : Acinetobacter baumannii is recognized as an important causative agent of nosocomial infection. Therefore, it is important to understand the changing patterns of antimicrobial resistance to guide for antimicrobial therapy of infection by A. baumannii. So we compared the rate of miltidrug-resistance between ICU and general wards and we analyzed the trends of antimicrobial resistan changes during the past seven years. Methods : Acinetobacter isolated from 1991 to 1997 at a tertiary hospital were classified according to species, wards, seasons and clinical specimens. We tested the antimicrobial resistance by the standard disk diffusion method and compared the multidrug-resistant patterns of A. baumannii isolated from ICU with those from general wards. Results : Among the 4,128 Acinetobacter isolates, A. baymannii was the most common species(91.5%), followed by A. Iwoff??(8.5%), Acinetobacter species were isolated mainly from respiratory specimens during the summer. A. baumannii showed high resistance rates to most of antibiotics except imipenem and ciprofloxacin and resistance rates were increasing year after year. Forty-five percent of A. baumannii was isolated from ICU and neonate room, it showed higher multidrug-resistance rate than those generated from general wards. Conclusion : Multidrug-resistant. A. baumannii was predominant in ICU than general wards. It will contribute to increase of mortality due to nosocomial infection in severly ill patients. In order to reduce occuranc of multidrug-resistant isolates and noscomial infection in ICU, it is necessary to organize the intensive surveillance system in ICU.

Afloqualone의 LC/MS/MS분석과 건강한 성인 지원자에 대한 약물동태 연구

이서판,이병요,윤휘열,이은주,권광일 충남대학교 약학대학 의약품개발연구소 2008 藥學論文集 Vol.23 No.-

Afloqualone is a centrally acting muscle relaxant that inhibits mono- and polysynaptic reflexes. The purpose of this study was to estimate the pharmacokinetic parameters of afloqualone in healthy volunteers. The pharmacokinetics of afloqualone tablet was examined on 24 healthy volunteers who received a single oral dose(20 Bg) of each preparation in the fasting state. Blood samples were ten at 0, 0.5, 1, 1.5 2 3 4 6 8 10, 12 and 24 hr after drug administration. Blood concentrations of afloqualone were determined using a liquid chromatography tandem mass spectrometry(LC/MS/MS) systems. A two compartment model was used to explain the pharmacokinetic properties of afloqualone. The pharmacokinetic parameters were calculated with model independent(AUC, C_max, T_max, CL_t, V/F) and model dependent(K_ei, K_a, K_cp, K_pc, t_1/2) Pharmacokinetic analysis using WinNonlin program. The estimated means of AUC_0-24hours, C_max, T_max CL_t and V/F were 148.99 ± 127.39 ng·hi/ml 35.11 ± 56.62 ng/ml, 1.81 士 1.34 hr, 189.01 士 79.67 L/hr and 848.61 ± 567.06 L, respectively. The model dependent parameters(K_ei, K_a, K_cp, K_pc, t_1/2) were 0.14 ± 0.18 hr^(-1), 11.64 ± 30.03 hr^(-1), 0.34 ± 0.39 hr^(-1), 0.1 ± 0.16 hr^(-1) and 10.56 ± 4.30 hr, respectively. In conclusion a two compartment model was best described the pharmacokinetic behavior of afloqualone in healthy human.