Piplartine과 전립선암 세포사멸

공은희,김광연,유선녕,이선이,안순철 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Background: Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide.Piper species have known anti-proliferation and anti-cancer activity. This study was to examine the anti-proliferation effects of piplartine on human prostate cancer cell. Methods: PC-3 human prostate cancer cells received piplartine 15 uM for 24 hours. Microarray was performed on piplartine-treated PC-3 cells. Results: Among 253 genes which were altered by piplartine-treated PC-3 cells (>3-4 folds), 143 genes were up-regulated and 110 genes were down-regulated by piplartine in microarray. Most of genes whichwere up-regulated by piplartine were functionally classified as apoptosis, immune response related genes. Genes which were down-regulated by piplartine were functionally classified as transcription, cell cycle related genes. Conclusion: Piplartine may induce anti-tumor activity for human prostate cancer along with regulated of cell cycle and apoptotic genes in piplartine-induced PC-cells.

활동적 생활도시 조성을 위한 부산 일부지역 보행환경 개선전략

고광욱,송성은 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Background : To spread the emerging concept 'active living city' as a process of healthy cities initiatives, there were need to collect the opinions of community leaders through various methods especially in the context of ecological perspective. So several kinds of studies needs to be done through various channels. Although there had been not those kind of approach, as a founding member of Alliance For Healthy Citeis in Western Pacific Regional Office of World Health Organization. innovative active living approaches were tried in part of Busan City. Method : Literature and case reviews, windshield survey and community opinion collecting have been done through various channels. Case reviews about domestic practical articles have been done. Fora were organized to present the concepts and to hear the real voice of community. Community opinion collecting using modified Kyonggi-Do Pedestrian Environment Survey Instruments was done to various citizen group(total 877) during 2005.09.1~12. 20Windshield survey have been done in major area of the District and some prominent point was photographed. Result : Through explorative literature and cases reviews, the concepts of active living and active living city were established. 9 model case were presented as separated booklet. Through community fora, practical and specific opinion and suggestion were received. Windshield survey and taking picture provided useful advocation material. According to the pedestrian environment survey, walking time for transport was somewhat desirable. But comprehensive pedestrian environment especially children safety was major concern. Specific negative event was experienced by citizen. Illegal car parking, deficiency of resting area, garbage was major area for improvement. Conclusion : More specified public officer survey needed to concrete policy making according to the active living city concept through Healthy Cities approach. Practical suggestion from community needs to transformed into specific policy. Increasing walking time through the improvements of walking environment may be good strategy for active healthy city making. Sustained advocation is needed using the results of this study.

Bacillus thuringiensis subsp. darmstadiensis 73E10-2의 σ-endotoxin 생산 및 용해조건

殷鍾克,李光培 대구보건대학 1992 대구보건대학 論文集 Vol.13 No.-

For the limition on the utility of chemical insecticides, numerous investigation have been focused on biological control of insect pests. Among many biological agents for insect pest control, Bacillus thuringiensis is considered to be one of most promising agents. In general, Bacillus thuringiensis subsp. darmstadiensis 73E10-2 produces α-endotoxin which is mosquitocidal toxin during sporulation. In the strain was produced a lot of α-endotoxin after cultivation at 28℃ for 8 days in T.Y.G. medium α-endotoxin in was highly toxic activity to mosquito larvae after dissociation of α-endotoxin in 50mM NaOH containing 10mM EDTA at 27℃ for 30 min.

외상후 스트레스 장애의 다면적 인성검사 특성

은헌정,이선미,장광철 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.2

본 연구는 외상후 스트레스 장애와 정상인을 의미있게 구별하여 주는 다면적 인성검사 반응 특성을 확인하고, 외상후 스트레스 장애군 내의 다면적 인성검사 프로화일 특성을 분류하고자 시도하였다. 연수 대상은 1991년 1월부터 1993년 3월까지 전주 예수병원에 입원 또는 외래로 내원한 외상후 스트레서 장애 환자 45명과 정상인 55명을 대상으로 하였다. 결과는 다음과 같다: 1) 외상후 스트레스 장애군이 L척도를 제외한 모든 척도에서 정상집단보다 의미있게 더 높은 점수를 보였다. 2) 판별 분석에서 두 집단을 잘 판별해주는 척도는 D, Mf, Pt,Si척도이고, 이 척도들은 외상후 스트레스 장애군을 88.9% 정확헤게 판별해 주었으며, 정상 대조군은 94.5% 정확하게 판별해주었다. 3) 외상후 스트레스 장애군의 다면적 인성검사 반응을 군집 분석한 결과 3개의 하위 집단이 추출되었다. a. 첫번째 집단은(54.3%) L, F, K척도의 프로화일이 역전된 'V' 형태이고 Hs, D, Hy, Pd , Pt, Sc척도의 점수가 60년에서 71점 사이의 점수를 보이고 있다. b. 두번째 집단은(36%) L, F, K척도의 점수가 47점에서 56점 사이의 범위를 보이고 있고, 모든 임상 척도가 42점에서 59점 사이의 점수를 보이고 있는 정상 프로화일이었다. c. 세번째 집단은 (11.1%) L, F, K척도가 56점에서 70점의 점수에 속하고, Mf척도를 제외한 모든 임상척도들이 60점에서 80점의 점수를 보이고 있다. 이러한 결과들은 다면적 인성검사가 외상후 스트레스 장애군을 구별하는데 신뢰할만한 판별력을 가진다는 것을 시사해 준다. This study was attempted to identify MMPI responses which significantly discriminate between the PTSD and the normal on the basis of MMPI scores. And it was designed to classify the types of MMPI profiles in the PTSD. Subjects were 55 healthy control and 45 PTSD who were inpatient or outpatient in Presbyterian Medical Center from January, 1991 to March, 1993. The results were as follows : 1) In MMPI subscales, except L scale, PTSD had significantly higher score than the normal group. 2) In discriminant analysis, it was D, Mf, Pt, ans Si that discriminate these two groups. Also, it classified 88.9% of PTSD group and 94.5% of normal group correctly. 3) Three subgroups were extracted from the PTSD by cluster analysis of MMPI. a. The first subgroups(54.3%) showed a profile which T score of L, F scale configured a reverted "V" pattern, and T scores of Hs, D, Hy, Pd, Pt, and Sc scale belonged to the range of 60 to 71 point. b. The second subgroup(36%) showed a normal profile which had L, F, and K scale with normal range of 47 to 56 T score and all clinical scales with 42 to 59 T score. c. The third subgroup(11.1%) showed a profile which had L, F, and K scale belonged to the range of 56 to 70 T score and all clinical scales belonged to the range of 60 to 80 T score except Mf scale. These findings suggest MMPI has a remarkable discriminant power in PTSD group.

대장암환자에서 자연살해세포의 변화

김광호,심강섭,박응범,강은숙,홍기숙 대한대장항문학회 1998 Annals of Coloproctolgy Vol.14 No.3

미주신경과 연결된 중추신경로내 Catecholamine성 신경세포에 관한 연구

황광민,이봉희,김은아,김명옥,이봉희,김은아,김명옥,백상호,이부영 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.1

위암수술 환자에서의 cp 개발과 cp적용에 따른 질 향상 활동에 관한 연구

임은주,황순휘,박도중,하광일,배현주,김형호 한국의료QA학회 2006 한국의료질향상학회지 Vol.13 No.2

Background : In an era of increasing medical costs, safe reduction in postoperative stay has become a major focus to optimize utilization of healthcare resources. The authors aimed to evaluate the clinical significance of the critical pathway(CP) for gastrectomy patients by implementing standardized postoperative management and electronic medical records. Method : From August 2006 to April 2007, critical pathways were introduced to inpatients and outpatients with gastric cancer. 60 consecutive patients undergoing distal gastrectomy were randomly divided into two groups; 30 CP group(A) and 30 non-CP group(B). Simultaneously, we also retrospectively reviewed the records of 438 patients(C:control group) who were able to be enrolled in CP program. We compared group(A) with (B), (C) in terms of hospital stay, complication rate, use of antibiotics and hospital costs. Patient satisfaction was surveyed by questionnaires. Result : There was no significant demographic difference between group(A) and (B). Of 30 patients in group(A), 5 drop-outs and 14 variances occurred. The mean postoperative hospital stays(Laparoscopy-assisted distal gastrectomy: LADG/Open distal gastrectomy: ODG) were 7.6/10.5 days for the group(A), 8.9/12.7 days for the group(B) and 12.6/14.5 days for the group(C) (p=0.02 in LADG). The total hospital cost of group(A) had a tendency to be less than that of group(B) and the amount of hospital cost per day in group(A) was significantly higher than that in group(B). The usage rates of the first generation antibiotics were 73.33%, 63.33%, and 59.2% in group(A), (B), and (C), respectively. Patients’ satisfaction had a tendency to be higher in the CP group than non-CP group. Conclusion : The mean hospital stay in LADG patients was shortened meaningfully and hospital cost per day was enlarged after introduction of clinical pathway. It is necessary to apply a number of patients to the critical pathway and to make an effort to reduce the variation and drop-out rates.

주변환경 방사선감시기 시스템에 관한 연구

박광현,정종은,김승연 大田産業大學校 1993 한밭대학교 논문집 Vol.10 No.2

원자력발전소내 공정계통들에서나, 핵시설 주변의 특정지역에서의 방사선누출을 감시하기 위해서 특정 지역주변 방사선 감시계통들이 설치되어져 있다. 환경오염 문제와 함께 주변환경 방사선 감시계통의 수요가 날로 증대할 것으로 예상되므로 국내에서 개발제작하기 위한 요소기술의 확보가 필요하다. 본 논문에서는, 외국업체들이 시판하고 있는 주변환경 방사선 감시계통을 조사분석하여, 채택된 기술과 장래의 발전방향이 고려된 주변환경 감시계통의 프로토타입(Prototype)을 설계·개발하였다. 개발·제작된 프로토타입에서는 평면표시소자(LCD)와 마이크로프로세서(Intel 8051 series)를 사용하여 하드웨어 부분을 구성하였으며, 소프트웨어 부분의 프로그램들은 A8051 ASM Language와 C-Language로 작성하였다. Area Radiation Monitoring Systems are installed to monitor radioative release of particular area around the nuclear facilities and process & effluent systems within the nu-clear power plants. With the environmental contamination problems, it if: expected that the need for the Environmental Radiation Monitoring System will increase in our country, and it needs to establish a generic technology for development and manufacturing of the Environ mental Radiation Monitoring System domestically. In this paper, Environmental Radiation Monitoring System(ERMS) of foreign-make which is on the market is surveyed and analyzed, and the prototype of ERMS is developed and manufactured with adopted technology by foreign country and considering of the direction of development in the future. In this prototype which is developed and manufactured, the hardware part consists of a flat display device(LCD device) and a microprocessor(Intel 8051 series), while the software part is comprised of the programs which are implemented by A8051 ASM language and C-language.

명암도 작용 길이에 따른 연삭 숫돌면의 이상 현상 분류

유은이,김광래 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.3

The grinding process plays a key role which decides the quality of a product finally. But the grinding process is very irregular, so it is very difficult to analyse the process accurately. Therefore it is very important in the aspect of precision and automation to reduce the idle time and to decide the proper dressing time by matching. In this study, we choose the method which can be observed directly by using of computer vision and then apply pattern classification technique to the method of measuring the wheel surface. Pattern classification technique is proper to analyse complicated surface image. We observe the change of the wheel surface by using of the gray level run length which are representative in this technique.

silver-age의 web-interface에 관한 연구 : 한국의 silver-age를 중심으로

조은정,이광호 건국대학교 조형연구소 2001 조형연구 Vol.9 No.-

Times have changed. And come to the time one man, one computer. Our social environment, into the web. And don't five about one-day without computer, silver-age is the Informal An elderly person degeneration of body and change state of mind. From social develop, grow a matter of concern and interest about silver-age, and for welfare facilities about silver-age. Now recent universalization of the web, the design has change to satisfy the user's needs, breaking from the convention supply-oriented concept, as a result of which the concept of the interface has spreaded all over the society. This change been on the level to provide users with ease and convenience in use. Saying that creating a Web is design is not exaggeration. A huge new market is being born. Mastering digital technology can be said to be a new requirrment for designers to survive in the profession. A method of study started for compose web-interface about silver-age, if they are use the web, he have to thinking. It is convenient. For welfare measures is as follows about silver-age. first, health-home and the spirit of filial piety and respect, second, social security one's old age, third, the health system for silver-age, last, social-activity. For that reason a necessary and sufficient condition use the web, with silver-age. So, this thesis's goal is research web site for silver-age, and offer convenience use computer.