개에서 발생한 신우신염 증례

유건우,이선희,임수정,박형진,김태신,송은식,송근호 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2009 動物醫科學硏究誌 Vol.16 No.1

A 6 years old Schunauzer dog (7.2kg, intact female) with history of hematuria for two days was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. Complete blood cell count showed no significant abnormalities and serum chemistry profile showed increased phosphate profile. On urinanalysis, there was evidence of bacterial infection. On ultrasonographic evaluation, irregular renal contour and increased echogenecity, pelvic and uretral dilation, and thickening of urinary bladder wall were observed. Based on these finding, the dog was diagnosed as pyelonephritis. The dog was treated with antibiotics based on antimicrobial susceptibility test results, then successfully resolved after 8 weeks of treatment.

SS 통신에서 적응 배열안테나와 ADF에 의한 간섭 제거

변건식,홍성일,정주수,이수영 동아대학교 공과대학 부설 한국자원개발연구소 1992 硏究報告 Vol.16 No.1

In realization of spread spectrum multiple access (SSMA), the reduction of interference signal of the same direction as the desired signals is very important in a practical communication. In order to solve this problem, this paper propose a modified adaptive array antenna including adaptive digital filter which reduce a interference of the same direction as the desired signals. As a result of simulation, we confirmed that the various demodulated error is reduced. Also, we confirmed that the proposed method accomplished a stable synchronization acquisition which had come influence of lock level.

Vincristine Sulfate가 백서 척수내 신경원의 Acetylcholinesterase 활성에 미치는 영향

이규식,이군자,정호삼,김승현,백태경 漢陽大學校 環境科學硏究所 1992 環境科學論文集 Vol.13 No.-

Vincristine은 협죽도과에 속하는 열대식물인 Madagascum periwinkle에서 추출한 천연 alkaloid계 항암제로서 암세포의 미소관 형성을 억제하고 미소관을 파괴하며 또한 핵산 및 단백질합성을 방해하여 암세포의 증식을 억제하므로 현재 백혈병 및 임파종등 혈액종양과 여러 충실성종양의 치료에 유용하게 사용된다. 그러나 다른 항암제와 마찬가지로 암세포에만 특이하게 작용하지 않고 정상세포에도 손상을 야기하므로 vincristinc을 투여받은 암환자에서 혈액독작용, 소화기장애, 피부장애 및 신경독작용등 여러 부작용이 유발되고 특히 신경독 작용은 vincristine을 사용을 제한하는 가장 심각한 장애로 알려져있다. 저자는 백서에 vincristine을 투여하면 vincristine이 실험동물의 척수내 신경원에 손상을 야기하여 척수내 신경원의 acetylcholinesterase활성에 변화가 초래될 것으로 사료되어 본 실험을 시도하였다. 실험동물로는 체중 200gm내외의 Wistar계의 웅성 백서 35마리를 사용하여 백서 체중 kg당 0.5mg의 vincristine sulfate(Abic Ltd.) 0.2cc를 1일 1회씩 5일간 복강내로 주사하였고 정상대조군 백서에는 동량의 생리적 식염수를 같은 방법으로 투여하였다. 실험동물은 최종 주사후 24시간 및 72시간 경과 후에 후두부 강타로 도살하고 10% neutral buffered formaline으로 관류시킨 후 육안으로 해부하여 척수를 절취하고 10% neutral buffered formaline에 4℃에서 18시간 고정후 일부 조직은 paraffin에 포매하여 Nissl체를 관찰하기 위한 cresyl violet염색을 시행하고, 일부조직은 -20℃로 조절된 cryostat로 두께 10㎛의 동결절편을 제작하여 Gredtzoff(1959)의 방법에 따라 acetyl-cholinesterase활성을 관찰하기 위한 조직화학적 처리를 한 후 광학현미경으로 관찰하여 다음과 같은 결과를 얻었다. 1. Vincristine투여군 백서의 척수내 체성운동신경원 및 내장성운동신경원에 chromatolysis가 유발되었으며, 소신경원의 수와 cresyl violet 에 대한 염색성이 감소되었다. 2. Vincristine투여군 백서 척수경부의 acetylcholinesterase활성은 1일 경과군의 복측각내 체성 운동신경원에서는 강한 양성반응을 나타내었고 배측각에서는 약한 양성반응을 나타내었으며 중간부에서는 미약한 양성반응을 나타내었으나 3일 경과군의 복측각내 체성운동신경원과 배측각내 교양질부에서는 중등도 양성반응을 나타내었으며 중간부에서는 미약한 양성반응을 나타내었다. 3. Vincristine투여군 백서 척수흉부의 acetylcholinesterase활성은 1일 경과군의 복측각내 체성운동신경원과 외측각내 내장성운동신경원에서는 약한 혹은 중등도 양성반응을 나타내었고 배측각에서는 약한 양성반응을 나타내었으며 척수수질의 중간부에서는 미약한 양성반응을 나타내었으나, 3일 경과군의 복측각내 체성운동신경원에서는 중등도 양성반응을 나타내었고 외측각내 내장성 운동신경원에서는 강한 양성반응을 나타내었으며 배측각내 교양질부에서는 중등도 양성반응을 나타내었으나 배측각의 나머지 부분에서는 약한 양성반응을 나타내었고 척수수질의 중간부에서는 미약한 혹은 약한 양성반응을 나타냈었다. 4. Vincristine 투여군 백서 척수요부의 acetylcholinesterase활성은 1일 경과군의 복측각내 체성운동신경원에서는 중등도 혹은 강한 양성반응을 나타내었고 배측각의 교양질부와 Lamina Ⅳ에서는 중등도 양성반응을 나타내었으며 배측각의 나머지 부분은 약한 양성반응을 나타내었고 척수수질의 중간부에서는 미약한 양성반응을 나타내었으나, 3일경과군의 복측각내 체성운동 신경원에서는 약한 혹은 중등도 양성반응을 나타내었고 배측각내 교양빌부와 Lamina Ⅳ에서는 약한 양성반응을 나타내었으며 척수수질의 중간부에서는 미약한 혹은 약한 양성반응을 나타내었다. 이상의 소견을 종합한 바, vincristine은 백서 척수내 신경원에 세포독으로 작용하여 신경원 손상을 초래하고 신경원의 acetylchlinesterase활성을 억제 하나, 이러한 손상은 시간이 경과함에 따라 일부 회복되는 것으로 사료된다. Vincristine, one vinca alkaloids, is widely used for chemotherapy of a variety of malignancy. The mechanism of anticancerous activity of this agent is based on inhibition of mitosis by interference with development of microtuble, of syntheses of nucleic acid and protein, and of destruction of cytoplasic membrane and microtubule. However, these inhibitory effects on cancer cell proliferation are non-specific, so clinical use of vincristine is frequently limited due to its toxic effects on the hematopoietic and nervous system especially. The author had undertaken this study to pursue the effect of vincristine on the nuerons in rat spinal cord histolgically and histochemically. Totals of 35 healthy male Wistar stain albino rats, weighing about 200 gm, were used as experimental animals. The experimental animals were divided into normal control and vincristine treated groups, and then vincristine treated rats were subdivided into 24 hours and 72hours groups by time passage. All vincristine treated rats were abministrated intraperitoreally with 0.5mg of vincristine per kg of rat body weight diluted in 0.2cc of normal saline for 5 days and rats of vincristine treated group were sacrificed by occipital blow at 24 hours and 72 hours after administration and then perfused by 10% neutral buffered formaline. The spedimen, spinal cord was collected and them fixed with 10% neutral buffered formaline during 18 hours at 4℃. For observing the histological change, cresyl violet stain was performed by routine pareffin method, and for histochemical study of acetylcholinesterase, frozen sedtions of 10 ㎛ in thickness were treated with Gerebtwoff method(1959). The results obtained were as follows : 1. In vincristine treated rat, a part of the somatic and visceral motor neurons were brought on chromatolysis. And the numer and the stain activities of small neurons were decreased in cresyl violet stain. 2. The activities of acetylcholinesterase of cervical segment in vincristine treated rat spinal cord were strongly positive at somatic motor meuron, weakly positive at dorsal horn and tracely positive at intermediate zone in 1 day passed group after the final administration, and moderately positive at somatic motor neuron and substantia gelatinosa, weakly positive at remainder of dorsal horn and tracely positive at intermediate zone in 3 days passed group. 3. The activities of acetylcholinesterase of thoracic segment in vincristine treated rat spinal cord weakly or moderately positive at somatic and visceral motor neurons, weakly positive at dorsal horn and tracely positive at intermdeiate zone in 1 day passed group after the final administration, and moderately positive at somatic motor mourons, strongly positive at visceral motor meurons, moderately positive in substantia gelatinosa, weakly positive at remainder of dorsal horn and tracely positive at intermediate zone in 3 days passed group. 4. The activities of acetylcholinesterase of lumbar segment in vincristine treated rat spinal cord were moderately or strong positive at somatic motor meurons, weakly positive at substantia gelatinosa and lamina Ⅳ, weakly positive at remainder of dorsal horn and tracely positive at intermediate zone in 1 day pssed group after the final administration, weakly or moderately positive at somatic motor neurons, weakly positive at sugstantia gelationsa and lamia Ⅳ and tracely or weakly positive at remainder of spinal medulla in 3 days passed group. It is consequently suggested that vincristine would induce the degeneration of neurons and inhibit acetylcholinesterase activity resulting from its neurotoxic effects on neurons in spinal cord of albino rats, but this damage would partially recover by time passage.

트래드밀 운동프로그램 적용이 성인비만자의 심폐기능과 혈청지질에 미치는 영향

최건식,정영자,김남익,황수관 대한스포츠의학회 1994 대한스포츠의학회지 Vol.12 No.2

The purpose of this study was to investigate the effect of treadmill exercise programs on cardiopulmonary functions and serum lipids in adult obesity men. The subjects consisted of 33 obese adults between 30 and 70 years old and all of them had no other complications. Subjects participated in treadmill exercise programs for 12 weeks according to the exercise prescriptions. They started to exercise for 20 minutes per day, six times a week at 50% of maximum O_2 consumption (V˙O_2max), and later exercised for 50 minutes at 80% of V˙O_2max, which was the maximum exercise intensity of the program (Exercise intensity has been increased gradually). The changes of body composition, serum lipids, and cardiopulmonary functions in the subjects before and after the treadmill exercise program have been measured. The results are as follows. 1. Body weight, percent body fat, and fat body weight were reduced(p<0.05, p<0.01), and body fluid were increased after exercise programs(p<0.01). The group below 50 years old and above 25% of body fat showed more decrease in body weight and percent body fat, and more increase than that above 50 years old below 25% of body fat. 2. Resting heart rate, systolic and diastolic blood pressure were significantly reduced after exercise programs(p<0.05, p<0.01), but these parameters decreased approximately same for the groups of ages and percent body fat. 3. Vital capacity, forced expiratory volume for 1 second percent and maximal voluntary ventilation were increased after exercise programs. The group below 50 years old and above 25% of body fat showed more increase than that above 50 years old and below 25% of body fat. 4. Total cholesterol, LDL cholesterol, total cholesterol/HDL cholesterol rate and triglycerides were reduced (p<.05, p<0.01), and HDL cholesterol levles were increased after exercise programs. The group below 50 years old and above 25% of body fat showed more decrease in total cholesterol, LDL cholesterol, total cholesterol/HDL cholesterol rate and triglycerides, and more increase than that above 50 years old and below 25% of body fat. 5. Heart rate increase during exercise were reduced after exercise programs. The group below 50 years old and above 25% of body fat showed more decrease than that above 50 years old and below 25% of body fat. 6. Blood pressure increase during exercise were reduced after exercise programs. The group above 25% of body fat showed more decrease than that below 25% of body fat. 7. Oxygen uptake of during exercise were increased after exercise programs. 8. Maximal oxygen uptake were significantly increased after exercise programs (p<0.01). 9. The regression equations between heart rate, systolic blood pressure, and oxygen uptake were obtained. These correlation coefficients of the post-programs showed higher that those of pre-programs. In this study, the treadmill exercise programs suitable for the obese was developed and applying this programs weight, percent of body fat, body fat weight, and serum lipids levels ere reduced. Thus cardiopulmonary functions was improved. The group below 50 years old and above 25% of body fat showed more decrease than that above 50 years old and below 25% of body fat. It is to be noted that both systolic blood pressure and oxygen uptake can be estimated by heart rate only using the regression equations.

1次 및 2次 演算增幅器 時定數 效果에 무관한 스위치 케퍼시터 濾波器에 관한 硏究

邊健植 동아대학교 공과대학 부설 한국자원개발연구소 1982 硏究報告 Vol.6 No.1

Infinite gain amplifiers independent of first and second operational amplifier time constant effects using three operational amplifier is presented. Amplifier that is presented is comprised of bandpass filter. This filter is convert to switch capacitor filter using bi-linear transform. The active portion of this filter with presented amplifier is readily integrable since it is comprised of conventional operational amplifier and resistor. Experimental results show excellent agreement with theory.

2차원 액체 ⁴He 내의 ³He 희석액에서 ³He 원자들의 유효상호작용

채건식,설정식,전철원 경남대학교 신소재연구소 1997 論文集 Vol.9 No.-

2차원 액체 ⁴He내에서 ³He 원자들 d사이의 유효상호작용이 고찰된다. 평균유효퍼텐셜과 화학퍼텐셜의 비는 ³He 농도에 독립으로 나타난다. 또한 ³He 준입자의 유효질량이 1+1/2F₁^(s)로 주어지고 매개변수 F₁^(s)가 ³He 농도의 함수로서 얻어진다. The effective interaction between ^{3}He atoms in two-dimensional liquid ^{4}He is investigated. It is shown that the ratio of the average effective potential to the chemical potential is independent of the 3He concentration. Also, the effective mass of the ^{3}He quasiparticle is given by 1+1/2F_{1}^{s} and the parameter F_{1}^{s} is obtained as a function of the ^{3}He concentration.

Bi₂Sr₂Ca₁(Cu₁-xFex)₂O8+δ (x=0, 0.003, 0.006, 0.009) 단결정의 전기적 이방성의 어닐링효과에 대한 연구

설정식,손인호,채건식,최기영 慶南大學校 附設 基礎科學硏究所 1998 硏究論文集 Vol.12 No.-

The annealing effect of Bi₂Sr₂Ca₁(Cu₁-xFex)₂O8+δ (x=0, 0.003, 0.006, 0.009) single crystal have been studied. The single crystal was grown in air by developed directional solidification method and subsequently annealed for 8 hours at 700℃. The structure of grown singel crystal is measured through X-ray diffraction measurement. We measured resistivity by standard four probe method in the range of temperature from 20 K to 250 K. As the quantity of Fe is increased from x=0 to x=0.009. Tc is decreased from 89 K to 77 K. Tc of annealed samples are smaller than that of as-grown sample.

철골구조의 고층건물에서 가새의 효율성에 관한 연구

김근덕,김상식 연세대학교 산업기술연구소 1981 논문집 Vol.13 No.2

This research is associated with the analysis of the behavior of bracings in steel framed structures and with the derivation of the approximate method for it. The behavior of bracings in steel frames has been investigated numerically by comparing the lateral deflection of braced frames to that of unbraced frames for lateral loads. An approximate method for moment-connected frames has been derived considering the moment equillbrium equation at node and the axial stiffness of the bracings under the assumption of slab diaphragm action. Rayleigh-Ritz's variational method has been adopted to derive the approximate method for the shear-connected frames. The calculated results by these methods show good matches with the computed values by SAP IV computer program. The approximate methods presented in this paper evaluate the effectiveness of bracings in steel frames explicitely, and can satisfactorily be used in the preliminary structural design of braced steel frames.

열확산법으로 만든 CdTe p-n 다이오드의 특성에 관한 연구

채건식,김영국,설정식,전동성 慶南大學校 附設 基礎科學硏究所 1990 硏究論文集 Vol.2 No.-

Single crystals of CdTe were grown by Bridgman method from a melt. They were contained the element of 0.1, 0.15, 0.2mole % In and 0.1mole % P as a dopant respectively. The crystallographic direction of the grown CdTe have zinc blende structure which is(331) plane 2θ=62.6。 in X-ray method. The etch pits on the (100), (110) and (111) surfaces grown to characteristics shapes with E-Ag or PBr was found to consider with the crystallographic direction denoted by simple Miller indices as is depicted schematically. Here the pits on (100), (110) and (111) show rectangular, triangular and conical shapes respectively. The results of PL measurements of undoped and In-doped CdTe showed the maximum peak at 7475 Å and 7503 Å, and P-doped CdTe by thermal diffusion showed the maximum peak at 6943 Å and 7478 Å , the former was shown by Al and the later by phosphorous. The values of the electrical chracteristics have been compared with the Yamada's and we showed the good agreements between them. The thickness if Al thermal diffusion to the CdTe crystals were propotional to the diffusion time. The properties of these cells have good rectification with forward and reverse voltage.

유육종증 3례

권건영,장은숙,주일,김정식,전영준,손수인 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.3

Sarcoidosis is a multisystem granulomatous disease of unknown cause, characterized by enhanced cellular immune process at the sites of involvement. Three Cases of sarcoidosis involving vilateral hilar lymph nodes, skin and lungs were presented. Each case was confirmed by characteristic non-caseating granuloma in biopsied thoracic lymph nodes and skin. They had abonormal pulmonary function test, elevated serum angiotensin converting enzyme, hilar and mediastinal lymphadenopathy and compatible clinincal features of sarcoidosis.