A Fuzzy Logic Expert System for Pricing Digital Services: The Case of Price Adjustment for a Mobile Service Provider

Adeolu Olukorede Dairo,Krisztian Sz?cs 한국지능시스템학회 2020 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.20 No.3

As connected smart devices and terminals continue to grow along with digital content, data traffic of mobile service providers is also growing, and the price war in mobile markets is driving traffic growth without a commensurable increase in revenue. As a result, network capital expenditure (CAPEX) investment, quality of experience, and customer experience are under enormous pressure. In a competitive mobile market, strategic pricing may play an essential role in managing this pressure only if appropriate tools are available for the service providers. In this paper, a fuzzy knowledge-based expert pricing system was developed with a focus on solving network traffic, price war, and business revenue challenges in a competitive mobile market. Its core lay in its ability to recommend digital- and data services-related price points within a competitive and price war mobile environment. The proposed pricing system was experimentally evaluated through a pilot conducted on a few segments of a mobile service provider’s customer base in an emerging market and later scaled up to a broader base. Upon implementation, data services revenue increased, and overall gross margin increased with a reduction in data traffic, resulting in better throughput and network quality and, consequently, better customer experience with improved net promoter score.

Role of Glutathione Redox System on the T-2 Toxin Tolerance of Pheasant (Phasianus colchicus)

Fernye, Csaba,Ancsin, Zsolt,Bocsai, Andrea,Balogh, Krisztian,Mezes, Miklos,Erdelyi, Marta Korean Society of ToxicologyKorea Environmental Mu 2018 Toxicological Research Vol.34 No.3

The purpose of the present study was to evaluate the effects of different dietary concentrations of T-2 toxin on blood plasma protein content, lipid peroxidation and glutathione redox system of pheasant (Phasianus colchicus). A total of 320 one-day-old female pheasants were randomly assigned to four treatment groups fed with a diet contaminated with different concentrations of T-2 toxin (control, 4 mg/kg, 8 mg/kg and 16 mg/kg). Birds were sacrificed at early (12, 24 and 72 hr) and late (1, 2 and 3 weeks) stages of the experiment to demonstrate the effect of T-2 toxin on lipid peroxidation and glutathione redox status in different tissues. Feed refusal and impaired growth were observed with dose dependent manner. Lipid-peroxidation was not induced in the liver, while the glutathione redox system was activated partly in the liver, but primarily in the blood plasma. Glutathione peroxidase activity has changed parallel with reduced glutathione concentration in all tissues. Based on our results, pheasants seem to have higher tolerance to T-2 toxin than other avian species, and glutathione redox system might contribute in some extent to this higher tolerance, in particular against free-radical mediated oxidative damage of tissues, such as liver.

Role of Glutathione Redox System on the T-2 Toxin Tolerance of Pheasant (Phasianus colchicus)

Csaba Fernye,Zsolt Ancsin,Andrea Bocsai,Krisztian Balogh,Miklos Mezes,Marta Erdelyi 한국독성학회 2018 Toxicological Research Vol.34 No.3

The purpose of the present study was to evaluate the effects of different dietary concentrations of T-2 toxin on blood plasma protein content, lipid peroxidation and glutathione redox system of pheasant (Phasianus colchicus). A total of 320 one-day-old female pheasants were randomly assigned to four treatment groups fed with a diet contaminated with different concentrations of T-2 toxin (control, 4 ㎎/㎏, 8 ㎎/㎏ and 16 ㎎/㎏). Birds were sacrificed at early (12, 24 and 72 hr) and late (1, 2 and 3 weeks) stages of the experiment to demonstrate the effect of T-2 toxin on lipid peroxidation and glutathione redox status in different tissues. Feed refusal and impaired growth were observed with dose dependent manner. Lipid-peroxidation was not induced in the liver, while the glutathione redox system was activated partly in the liver, but primarily in the blood plasma. Glutathione peroxidase activity has changed parallel with reduced glutathione concentration in all tissues. Based on our results, pheasants seem to have higher tolerance to T-2 toxin than other avian species, and glutathione redox system might contribute in some extent to this higher tolerance, in particular against free-radical mediated oxidative damage of tissues, such as liver.

The surmountable effect of FSCPX, an irreversible A1 adenosine receptor antagonist, on the negative inotropic action of A1 adenosine receptor full agonists in isolated guinea pig left atria

Rudolf Gesztelyi,Zita Wachal,Bela Juhasz,Mariann Bombicz,Evelin Csepanyi,Krisztian Pak,Judit Zsuga,Csaba Papp,Zoltan Galajda,Klara Branzaniuc,Robert Porszasz,Andras Jozsef Szentmiklosi,Arpad Tosaki,Zs 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.3

A1 adenosine receptors (A1 receptors) arewidely expressed in mammalian tissues; therefore attainingproper tissue selectivity is a cornerstone of drug development. The fact that partial agonists chiefly act on tissueswith great receptor reserve can be exploited to achieve anappropriate degree of tissue selectivity. To the best of ourknowledge, the A1 receptor reserve has not been yetquantified for the atrial contractility. A1 receptor reservewas determined for the direct negative inotropic effect ofthree A1 receptor full agonists (NECA, CPA and CHA) inisolated, paced guinea pig left atria, with the use of FSCPX, an irreversible A1 receptor antagonist. FSCPXcaused an apparently pure dextral displacement of theconcentration–response curves of A1 receptor agonists. Accordingly, the atrial A1 receptor function converging toinotropy showed a considerably great, approximately80–92 % of receptor reserve for a near maximal (about91–96 %) effect, which is greater than historical atrial A1receptor reserve data for any effects other than inotropy. Consequently, the guinea pig atrial contractility is verysensitive to A1 receptor stimulation. Thus, it is worthwhileconsidering that even partial A1 receptor agonists, given inany indication, might decrease the atrial contractile force,as an undesirable side effect, in humans.

Analysis of structure-function relationship in porcine rotavirus A enterotoxin gene

Sharad Saurabh,Shubhankar Sircar,Jobin J. Kattoor,Souvik Ghosh,Nobumichi Kobayashi,Krisztian Banyai,Obli R. VinodhKumar,Ujjwal K. De,Nihar R. Sahoo,Kuldeep Dhama,Yashpal S. Malik 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.1

Rotavirus (RV)-infected piglets are presumed to be latent sources of heterologous RV infection in humans and other animals. In RVs, non-structural protein 4 (NSP4) is the major virulence factor with pleiotropic properties. In this study, we analyzed the nsp4 gene from porcine RVs isolated from diarrheic and non-diarrheic cases at different levels of protein folding to explore correlations to diarrhea-inducing capabilities and evolution of nsp4 in the porcine population. Full-length nsp4 genes were amplified, cloned, sequenced, and then analyzed for antigenic epitopes, RotaC classification, homology, genetic relationship, modeling of NSP4 protein, and prediction of post-translational modification. RV presence was observed in both diarrheic and non-diarrheic piglets. All nsp4 genes possessed the E1 genotype. Comparison of primary, secondary, and tertiary structure and the prediction of post-translational modifications of NSP4 from diarrheic and non-diarrheic piglets revealed no apparent differences. Sequence analysis indicated that nsp4 genes have a multi-phyletic evolutionary origin and exhibit species independent genetic diversity. The results emphasize the evolution of the E9 nsp4 genotype from the E1 genotype and suggest that the diarrhea-inducing capability of porcine RVs may not be exclusively linked to its enterotoxin gene.

An outbreak of neonatal enteritis in buffalo calves associated with astrovirus

Paolo Capozza,Vito Martella,Gianvito Lanave,Cristiana Catella,Georgia Diakoudi,Farzad Beikpour,Michele Camero,Barbara Di Martino,Giovanna Fusco,Anna Balestrieri,Krisztian Banyai,Giuseppe Campanile 대한수의학회 2021 Journal of Veterinary Science Vol.22 No.6

Background: Enteritis of an infectious origin is a major cause of productivity and economic losses to cattle producers worldwide. Several pathogens are believed to cause or contribute to the development of calf diarrhea. Astroviruses (AstVs) are neglected enteric pathogens in ruminants, but they have recently gained attention because of their possible association with encephalitis in humans and various animal species, including cattle. Objectives: This paper describes a large outbreak of neonatal diarrhea in buffalo calves (Bubalus bubalis), characterized by high mortality, which was associated with an AstV infection. Methods: Following an enteritis outbreak characterized by high morbidity (100%) and mortality (46.2%) in a herd of Mediterranean buffaloes (B. bubalis) in Italy, 16 samples from buffalo calves were tested with the molecular tools for common and uncommon enteric pathogens, including AstV, kobuvirus, and torovirus. Results: The samples tested negative for common enteric viral agents, including Rotavirus A, coronavirus, calicivirus, pestivirus, kobuvirus, and torovirus, while they tested positive for AstV. Overall, 62.5% (10/16) of the samples were positive in a single round reverse transcription polymerase chain reaction (PCR) assay for AstV, and 100% (16/16) were positive when nested PCR was performed. The strains identified in the outbreak showed a clonal origin and shared the closest genetic relationship with bovine AstVs (up to 85% amino acid identity in the capsid). Conclusions: This report indicates that AstVs should be included in a differential diagnosis of infectious diarrhea in buffalo calves.