http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Kochetkova (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Features Of Pedagogical Support Of Digital Competence Formation In Educational Activity
Kharkivsky, Valeriy,Romanyshyn, Ruslana,Broiako, Nadiia,Kochetkova, Iryna,Khlystu, Olena,Kobyzhcha, Natalya,Poplaska, Alina International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.8
The article presents the concept of ICT - competence, which is considered as the most important characteristic of professional competence, which includes a combination of the following components: motivational-value (orientation of the individual to the development of his ITC-competence in future professional activities); technological (complex of skills and abilities of ICT activities); cognitive (a system of knowledge of modern technologies of future professional activity); it is determined that the pedagogical support of the formation of ICT competence of future specialists is the individualization of the process training, due to their personal and professional needs and the specifics of a regional university, providing the necessary conditions for the implementation of this process.
-
Regulatory T-cell vaccination independent of auto-antigen
David W Pascual,Xinghong Yang,Kathryn Holderness,전상무,Massimo Maddaloni,Irina Kochetkova 생화학분자생물학회 2014 Experimental and molecular medicine Vol.46 No.-
To date, efforts to treat autoimmune diseases have primarily focused on the disease symptoms rather than on the cause of the disease. In large part, this is attributed to not knowing the responsible auto-antigens (auto-Ags) for driving the self-reactivity coupled with the poor success of treating autoimmune diseases using oral tolerance methods. Nonetheless, if tolerogenic approaches or methods that stimulate regulatory T (Treg) cells can be devised, these could subdue autoimmune diseases. To forward such efforts, our approach with colonization factor antigen I (CFA/I) fimbriae is to establish bystander immunity to ultimately drive the development of auto-Ag-specific Treg cells. Using an attenuated Salmonella vaccine expressing CFA/I fimbriae, fimbriae-specific Treg cells were induced without compromising the vaccine’s capacity to protect against travelers’diarrhea or salmonellosis. By adapting the vaccine’s anti-inflammatory properties, it was found that it could also dampen experimental inflammatory diseases resembling multiple sclerosis (MS) and rheumatoid arthritis. Because of this bystandereffect, disease-specific Treg cells are eventually induced to resolve disease. Interestingly, this same vaccine could elicit the required Treg cell subset for each disease. For MS-like disease, conventional CD25þ Treg cells are stimulated, but for arthritisCD39þ Treg cells are induced instead. This review article will examine the potential of treating autoimmune diseases without having previous knowledge of the auto-Ag using an innocuous antigen to stimulate Treg cells via the production of transforming growth factor-b and interleukin-10.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
