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Antimicrobial Activities of Hydroxybiphenyl Derivatives
Kihwan Bae,Sunghyen Koo,Wonjun Seo 한국생약학회 1986 생약학회지 Vol.17 No.1
It has been elucidated that magnolol and honokiol, isolated from the stem bark of Magnolia obovata, had potent antibacterial activity against a cariogenic bacterium Streptococcus mutans. They also show a significant antibacterial activity against Bacillus anthracis, which causes malignant pustule and woolsorter disease in human. Some hydroxybiphenyl derivatives are synthesized from starting materials, phenylphenols and biphenols by means of Claisen`s rearrangement and Elb`s method to develop more potent antibacterial chemicals and to investigate the structure-activity relationships. The introduction of allyl groups to the aromatic rings of starting materials shows increase of antibacterial activities, but the number and positions of them do not effect their activities. Furthermore, the introduction of hydroxy group to aromatic rings also increases the activity.
Detects abnormal behavior using motor power consumption
KiHwan Kim(김기환),Su-Mi Ryu(류수미),Min-Kyu Kim(김민규),Young-Jin Kang(강영진),HyunHo Kim(김현호),HoonJae Lee(이훈재),Jin-Heung Lee(이진흥) 한국컴퓨터정보학회 2018 韓國컴퓨터情報學會論文誌 Vol.23 No.10
In this paper, we used LSTM as a method to detect abnormal behavior of motors. We fixed the high layout size to 1 and changed the range of the input values and the neural network structure to see what change in power consumption prediction. Now, as the fourth industrial revolution era, smart factories are attracting attention. All the physical actions of smart factories are done using motors. Continuous monitoring of motor malfunctions helps to detect malfunctions and efficient operation. However, it is difficult to acquire the power consumption constantly due to the influence of the noise. We have experimented with a simple experimental environment, a method of predicting similarity to input data by adjusting the range of the input data or by changing the neural network structure.
Technology Trends Analysis of Airbone Network
KiHwan Kim,HyunHo Kim,SangGon Lee,HoonJae Lee,YoungJae Ryu 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.10
Development with IT technology has wide effect for military sector. For this reasons, the important sources is ‘First see, and first determine, and first attack’ in modern and future warfare. And there are also importance with patriot robot such as drone for understand the movement pattern with enemy. Therefore, in develop country; they process with sensor system, delicate attack system, informationization and identification proactively. For now, the connection between equipment is essential in the war environment, so the secure with these things is important. But this is planned with using network structure based on TCP/IP, So there is a raised problem that plan which I mentioned has difficult to deal with attack from using structural weakness. In this paper, the attack type which is possible in the Airborne Network is made an inquiry and it analyze.
Next generation therapeutic antibody - ADC expands beyond cytotoxic payloads for cancer therapy
Kihwan Chang 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Biopharmaceuticals became prominent in the fields of industry, investment, and job market, showing high success rate in clinical trials, high development efficiency, and promising market values. The benefits of antibody drugs include a wide range of accessible antigens, high target specificity, various mechanisms, the rate of success development as high as 15%, and the possibility for industrialization. The benefits are proven effective in market when antibody drugs dominated drug sales in 2019, taking up two thirds of the top 15 drugs. Initially antibody drugs were developed as a group of IgG variants, but more than 1,800 antibodies were in their research and development (R&D) phases by 2017 and within the next few years the R&D activities spawned a huge diversity of platform-based designs supported by multiple configurations and new scaffolds. Consequently, the expansion of platform technologies and the resulting number of druggable targets became a tough barrier to entry; still, next-generation antibody drug development continues to flourish. Under the vision “Drugging the Undruggable,” Orum Therapeutics is focusing on developing next-generation antibody-drug conjugates (ADCs). We have developed a novel ADC technology named antibody-neo Degrader conjugate (AnDC) that specifically induces the death of cancer cells by eliminating intracellular proteins essential for cancer cell growth. Cancer specificity is achieved by antibodies and the cell-killing effect is facilitated by an intrinsic proteolysis mechanism. Our two leading AnDCs are entering into their preclinical stages as we confirm their significance in efficacy and safety via mouse and monkey studies. We are preparing for our next pipelines employing world-class proficiency in drug development geared to discovering and optimizing the key components of an AnDC, namely antibodies, linkers, and payloads. Orum Therapeutics’ AnDC platform is demonstrating the potential to lead future drug development, pioneering ADCs targeting the intracellular proteolysis mechanism.
Kihwan Kim,Saeroonter Oh 대한전자공학회 2019 Journal of semiconductor technology and science Vol.19 No.1
We investigate the effect of strain on the device characteristics of gate-all-around (GAA) NMOS with various configurations, including crystal orientation, cross-sectional shape, and strain conditions, via device simulation. After verifying the strain dependence of mobility of various surface orientations with the literature, we apply the strain transport model to GAA MOSFETs which have different sidewall orientations depending on the channel direction. Drive current enhancement is the largest for the (001)/<110> case under large uniaxial tensile strain values exceeding 1%. In addition, we found that cross-sectional width of the nanosheet is a key parameter in maximizing the drive current for a given footprint. Optimization of device and strain configuration of single-stacked GAA devices is necessary to meet device performance specifications for sub-7nm technology.