카이토산을 이용한 방사성스트론튬 오염의 치료

김지열,송호천,양광희,최근희,채기문,범희승,김광윤 대한방사선 방어학회 1994 방사선방어학회지 Vol.19 No.3

본 연구에서는 마우스에 이미 오염된 방사성스트론튬(Sr-85)을 제거하는데 수용성카이토산이 어느정도 효과가 있는지 알아보고자 하였다. Sr-85를 정맥주사한 경우 주사후 1일째의 체내 잔류량은 72.9 ±5.7%, 5일째는 57.7 ±1.9%, 7일째는 54.2 ±1.4%로 서서히 감소하였으며, Sr-85를 복강내 주사한 경우는 주사후 5일째 54.4 ±1.2%, 15일째 50.6 ±0.8%로 정맥주사에 비해 낮은 잔류량을 보였다(5일째 잔류량의 비교, P<0.05), 0.3% 수용성카이토산을 1회 정맥주사해준 제21군 및 10% 수용성카이토산을 식이중에 섞어 먹인 제5군은 각각의 대조군에 비해 체내 잔류방사능의 차이가 없었으나 (P>0.05), 0.3% 수용성카이토산을 3일간 정맥주사한 제3군과 3% 수용성카이토산을 이틀 간격으로 15일간 복강내 주사한 제6군에서는 각각의 대조군에 비해 낮은 잔류방사능을 보였다. (P<0.01). 결론적으로 수용성카이토산을 연속적으로 정맥투여하거나 복강내 투여하는 경우에는 스트론튬의 골대사촉진 또는 골중의 스트론튬과의 반응등을 통해 그 배출을 촉진시킬 것으로 사료되었다. The aim of the present study was to elucidate the effect of the water soluble chitosans on the removal of contaminated radiostrontium(Sr-85) from the bone of mice. The remaining radioactivities in intravenously injected controls(group 1) were higher than in intraperitoneally injected controls (group 4, P<0.01). The % retention at day 5 were 57.7 ±1.9%, 54.4 ±1.2%, respectively. Single intravenous injection of 0.3% water soluble chitosan and continuous oral ingestion of 10% water soluble chitosan for 15 days were ineffective on the removal of contaminated radiostrontiums. Multiple intravenous or intraperitoneal injections of water soluble chitosan effectively removed contaminated radiostrontiums (P<0.01 vs controls). In conclusion, water soluble chitosan might remove once incorporated radiostrontium from bones of mice. further studies were needed to elucidate the mechanism of the removal.

Al_(0.3)Ga_(0.7)As/GaAs HEMT 구조에서의 Photoreflectance에 관한 연구

이정열,김기홍,배인호,박성배,신영남 대구대학교 기초과학연구소 2000 基礎科學硏究 Vol.16 No.2

The optical characteristics of Al_(0.3)Ga_(0.7)As/GaAs HEMT structure were investigated by using the photoreflectance method. From the PR measurement, 2DEG transition energy related signal were obtained by between GaAs buffer and Al_(0.3)Ga_(0.7)As/GaAs spacer layer at the temperature of below about 150 K. And the transition energy is shift to low energy about 21 meV. We obtained that 2DEG transition energy, interface field and carrier concentration are 1.455 eV, 5.26 × 10⁴ V/cm and 7.18 × 10⁴cm^(-3), respectively.

임신마우스에서 수용성카이토산에 의한 태아의 방사성스트론튬 오염 억제

채기문,최근희,양광희,범희승,김지열,김광윤 대한방사선 방어학회 1994 방사선방어학회지 Vol.19 No.3

핵분열생성물중의 하나인 방사성스트론튬은 임신한 쥐에서 태반을 빠르게 통과하여 태아를 오염시킨다. 독성이 적은 천연착화제로서 마우스체내의 방사성스트론튬(Sr-85)의 제거에 효과적인 것으로 알려진 카이토산을 이용하여 Sr-85의 태반오염억제에 관한 연구를 하였다. 실험군은 일반식이를 공급한 대조군과 임신 17일째에 수용성카이토산을 피하(1% 카이토산), 구강(10% 카이토산), 복강(0.3% 카이토산)으로 주사한 카이토산군으로 분류하였다. 피하주사군은 Sr-85 오염후 카이토산을 주사한 군이며 복강과 구강주사군은 Sr-85 오염젼 15일간 카이토산을 공급한 군이었다. 출산과 동시에 어린마우스의 전신을 측정한 겨러과 출생후 7일째에 대조군이 2.8 ±0.3%의 전신축적율을 나타낸 반면 피하, 구강, 복강, 주사군은 각각 1.2 ±0.1%, 1.4 ±0.1%, 1.6 ±0.2%로 나타났다. 결과적으로 임신한 마우스에서 수용성카이토산은 방사성스트론튬의 태반오염을 유의하게 억제하는 것으로 사료된다. Radiostrontium passes the placental barrier in pregnant rodents very well. Chitosan, a natural nontoxic chelator, was reported to reduce whole body retention of radiostrontium in mice. The aim of the present study was to evaluate water soluble chitosan as a blocking agent of transplacental transfer of radiostrontium in pregnant mice. Twenty pregnant mice wre divided into four groups : control and three groups of chitosan treatment(groups 1 to 3). Sr-85(15KBq in 0.2ml saline) was subcutaneously injected into pregnant mice at the 17th day of pregnancy. In control mice, 0.2ml saline was given 5 hours after the injection of Sr-85. In group 1.1% water soluble chitosan was given subcutanously for two days, twice daily after the injection of Sr-85. In group 2, 10% water soluble chitosan was given orally for 15 days before conception. In group 3, 0.3% water soluble chitosan was injected intravenously for 15 days, once daily before conception. Gamma counting of newborns were done at days 0, 2 and 7 after their births. Whole body retention of Sr-85 in newborns of control mice at days 0, 2, 7 were 3.1 ±0.3%, 2.9 ±0.3%, 2.8 ±0.3% respectively. In experimental groups, whole body retention of Sr-85 was significantly lower thanthat of control(p<0.01) and no statistical difference was noted between them. In group 1, the values were 2.1 ±0.3%, 1.4 ±0.1%, 1.4 ±0.1%, respectively. In group 3, they were 2.1 ± 0.2%, 1.7 ± 0.2%, 1.6 ± 0.2%, respectively. In conclusion, the water soluble chitosan reduced transplacental contamination of radiostrontium in pregnant mice.

無酸素性 運動能力과 生理學的 變因의 關聯性

김기진,윤성원,김학열,정정진,우도영,노성규,손태열,안의수 江原大學校附設 體育科學硏究所 1991 江原大學校附設體育科學硏究所論文集 Vol.- No.16

Wingate test 및 Supramaximal exercise를 이용한 무산소성 운동능력의 측정시 나타난 변인의 관련성을 살펴본 본 연구를 요약하면 다음과 같다. Wingate test시 혈중젖산농도 최고치는 9.04±0.62mM로서 Supramaximal exercise시 보다 유의하게 높았으며, 혈장 LDH 및 CPK활성도는 두가지 운동부하후 모두 유의한 변화는 나타나지 않았다. 근전도상의 적분치, 중간파형빈도 및 평균파형빈도도 유의한 변화는 없었다. 등속성 수축시의 최대토오크는 양쪽 다리 모두에서 초당 60도의 각속도에서가장 높았다. Wingate test시의 최대파워는 등속성 수축시 최대토오크 및 Wingate test시 중간파형빈도의 직접적인 영향을 받는 것으로 나타났으며, 평균파워는 Wingate test시의 적분치 변화, 듣는 쪽 슬관절의 등속성 수축시최대토오크 및 Supramaximal exercise시 혈장 LDH 활성도의 직접적인 영향을 받는 것으로 나타났다. 이상의 결과에서 무산소성 운동능력과 관련지어 그 기전을 살피고자 할 때 체내 화학적 변화, 전기생리적 변화 및 발현능력의 복합성을 고려해야 하며 최대누적 산소결핍량의 활용가능성은 측정강도 결정방법을 중심으로한 계속적인 연구가 요구된다. The present study examined the relationship of variables related to anaerobic capacity with Wingate test and supramaximal exercise. Peak value of blood lactate concentration with Wingate test showeda significantly higher than suprammaximal exercise, and plasma LDH & median power frequency and mean power frequency were not any difference between two tests. Peak torque of isokinetic contractionh on knee joint showed a highest value in 60 degrees of angular velocity among a various angular velocity. Peak power of Wingate test was related to peak torque of isokinetic contraction and median power frequency of EMG with Wingate test, and mean power of Wingate test was related to integrated EMG with Wingate test, peak torque with isokinetic contraction of dominant knee joint and plasma LDH activity with supramaximal exercise. In this result, when it analyzed the mechanism of anaerobic capacity, ti was required the consideration of complexity according to biochemical alteration, electrophysiological alteration and revelation of performance, Appicapability of maximal accumulated O₂deficit was demaned a continuous study with the focus of exercise intensity.

광주광역시 도시기능의 공간분포패턴에 관한 연구

권준오,원열,강기수 조선대학교 국토개발연구소 1997 국토개발연구 Vol.17 No.1

This study has been carried out in order to offer basic data necessary to effective planning in space structure of city by examining the concentration degree of city functions in administrative parts through analyzing space distribution of Kwangju City. This study has been resulted in ; First, service works are mostly distributed in down areas(43.2%), and particularly high in Dong-Ku which has least space for administrative part and Seo-Ku, Puk-Ku and Kwangsan-Ku was in order. It showed that the functions of the city is preponderated. Second, the area with high rate of population allotment is relatively far from downtown areas and one with high rate of indusrtrial allotment is relatively near from downtown areas. It showed us the internal space structure in Kwangju shaping a concentric circle. Third, the following areas show specialization in particular works ; ⓐ Ariculture; Tae-Ye, Ssang-Chon2, Nong-Seong, ⓑ Mining Industry; Tae-Kum, ⓒ Manufacturing Industry; Ha-Nam, You-Deuk, Bon-Chon, ⓓ Elecrical Industry; Yong-Bong, Seo-San, So-Chon, ⓔ Construction; Tae-Kum, ⓕ Wholesacle and detail; Chung-Kum, Tae-Kum, ⓖ Transportation business; Shin-An, Tae-Kum, ⓗ Financial business; Chung-Kum, Tae-Kum, ⓘ Social works; Seo-Seuk, Fourth, manufacturing industry was concentrated in industrial complex area and transportation industry in the area of gateway to Kwangju and social works in the area of educational facilities respectively.

赤血球膜蛋白의 變化에 依한 赤血球變形能의 變動

李民化,李起榮,梁誠烈,朴昞柱,尹士炫 全南大醫大 1985 전남의대학술지 Vol.22 No.1

정신과 의약분업에 대한 5년 후 추적조사

박정수,정재열,홍진표,백기청,박영현,박종익 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.4

Objectives : This study is designed to discuss the pros and cons related to the 'separation of drug prescription and dispensation' system when 5 years have passed by since the introduction of this system. Methods : The 592 psychiatrists from 1,107 working places took part in nationwide survey by mail or E-mail from June to September, 2005. The response rate was 23.8%, most of respondents came from private clinics. Results : The average age of psychiatrist was 44.6 years old, ranging from 25 to 75, most of them was predominantly male. The main results were as followings : 1) The ratio of psychiatric prescription out of hospital based on out-patients departments was the lowest in clinics, following by hospitals, general hospitals and university hospitals by order. 2) The main reasons of customer's preference for out of hospital prescription were economic advantage and self-awareness of prescription. As for the disliking for it, the most complaints were the anxiety about disclosure of psychiatric treatment, in convenience for delay and concern about drug change. Conclusion : Five years didn't seem to give a change on how the psychiatrists perceive the 'separation of drug prescription and dispensation' system at all. The confidentiality and human right issues on the part of psychiatric patients should never be ignored in order to manage this system successfully.

十全大補湯의 免疫增强 및 抗癌 效果

崔承勳,吳旼錫,宋泰元,남기열 대전대학교 한의학연구소 2002 혜화의학회지 Vol.11 No.1

Objectives : Sipjundaebo-tang is prepared by ten medical herbs that tone the blood and vital energy, and strengthen health. This prescription has long been used traditionally against anemia, anorexia, extreme exhausion and fatigue. The purpose of this thesis was to review the effects of Sipjundaebo-tang that are about immunopotentiation effects, antitumor activities and potentiation, detoxification of antitumor drugs Methods : We studied the research methods and results of experiments which were selected from Korean, Japaness and American theses were on the topic of immunopotentiation effects, antitumor activities and potetiation, detoxification of antitumor drugs from Sipjundaebo-tang Results and conclusions : Sipjundaebo-tang not only potentiates the effects of the combined use of chemotherapy, but also reduces and elimimate the immunotoxicity of antitumor drugs and radiotherapy. And it strengthen immunity and improve QOL, S/OH of cancer patients.

수무지 다지증의 교정

차규호,최시호,설정현,김기열 대한성형외과학회 1992 Archives of Plastic Surgery Vol.19 No.3

There has been steady decrease in the number of traumatic injuries and inflammatory diseases of the hand, hence, the relative percentage of congenital malformation of the hand is becoming greater. The most common congenital anomaly of the hand is polydactyly and the principal goal of correction is the accurate establishment of the longitudinal skeletal axis. We have experienced 11 cases of duplicted thumbs and type IV by Wassel's classification was the most common type. For surgical correction, we used bone -ligament flap for joint rein forcement. Unnecessary metacarpal head was trimmed on both sides for centralization. We obtained a favorable results.

결핵성 육아종에서 Thioredoxin peroxidase-2 의 발현

박근호,유형륜,정영진,윤기중,한원철,유대열,문형배 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Background: Thioredoxin peroxidase(TPX) is a kind of recently discovered antioxidant enzyme which react as rapid hydrogen ion donor for the removal of hydroperoxide. The action and distribution of the TPX was poorly understood in the human diseases. This experiments were designed for the study about the distribution of the TPX in the chronic granulomatous inflammation and about the correlation between the expression of TPX and the site of inflammation, histological activities of tuberculous inflammation or existence of mycobacterium in the inflammatory foci. Methods: The immunohistochemical stains were performed for the localization of the TPX-2 in the epithelioid cells, giant cells and lymphocytes in the chronic granulomatous inflammation. The tissue sections were obtained from the paraffin blocks of the 54 cases of tuberculosis (lung 21 cases, lymph node 12 cases, bone and soft tissue 12 cases, kidney 9 cases; active 33 cases, inactive 21 cases by the histologic classification; presence of mycobacterium 15 cases, no mycobacterium 39 cases by PCR reaction). Results: The expression of TPX-2 was 16.7% in the giant cells, 27.8% in the epithelioid cells and 100% in the lymphocytes of tuberculous inflammations. The expression of TPX-2 in the giant cells and epithelioid cells of the tuberculosis were 28.6% and 57.1% of the pulmonary tuberculosis; 33.3% in each cells of the renal tuberculosis; 0% in each cells of the lymph node or bone and soft tissue tuberculosis. The expression of TPX-2 in the giant cells and epithelioid cells were 9.1% in each cells of the active tuberculosis and were 28.6% and 57.1% in each cells of the inactive tuberculosis by histologic classification. The expression of TPX-2 in the giant cells and epithelioid cells was 40% in each cells of tuberculosis which mycobacteria were detected and the expression of TPX-2 was 7.7% and 23.1% in each cells which mycobacteria were not detected by PCR reaction in the paraffin embedded tissue. Conclusions: The above results were summarized that the TPX-2 in the giant cells and epithelioid cells were more frequently expressed in the inactive tuberculosis than in the active tuberculosis. These results suggest that the TPX-2 is a kind of regulating or suppressing factors in the activity of the tuberculosis.