뇌동맥류 수술시 체성감각유발전위의 모니터링

염기훈,김국기,이기택,박종태,임영진,김태성,이봉암,임언 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.4

BMB Reports : Connexin32 inhibits gastric carcinogenesis through cell cycle arrest and altered expression of p21^Cip1 and p27^Kip1

( Hyang Jee ),( Su Hyung Lee ),( Jun Won Park ),( Bo Ram Lee ),( Ki Taek Nam ),( Dae Yong Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2013 BMB Reports Vol.46 No.1

Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition, after Cx32 overexpression in the human gastric cancer cell line AGS, cell proliferation, cell cycle analyses, and p21^Cip1 and p27^Kip1 expression levels were examined by bromodeoxyuridine assay, flow cytometry, real-time RT-PCR, and western blotting. Immunohistochemical study noted a strong inverse correlation between Cx32 and Ki67 expression pattern as well as their location. In vitro, overexpression of Cx32 in AGS cells inhibited cell proliferation significantly. G1 arrest, up-regulation of cell cycle-regulatory proteins p21^Cip1 and p27^Kip1 was also found at both mRNA and protein levels. Taken together, Cx32 plays some roles in gastric cancer development by inhibiting gastric cancer cell proliferation through cell cycle arrest and cell cycle regulatory proteins. [BMB Reports 2013; 46(1): 25-30]

순막조건화에서의 소뇌 피질의 기능

김현택,류재욱,김기석 한국심리학회 2002 한국심리학회지 생물 및 생리 Vol.3 No.1

토끼 순막조건화에 관여하는 소뇌피질의 기능을 검토하고자 소뇌의 심부핵중 하나인 중간핵 그리고 소뇌피질 단소엽을 연구대상으로 선정하였다. 실험 1에서는 전통적 학습형태와 대조적 학습형태인 청각자극 무제시와 무조건자극의 배쌍이 조건반응을 일으키는지의 여부를 알아보았다. 이러한 배쌍에서도 토끼는 신속한 조건반응을 획득하였는데 이 결과는 소뇌피질의 학습형성기전에 대한 기존의 설명 즉 조건자극제시에 의한 태상섬유 활동 증가와 무조건자극제시에 의한 등상섬유 활동증가가 태상섬유활동을 전해 받는 과립세포의 축색인 평행섬유와 퍼킨지세포사이의 시냅스 변화를 일으켜서 조건반응을 나타나게 한다는 설명과는 부합되지 않는 것이다. 실험 2에서는 소뇌피질의 반응시간조절기능가설을 검증하기 위하여 조건자극의 기간을 전형적 조건화 지수의 2배인 800msec로 하였다. 그리하여 소뇌피질의 손상이 손상후 시행의 조건자극제시기간동안의 조건화된 순막반응에 어떤 변화를 초래하는지 관찰하기 용이하게 하였다. 피험동물은 손상후 조건반응에서 부분적 폐지만을 보였는데 이는 전반적인 조건반응진폭의 축소에서 기인한 것이 아니라 손상후 회기에서 조건반응 개시 시각의 큰 변산에서 기인한 결과임을 관찰하였다. 이것은 소뇌피질이 중간핵과 기능적 연관성을 가지며 조건반응출현의 시간조절역할을 한다는 가설을 지지해 주는 결과라 하겠다. The cerebellar lobule HVI was investigated in terms of plastic structure mediating the classical conditioning of the rabbit's nictitating membrane response(NMR). In experiment 1, animals were received tone stimulus(80㏈, 1㎑, sine wave, without white noise) continually during the intertrial interval(ITI). The tone stimulus was turned off during the CS period. This withdrawal of tone stimulus was adopted as CS^(-). Animals received the CS^(-) and corneal airpuff US parings in delay conditioning paradigm rapidly reached criterion like animals received CS-US pairings. Moreover, the electrolytic leisions of the interpositus nucleus selectively disrupted the CR aquired by CS^(-)-US pairings. The result suggests that this type of conditioning is mediated by the cerebellum as well and the cerebellum can associate the changes of stimuli itself. In addition, there was no transfer effect between CS^(-)-US and CS-US learning. The findings are discussed in terms of the convergence of the climbing and the mossy fibers on the Purkinje cells and the associative functions of the cerebellar neural network. In experiment 2, the long ISI was adopted(800msec CS duration, delay conditioning paradigm) in order to investigated the timing regulation function of the cerebellar cortex on motor learning. After the NMR conditioning(CS^(-)-US, group1 and CS-US, group2) reached the criterion, the cerebellar lobule HVI was electrolytically lesioned with four electrodes. The result showed that the CR was reduced about 50% in both groups and the effects were due to the disruption of timing regulation of the CR onset. Results indicated that the cerebellar lobule HVI is essential for the timing regulation of the CR onset. However, to understand the detailed neural mechanism of the conditioning of NMR, it was suggested that neural network approach including several structures resided in the cerebellum and in the brain stem(especially inferior olive) is more desirable than finding only one essential structure approach.

partial pulpotomy를 이용한 미성숙 영구치의 치수 치료: 증례 보고

장기택,노승철,한세현,김정욱,김용수 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.4

치수치료의 주요한 목적은 구강조직의 본래의 건강을 유지하는 것이며, 치수치료 시 가장 중요하고 어려운 점은 치수조직의 건강상태 또는 염증의 정도를 결정함으로써 최선의 치료방법을 결정하는 것이다. 미성숙 영구치는 풍부한 혈류 공급으로 다양한 손상에 성공적으로 반응하게끔 치수의 능력을 향상시킴으로써 많은 치수치료 술식을 위한 좋은 조건을 가지고 있다. 기저재(base) 또는 이장재(liner), 간접 치수복조술, 직접 치수복조술, 그리고 치경부 치수절단술을 포함한 여러 종류의 보존적인 치수치료가 미성숙 영구치를 위해 추천되어 왔다. 근래에는 외상으로 인하여 치수노출된 영구절치를 치료하는데 있어 주로 제시된 부분 치수절단술(partial pulpotomy)이 우식으로 인해 치수노출된 영구대구치를 치료하는 또다른 술식으로 제안되고 있다. 부분 치수절단술 후 치아가 다음의 criteria를 만족시킬 때 치유가 되었다고 결론지었다. 1. 임상적 무증상 2. dentin bridge 형성의 방사선학적 증거 3. 방사선상에 치수내 또는 치근단 병소가 없다는 증거 4. 지속적인 치근 발육과 미성숙 치아의 치근첨 형성 5. 성숙된 치아에서 정상적인 상아질의 축적 6. 전기치수검사에서 양성 반응 이에 저자는 미성숙 영구치에서 우식 또는 외상으로 인한 치수노출시 부분 치수절단술을 행하여 양호한 결과를 얻었기에 이를 보고하는 바이다. The primary objective of pulp treatment is to maintain the integrity and health of the oral tissues. The most important and difficult aspect of pulp therapy is determining the health of the pulp, or its stage of inflammation, so that a decision can be made regarding the best form of treatment. Immature permanent teeth are good candidates for many pulp healing procedures, due to their rich blood supply, which is believed to enhance the pulp's ability to react successfully to various insults. Healing was considered to have taken place when the tooth fulfilled the following criteria: 1. Abscence of clinical symtoms 2. Radiographic evidence of dentin bridge formation 3. No intrapulpal or periapical pathosis was evident radiographically 4. Continued root development and closure of the apex in immature teeth 5. Normal dentin apposition in mature teeth 6. Positive response to electrical pulp test This presents a report of cases in which immature permanent teeth, pulp-exposed by caries or trauma, was treated successfully by partial pulpotomy

5세 된 유전성 구상 적혈구증 환아에서 폐쇄성 황달을 동반한 다발성 담석증 1례

민택기,이인규,박경배,박준수 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Hereditary spherocytosis is a common cause of hemolysis and hemolytic anemia. Some children remain asymptomatic into adulthood but others may have severe anemia with pallor, jaundice and fatigue. After infancy, the spleen is usually enlarged, and pigmentary gallstones may form as early as age 4~5 year. But it increases abruptly after age 10 year. At least 50% of unsplenectomized patients ultimately form gallstones, although for the most part they remain asymptomatic. We report herewith a case of multiple gallstone with obstructive jaundice in 5 years old patient with hereditary spherocytosis.

한랭환경하에서 면양의 Glucose 및 Insulin 분비의 Adrenalin 작동성 분비조절에 관한 연구

남기택 안성산업대학교 2006 論文集 Vol.38 No.-

In the present work, using sheep, we studied in detail the effects of α- and β-adrenergic receptor activation on the secretory response of both glucose and insulin by various doses of adrenergic blockers to obtain further information about the adrenergic modulation of insulin secretion in ruminant animals in cold environment. The plasma concentrations of glucose and insulin were determined at 15min intervals during before (2hour) and after 8(hour) intravenous infusion of adrenergic antagonist. The effects of intravenous infusion of adrenergic antagonist, Phenoxybenzamine(α-antagonist, 50nmol/kg/min), Propranolol(β-antagonist, 1 00nmol/kg/min), and Phenoxybenzamine + Propranolol, on the secretion insulin, were studied in six cross-bred castrated adult male sheep. The effects of β-receptor antagonist infusion (propranolol) was not clear, but the plasma insulin concentration was increased significantly by α-receptor antagonist infusion (phenoxybenzamine) in cold exposure. In the α- and β-receptor antagonist coinfusion, plasma insulin concentration was decreased significantly compared with saline infusion, but there was no difference in comparison with β-receptor antagonist infusion. Therefore it has been thought plasma insulin concentration was controlled by β-receptor in cold environment. Plasma glucose concentration was increased drastically by β-receptor antagonist infusion, however, there was no effect of α-receptor antagonist infusion. In both the α- and β-receptor antagonist coinfusion, plasma glucose concentration was increased. This result blood glucose was controlled through both α- and β-receptor under cold exposure. Furthermore, the action mechanism of α-receptor is prior to that of β-receptor.

全歐洲安保會議와 MBFR

李基鐸 연세대학교 행정대학원 1973 延世行政論叢 Vol.1 No.-

液體麴製造에 關한 硏究 : 異種菌株의 混合培養時 麴菌 移植方法에 關하여 Studies on inoculating method, cultivating different organisms of Aspergillus genus in the same medium

鄭基澤,兪大植 慶北大學校 1968 論文集 Vol.12 No.-

駐韓美軍撤收와 韓國의 安全

李基鐸 경북대학교 평화문제연구소 1978 평화연구 Vol.3 No.-

발포성 사과주 제조에 관한 연구

정기택,유대식 경북대학교 1971 生産技術 Vol.5 No.-

We experimented about the selection of strains, adding sugar and materials for increasing a foam-retention, as a basis study to brew a sparkling apple wine. The results are such as following. a) B-1 strain was selected and fixed as a suitable yeast to a fermentation in low temperature. b) B-1 strain had a fermentation form that was very slowly at first time and was very fast as the time goes. c) The concentration of optimum alcohol was 12%, also 6% is possible. d) Sucrose was better than glucose as adding sugar for the after fermentation, and its adding quantity was 4% and good. e) Malt extract solution was considered to be most effective as an increasing materials for a foam-retention, and its adding quautity was 50% best and 20% good.