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李基浩,安惠玲 梨花女子大學校 韓國生活科學硏究院 1987 韓國生活科學硏究院 論叢 Vol.39 No.-
본 논문에서는 함수적 프로그래밍 언어인 LISP에서의 논리적 연역 기능의 부여에 관하여 연구하였다. 이연구는 기존의 ㅍ언어에 사실과 규칙으로 구성되는 데이타 베이스를 구축할 수 있는 기능과 이를 기반으로 질의에 응답할 수 있는 시스템을 제공한다. 질의에 대한 응답은 단일화 단계를 포함하는 비교흡수 단계를 통한 논리적 연역의 결과로써 얻어진다. 또한 불필요한 백트래킹을 방지할 수 있는 방법도 제공된다. 따라서 이 연구의 결과, 기존의 LISP언어에 추론의 능력이 내장됨으로써 인공지능 연구에 더욱 효과적으로 쓰일 수 있는 LISP 프로그래밍 환경이 제공된다. In this thesis, the logical function on the LISP system is proposed and implemented. As a result of implementing logical deduction on the LISP system, users can raise some queries and the system answers them. These queries are processed through a logical deduction which has three steps: unification step, resolution step, and deduction step. In the resolution step, a method which can prevent some needless backtr-acking is proposed. Therefore, this system will support more useful and efficient LISP pro-gramming environment for the research in Artificial Intelligence field.
朴聆俊,朴涌基 대한본초학회 2000 大韓本草學會誌 Vol.15 No.2
The antioxidation effects of Cinnamomi Cortex (CC), Cinnamomi Ramulus (CR), Cinnamomi Petiole (CP) on the radical scavenging ability from 1,1'-Diphenyl-2-picrylhydrazyl (DPPH), activities of nitrate reductase (NR), superoxide dismutase (SOD), xanthine oxidase and lipid peroxidase (LPO) in rat liver cells were examined. In in vitro studies, CR extract had greater DPPH-radical scavenging ability than CC and CP. The NR acitivity in the cells was more increased by the treatments of CC and CR extracts than CP extract. The enzyme activity of Xanthine oxidase of CC was decreased. Also, levels of lipid peroxidation were proportionally decreased to concentrations of CR. The recovery by CR extract treatment was similar to the level of ascorbic acid treatment. Therefore, it seems that CR extract has similar effects on the antioxidation compared with ascorbic acid, well-known antioxidant. The data indicate that CR has a depressive effect on the production of free radicals and changes in the acitivities of enzymes involved in the antioxidation. Compared to others, CP had smaller effects on the antioxidation. These results suggest that CR seems to have more potent effects on the antioxidation than other parts of Cinamomum cassia and different mechanisms might be involved in the anitoxidation processes of CC, CP, and CR.
박기령,조성민,우가은,이기현,손혜영,임정윤,최진혁,이순남,정화순 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.2
Chronic neutrophilic leukemia(CNL) is a very rare myeloproliferative disease, characterized by sustained mature neutrophilic leukocytosis with granulocytic bone marrow infiltration, high NAP(neutrophilic alkaline phosphatase) score and absence of philadelphia chromosome, It is frequently accompanied by hepatosplenomegaly, elevated serum vitamin B_12 and uric acid level. For the diagnosis of CNL, the leukemoid reaction, especially secondary to neoplasia, infection and autoimmune diseases, should be excluded. Since Tuohy's first description in 1920, more than 50 cases fullfilling the above criteria have been reported worldwide, and 4 cases in Korea. Several authors have demonstrated the defect of intracellualr killing in the mature neutrophil and this finding correlates well with the very high incidence of fatal infection, The hemorrhagic diasthesis in CNL is caused by functional abnormality of the platelet. This disease has tendency to transform to blastic crisis and acute leukemia as in other myeloproliferative disease, but characteristically shows frequent coexistence with multiple myeloma. Until now , the therapeutic trials in CNL have been disappointing. Hydroxyrea and busulfan can control hyperleukocytosis. On the basis of functional defect in neutrophil, alpha-2b-interferon has been tried and several reports have demonstrated the clinical and functional effect of interferon on CNL. CNL is very rate hematologic disease and there are few report about general aspect of disorder. We report here a typical CNL case presenting with splenomegaly and leukocytosis with a review of the literature.
만성 골수성 백혈병 환자에서 발생한 거대 후복막강내 혈종 1예
박기령,김영선,박사영,최진혁,이순남,정화순 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.1
Thrombohemorrhagic complications in chronic myeloproliferative disease(CMPD) including chronic myelogenous leukemia(CML) are not rare. Lower incidence of disordered hemostasis is reported in CML compared with other CMPD. The mechanism of thrombohemorrhagic complications might be a consequence of qualitative platelet abnormalites and prolonged bleeding time rather than that of thrombocytosis. Although defect of platelet function has been extensively investigated, there was no established consistent correlation between clinical bleeding and number and function of platelet. The most common site of bleeding complications in the CMPD is superficial mucosa. Bleeding in deep tissue and viscera is very unusual. We report a case of CML which developed a huge spontaneous retroperitoneal hematoma.
朴?俊,朴用基 동국대학교 한의학연구소 2000 東國韓醫學硏究所論文集 Vol.9 No.-
韓藥材의 癌治療에 應用 可能性을 硏究한 23種의 論文을 對象으로 하여 文獻的으로 考察한바, 韓醫學에서는 淸熱解毒, 淸熱解血, 活血化瘀, 理氣補神養血, 化痰軟堅, 健脾化濕, 理氣散結하는 韓藥材를 이용하여 扶王法, 祛邪法, 扶正祛邪法으로써 癌治療에 應用하고 있으며, 實驗에 使用된 약물ms 總103種으로 이 中에서 魚腥草는 癌細胞株에 대한 感受性도 높게 나타났지만 正常細胞에 대한 柳制效果는 낮게 나타났고, 吳茱萸, 木香, 黑丑은 20여종의 癌細胞株에 모두 높은 細胞毒性이 나타났으며, 二白草는 HT-29, melanoma, 나-MEL-5에, 知母는 卵??癌 細胞柱에, 三白草는 HT-29 細胞柱에 특히 높은 活性을 보였다. 또한 實驗에 사용된 癌細胞柱 중에서 생쥐 유래의 P815, Yac-1 細胞柱와 사람의 Sarcoma 180, K562, SNU-1 細胞柱가 가장 多用되었다. This studies were examined in orther to investigate the object and the method of animal experimental papers on medicinal herbs of cancer therapeutic activities from the reported 23 literatures containing anti-cancer effects of medicinal herbs. The results were obtained as follows: 1. The oriental medicinal therapies on cancer were Pujeung(扶王法), Kuesa(祛邪法), Pujeungkuesa(扶正祛邪法). 2. The experimental medicinal herbs of cancers therapy were 103 species, which was used for experimental cancer single or combine. Among then, Houttuyniae herba, Polyporus, Manitis squama, Evodiae fructus, Aucklandiae radix and Pharbitidis semen were effective for cancer treatment, while Houttuyniae herbu inhibited tumor cells, but not normal cells. Also, Euodiae fructus, Auckhdiae radix and Pharbitidis semen showed strong cytoxicities on 20 different tumor cell lines, whereas Saururi herba seu rhizomu showed cytoxicity against HT-29 cell, melanoma, SK-MEL-5 cell, and Anemarrhenue rhizoma against ovarian tumor cell only, and Schizonepetae herba against HT-29 cell line only with a potent inhivitory activities. 3. P815 cell, Yac-1 cell, Sarcoma 180 cell, K 562 cell, and SNU-1 cells were frequently used as experimental cancer therapy.
김기령 고려대학교 교육문제연구소 1996 敎育問題硏究 Vol.8 No.-
본 연구는 공변량구조분석에서 무선측정오차와 모델표시오차가 미치는 영향을 조사하려고 하였다. 먼저 LISREL모델을 간단하게 설명하고, 무선측정오차가 중다회귀분석과LISREL에 미치는 영향을 찾아 보았다. 마지막으로, 모델표시오차가 LISREL에 미치는 영향도 조사하였다. 일반적으로 측정오차를 무시하면 변인간의 관계가 그릇되게 구성될 수 있고, 비일관적인 추정치를 찾아내게 된다. 이런 문제를 해결하기 위하여 측정과정에 대한 보다 철저한 이해가 필요하다. 하지만 모델표시는 이론적인 문제이기에, 더 많은 선행연구와 이론들을 고려하여 모델표시 과정을 시행하여야 한다.