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조근희 ( Cho¸ Keunhee ),김병석 ( Kim¸ Byung Suk ),이영호 ( Lee¸ Young Ho ) 한국구조물진단유지관리공학회 2002 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.6 No.2
The section optimization for FRP-concrete composite slab is carried out using physical programming and genetic algorithm, and it is verified that two methods can be successfully applied in section optimization. Ultimate moment, section stiffness and required FRP quantity are selected as design metrics for ultimate limit state, serviceability limit state and cost, respectively. Although the target safety factor is defined in terms of deflection, the safety factor of optimized section is consisted of safety factors for both ductility capacity and ultimate strength, which is coincident with desirable design method.
Comparison of Prediction Performance Using Statistical Postprocessing Methods
Keunhee Han,최준태,김찬수 한국기상학회 2016 Asia-Pacific Journal of Atmospheric Sciences Vol.52 No.5
As the 2018 Winter Olympics are to be held in Pyeongchang, both general weather information on Pyeongchang and specific weather information on this region, which can affect game operation and athletic performance, are required. An ensemble prediction system has been applied to provide more accurate weather information, but it has bias and dispersion due to the limitations and uncertainty of its model. In this study, homogeneous and nonhomogeneous regression models as well as Bayesian model averaging (BMA) were used to reduce the bias and dispersion existing in ensemble prediction and to provide probabilistic forecast. Prior to applying the prediction methods, reliability of the ensemble forecasts was tested by using a rank histogram and a residualquantile- quantile plot to identify the ensemble forecasts and the corresponding verifications. The ensemble forecasts had a consistent positive bias, indicating over-forecasting, and were under-dispersed. To correct such biases, statistical post-processing methods were applied using fixed and sliding windows. The prediction skills of methods were compared by using the mean absolute error, root mean square error, continuous ranked probability score, and continuous ranked probability skill score. Under the fixed window, BMA exhibited better prediction skill than the other methods in most observation station. Under the sliding window, on the other hand, homogeneous and non-homogeneous regression models with positive regression coefficients exhibited better prediction skill than BMA. In particular, the homogeneous regression model with positive regression coefficients exhibited the best prediction skill.
Oh, Keunhee,Seo, Myung Won,Kim, Young Whan,Lee, Dong-Sup The Korean Association of Immunobiologists 2015 Immune Network Vol.15 No.3
Lung fibrosis is a life-threatening disease caused by overt or insidious inflammatory responses. However, the mechanism of tissue injury-induced inflammation and subsequent fibrogenesis remains unclear. Recently, we and other groups reported that Th17 responses play a role in amplification of the inflammatory phase in a murine model induced by bleomycin (BLM). Osteopontin (OPN) is a cytokine and extracellular-matrix-associated signaling molecule. However, whether tissue injury causes inflammation and consequent fibrosis through OPN should be determined. In this study, we observed that BLM-induced lung inflammation and subsequent fibrosis was ameliorated in OPNdeficient mice. OPN was expressed ubiquitously in the lung parenchymal and bone-marrow-derived components and OPN from both components contributed to pathogenesis following BLM intratracheal instillation. Th17 differentiation of $CD4^+$ ${\alpha}{\beta}$ T cells and IL-17-producing ${\gamma}{\delta}$ T cells was significantly reduced in OPN-deficient mice compared to WT mice. In addition, Th1 differentiation of $CD4^+$ ${\alpha}{\beta}$ T cells and the percentage of IFN-$\gamma$-producing ${\gamma}{\delta}$ T cells increased. T helper cell differentiation in vitro revealed that OPN was preferentially upregulated in $CD4^+$ T cells under Th17 differentiation conditions. OPN expressed in both parenchymal and bone marrow cell components and contributed to BLM-induced lung inflammation and fibrosis by affecting the ratio of pathogenic IL-17/protective IFN-$\gamma$ T cells.
Oh, Keunhee,Shon, Suh Youn,Seo, Myung Won,Lee, Hak Mo,Oh, Ju-Eun,Choi, Eun Young,Lee, Dong-Sup,Park, Kyong Soo Nature Publishing Group 2015 Experimental and molecular medicine Vol.47 No.10
<P>The direct differentiation of hepatocytes from bone marrow cells remains controversial. Several mechanisms, including transdifferentiation and cell fusion, have been proposed for this phenomenon, although direct visualization of the process and the underlying mechanisms have not been reported. In this study, we established an efficient <I>in vitro</I> culture method for differentiation of functioning hepatocytes from murine lineage-negative bone marrow cells. These cells reduced liver damage and incorporated into hepatic parenchyma in two independent hepatic injury models. Our simple and efficient <I>in vitro</I> protocol for endodermal precursor cell survival and expansion enabled us to identify these cells as existing in Sca1<SUP>+</SUP> subpopulations of lineage-negative bone marrow cells. The endodermal precursor cells followed a sequential developmental pathway that included endodermal cells and hepatocyte precursor cells, which indicates that lineage-negative bone marrow cells contain more diverse multipotent stem cells than considered previously. The presence of equivalent endodermal precursor populations in human bone marrow would facilitate the development of these cells into an effective treatment modality for chronic liver diseases.</P>
Oh, Keunhee,Seo, Myung Won,Kim, In Gyu,Hwang, Young-Il,Lee, Hee-Yoon,Lee, Dong-Sup The Korean Association of Immunobiologists 2013 Immune Network Vol.13 No.6
Although pathogenesis of human rheumatoid arthritis (RA) remains unclear, arthritogenic T cells and downstream signaling mediators have been shown to play critical roles. An increasing numbers of therapeutic options have been added for the effective control of RA. Nevertheless, there is still a category of patients that fails treatment and suffers from progressive disease. The recently developed immunosuppressant CP-690550, a small molecule JAK kinase inhibitor, has been implicated as an important candidate treatment modality for autoimmune arthritis. In this study, we evaluated the therapeutic effect of CP-690550 on established arthritis using an SKG arthritis model, a pathophysiologically relevant animal model for human RA. CP-690550 treatment revealed remarkable long-term suppressive effects on SKG arthritis when administered to the well-advanced disease (clinical score 3.5~4.0). The treatment effect lasted at least 3 more weeks after cessation of drug infusion, and suppression of disease was correlated with the reduced pro-inflammatory cytokines, including IL-17, IFN-${\gamma}$, and IL-6 and increased level of immunoregulatory IL-10.
Lee, Keunhee,Ki, Hyungson Elsevier 2017 APPLIED SURFACE SCIENCE - Vol.420 No.-
<P><B>Abstract</B></P> <P>In this article, we propose a systematic method of optimizing the properties of transparent conductive films that possess high electrical conductivity and low optical transparency, by using laser patterning and doping. Prediction maps were constructed, which show the effects of patterning and doping for all possible combinations of initial film conditions (in terms of sheet resistance and transparency) and the degrees of patterning. Using these maps, the properties of transparent conductive films can be easily optimized. We first fabricated graphene-based transparent conductive films on fused silica glass by laser annealing of diamond-like carbon films, and then picosecond laser patterning and doping were successively conducted employing the processing conditions suggested by the maps. For patterning, two types of patterns, circular and square, were considered and prediction maps were separately constructed for both patterns. In this study, a film originally having a sheet resistance of 578Ω/sq and a transparency of 25% was transformed to a 2823Ω/sq and 80.6% film when 73% of the film was removed using square patterns and doped by nitric acid. Experimental data agreed well with predicted values.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fabricated graphene-based transparent conductive films using laser annealing. </LI> <LI> Employed picosecond laser patterning and chemical doping to optimize film quality. </LI> <LI> Constructed prediction maps for transparency and resistance after patterning/doping. </LI> </UL> </P>
Oh, Keunhee,Kim, Sae Rom,Kim, Dae-Kyum,Seo, Myung Won,Lee, Changjin,Lee, Hak Mo,Oh, Ju-Eun,Choi, Eun Young,Lee, Dong-Sup,Gho, Yong Song,Park, Kyong Soo American Chemical Society 2015 ACS NANO Vol.9 No.12
<P>The current diabetes mellitus pandemic constitutes an important global health problem. Reductions in the mass and function of β-cells contribute to most of the pathophysiology underlying diabetes. Thus, physiological control of blood glucose levels can be adequately restored by replacing functioning β-cell mass. Sources of functional islets for transplantation are limited, resulting in great interest in the development of alternate sources, and recent progress regarding cell fate change <I>via</I> utilization of extracellular vesicles, also known as exosomes and microvesicles, is notable. Thus, this study investigated the therapeutic capacity of extracellular vesicle-mimetic nanovesicles (NVs) derived from a murine pancreatic β-cell line. To differentiate insulin-producing cells effectively, a three-dimensional <I>in vivo</I> microenvironment was constructed in which extracellular vesicle-mimetic NVs were applied to subcutaneous Matrigel platforms containing bone marrow (BM) cells in diabetic immunocompromised mice. Long-term control of glucose levels was achieved over 60 days, and differentiation of donor BM cells into insulin-producing cells in the subcutaneous Matrigel platforms, which were composed of islet-like cell clusters with extensive capillary networks, was confirmed along with the expression of key pancreatic β-cell markers. The resectioning of the subcutaneous Matrigel platforms caused a rebound in blood glucose levels and confirmed the source of functioning β-cells. Thus, efficient differentiation of therapeutic insulin-producing cells was attained <I>in vivo</I> through the use of extracellular vesicle-mimetic NVs, which maintained physiological glucose levels.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-12/acsnano.5b02997/production/images/medium/nn-2015-02997m_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b02997'>ACS Electronic Supporting Info</A></P>