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한국 청소년에서 물질 사용과 위험한 성 행동 사이의 연관성
이건희(Keon Hui Lee),김준원(Jun Won Kim),최태영(Tae Young Choi),윤서영(Seo Young Yoon),이종훈(Jong Hun Lee) 한국중독정신의학회 2020 중독정신의학 Vol.24 No.2
Objectives : This study aimed to investigate the association between substance use and risky sexual behavior in Korean adolescents. Methods : A cross-sectional survey using a self-administered questionnaire was conducted in 12-18 year-old adolescents in Korea in 2018. The data of 60,040 adolescents who participated in the survey were analyzed. Logistic regression was performed to investigate the association between substance use (alcohol use, tobacco use, and the use of other drugs) and risky sexual behavior (having sexual intercourse during adolescence, and having unprotected sexual intercourse), for males and females, separately. Results : The percentage of adolescents who had sexual intercourse was 5.3%. Among those who had sexual intercourse, 53.9% had unprotected sexual intercourse. Logistic regression analyses showed that all types of substance use were associated with having an early sexual debut and having unprotected sexual intercourse. Conclusion : The study showed that substance use, including alcohol use, tobacco use, and the use of other drugs, was associated with risky sexual behavior among Korean adolescents. Sexual health education and interventions are necessary for adolescents with a history of substance use.
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Adventitial Fibroblast Abormality in Thoracic Aortic Aneurysms and Aortic Dissections
Jong Hui Suh,Jeong-Seob Yoon,Hwan Wook Kim,Keon Hyon Jo 대한흉부외과학회 2011 Journal of Chest Surgery (J Chest Surg) Vol.44 No.6
Development of thoracic aortic aneurysms and aortic dissections (TAAD) is attributed to unbearable wall tension superimposed on defective aortic wall integrity and impaired aortic repair mechanisms. Central to this repair mechanisms are well-balanced and adequately functional cellular components of the aortic wall, including endothelial cells, smooth muscle cells (SMCs), inflammatory cells, and adventitial fibroblasts. Adventitial fibroblasts naturally produce aortic extracellular matrix (ECM), and, when aortic wall is injured, they can be transformed into SMCs, which in turn are involved in aortic remodeling. We postulated the hypothesis that adventitial fibroblasts in patients with TAAD may have defects in ECM production and SMC transformation. Materials and Methods: Adventitial fibroblasts were procured from the adventitial layer of fresh aortic tissues of patients with TAAD (Group I) and of multi-organ donors (Group II), and 4-passage cell culture was performed prior to the experiment. To assess ECM production, cells were treated with TNF-α (50 pM) and the expression of MMP-2 / MMP-3 was analyzed using western blot technique. To assess SMC transformation capacity, cells were treated with TGF-β1 and expression of SM α-actin, SM-MHC, Ki-67 and SM calponin was evaluated using western blot technique. Fibroblasts were then treated with TGF-β1 (10 pM) for up to 10 days with TGF-β1 supplementation every 2 days, and the proportion of transformed SMC in the cell line was measured using immunofluorescence assay for fibroblast surface antigen every 2 days. Results: MMP-3 expression was significantly lower in group I than in group II. TGF-β1-stimulated adventitial fibroblasts in group I expressed less SM α-actin, SM-MHC, and Ki-67 than in group II. SM-calponin expression was not different between the two groups. Presence of fibroblast was observed on immunofluorescence assay after more than 6 days of TGF-β1 treatment in group I, while most fibroblasts were transformed to SMC within 4 days in group II. Conclusion: ECM production and SMC transformation are compromised in adventitial fibroblasts from patients with TAAD. This result suggests that functional restoration of adventitial fibroblasts could well be a novel approach for the prevention and treatment of TAAD.
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선휘경,박봉건,이상준,양대열,고부준,문정섭,전영빈,유권,백인욱 인제대학교 2000 仁濟醫學 Vol.21 No.2
Chylous mesenteric cyst in adult is extremely rare and do not hale any specific signs or symptoms to facilitate their clinical diagnosis. Most cysts are noticed as a palpable abdominal mass or by nonspecific abdominal symptoms such as pain, nausea and vomiting. In some cases, they are detected incidentally by routine abdominal examination, but in symptomatic patient, the possibility of complication must be considered. The diagnosis can be done by radiologic studies such as sonography and computerized tomography but confirmative diagnosis is done by surgical excision. We describm a case of large mesenteric cyst which was cured by surgical excision in a 31-year-old man.
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Optimization of the Spreadable Modified Butter Manufacturing by Response Surface Methodology
Mun Hui Suh,Keon Bong Lee,Seung Chun Baick 한국축산식품학회 2012 한국축산식품학회지 Vol.32 No.6
The aim of this study was to optimize the manufacturing condition of spreadable modified butter by RSM. Based on the central composite design, the degree of optimization was expressed as a SFC as a dependent variable (Y, %) determined by NMR with 23 experimental groups. Three independent variables were the contents of butter (X1, 35-75%), the contents of grape seed oil (X2, 15-35%), and the contents of hydrogenated soybean oil (X3, 0-4%). As the result, SFC at 10oC was ranged from 32.37 to 42.76%. In addition, the regression coefficients were calculated for SFC at 10oC by RSREG. The regression model equation for the SFC was Y=39.18-0.04X1X3. Consequently, the optimal contents for manufacturing spreadable modified butter were determined as 55.18% for butter, 40.78% for grape seed oil, and 4.08% for hydrogenated soybean oil, respectively. The predicted response value for SFC at 10oC was 30.20%, comparable to the actual experimental SFC value as 29.85%. Finally hardness and spreadability in reference butter and spreadable modified butter produced under the optimal conditions was measured. The hardness in spreadable modified butter was 31.80 N as compared to 69.92 N in reference butter. The spreadability in spreadable modified butter was 5.6 point as compared to reference butter. This difference may be due to the contents of solid fat by butter and hydrogenated soybean oil. This study showed that the SFC value at 10oC could be a suitable indicator for the manufacturing spreadable modified butter to predict important attributes such as mouth feel, hardness and spreadability.
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STIM1 negatively regulates Ca2? release from the sarcoplasmic reticulum in skeletal myotubes.
Lee, Keon Jin,Woo, Jin Seok,Hwang, Ji-Hye,Hyun, Changdo,Cho, Chung-Hyun,Kim, Do Han,Lee, Eun Hui Biochemical Society 2013 The Biochemical journal Vol.453 No.2
<P>STIM1 (stromal interaction molecule 1) mediates SOCE (store-operated Ca2? entry) in skeletal muscle. However, the direct role(s) of STIM1 in skeletal muscle, such as Ca2? release from the SR (sarcoplasmic reticulum) for muscle contraction, have not been identified. The times required for the maximal expression of endogenous STIM1 or Orai1, or for the appearance of puncta during the differentiation of mouse primary skeletal myoblasts to myotubes, were all different, and the formation of puncta was detected with no stimulus during differentiation, suggesting that, in skeletal muscle, the formation of puncta is a part of the differentiation. Wild-type STIM1 and two STIM1 mutants (Triple mutant, missing Ca2?-sensing residues but possessing the intact C-terminus; and E136X, missing the C-terminus) were overexpressed in the myotubes. The wild-type STIM1 increased SOCE, whereas neither mutant had an effect on SOCE. It was interesting that increases in the formation of puncta were observed in the Triple mutant as well as in wild-type STIM1, suggesting that SOCE-irrelevant puncta could exist in skeletal muscle. On the other hand, overexpression of wild-type or Triple mutant, but not E136X, attenuated Ca2? releases from the SR in response to KCl [evoking ECC (excitation-contraction coupling) via activating DHPR (dihydropyridine receptor)] in a dominant-negative manner. The attenuation was removed by STIM1 knockdown, and STIM1 was co-immunoprecipitated with DHRP in a Ca2?-independent manner. These results suggest that STIM1 negatively regulates Ca2? release from the SR through the direct interaction of the STIM1 C-terminus with DHPR, and that STIM1 is involved in both ECC and SOCE in skeletal muscle.</P>
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이종건(Jong-Keon Lee),김명희(Myung-Hui Kim),성상현(Sanghyeon Sung) 한국인사조직학회 2012 인사조직연구 Vol.20 No.2
본 연구는 다양성이 팀 성과에 미치는 영향과 이들 두 변인 간 관계에서 팀 목표 의존이 갖는 조절효과를 분석하였다. 팀 구성의 다양성이 갖는 대표적인 세 가지 측면인 인구통계학적 차이, 정보지식 차이, 가치관 차이가 미치는 영향을 분석하고자 연령, 경력 및 교육배경, 가치관을 사용하였고, 팀 성과는 팀 만족, 팀 몰입, 팀 응집성, 팀의 창의적 행동을 분석하였다. 실증분석은 기업의 실제 팀 58개에 소속된 599명으로부터 수집한 자료를 사용하였다. 분석 결과, 다양성은 팀 성과에 부분적으로 유의한 영향을 미치는 것으로 밝혀졌다. 연령다양성은 팀의 창의적 행동에 대하여 정(+)의 미치는 반면, 교육배경 다양성은 팀의 창의적 행동 및 팀 응집성에 대하여 부(-)의 영향을 미치는 것으로 나타났다. 가치관 다양성은 팀 만족, 팀 몰입, 팀 응집성에 대하여 부(-)의 영향을 미치는 것으로 나타났다. 그리고 팀 목표의 상호의존은 다양성-팀 성과 간 관계를 부분적으로 조절하였다. 팀 목표의 상호의존은 교육배경 다양성- 팀 몰입 관계, 가치 다양성-팀 몰입 관계, 그리고 경력 다양성-팀 응집성 관계를 긍정적으로 조절하는 것으로 나타났다. 마지막으로, 연구결과에 대한 이론적·실무적 시사점에 대하여 논의하였다. Due to the increase of economic activities by women, employment flexibility, task diversity, and globalization, human resources in current enterprises have become increasingly diverse. Workforce diversity is related to enriched perspectives, skills, and insights, which in turn increase the group’s creativity and problem-solving capabilities. In contrast, the process of categorizing similar in-group members and dissimilar out-group members on the basis of similarity and differences between team members causes conflict within group processes. As a result, effective management of diversity has become an essential part of gaining a sustainable competitive advantage through the diverse workforce. Despite long interests in diversity management, it is not clear yet how various types of diversity influence group processes and what effective management is on diversity. Most research on diversity are overly inconsistent. In particular, most studies on workforce diversity are conducted in Western enterprises where sources of workforce diversity are much more diverse than Asian companies in terms of race, nationality, gender orientation, individuality, etc. Moreover, since culture and structure of Asian and Western companies stand apart, questions are raised whether effects of work team diversity are the same in different organizational contexts. Thus, this study explores the effects of various types of diversity in Korean firms and the moderating role of team goal interdependence. The purpose of this study was to examine the effects of diversity on team outcomes and moderating effects of perceived team goal interdependence on the diversity-team performance relationship. Based on the literature review, we propose: Hypothesis 1. Age diversity will be negatively related to (a) team satisfaction, (b) team commitment, (c) team cohesion, and positively related to (d) teams creative behavior. Hypothesis 2. Career diversity will be negatively related to (a) team satisfaction, (b) team commitment, (c) team cohesion, and positively related to (d) team creative behavior. Hypothesis 3. Educational background diversity will be negatively related to (a) team satisfaction, (b) team commitment, (c) team cohesion, and positively related to (d) team creative behavior. Hypothesis 4. Values diversity will be negatively related to (a) team satisfaction, (b) team commitment, (c) team cohesion, and (d) team creative behavior. Hypothesis 5. The interaction of team perceived goal interdependence and (a) age diversity, (b) career diversity, (c) educational background diversity, and (d) values diversity will be positively related to team satisfaction. Hypothesis 6. The interaction of team perceived goal interdependence and (a) age diversity, (b) career diversity, (c) educational background diversity, and (d) values diversity will be positively related to team commitment. Hypothesis 7. The interaction of team perceived goal interdependence and (a) age diversity, (b) career diversity, (c) educational background diversity, and (d) values diversity will be positively related to team cohesion. Hypothesis 8. The interaction of team perceived goal interdependence and (a) age diversity, (b) career diversity, (c) educational background diversity, and (d) values diversity will be positively related to team creative behavior. To test the hypotheses, we collected questionnaires from 559 team members from 58 work teams in a Korean conglomerate. Four variables were used to measure team diversity: age, career, educational background, and values. To measure the context effects, perceived goal interdependence was introduced as the moderating variable. Team outcomes included four variables: team commitment, team satisfaction, team cohesion, and team creative behavior. Also, the study controlled two variables that might affect the hypothesized relationships, team size and the length of service of team members.
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