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Genetic Diversity among Waxy Corn Inbred Lines Revealed by CACTA-TD Markers
Andrew Keeping,Ju Kyong Lee,Soon Jae Kwon,Jong Yeol Park,Ki Jin Park,Hwang Kee Min,Nam Soo Kim 한국육종학회 2004 한국육종학회지 Vol.36 No.4
CACTA is a class 2 transposon superfamily found exclusively in plants. In this study, we have applied CACTA-TD technique to study the genetic diversity among 90 waxy corn inbred lines. While CACTA-TD fragments ranged approximately from 100 to 650 bp in si
( Sam Keeping ),( Keith Chan ),( Eric Druyts ),( Shelby Corman ),( Chizoba Nwankwo ),( Park Hye-min ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Genotype 1b accounts for the majority of chronic hepatitis c virus (HCV) infections in high income countries in Asia. The combination of daclastasvir plus asunaprevir for 24 weeks (DCV24 + ASV24) is currently licensed for the treatment of genotype 1b patients in Japan, Korea and Taiwan, and can be considered one of the current standard of care in this population. The fixed-dose combination of elbasvir/grazoprevir taken for 12 weeks (EBR/GZR12) has also demonstrated high rates of sustained viral response (SVR) in genotype 1b patients. We performed a systematic review and indirect treatment comparison of EBR/GZR12 and DCV24 + ASV24 in HCV patients with genotype 1b. Methods: Randomized or single-arm clinical trials of at least one of the treatments of interest were identified by searching Medline (including Medline in Process), Embase, and Cochrane Central Register of Controlled Trials. For each intervention, an overall SVR across all trials was calculated using a fixed-effects model with inverse- variance weighting and no transformation of the underlying data. A naive comparison was then made using standard statistical methods (2x2 contingency tables, Normal test for difference), without accounting for differences across trial populations. Analyses were conducted for the overall population as well as subgroups stratified by prior-treatment experienced and cirrhosis status. Results: A total of 27 relevant citations were identified with information from 15 clinical trials (9 for EBR/GZR, 6 for DCV + ASV). The pooled SVRs in all patients were 98.28% (95% CI 97.07%, 99.48%) for EBR/GZR12, and 86.68% (95% CI 84.73%, 88.62%) for DCV24 + ASV24. In the naive comparison, a statistically significant difference was observed between the two treatments with a relative risk (RR) of 1.12 (95% CI 1.09, 1.16). The subgroup analysis showed that EBR/GZR12 had higher SVRs than DCV24 + ASV24 in all subgroups that were assessed. These differences in SVRs were also statistically significant in all patient groups except in treatment-naive patients with compensated cirrhosis (RR 1.10 [95% CI 0.99, 1.23]), where the lower bound of the confidence interval approached 1 (see Table 1). Due to a lack of head-to-head trials within the evidence base or trials with a common control group, it was not possible to carry out a network meta-analysis. Conclusions: These results suggest that EBR/GZR12 is likely to offer clinical benefits over DCV24 + ASV24 in terms of higher SVRs in patients with genotype 1b chronic hepatitis C infection.
Genetic Diversity among Waxy Corn Inbred Lines Revealed by CACTA-TD Markers
Andrew Keeping,이주경,권순재,박종열,박기진,민황기,김남수 한국육종학회 2004 한국육종학회지 Vol.36 No.5
CACTA is a class 2 transposon superfamily found exclusively in plants. In this study, we have applied CACTA-TD technique to study the genetic diversity among 90 waxy corn inbred lines. While CACTA-TD fragments ranged approximately from 100 to 650 bp in size, the fragments in the range of 100-500bp showed high profiles of polymorphisms. Analysis of the 90 inbred lines with 5 CACTA-TD primer combinations detected a total of 204 fragments, of which 165 (80.9%) were polymorphic among the inbreds. The GDs of among all inbreds measured by CACTA-TD markers showed 38.8±7.6. The GDs between groups (KW vs QL) were slightly higher than the GDs within groups. GDs of KW vs QL were 42.1±5.1, while the GDs of KW vs KW and QL vs QL showed 37.0±7.6 and 38.9±10.2, respectively. In cluster analysis of the 90 waxy corn inbred lines, three major groups were recognized; Group I contained 5 KW lines, 29 QL lines and 1 HW line, with 0.65~0.75 similarity between them. Group II contained 9 KW lines, 5 QL lines and 1 HW line, with 0.62~0.87 similarity between them. Group III contained 3 KW lines and 37 QL lines, with 0.61~0.71 similarity between them. The results of current study will be utilized for the dissection of quantitative traits and the identification of superior QTLs from the waxy corn hybrid, and will be used for the further genetic analysis and maize breeding programs.
Nahm, Keep-Yung Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.10
The transition structures for the epoxidations of ethylene and the disproportionations by the dioxiranes of phosphines, phosphites and sulfides were studied with density function theory methods using the Becke3LYP functional and 6-311+G(2d,p) basis set. When the dioxiranes have methyl substituents rather than hydrogen substituents, the reaction barriers ($E_{TS}$) become higher in their epoxidations of ethylene by the steric hindrance, but become lower in their disproportionations of phosphines, phosphites and sulfides, which indicates that the nature of the dioxiranes seems to be electrophilic and in their disproportionations the reaction barriers are effected both by the electrophilicity and the steric hindrance. The steric factors in the disproportionations were calculated and more bulky substituents at dioxiranes may be necessary to retard the disproportionation and to enhance the epoxidation.