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Kang, Keejung,Park, Yongju,Hwang, Hye-Jeong,Kim, Seong-Ho,Lee, Jeong-Gu,Shin, Hyeon-Cheol The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.4
Several polyphenolic compounds and complex mixtures were isolated from brown algae species. The 1,1-diphenyl-2-picryhydarzyl (DPPH) radical scavenging activity and ferric reducing antioxidant power (FRAP) of these compounds were evaluated to determine their physiological usefulness as antioxidants for vascular protection. The antioxidative protection of low-density lipoprotein (LDL) was also evaluated and compared with that of catechin, because the generation of oxidized LDL is one of the most active and specific risk factors contributing to atherogenesis. Oral administration to rats of a commercially available sample ($VNP^{TM}$) containing 30% of these polyphenolic compounds and 70% dietary fiber revealed that the serum reducing capacity measured in terms of FRAP value was significantly elevated 30 min after the treatment, but declined rather quickly thereafter, indicating the good oral absorption of the compounds and their fast binding to the lumenal surface of the blood vessels. An eight-week, human, clinical trial (n=31) of $VNP^{TM}$ showed significant improvement in erectile function measured by IIEF (international index of erectile function) score. These results collectively demonstrated the usefulness of these polyphenolic compounds as fundamental chemopreventive agents against vascular risk factors originating from oxidative stress.
조기정(KeeJung Cho),이순옥(SoonOk Lee) 한국차학회 2011 한국차학회지 Vol.17 No.1
This paper deals with the pharmacological effects and practical role of tea and past tea-making methods through literature on Traditional medicinal - herb tea (香藥茶). Even though our culture of tea drinking was limited to a privileged class in the past, it has become one of the most important ways to obtaining a peaceful mind, in addition to its medical effects. In order to make medicinal herb tea more modern, more effort must be made to diversify our tea drinking culture. By developing the excellence and uniqueness of medicinal herb tea, we can place emphasis on studying the effects of tea and generalizing tea drinking, with medicinal herb tea as the main topic. This study aims to be a basis for expanding interest in tea, as consumption of tea is decreasing due to lack of various goods, primary cost, and lack of consumers’ recognition, and popularizing medicinal - herb tea (香藥茶).
방기정 ( Keejung Barng ),김윤 ( Youn Kim ) 한국패션비즈니스학회 2016 패션 비즈니스 Vol.20 No.4
This study is conducted in grades 4, 5, and6 of Elementary schools located in Seoul. The results would be recognized by the Consumer Behavior Survey and the Use of Beauty. Students in the higher grades of elementary schools are exposed to beauty products for the first time. This is a crucial age, where they start becoming interested in their appearance. This behavior is being exploited to increase the desire to use beauty products. Although the initial use is self-motivated, choosing a quality product is highly influenced by peers, reasonable pricing, and internet impact. The higher the grade of the elementary school, we observed an increase in this trust and impulsiveness in the consumer behavior. More than 2 million students spent considerable amounts of money, and showed trends of consumer behavior of the impulsive type. The results of this study can provide a significant base to further study trends of beauty usage in higher grades of elementary schools, and give an indication of the consumer behavior based on the beauty culture and use of health products.
AKT1-targeted proapoptotic activity of compound K in human breast cancer cells
Eunju Choi,Eunji Kim,김지혜,Keejung Yoon,Sunggyu Kim,Jongsung Lee,Jae Youl Cho 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.4
Background: Breast cancer is a severe disease and the second leading cause of cancer death in womenworldwide. To surmount this, various diagnosis and treatment options for breast cancer have beendeveloped. One of the most effective strategies for cancer treatment is to induce apoptosis using naturallyoccurring compounds. Compound K (CK) is a ginseng saponin metabolite generated by humanintestinal bacteria. CK has been studied for its cardioprotective, antiinflammatory, and liver-protectiveeffects; however, the role of CK in breast cancer is not fully understood. Methods: To investigate the anticancer effects of CK in SKBR3 and MDA-MB-231 cells, cell viability assaysand flow cytometry analysis were used. In addition, the direct targets of CK anticancer activity wereidentified using immunoblotting analysis and overexpression experiments. Invasion, migration, andclonogenic assays were carried out to determine the effects of CK on cancer metastasis. Results: CK-induced cell apoptosis in SKBR3 cells as determined through 3-(4-5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide assays, propidium iodide (PI) and annexin V staining, and morphologicalchanges. CK increased the cleaved forms of caspase-7, caspase-8, and caspase-9, whereas the expressionof Bcl-2 was reduced by CK. In assays probing the cell survival pathway, CK activated only AKT1 and notAKT2. Moreover, CK inhibited breast cancer cell invasion, migration, and colony formation. Throughregulation of AKT1 activity, CK exerts anticancer effects by inducing apoptosis. Conclusion: Our results suggest that CK could be used as a therapeutic compound for breast cancer.
스마트 디바이스 환경의 디지털 퍼블리싱 커뮤니케이션 연구
김상욱 ( Kim Sanguck ),권기정 ( Kwon Keejung ) 한국디자인트렌드학회 2013 한국디자인포럼 Vol.38 No.-
퍼블리싱 업계는 아이폰, 아이패드, 갤럭시 탭 등 다양한 스마트 디바이스의 등장으로 읽기 문화의 변화와 함께 혁신적인 혁명기를 맞이하고 있다. 본 연구의 목적은 스마트 디바이스 환경에서의 디지털 퍼블리싱 콘텐츠의 특성을 조사하고 전통 퍼블리싱 산업의 진보에 관해 커뮤니케이션 디자인의 견지에서 그 방법론과 시장 환경에 관한 조사를 통해, 새로운 콘텐츠 커뮤니케이션 패러다임에 관한 디자인 프로세스를 제시함에 있다. 디지털 퍼블리싱 1세대(v1.0)가 대형 인터넷 서점을 중심으로 대량의 도서 콘텐츠를 효율적인 디지털 전환을 거쳐 경제성을 확보하는 유통구조를 의미했다면, 스마트 디바이스를 통해 새롭게 열리고 있는 디지털 퍼블리싱 2세대(v2.0)는 감성적인 콘텐츠 커뮤니케이션과 창조적인 미디어 융합이 그 중심 개념이 되고 있다. 이에 본 논문에서는 디지털 퍼블리싱 콘텐츠가 사용자의 새로운 라이프 스타일을 이끄는 미디어 혁신성을 구현하기 위해 어떤 디자인 공정이 필요하고 그에 따른 지향점은 무엇인지, 디지털 환경과 그 커뮤니케이션 구조 연구를 통해 제시하였다. Publishing industry confronts with the revolution of reading experience by the advent of smart devices such as iphone, ipad and android tablet PC. This research aims to describe the design process about new paradigm of contents communication in digital publishing through studying the attribute of digital contents and the revolutionary progress of its communication structure in terms of communication design perspective In the era of digital publishing 1.0, the industry mainly focused on the efficiency of conversing process from off-line feature to digital and the economic feasibility in digital distribution structure. However, the advent of digital publishing 2.0 era, which was followed up by thriving of smart devices, the emotional contents communication and creative media fusion are emerged as core concept for new reading experience. This research depicts the creative methodology to come up media innovation to lead reader`s new life style in developing digital publishing ecosystem.