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Zhanjie Ren,Na Ji,Kebao Jia,Li Wang,Harvest F. Gu,Jun Ma 한국유전학회 2015 Genes & Genomics Vol.37 No.1
Intercellular adhesion molecule-1 (ICAM-1) isan inflammation cytokine. Previous studies have demonstratedthat genetic polymorphisms in the ICAM-1 gene areassociated with chronic inflammation and diabeticnephropathy. The present study aimed to investigate theassociation of ICAM-1 gene polymorphisms with type 2diabetes (T2D) and diabetic peripheral neuropathy (DPN)in a Chinese Han population. Four valid single nucleotidepolymorphisms (SNPs) in the ICAM-1 gene were genotypedin 672 control subjects, 787 T2D patients with andwithout DPN with TaqMan allelic discrimination. Singlemarker association analyses indicated that A allele of SNPrs5498 was associated with DPN (P = 0.037, OR 1.715,95 % CI 1.027–2.865). Further analyses of clinicalparameters according to the genotypes of this polymorphismdemonstrated that T2D patients with DPN carryingAA and AG genotypes had higher risk of coronary heartdisease compared with those carrying GG genotype(30.6 % vs. 11.5 %, P = 0.040). In SNP rs1799969, thedifference of minor allele frequencies between the patientswithout and with DPN was found (0.02 vs 0.01, P = 0.014,OR 3.695, 95 % CI 1.211–11.277). SNP rs281432 hadhigher frequency of G allele in all T2D patients comparedwith control subjects (0.35 vs. 0.31, P = 0.041, OR 1.200,95 % CI 1.008–1.428). The present study provides evidencethat rs5498 (A/G E469K) polymorphism is associatedwith DPN in T2D, and also implicates that theassociation of ICAM-1 with DPN may be related to othervascular complications.
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