Early Efficacy of Endostar Combined with Chemoradiotherapy for Advanced Cervical Cancers

Ke, Qing-Hua,Zhou, Shi-Qiong,Huang, Min,Lei, Yong,Du, Wei,Yang, Ji-Yuan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

The aim of this study was to investigate the early outcome of Endostar combined with chemoradiotherapy for advanced cervical cancer. Fifty-two cases (FIGO IIb to IVa) were divided randomly into two groups, receiving chemoradiotherapy alone (CRT group) and Endostar combined with chemoradiotherapy (CRT+E group). For the patients in the CRT+E group, Endostar was administered daily with the dosage of 7.5 $mg/m^2$, and cisplatin was administered weekly with the dosage of 20 $mg/m^2$ during the radiation. The regimens lasted for 4 weeks with no difference in chemoradiotherapy between the two groups. The early outcome complete remission rate was 73.1%, partial remission rate was 23.1% and the total response rate was 96.2% in CRT+E group, a significant improvement on the 34.6%, 42.3% and 76.9%, respectively, in the CRT group. One year survive rates were 100% and 84.6% in the CRT+E group and CRT groups, the difference being significant. Endostar combined with chemoradiotherapy can improve the early outcome of the advanced cervical cancer, and adverse effects were not encountered.

Glacier Change in the Yigong Zangbo Basin, Tibetan Plateau, China

Ke, Chang-Qing,Lee, Hoonyol,Han, Yan-Fei The Korean Society of Remote Sensing 2019 大韓遠隔探査學會誌 Vol.35 No.4

Distinguishing debris-covered glaciers from debris-free glaciers is difficult when using only optical remote sensing images to extract glacier boundaries.According to the features that the surface temperature of debris-covered glacier is lower than surrounding objects, and higher than clean glaciers, glacial changes in the Yigong Zangbo basin was analyzed on the basis of visible, near-infrared and thermal-infrared band images of Landsat TM and OLI/TIRS in the support of ancillary digital elevation model (DEM). The results indicated that glacier area gradually declined from $928.76km^2$ in 1990 to $918.46km^2$ in 2000 and $901.51km^2$ in 2015. However, debris-covered glacier area showed a slight increase from $63.39km^2$ in 1990 to $66.24km^2$ in 2000 and $71.16km^2$ in 2015. During 25 years, the glacier length became shorter continuously with terminus elevation rising up. The area of moraine lakes in 1990 was $1.43km^2$, which increased to $1.98km^2$ in 2000 and $3.41km^2$ in 2015. In other words, the total area of the moraine lakes in 2015 is 2.38 times of that in 1990. This increase in moraine lake area could be the result of accelerated glacier melt and retreat, which is consistent with the significant warming trend in recent decades in the basin.

Optimization of L-shaped Corner Dowel Joint in Modified Poplar using Finite Element Analysis with Taguchi Method

Qing Ke,Fan Zhang,Yachi Zhang 한국목재공학회 2016 목재공학 Vol.44 No.2

Modified poplar has emerged as a potential raw material for furniture production. Lack of specific modified poplar strength information; however, restricts applications in the furniture industry especially as related to strength in corner-joints. Optimization of strength in L-shaped corner dowel modified poplar joints under compression loads utilizing finite element analysis (FEA) by Taguchi method with the focus of this study. Four experiment factors (i.e., Structure Style, Tenon Length, Tenon Diameter, and Tenon Gap), each at three levels, were conducted by adopting a L9-34 Taguchi orthodoxy array (OA) to determine the optimal combination of factors and levels for the von Mises stress utilizing ANSYS software. Results of Signal-to-Noise ratio (S/N) analysis and the analysis of variance (ANOVA) revealed the optimal L-shaped corner dowel joint in modified poplar is 45° Bevel Butt in structure style, 24 mm in tenon length, 6 mm in tenon diameter, and 20 mm in tenon gap. Tenon length and tenon gap are determined to be significant design factors for affecting von Mises Stress. Confirmation tests with optimal levels and experimental test indicated the predicted optimal condition is comparable to the actual experimental optimal condition.

InSAR-based Glacier Velocity Mapping in the Parlung Zangbo River Basin, Tibetan Plateau, China

Ke, Chang-Qing,Lee, Hoonyol,Li, Lan-Yu The Korean Society of Remote Sensing 2019 大韓遠隔探査學會誌 Vol.35 No.1

By applying the method of SAR interferometry to X-band synthetic aperture radar (SAR) image of COSMO-SkyMed, detailed motion patterns of five glaciers in the Parlung Zangbo River basin, Tibetan Plateau, in January 2010 have been derived. The results indicate that flow patterns are generally constrained by the valley geometry and terrain complexity. The maximum of $123.9ma^{-1}$ is observed on glacier No.1 and the minimum of $39.4ma^{-1}$ is found on glacier No.3. The mean values of five glaciers are between 22.9 and $98.2ma^{-1}$. Glaciers No.1, No.2, No.4 and No.5 exhibit high velocities in their upper sections with big slope and low velocities in the lower sections. A moraine lake accelerates the speed of mass exchange leading to a fast flow at the terminal of glacier No.3. These glaciers generally move along the direction of decreased elevation and present a macroscopic illustration of the motion from the northwest to the southeast. The accuracy of DEM and registration conditions of DEM-simulated terrain phases has certain effects on calculations of glacier flow direction and velocity. The error field is relatively fragmented in areas inconsistent with the main flow line of the glaciers, and the shape and uniformity of glacier are directly related to the continuous distribution of flow velocity errors.

Novel Three-Phase PWM Voltage-Fed Rectifier with an Auxiliary Resonant Commutated Pole Link

Ke-Qing Qu,Jin-Bin Zhao 전력전자학회 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.4

A novel auxiliary resonant commutated pole (ARCP) link for three-phase PWM voltage-fed converter is presented. The ARCP link consists of two auxiliary switches, one resonant inductance, and six diodes, which is simpler than the conventional ARCP designs. Based on the phase and amplitude control, the proposed converter can take a minimum switching times PWM method, which results in reduced losses and a simplified control. In addition, the zero-voltage resonance modes are analyzed. Finally, simulation and experimental results show that the system can realize zero-voltage switching with a unity power factor.

Early Efficacy of Taxotere and Cisplatin Chemo-Radiotherapy for Advanced Cervical Cancer

Ke, Qing-Hua,Zhou, Shi-Qiong,Du, Wei,Lei, Yong,Huang, Min,Luo, Fei,Yang, Ji-Yuan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

The aim of this study was to investigate the early outcome of the taxotere and cisplatin chemoradiotherapy for advanced cervical cancer. Fifty-six cases (FIGO II b to IVa) were divided randomly into two groups: radiotherapy alone (28 cases) and radiation plus chemotherapy (TP) group. There was no difference in radiotherapy between the two groups. The RT+C cases who received TP regimen during the radiation, and DDP once weekly injection of vain, according to 20$mg/m^2$ and taxotere once weekly iv according to 35 $mg/m^2$. These regimens were given for 4~5weeks, and some medicines to control vomiting were available for the RT+C cases. The two groups received an oral medicine MA 160mg every day during the treatment. Regarding early outcome, the complete remission rate was 64.3% and partial remission rate was 35.7% in RT+C. The complete remission rate was 32.1% and partial remission rate was 39.3% in RT. The total response rate and complete remission in the RT+C group were higher than that in the RT group. We conclude that taxotere and cisplatin chemoradiotherapy can improve the early outcome of the advanced cervical cancer, the adverse effects being endurable.

Novel Three-Phase PWM Voltage-Fed Rectifier with an Auxiliary Resonant Commutated Pole Link

Qu, Ke-Qing,Zhao, Jin-Bin The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.4

A novel auxiliary resonant commutated pole (ARCP) link for three-phase PWM voltage-fed converter is presented. The ARCP link consists of two auxiliary switches, one resonant inductance, and six diodes, which is simpler than the conventional ARCP designs. Based on the phase and amplitude control, the proposed converter can take a minimum switching times PWM method, which results in reduced losses and a simplified control. In addition, the zero-voltage resonance modes are analyzed. Finally, simulation and experimental results show that the system can realize zero-voltage switching with a unity power factor.

A hemoglobin-based oxygen-carrying biomimetic nanosystem for enhanced chemo-phototherapy and hypoxia alleviation of hepatocellular carcinoma

Jing-Qing Le,Fang Yang,Xun-Huan Song,Ke-Ke Feng,Ling-Wu Tong,Meng-Die Yin,Wen-Zhong Zhang,Ying-Qi Lin,Hui Wu,Jing-Wei Shao 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-

Tumor microenvironment is characterized by low pH, high reactive oxygen species and hypoxia, whichprovides a suitable environment for cancer growth. The hypoxia not only elevates tumor angiogenesisand metastasis, but also is responsible for the development of treatment resistance, which graduallybecomes a significant impediment for cancer therapy. Therefore, we developed a biomimetic nanosystemcontaining hemoglobin extracted from red blood cells, chemotherapy drug sorafenib, sensitizer ursolicacid and photosensitizer indocyanine green for enhanced chemo-photo combination therapy of hepatocellularcarcinoma, which could not only enhance the chemotherapy effect of sorafenib bowing to thesensitizing effect of ursolic acid, but also achieved synergetic phototherapy in virtue of indocyaninegreen. Besides, the nanoparticles could effectively delivery exogenous oxygen to tumor site and amelioratethe tumor hypoxic environment with the assistance of hemoglobin. The dual-sensitization drugdelivery system was expected to effectively reduce the resistance of traditional treatment methodsagainst tumor hypoxia, providing a novel prospect for the synergistic hepatocellular carcinomatreatment.

Glacier Change in the Yigong Zangbo Basin, Tibetan Plateau, China

Chang-Qing Ke,Hoonyol Lee,Yan-Fei Han 대한원격탐사학회 2019 大韓遠隔探査學會誌 Vol.35 No.4

Distinguishing debris-covered glaciers from debris-free glaciers is difficult when using only optical remote sensing images to extract glacier boundaries. According to the features that the surface temperature of debriscovered glacier is lower than surrounding objects, and higher than clean glaciers, glacial changes in the Yigong Zangbo basin was analyzed on the basis of visible, near-infrared and thermal-infrared band images of Landsat TM and OLI/TIRS in the support of ancillary digital elevation model (DEM). The results indicated that glacier area gradually declined from 928.76 km2 in 1990 to 918.46 km2 in 2000 and 901.51 km2 in 2015. However, debriscovered glacier area showed a slight increase from 63.39 km2 in 1990 to 66.24 km2 in 2000 and 71.16 km2 in 2015. During 25 years, the glacier length became shorter continuously with terminus elevation rising up. The area of moraine lakes in 1990 was 1.43 km2, which increased to 1.98 km2 in 2000 and 3.41 km2 in 2015. In other words, the total area of the moraine lakes in 2015 is 2.38 times of that in 1990. This increase in moraine lake area could be the result of accelerated glacier melt and retreat, which is consistent with the significant warming trend in recent decades in the basin.

Three new diphenylpropanes from Celastrus hindsii

Xian Qing Hu,Wei Han,Zhu Zhen Han,Qing Xin Liu,Xi-Ke Xu,Peng Fu,Hui-Liang Li 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.11

Three new diphenylpropanes, HindsiipropaneA–C (1–3), together with one known arylpropyl quinoneGriffithane D (4), were isolated from Celastrus hindsii. Their structures were established by 1D and 2D nuclearmagnetic resonance spectroscopic analysis, and massspectroscopy. Compound 4 was firstly obtained in thisgenus. All the isolated compounds were evaluated in vitrofor cytotoxicity against four human tumor cell lines (A549,HCT116, MDA-MB-231, BEL7404) by the MTT assay.