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Natalie Scherrer,Francois Fays,Beat Mueller,Andreas Luft,Felix Fluri,Mirjam Christ-Crain,Yvan Devaux,Mira Katan 대한뇌졸중학회 2017 Journal of stroke Vol.19 No.3
Background and Purpose Micro ribonucleic acid-150-5p (miR-150-5p) regulates proinflammatory cytokines as well as vessel integrity. We evaluated the incremental prognostic value of logarithm (log) of miR-150-5p plasma levels after ischemic stroke. Methods In a prospective cohort study, levels of miR-150-5p were measured within 72 hours of symptom onset in 329 ischemic stroke patients. The outcome measures were unfavorable functional outcome (assessed by the modified Rankin Scale score >2) and mortality within 90 days. Logistic regression and Cox proportional hazards models were fitted to estimate odds ratio (OR), respectively hazard ratio (HR) and 95% confidence interval (CI) for the association between log-miR-150-5p and the outcome measures. The discriminatory accuracy was assessed with the area under the receiver-operating-characteristic curve (AUC) and the incremental prognostic value was estimated with the net reclassification index. Results After adjusting for demographic and vascular risk factors, lower log-miR-150-5p levels were independently associated with mortality (HR 0.21 [95% CI, 0.08–0.51], P=0.001) but not functional outcome (OR 1.10 [95% CI, 0.54–2.25], P=0.79). Adding log-miR-150-5p improved the discriminatory accuracy of the best multivariate model to predict mortality from an AUC of 0.91 (95% CI, 0.88–0.95) to 0.92 (95% CI, 0.88–0.96 Likelihood-ratio test-P<0.001), and resulted in a net reclassification index of 37.3% (95% CI, 0.28–0.52). Conclusions In patients with ischemic stroke, log-miR-150-5p is a novel prognostic biomarker, highly associated with mortality within 90 days, improving risk classification beyond traditional risk factors.
Kistler, H. C.,Alabouvette, C.,Baayen, R. P.,Bentley, S.,Brayford, D.,Coddington, A.,Correll, J.,Daboussi, M.-J.,Elias, K.,Fernandez, D.,Gorden, T. R.,Katan, T.,Kim, H. G.,Leslie, J. F.,Martyn, R. D. 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-
Fusarium oxysporum Schlechtend.:Fr is a cosmopolitan fungal pathogen (4) responsible for wit and cortical rot diseases of more than 100 economically important plant hosts (3). Genetic diversity within F. oxysporum has been categorized extensively by vegetative compatibility grouping in laboratories around the world. Detailed studies indicate that isolates belonging to the same vegetative compatibility group (VCG) typically possess very similar or identical multilocus haplotypes and belong to the same clonal lineage(19). VCG. therefore, can be good predictors of genetic similarity, clonal lineage. or both. In this communication, we propose a standardization of the system currently used for categorizing genetic diversity within this taxon. Our primary objective is to make the system more understandable and useful by reducing ambiguity and increasing the rigor with which the current system is applied. A secondary goal of this undertaking is to promote international communication and cooperation in this endeavor.