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Katagiri, Nobuko,Shimatani, Yuichi,Katagiri, Yasuo Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
The inverted retina of the Onchidium dorsal eye (DE) is composed only of ciliary-type photoreceptor cells (CC's). The outer segment (OS) of the CC is a concentric lamellar structure consisting of many modified ciliary membranes and stains positively with anti-$\beta$-tubulin antibody. Near the base of the OS there are about 30 basal bodies each connecting individually to a cilium. The cilia are rod-shaped at the base, progressing upwards to a flattened sheet-like shape with increasing surface area. Three-dimensional analysis on serial sections demonstrates the ladle-shape of a modified cilium. Many modified cilia wrap around each other like the leaves of a cabbage. Nine pairs of microtubules (MT's) are located regularly in a ring at the base of the cilium, gradually losing their regular arrangement towards the periphery, where they separate into two subgroups that are contained within two swollen portions of a modified cilium. Within the CC of the Onchidium DE, MT's in the modified cilium exist as two poles extending longitudinally in a thin expanded ciliary membrane. This arrangement may support the photoreceptive OS and serve to maintain its structural integrity.
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( Katagiri Yuki ) 아세아여성법학회 2013 아세아여성법학 Vol.16 No.-
The Social Security fund was made of our tax and premium. So, the nature is very public and we are forbidden to receive social security benefit on the base of wrong ways. Public assistant system is funded by 100% tax and there is strict means test before getting the assistance. In this system, trouble on wrong way is sometimes caused by gap of understanding it between the government and recipient. The government prohibit recipient has a car in general. When authority finds out recipient has a car, it give recipient legal sanction, that`s suspension or cancel of public assistance. In the case, the law requires the authority should observe Due Process. It means that when authority gives a sanction, at first the sanction has to be the mildest one. In Social Security system, legal sanction must be taken carefully, keep Due Process and have a regard for recipients.
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Angiogenesis in newly regenerated bone by secretomes of human mesenchymal stem cells
Katagiri, Wataru,Kawai, Takamasa,Osugi, Masashi,Sugimura-Wakayama, Yukiko,Sakaguchi, Kohei,Kojima, Taku,Kobayashi, Tadaharu Korean Association of Maxillofacial Plastic and Re 2017 Maxillofacial Plastic Reconstructive Surgery Vol.39 No.-
Background: For an effective bone graft for reconstruction of the maxillofacial region, an adequate vascular network will be required to supply blood, osteoprogenitor cells, and growth factors. We previously reported that the secretomes of bone marrow-derived mesenchymal stem cells (MSC-CM) contain numerous growth factors such as insulin-like growth factor (IGF)-1, transforming growth factor $(TGF)-{\beta}1$, and vascular endothelial growth factor (VEGF), which can affect the cellular characteristics and behavior of regenerating bone cells. We hypothesized that angiogenesis is an important step for bone regeneration, and VEGF is one of the crucial factors in MSC-CM that would enhance its osteogenic potential. In the present study, we focused on VEGF in MSC-CM and evaluated the angiogenic and osteogenic potentials of MSC-CM for bone regeneration. Methods: Cytokines in MSC-CM were measured by enzyme-linked immunosorbent assay (ELISA). Human umbilical vein endothelial cells (HUVECs) were cultured with MSC-CM or MSC-CM with anti-VEGF antibody (MSC-CM + anti-VEGF) for neutralization, and tube formation was evaluated. For the evaluation of bone and blood vessel formation with micro-computed tomography (micro-CT) and for the histological and immunohistochemical analyses, a rat calvarial bone defect model was used. Results: The concentrations of IGF-1, VEGF, and $TGF-{\beta}1$ in MSC-CM were $1515.6{\pm}211.8pg/mL$, $465.8{\pm}108.8pg/mL$, and $339.8{\pm}14.4pg/mL$, respectively. Tube formation of HUVECs, bone formation, and blood vessel formation were increased in the MSC-CM group but decreased in the MSC-CM + anti-VEGF group. Histological findings suggested that new bone formation in the entire defect was observed in the MSC-CM group although it was decreased in the MSC-CM + anti-VEGF group. Immunohistochemistry indicated that angiogenesis and migration of endogenous stem cells were much more abundant in the MSC-CM group than in the MSC-CM + anti-VEGF group. Conclusions: VEGF is considered a crucial factor in MSC-CM, and MSC-CM is proposed to be an adequate therapeutic agent for bone regeneration with angiogenesis.
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( Katagiri Yuki ) 아세아여성법학연구소 2002 아세아여성법학 Vol.5 No.-
In recent years, the increase of child abuse has been featured in the mass media. This is one of hot issue in the field of Social Security Law. Most of child abuse are done by the person with parental authority. Against such a situation, we have some legislations in Japan. Child Welfare Law plays the most important role, and when the case is so serious, the Penal Code can be applied. For dealing with the increase of child abuse, the Law concerning the Prevention of Child Abuse on May 2000. Our actual condition of Child Abuse is as follows. There were l7, 725 consultations(2000) to the child guidance center. The breakdown is physical abuse (49.7%), neglect (36.5) %, sexual abuse(3.7%) and emotional abuse(l0.l%) in 2000. These are done by mother (6L6%), farter (23.7%), stepmother and stepfather followed them. In the case of child abuse, it is desirable to separate the child and their parent. The child Welfare Law provides the some institutions for child who was separated from their parent (§ 27(1)-3). Then the consent from the parent is indispensable far sending the child to the institutions. Bar without this consent, they can send the child there after getting the approval from Family Court(Child Welfare Law § 28). There were 142 applications for the approval in 2000 and 10 1 of them were accepted, When the Child abuse is very serious, the director of child guidance center can ask the loss sentence parental authority for Family Court( § 33-6). In the case for asking the approval on the Child Welfare Law § 28, there are some regal issue. At first, it is whether Family Court can give the comprehensive approval or nor. Concerning this problem, some gave the comprehensive approval, but in most of cases, Family Court expressed the concrete referral. The judgement of the Court of Appeal in fukuoka 1989/4/28 is the leading case in this point. It is not a final solution to separate the .child from their parent. We can say it is the act of necessity. The ultimate goal is reproduction of family. For this purpose, Child Welfare Law § 27(1)-2 provides that the child welfare officer give instruction to the child and parent. Through this article, We can hope they learn how to make a good relationship between them. In addition, the Law concerning the Prevention of Child Abuse provides the heating from the child welfare officer as an important marter of referral rescission. In the cases, we can see some judge expects such an instruction by the child guidance center. Lastly 1 would like to dose this paper by pointing out this. It is that on solving the child abuse, we may not make use of the judiciary proceedings. As stated above, although the number of consultation on child abuse is about 18.000, the application to Family Coon is only 142. We can say this is the reason why most of them are solved at the level of child guidance center. Bur we can also indicate some child guidance center hesitate to apply to Family Court and some Family Court show a negative attitude toward the accept of such an application. Considering the important role of the law playing on relief of child abuse, we should actively use the judiciary proceedings in future.
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Wataru Katagiri,Daisuke Saito,Satoshi Maruyama,Makiko Ike,Hideyoshi Nisiyama,Takafumi Hayashi,Jun-ichi Tanuma,Tadaharu Kobayashi 대한악안면성형재건외과학회 2023 Maxillofacial Plastic Reconstructive Surgery Vol.45 No.-
Background Masticatory muscle tendon-aponeurosis hyperplasia (MMTAH) is a relatively newly identified clinical condition that manifests as trismus with a square-shaped mandible. Herein, we report a case of MMATH that was initially misdiagnosed for polymyositis due to trismus and simultaneous lower limb pain, with literature review. Case presentation A 30-year-old woman had a history of lower limb pain after exertion for 2 years. Initial physical examination had been performed at the Department of General Medicine in our hospital. There was also redness in the hands and fingers. Although polymyositis was suspected, it was denied. The patient visited our department for right maxillary wisdom tooth extraction. Clinical examination revealed that the patient had a square-shaped mandible. The maximal mouth opening was 22 mm. There was no temporomandibular joint pain at the time of opening. Furthermore, there was awareness of clenching while working. Panoramic radiography revealed developed square mandibular angles with flattened condyles. Computed tomography showed enlarged masseter muscles with high-density areas around the anterior and lateral fascia. Magnetic resonance imaging also showed thickened tendons and aponeuroses on the anterior surface and inside bilateral masseter muscles. Finally, the patient was diagnosed with MMTAH. Bilateral aponeurectomy of the masseter muscles with coronoidectomy and masseter muscle myotomy was performed under general anesthesia. The maximum opening during surgery was 48 mm. Mouth opening training was started on day 3 after surgery. Histopathological examination of the surgical specimen showed that the muscle fibers were enlarged to 60 μm. Immunohistochemistry testing for calcineurin, which was associated with muscle hypertrophy due to overload in some case reports, showed positive results. Twelve months after surgery, the mouth self-opening and forced opening were over 35 mm and 44 mm, respectively. Conclusions Herein, we report a case of MMATH. Lower limb pain due to prolonged standing at work and overload due to clenching were considered risk factors for symptoms onset of MMATH.
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片桐由喜(Katagiri, Yuki) 한국사회보장법학회 2013 사회보장법학 Vol.2 No.2
복지국가를 지향하는 하는 많은 나라들은 국민에게 건강하고 문화적인 최저한도의 생활을 보장하는 책임을 지며, 그 목적을 위해 사회보장입법을 하고, 제도를 정비·발전시킨다. 한편, 복지국가의 기본이념으로서는 국민 자신의 생활이 어려울 때 스스로 해결할 수 없다면 사회보장제도에 의지하기 전에 가족, 즉 사적인 부양으로 생계를 유지해야 한다. 그러나 가족기능이 저하되고, 가족 간의 부양의식도 이전과 비교하였을 때 크게 변화한 시점에서는 사적부양이 공적인 부양에 우선적으로 적용될 수 있는 시스템을 기반으로 한 제도의 설계 역시 검토되어야 한다. 이러한 재검토에 있어서는 생존권을 규정한 헌법 25조뿐만 아니라 개인의 존엄을 보장하는 헌법 13조 역시 고려하면서 사적부양과 공적부양의 관계를 생각할 필요가 있다. The Welfare states in modern society have liability for their nation to give the minimum standard of living based on law. To carry out this task, the states have made and developed social security laws. On the other hand, as the philosophy of welfare states, there are idea of self-help or self-responsibility, therefore we are, of course, required to manage our life by our efforts. It means that when we are in want but cannot maintain our life by ourselves, we have to make use of family support before depending on national social security system. However, it need to rethink such an idea because family has less power to help each other than before. In addition, the sense of support among family has also widely changed now. Rethinking the priority between public assistance and family support, it is very important to put into view not only §25 of Japanese Constitution, that article refers the right of life, but also §13, which declares the nation shall be respected as individuals.
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Recent Topics in Fibrodysplasia Ossificans Progressiva
Takenobu Katagiri,Sho Tsukamoto,Yutaka Nakachi,Mai Kuratani 대한내분비학회 2018 Endocrinology and metabolism Vol.33 No.3
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease that is characterized by the formation of heterotopic bone tissuesin soft tissues, such as skeletal muscle, ligament, and tendon. It is difficult to remove such heterotopic bones via internal medicineor invasive procedures. The identification of activin A receptor, type I (ACVR1)/ALK2 gene mutations associated with FOP hasallowed the genetic diagnosis of FOP. The ACVR1/ALK2 gene encodes the ALK2 protein, which is a transmembrane kinase receptorin the transforming growth factor-β family. The relevant mutations activate intracellular signaling in vitro and induce heterotopicbone formation in vivo. Activin A is a potential ligand that activates mutant ALK2 but not wild-type ALK2. Various types of smallchemical and biological inhibitors of ALK2 signaling have been developed to establish treatments for FOP. Some of these are inclinical trials in patients with FOP.
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片桐由喜 ( Katagiri Yuki ) 아세아여성법학회 2021 아세아여성법학 Vol.24 No.-
주택은 인간 생활의 기반이며 개인의 자율적 삶을 영위하는 데 필요한 공간이다. 그런데도 현 상황은 기업이나 가족에 의지하는 부분이 크며 공적인 주택 보장은 충분하지 않다. 이러한 가운데 2021년 현재, 신종 코로나바이러스 감염 방지 대책을 통한 경제 활동의 강제적인 자숙으로 인해 많은 노동자들은 수입이 줄어들거나 실직으로 인해 곤경에 처해 있다. 그 결과 주택을 잃었거나 잃을 위기에 처한 사람도 있으나 충분한 공적 지원을 받을 수 없는 상황이다. 이번 코로나 사태를 계기로 일본의 취약한 공적 주택보장제도가 표면에 드러났다. 앞으로는 주택 공급에 대한 공적 관여를 강화하고 보편적인 주택보장제도를 정비해 나갈 것이 요구된다. Housing is the base of human life. Nevertheless, we highly depend on private sector, that is the companies or families, for the housing. Because the public responsibility, which means Governmental responsibility, for housing is not sufficient. By the way, as of 2021, many workers are suffering from reduced income or unemployment due to restraining the economic activities forced to prevent infection with the COVID-19. Now, due to reduced income or unemployment, some have lost or are at risk of losing their homes but have not received sufficient housing benefit from public sector. And by (thanks to) COVID-19, we noticed the weakness of public housing benefit in Japan. In the future, it will be necessary to strengthen public involvement in housing supply and develop a universal housing benefit.
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