Measurement of Neutron Capture Cross Section and Gamma-Ray Spectra of ^(88)Sr in keV Energy Region

T. Katabuchi,N. C. Hai,M. Igashira,S. Kamada,M. Tajika,M. Mizumoto 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23

The neutron capture cross section of ^(88)Sr at incident neutron energies E_n = 10 - 89 keV and 510 keV has been measured by the time-of-flight method. Capture γ-rays were detected with an anti-Compton NaI(Tl) spectrometer and the pulse height weighting technique was applied to derive the neutron cross section as a function of incident neutron energy. Capture γ-ray spectra were also measured. The obtained capture cross section was compared with previous experimental data and evaluated data from ENDF/B-VII.0.

Systematic Study on KeV-Neutron Capture Reaction of Se Isotopes

M. Igashira,S. Kamada,T. Katabuchi,M. Mizumoto 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23

Systematic measurements and calculations of neutron capture cross sections and capture gamma-ray spectra of all stable Se isotopes ^(74, 76, 77, 78, 80, 82)Se were performed in a neutron energy region from 10 to 600 keV, using a pulsed neutron source by the ^7Li(p,n)^7Be reaction. Highly isotopically enriched Se samples and standard Au samples were used. The capture gamma rays from each sample were detected with an anti-Compton NaI(Tl) spectrometer by means of a time-of-flight method. The capture cross sections were derived by using a pulse-height weighting technique and the standard capture cross sections of ^(197)Au. The capture gamma-ray spectra were obtained by unfolding the observed capture gamma-ray pulse-height spectra. In the calculations, a computer code, POD, was utilized. The calculated results were compared with the experimental results. The present experimental and calculated results were compared with previous measurements and evaluated values.

Quality indicators for cervical cancer care in Japan

Tomone Watanabe,Mikio Mikami,Hidetaka Katabuchi,Shingo Kato,Masanori Kaneuchi,Masahiro Takahashi,Hidekatsu Nakai,Satoru Nagase,Hitoshi Niikura,Masaki Mandai,Yasuyuki Hirashima,Hiroyuki Yanai,Wataru Ya 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.6

Objective: Choice of hysterectomy and adjuvant treatment for International Federation of Gynecology and Obstetrics (FIGO) 2009 stage II endometrioid endometrial cancer (EEC) is still controversial. Aims of this study were to evaluate survival benefits and adverse effects of different hysterectomies with or without adjuvant radiotherapy (RT), and to identify prognostic factors. Methods: The patients at 14 member hospitals of the Taiwanese Gynecologic Oncology Group from 1992 to 2013 were retrospectively investigated. Patients were divided into simple hysterectomy (SH) alone, SH with RT, radical hysterectomy (RH) alone, and RH with RT groups. Endpoints were recurrence-free survival (RFS), overall survival (OS), disease-specific survival (DSS), adverse effects and prognostic factors for survival. Results: Total of 246 patients were enrolled. The 5-year RFS, OS, DSS and recurrence rates for the entire cohort were 89.5%, 94.3%, 96.2% and 10.2%, respectively. Patients receiving RH had more adverse effects including blood loss (p<0.001), recurrent urinary tract infections (p=0.013), and leg lymphedema (p=0.038). Age over 50-year (HR=9.2; 95% confidence interval [CI], 1.2–70.9) and grade 3 histology (HR=7.28; 95% CI, 1.45–36.6) were independent predictors of OS. Grade 3 histology was an independent predictor of RFS (HR=5.13; 95% CI, 1.38–19.1) and DSS (HR=5.97; 95% CI, 1.06–58.7). Patients receiving adjuvant RT had lower locoregional recurrence (p=0.046), but no impact on survival. Conclusion: Different treatment modalities yield similar survival outcomes. Patients receiving SH with RT had lower locoregional recurrent with acceptable morbidity. Age and tumor grading remained significant predictors for survival among patients with FIGO 2009 stage II EEC. Objective: We aimed to propose a set of quality indicators (QIs) based on the clinical guidelines for cervical cancer treatment published by The Japan Society of Gynecologic Oncology, and to assess adherence to standard-of-care as an index of the quality of care for cervical cancer in Japan. Methods: A panel of clinical experts devised the QIs using a modified Delphi method. Adherence to each QI was evaluated using data from a hospital-based cancer registry of patients diagnosed in 2013, and linked with insurance claims data, between October 1, 2012, and December 31, 2014. All patients who received first-line treatment at the participating facility were included. The QI scores were communicated to participating hospitals, and additional data about the reasons for non-adherence were collected. Results: In total, 297 hospitals participated, and the care provided to 15,163 cervical cancer patients was examined using 10 measurable QIs. The adherence rate ranged from 50.0% for ‘cystoscope or proctoscope for stage IVA’ to 98.8% for ‘chemotherapy using platinum for stage IVB’. Despite the variation in care, hospitals reported clinically valid reasons for more than half of the non-adherent cases. Clinically valid reasons accounted for 75%, 90.9%, 73.4%, 44.5%, and 88.1% of presented non-adherent cases respectively. Conclusion: Our study revealed variations in pattern of care as well as an adherence to standards-of-care across Japan. Further assessment of the causes of variation and non-adherence can help identify areas where improvements are needed in patient care.

Impact of institutional accreditation by the Japan Society of Gynecologic Oncology on the treatment and survival of women with cervical cancer

Mikio Mikami,Masako Shida,Takeo Shibata,Hidetaka Katabuchi,Junzo Kigawa,Daisuke Aoki,Nobuo Yaegashi 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.2

Objective: The Japan Society of Gynecologic Oncology (JSGO) initiated a nation-wide training system for the education and certification for gynecologic oncologists in 2005. To assess the impact of the quality of the JSGO-accredited institutions, JSGO undertook an analysis of the Uterine Cervical Cancer Registry of the Japan Society of Obstetrics and Gynecology (JSOG) to determine the effectiveness of the JSGO-accredited institutions on the treatment and survival of women with cervical cancer. Methods: The effectiveness of 119 JSGO-accredited institutions and 125 non-JSGO-accredited institutions on the treatment and survival of women with cervical cancer were compared by analyzing the tumor characteristics, treatment patterns, and survival outcomes of women with stage T1B–T4 cervical cancer utilizing the data in the JSOG nation-wide registry for cervical cancer (2006–2009). Results: A total of 14,185 eligible women were identified: 10,920 (77.0%) cases for 119 JSGO-accredited institutions and 3,265 (23.0%) cases for 125 non-accredited institutions. A multivariate analysis showed that age, stage, histology type, and treatment pattern were independently associated with mortality. Moreover, women who received treatment at the JSGO-accredited institutions had a significantly decreased mortality risk compared to non-accredited institutions (adjusted hazard ratio [aHR]=0.843; 95% confidence interval [CI]=0.784–0.905). Similar findings on multivariate analysis were seen among subset of women who received surgery alone (aHR=0.552; 95% CI=0.393–0.775) and among women who received radiotherapy (aHR=0.845; 95% CI=0.766–0.931). Conclusion: Successful implementation of gynecologic oncology accrediting institution was associated with improved survival outcome of women with cervical cancer in Japan.

STAT3 pathway of epithelial ovarian cancer cells and M2 macrophages in the cancer microenvironment are inactivated by Onionin A

( Junko Tsuboki ),( Kiyomi Takaishi ),( Fumiko Ito ),( Ritsuo Honda ),( Hironori Tashiro ),( Hidetaka Katabuchi ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

Objective: In epithelial ovarian cancer (EOC), M2-polarized macrophage (Mø), a component of the cancer microenvironment in ascitic fluid as well as primary tumor, is thought to play an important role in cell- proliferation via paracrine activation of the STAT3 pathway. Onionin A (ONA), a natural compound purified from onions, biologically inhibits M2 polarization, and molecularly inactivates STAT3 signaling of Mø and tumor cells. Here we elucidated the indirect and direct anti-cancer effects of ONA via the STAT3 pathway. Methods: The indirect effects of ONA on EOC cells were analyzed under the co-culture system with human monocyte- derived Mø using BrdU ELISA assay. The direct effects of ONA alone and combinations with anti-cancer drugs (PTX, CBDCA, or CDDP) on proliferation and STAT3 activation of the human EOC cell lines (SKOV3, RMG1, or ES2) were evaluated using WST assay and western blot analysis. Results: M2Mø in the co-culture system enhanced proliferation of EOC cells, whereas ONA significantly reduced the enhancement of the cell-proliferation by inhibition of M2-polarization. In addition, ONA directly inhibited STAT3-activation and proliferation of EOC cells (P value < 0.01-0.05). Moreover, the suppressive effects against EOC cell proliferation were significantly increased by the combination of ONA with anti-cancer drugs (P value < 0.01-0.05). Conclusions: ONA exhibited direct anti-cancer effects in EOC as well as indirect effects by suppression of M2-polarization in co-culture system. It was suggested that the combination of ONA and anti-cancer drugs presents a new therapeutic strategy for treatment of EOC.

Lymphadenectomy for primary ovarian cancer: a systematic review and meta-analysis

Tatsuyuki Chiyoda,Manabu Sakurai,Toyomi Satoh,Satoru Nagase,Mikio Mikami,Hidetaka Katabuchi,Daisuke Aoki 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.5

Objective: To assess the effectiveness of lymphadenectomy at primary debulking surgery(PDS) on the survival of patients with epithelial ovarian cancer (EOC). Methods: We searched PubMed, Ichushi, and the Cochrane Library. Randomized controlledtrials (RCTs) and retrospective cohort studies comparing survival of women with EOCundergoing lymphadenectomy at PDS with that of women without lymphadenectomy wereincluded. We performed a meta-analysis of overall survival (OS), progression-free survival(PFS), and adverse events. Results: For advanced-stage EOC, 2 RCTs including 1,074 women and 7 cohort studiescomprising 3,161 women were evaluated. Meta-analysis revealed that lymphadenectomy wasassociated with improved OS (hazard ratio [HR]=0.80; 95% confidence interval [CI]=0.70–0.90). However, meta-analysis of 2 RCTs revealed no significant difference in OS betweenthe lymphadenectomy and no-lymphadenectomy groups (OS: HR=1.02; 95% CI=0.85–1.22). For early-stage EOC, 1 RCT comprising 268 women and 4 cohort studies comprising 14,228women were evaluated. Meta-analysis showed that lymphadenectomy was associatedwith improved OS (HR=0.75; 95% CI=0.68–0.82). A RCT of early-stage EOC reported thatlymphadenectomy was not associated with improved OS (HR=0.85; 95% CI=0.49–1.47). Surgery-related deaths were similar in both groups (risk ratio [RR]=1.00; 95% CI=0.99–1.01);however, blood transfusion was required less frequently in the no-lymphadenectomy group(RR=0.74; 95% CI=0.63–0.86). Conclusions: Meta-analysis of RCTs and observational studies suggest thatlymphadenectomy was associated with improved OS in advanced- and early-stage EOC. However, results from RCTs demonstrate that lymphadenectomy was not associated withimproved OS in advanced- and early-stage EOC.

International Young Doctors` Session : Session 2 ; Epithelial cell adhesion molecule, a potential marker of cancer stem cells, is associated with resistance to platinum-based chemotherapy in epithelial ovarian cancer

( Shingo Tayama ),( Takeshi Motohara ),( Francisca Tjhay ),( Kiyomi Takaishi ),( Hironori Tashiro ),( Hidetaka Katabuchi ) 대한산부인과학회 2013 서울심포지움 Vol.18 No.-

Opportunistic bilateral salpingectomy during benign gynecological surgery for ovarian cancer prevention: a survey of Gynecologic Oncology Committee of Japan Society of Obstetrics and Gynecology

Mikio Mikami,Satoru Nagase,Wataru Yamagami,Kimio Ushijma,Hironori Tashiro,Hidetaka Katabuchi 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.4

Objective: Recent evidence has supported the concept that epithelial ovarian cancer (EOC)arises from the cells of the fallopian tube or endometrium. This study investigated currentpractice in Japan with respect to performing opportunistic bilateral salpingectomy (OBS)during gynecological surgery for benign disease for Ovarian Cancer Prevention. Methods: We mailed a questionnaire to 767 hospitals and clinics, comprising 628 accreditedtraining institutions of the Japan Society of Obstetrics and Gynecology (JSOG), Japan Societyof Gynecologic Oncology (JSGO), or Japan Society of Gynecologic and Obstetric Endoscopyand Minimally Invasive Therapy (JSGOE) and 139 private institutions with at least one JSGOEcertifiedlicensed gynecologic laparoscopist. Results: Among the 767 institutions, 444 (57.9%) provided responses, including 91 (20.6%)that were both JSGOE and JSGO accredited, 71 (16.0%) that were only JSGO accredited, 88(19.8%) that were only JSGOE accredited, and 194 (43.7%) that were unaccredited. It wasfound that awareness and performance of OBS largely depended on the JSGO and/or JSGOEaccreditation status. OBS was only performed at 54.0% of responding institutions and just6.8% of the institutions were willing to participate in randomized controlled trials to validatethis method for reducing the incidence of ovarian cancer. Conclusion: The JSOG Gynecologic Tumor Committee will announce its opinion onsalpingectomy for ovarian cancer prevention to all JSOG members and will develop a systemfor monitoring the number of OBS procedures in Japan.

Double-edged Sword Role of Iron-loaded Ferritin in Extracellular Vesicles

Shinya Toyokuni,Yingyi Kong,Hao Zheng,Danyang Mi,Misako Katabuchi,Yashiro Motooka,Fumiya Ito 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.4

Human epidemiological and animal studies have demonstrated that excess iron is a risk for cancer. The responsible mechanisms are: 1) increased intracellular iron catalyzes the Fenton reaction to generate hydroxyl radicals, leading to mutagenic oxidative DNA lesions; 2) iron is necessary for cellular proliferation as cofactors of many enzymes. Thus, iron-excess milieu promotes selecting cellular evolution to ferroptosis-resistance, a major basis for carcinogenesis. Ferritin is a 24-subunit nanocage protein required for iron storage under the regulation of the iron-regulatory protein (IRP)/iron-responsive element (IRE) system. Ferritin is a serum marker, representing total body iron storage. However, how ferritin is secreted extracellularly has been unelucidated. We recently discovered that an exosomal marker CD63 is regulated by the IRP/IRE system and that iron-loaded ferritin is secreted as extracellular vesicles under the guidance of nuclear receptor coactivator 4 (NCOA4). On the other hand, we found that macrophages under asbestos-induced ferroptosis emit ferroptosis-dependent extracellular vesicles (FedEVs), which are received by nearby mesothelial cells, resulting in significant mutagenic DNA damage. Therefore, cells, including macrophages, can share excess iron with other cells, via iron-loaded ferritin packaged in extracellular vesicles as safe non-catalytic iron. However, similar process, such as one involving FedEVs, may cause accumulation of excess iron in other specific cells, which may eventually promote carcinogenesis. Key Words Ferritin, Extracellular vesicles, Iron, Ferroptosis, Asbestos

Study of Neutron Capture Reactions Using the 4π Ge Spectrometer

H. Harada,S. Goko,A. Kimura,M. Ohta,M. Oshima,F. Kitatani,M. Igashira,T. Katabuchi,M. Mizumoto,T. Ohsaki,J. Hori,T. Fujii,K. Takamiya,J. Goto,Y. Kiyanagi,K. Kino,M. Furusaka,F. Hiraga,T. Kamiyama 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23

The 4π Ge spectrometer composed of 22-30 Ge detectors was developed, and it has been used to study neutron capture reactions with a neutron time-of-flight (TOF) technique. Since the distances between the sample position and the Ge detectors are variable, it can be used as a multifunctional spectrometer. At first, it was used as a sum energy spectrometer, and resonances in ^(nat)Ag were identified as those of ^(1070Ag or ^(109)Ag. In second, it was used to deduce γ-ray intensity distribution for each resonance, and the results for ^(238)U were presented. In third, it was used to measure neutron capture cross sections of minor actinides and fission products at the electron linear accerelator facility of KURRI and at the accurate neutron-nucleus reaction measurement instrument (ANNRI) in MLF of J-PARC The preliminary results are discussed mainly based on measurements of neutron capture cross section for ^(241)Am, together with related techniques.