Expression

Kanta Bhuraria KANTA 한국색채학회 2021 International Invitation Exhibition of Color Works Vol.- No.-

Expression

Kanta Bhuraria KANTA 한국색채학회 2020 International Invitation Exhibition of Color Works Vol.- No.-

Methanolic Extract from Sea Cucumber, Holothuria scabra, Induces Apoptosis and Suppresses Metastasis of PC3 Prostate Cancer Cells Modulated by MAPK Signaling Pathway

( Kanta Pranweerapaiboon ),( Kunwadee Noonong ),( Somjai Apisawetakan ),( Prasert Sobhon ),( Kulathida Chaithirayanon ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.6

Sea cucumber, Holothuria scabra, is a well-known traditional Asian medicine that has been used for suppressing inflammation, promoting wound healing, and improving immunity. Moreover, previous studies demonstrated that the extract from H. scabra contains many bioactive compounds with potent inhibitory effect on tumor cell survival and progression. However, the effect of the methanolic extract from the body wall of H. scabra (BWMT) on human prostate cancer cells has not yet been investigated. In this study, we aimed to investigate the effects and underlying mechanism of BWMT on prostate cancer cell viability and metastasis. BWMT was obtained by maceration with methanol. The effect of BWMT on cell viability was assessed by MTT and colony formation assays. The intracellular ROS accumulation was evaluated using a DCFH-DA fluorescence probe. Hoechst 33342 staining and Annexin V-FITC/PI staining were used to examine the apoptotic-inducing effect of the extract. A transwell migration assay was performed to determine the anti-metastasis effect. BWMT significantly reduced cell viability and triggered cellular apoptosis by accumulating intracellular ROS resulting in the upregulation of JNK and p38 signaling pathways. In addition, BWMT also inhibited the invasion of PC3 cells by downregulating MMP-2/-9 expression via the ERK pathway. Consequently, our study provides BWMT from H. scabra as a putative therapeutic agent that could be applicable against prostate cancer progression.

An Adaptive Flight Control Law Design for the ALFLEX Flight Control System

Kanta Imai,Yuzo Shimada,Kenji Uchiyama 제어로봇시스템학회 2001 제어로봇시스템학회 국제학술대회 논문집 Vol.2001 No.10

Simulation on the Drying Process of the Waste in Landfill under Arid Climate

( Kanta Okamoto ),( Yasumasa Tojo ),( Takayuki Matsuo ),( Toshihiko Matsuto ) 한국폐기물자원순환학회(구 한국폐기물학회) 2016 한국폐기물자원순환학회 춘계학술발표논문집 Vol.2016 No.-

In arid climate, evaporation from the ground surface is superior to precipitation. Consequently, in landfill under arid climate, the solid waste disposed of is thought to be gradually drying. The drying of waste causes an obstacle in biodegradation of organic matter and results in delay of the stabilization of the waste. Therefore, for the proper landfill management, it is important to clarify how the drying process of the waste progresses; the drying speed of the waste and the reaching depth of the drying in landfill. In this study, long-term drying process of the waste in landfill under arid climate was estimated by simulation with numerical model. The numerical model consists of the coupled equations of mass and energy balance equations for water, water vapor and heat in porous media, and was solved simultaneously using the COMSOL Multiphysics software that is based on the finite element method. Moreover, in order to validate the numerical model, the authors performed column experiments, and then compared their results with the ones in simulation of which condition coincided with experimental condition. Since both results coincided well, full scale simulation was carried out by using the numerical model created. In the simulation, a depth of landfill was set to 10 meters and the simulation was run for 20 years. The simulation results demonstrated that the waste layer in the landfill dried to the total depth of 2.7 meters in 20 years. In the first 1 year, the waste layer dried rapidly from the surface, and then the depth reached to 1.3 meters, which is about 50% of total drying depth. But, the drying speed gradually decreased. During 4 years after the first 1 year, the drying progressed only 0.7 meters, further. It can be concluded that the drying speed of the waste decreases as the drying of the waste layer progresses. Based on the results of this study, it was found that the waste layer close to the surface dries easily, and the waste layer below a certain depth keeps wet condition. This implies that biodegradation of organic matter existing below a certain depth keeps progressing even if the landfill is located in arid area.

Mathematical analysis for Brownian motion of nonlinear thermal bioconvective stagnation point flow in a nanofluid using DTM and RKF method

Surya Kanta Mondal,Dulal Pal 한국CDE학회 2020 Journal of computational design and engineering Vol.7 No.3

In the present paper, bioconvective stagnation point flow of nanofluid containing gyrotactic microorganisms over a nonlinearly stretching sheet embedded in a porous medium is considered. The scaling group transformation method is introduced to obtain the similarity transformation to convert the governing partial differential equations to a set of ordinary differential equations. The reduced governing nonlinear differential equations are then solved numerically with Runge–Kutta–Fehlberg method. Differential transform method is employed to justify the results obtained by the numerical method. It is found that both the results matched nicely. It is noticed that the density of motile microorganism distribution grows high with an increase in the values of the bioconvection Peclet number. Further, the rate of heat transfer and the rate of mass transfer increase rapidly with an increment in the thermophoresis parameter, heat source parameter, chemical reaction parameter, and Brownian motion parameter, respectively. This work is relevant to engineering and biotechnological applications, such as in the design of bioconjugates and mass transfer enhancement of microfluidics.

Himalayan rock mass and possibility of limiting concrete lined pressure tunnel length in hydropower projects in the Himalaya

Krishna Kanta Panthi 한국자원공학회 2015 Geosystem engineering Vol.18 No.1

In recent past, the development activity in hydropower sector got momentum in theHimalayan region. However, the investment cost is considered considerably higher than in other part of the world, and there is a strong need to look for alternative solutions that reduces the investment cost.Civil engineering part of the costs is one of themajor areaswhere cost reductions could bemade by involving today’s construction technology. As it is well known, the use of underground space, such as waterway tunnels, shafts, and underground caverns, are inevitable in the development of hydropower projects in the Himalaya. Finding innovative solutions in underground construction is therefore a key issue where cost reductions can be achieved to improve financial viability. It is highlighted here that the traditionally used fully concrete linedwaterway systemhas proven to be costly solutions; therefore, innovative solutions are needed to reduce the fully concrete lined length of the pressure tunnels. However, applied solutions must guarantee long-term stability and sustainability, cost-effectiveness, and construction time savings. This paper presents some design considerations that could be used to reduce fully concrete lined tunnel length for low to medium pressure waterway tunnels. Adoption of such an approach will help reduce overall construction costs and times. However, one should make sure that the prevailing rockmass conditions and applied tunnel rock support consisting of sprayed concrete and systematic bolting are enough to secure long-term stability and safety of the waterway system.

A Regression Test Selection Technique for SOA Based Applications

Rajani Kanta Mohanty,Binod Kumar Pattanayak,Durga Prasad Mohapatra 보안공학연구지원센터 2014 International Journal of Software Engineering and Vol.8 No.3

A Study of Tourism Sector on Employment Creation and Income Generation in Pokhara Valley of Nepal

( Laxmi Kanta Sharma ) 전남대학교 지역개발연구소 2018 지역개발연구 Vol.50 No.1

This paper discusses how the investment on tourism sector created direct employment opportunities in Pokhara valley. The type of business, frequency of tourist visits; time and size of employment, investmentand location information have been brought under consideration in the study. Initial survey was carried out through person to person interviews in respondent's homes and offices in all business households of Pokhara valley in the year 2009 whereas a short-term follow up survey was conducted with some key informants and major stakeholders in the year 2017. A few government officials, major stakeholders and key persons of the different business associations were also asked questions in a follow up survey about the trend of employment and income generation through tourism in July 2017. The result of initial survey reported that total annual income generation from tourism related business is Rs. 2699.75 million. In average, with every million Rupees of investment on Hotel and Lodge, the employment of 13.66 persons can be generated. Likewise, Banks and Financial institutions also create employment of 13.34 persons with the same level of investment. The total direct employment generated by the tourism industry in Pokhara is 12343. Fooding and Lodging business occupies 54.64 percentage of employment, institutional sources occupy 17.52 percent, retail trade businesses occupy 14.53 percent, tourist product businesses occupy 7.38 percent and travel related business occupies only 5.37 percent share. It was reported that there are more than 1908 households directly involved in tourism related business. The opinions of the key informants and stakeholders involved in the survey of 2017 revealed that there is an increment of number of business households by 43.8% in comparison to 2009 and Employment created by those businesses was 85.29% more than the survey of 2009. Finally, the result shows that the additional investment on retail trade business and tourist product business also has high potential to generate more employment opportunities. The study also shows that there has been a tremendous increase in number of tourists and businesses due to which very big size of investments have been made in the industry.

Lateral deformation capacity and stability of layer-bonded scrap tire rubber pad isolators under combined compressive and shear loading

Huma Kanta Mishra,Akira Igarashi 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.48 No.4

This paper presents the experimental as well as analytical study conducted on layer-bonded scrap tire rubber pad (STRP) isolators to develop low-cost seismic isolators applicable to structures in developing countries. The STRP specimen samples were produced by stacking the STRP layers one on top of another with the application of adhesive. In unbonded application, the STRP bearings were placed between the substructure and superstructure without fastening between the contact surfaces which allows roll-off of the contact supports. The vertical compression and horizontal shear tests were conducted with varying axial loads. These results were used to compute the different mechanical properties of the STRP isolators including vertical stiffness, horizontal effective stiffness, average horizontal stiffness and effective damping ratios. The load-displacement relationships of STRP isolators obtained by experimental and finite element analysis results were found to be in close agreement. The tested STRP samples show energy dissipation capacity considerably greater than the natural rubber bearings. The layer-bonded STRP isolators serve positive incremental force resisting capacity up to the shear strain level of 150%.