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Mixed H2/H∞ Control for Linear Infinite-Dimensional Systems
Kai-Ning Wu,Baozhu Guo,Weihai Zhang,Bor-Sen Chen 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.1
In this paper, we consider mixed H2=H∞ control problems for linear infinite-dimensional systems. Thefirst part considers the state feedback control for the H2=H∞ control problems of linear infinite-dimensional systems. The cost horizon can be infinite or finite time. The solutions of the H2=H∞ control problem for linear infinitedimensionalsystems are presented in terms of the solutions of the coupled operator Riccati equations and coupleddifferential operator Riccati equations. The second part addresses the observer-based H2=H∞ control of linearinfinite-dimensional systems with infinite horizon and finite horizon costs. The solutions for the observer-basedH2=H∞ control problem of linear infinite-dimensional systems are represented in terms of the solutions of coupledoperator Riccati equations. The first-order partial differential system examples are presented for illustration. Inparticular, for these examples, the Riccati equations are represented in terms of the coefficients of first-order partialdifferential systems.
Two Androstane Derivatives from the Cultures of Fungus Marasmiellus ramealis (Bull.) Singer
Ning-Ning Yang,Qing-Yun Ma,Sheng-Zhuo Huang,Hao-Fu Dai,Zhi-Kai Guo,Zhi-Fang Yu,You-Xing Zhao 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.11
A new androstane derivative, 4β-methyl-15-oxa-14β-androstane-7-ene-4α-carboxylic acid (1) and a known one 4β-methyl-15-oxa-14β-androstane-7-ene-4α-hydroxyl (2) were isolated from the EtOAc extract of the cultures of the fungus Marasmiellus ramealis (Bull.) Singer. Their structures were elucidated on the basis of 1D and 2D NMR as well as MS spectroscopic data analysis. The inhibitory activity of two isolates against acetylcholinesterase (AChE) revealed that compound 1 exhibited definitely inhibitory activity.
Two Androstane Derivatives from the Cultures of Fungus Marasmiellus ramealis (Bull.) Singer
Yang, Ning-Ning,Ma, Qing-Yun,Huang, Sheng-Zhuo,Dai, Hao-Fu,Guo, Zhi-Kai,Yu, Zhi-Fang,Zhao, You-Xing Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.11
A new androstane derivative, $4{\beta}$-methyl-15-oxa-$14{\beta}$-androstane-7-ene-$4{\alpha}$-carboxylic acid (1) and a known one $4{\beta}$-methyl-15-oxa-$14{\beta}$-androstane-7-ene-$4{\alpha}$-hydroxyl (2) were isolated from the EtOAc extract of the cultures of the fungus Marasmiellus ramealis (Bull.) Singer. Their structures were elucidated on the basis of 1D and 2D NMR as well as MS spectroscopic data analysis. The inhibitory activity of two isolates against acetylcholinesterase (AChE) revealed that compound 1 exhibited definitely inhibitory activity.
Modeling and Analysis of CM Noise Behaviors of Transformers in Power Converters
Fu Kai-Ning,Dai Lin-Shan,Lan Wei 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.1
In isolated power converters, electromagnetic feld coupling inside the transformer signifcantly afects its conducted common mode (CM) characteristics. Special concern must be focused on the sophisticated efects of electromagnetic felds on the high-frequency conducted CM noise behaviors of the transformer. The efective frequency range of the existing transformer CM characteristic modeling approaches cannot cover the frequency range from 150 kHz to 30 MHz. Accurately predicting the high frequency conducted CM behavior of transformers is necessary for electromagnetic compatibility design, which avoids the use of unnecessary time in trial and error. In this paper, the scattering parameter is introduced to investigate the high-frequency CM noise behaviors and conducted mechanism of transformers by fnite element method (FEM) simulation tool, and the sensitive factors generating CM noise and causing nonlinear behaviors in the high-frequency range are determined. Good agreement is achieved between FEM simulation results and the measurement in the range of 150 kHz–30 MHz. The proposed simulation modeling method can accurately predict the electric and magnetic feld distribution variation with frequency inside transformer winding window in the design stage, then the high frequency conducted CM noise behavior can also be efectively predicted.
Norlignan Derivatives from Curculigo crassifolia and Their DPPH Radical Scavenging Activity
Kai-Jin Wang,Ning Li 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10
A novel norlignan derivative, crassifogenin C (1), and a known compound, curcapital (2), were isolated from the ethanolic extract of the rhizomes of Curculigo crassifolia. Their structures were elucidated on the basis of spectroscopic evidence and comparisons with literature data. Curcapital (2) was isolated from this plant for the first time. The free radical scavenging activity of the isolated compounds along with crassifoside E (3) and crassifoside F (4), which were reported previously, was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. All compounds showed strong radical scavenging activity. The primary structure-activity relationship is also discussed.
Antioxidant Phenolic Compounds from Rhizomes of Curculigo crassifolia
Kai-Jin Wang,Ning Li 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1
A pair of new phenolic glycosides, crassifoside G (5) and isocrassifoside G (6), along with five known phenolic compounds (1-4 and 7), were isolated from the ethanolic extract of the rhizomes of Curculigo crassifolia. Their structures were established by spectroscopic techniques and chemical methods. Most of the isolated compounds exhibited strong antioxidant activity in the 1, 1-diphenyl-2-picryldydrazyl (DPPH) radical scavenging assay.
Molecular Characteristics and Potent Immunomodulatory Activity of Fasciola hepatica Cystatin
Kai Zhang,Yucheng Liu,Guowu Zhang,Xifeng Wang,Zhiyuan Li,Yunxia Shang,Chengcheng Ning,Chunhui Ji,Xuepeng Cai,Xianzhu Xia,Jun Qiao,Qingling Meng 대한기생충학ㆍ열대의학회 2022 The Korean Journal of Parasitology Vol.60 No.2
Cystatin, a cysteine protease inhibitor found in many parasites, plays important roles in immune evasion. This study analyzed the molecular characteristics of a cystatin from Fasciola hepatica (FhCystatin) and expressed recombinant FhCystatin (rFhcystatin) to investigate the immune modulatory effects on lipopolysaccharide-induced proliferation, migration, cytokine secretion, nitric oxide (NO) production, and apoptosis in mouse macrophages. The FhCystatin gene encoded 116 amino acids and contained a conserved cystatin-like domain. rFhCystatin significantly inhibited the activity of cathepsin B. rFhCystatin bound to the surface of mouse RAW264.7 cells, significantly inhibited cell proliferation and promoted apoptosis. Moreover, rFhCystatin inhibited the expression of cellular nitric oxide, interleukin-6, and tumor necrosis factor-α, and promoted the expression of transforming growth factor-β and interleukin-10. These results showed that FhCystatin played an important role in regulating the activity of mouse macrophages. Our findings provide new insights into mechanisms underlying the immune evasion and contribute to the exploration of potential targets for the development of new drug to control F. hepatica infection.
( Ning Yang ),( Zhenmin Ling ),( Liang Peng ),( Yanlai Liu ),( Pu Liu ),( Kai Zhang ),( Aman ),( Juanjuan Shi ),( Xiangkai Li ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.9
Fusarium oxysporum trypsin (FOT) is a fungal serine protease similar to mammal trypsin. The FOT could be successfully expressed in Pichiapastoris by engineering the natural propeptide APQEIPN. In this study, we constructed two recombinant enzymes with engineered amino acid sequences added to the N-terminus of FOT and expressed in P. pastoris. The N-terminal residues had various effects on the structural and functional properties of trypsin. The FOT, and the recombinants TE (with peptide YVEF) and TS (with peptide YV) displayed the same optimum temperature (40°C) and pH (8.0). However, the combinants TE and TS showed significantly increased thermal stability at 40°C and 50°C. Moreover, the combinants TE and TS also showed enhanced tolerance of alkaline pH conditions. Compared with those of wildtype FOT, the intramolecular hydrogen bonds and the cation π-interactions of the recombinants TE and TS were significantly increased. The recombinants TE and TS also had significantly increased catalytic efficiencies (referring to the specificity constant, k<sub>cat</sub>/K<sub>m</sub>), 1.75- fold and 1.23-fold than wild-type FOT. In silico modeling analysis uncovered that the introduction of the peptides YVEF and YV resulted in shorter distances between the substrate binding pocket (D174, G198, and G208) and catalytic triad (His42, Asp102, and Ser180), which would improve the electron transfer rate and catalytic efficiency. In addition, N-terminal residues modification described here may be a useful approach for improving the catalytic efficiencies and characteristics of other target enzymes.
Antioxidant Phenolic Compounds from Rhizomes of Curculigo crassifolia
Wang, Kai-Jin,Li, Ning 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1
A pair of new phenolic glycosides, crassifoside G (5) and isocrassifoside G (6), along with five known phenolic compounds (1-4 and 7), were isolated from the ethanolic extract of the rhizomes of Curculigo crassifolia. Their structures were established by spectroscopic techniques and chemical methods. Most of the isolated compounds exhibited strong antioxidant activity in the 1, 1-diphenyl-2-picryldydrazyl (DPPH) radical scavenging assay.
Norlignan Derivatives from Curculigo crassifolia and Their DPPH Radical Scavenging Activity
Wang, Kai-Jin,Li, Ning 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10
A novel norlignan derivative, crassifogenin C (1), and a known compound, curcapital (2), were isolated from the ethanolic extract of the rhizomes of Curculigo crassifolia. Their structures were elucidated on the basis of spectroscopic evidence and comparisons with literature data. Curcapital (2) was isolated from this plant for the first time. The free radical scavenging activity of the isolated compounds along with crassifoside E (3) and crassifoside F (4), which were reported previously, was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. All compounds showed strong radical scavenging activity. The primary structure-activity relationship is also discussed.