간흡충감염 마우스에 있어 담관상피세포의 병리조직학적 변화에 대한 Aflatoxin B_1의 영향

정경숙,민홍기,전계식 梨花女子大學校 醫科大學 醫科學硏究所 1987 EMJ (Ewha medical journal) Vol.10 No.2

The present study was carried out to examine the effect of a carcinogen, aflatoxin B_1 on the pathogenesis of the bile duct changes in mice experimentally infected with Clonorchis sinensis metacercariae. A total of 75 male albino mice of the BALB/c strain was used, and divided into 3 group; group Ⅰ, treated with 1.0ppm aflatoxin B_1 in drinking water alone for 12 weeks; group Ⅱ, given 50 Clonorchis sinensis metacercariae alone and group Ⅲ, given 50 metacercariae at the beginning of the 12 week treatment with 1.0ppm aflatoxin B_1 in drinking water. Three mice were served as untreated-uninfected normal control. All mice were fed the standard protein diet which was synthesized and supplied by the Laborarory of Sam-Lip Food Co. Since the 4th week three mice from each group were removed and sacrigiced at 4 week interval up to the 32nd week. The hepatobiliary tissues were extracted and subsequently prepared for light microscopic examination. The tissue specimens were stained with hematoxylin and eosin. Mice in group Ⅰ showed no significant changes except the lower degrees of bile ductular proliferation and inflammatory cell infiltration at the portal regions at an earlier stage. In groups Ⅱ and Ⅲ there were remarkable together with extensive acute and chronic inflammatory cell infiltrations, cellular atypia and periductal fibrosis from earlier stages. However, in group Ⅲ the histopathological changes observed were more prominent than those in group Ⅱ throughout the observation. As the time elapsed, they showed gradual regression with some fluctuations in the degrees. No any evidences of malignant changes of epithelial cells were noted in group Ⅱ, but in group Ⅲ the first tumor was found at the 28th week and the second one was at the 32nd week, respectively. Histologically the tumors observed were well differentiated adenocarcinoma of the bile duct. It was appeared that the tumors were of peripheral origin with a tendency of multifocal growth. They also showed an infiltrative growth pattern, increased mucin droplets, increased nuclear-cytoplasmic ratio and nuclear hyperchromatism. No hepatocellular carcinoma was noticed throughout the observation. In conclusion, it was suggested that Clonorchis sinensis infection promotes carcinogenic action aflatoxin B_1, a carcinogenic agent.

중공슬래브 연속교의 거동시험 및 격자구조해석

곽계환,장기웅,곽경헌 圓光大學校大學院 1995 論文集 Vol.14 No.-

본 연구의 목적은 중공슬래브 연속교의 실제거동에 근접하는 합리적인 격자해석모델(grillage analysis model)을 제시하고 이방성(orthotropic)고 등방성(isotropic)에 대한 거동 특성을 비교 분석하는데 있다. 중공슬래브 연속교의 구조거동을 잘 표현함과 동시에 해석하는데 시간과 노력이 비교적 적게 드는 격자망을 구성하기 위해 교축방향과 교축직각방향의 부재수가 각기 다른 세가지의 격자모델에 대해 해석을 실시하고, 각각의 모델에 대해 이방성과 등방성의 단면상수를 적용하여 그 결과를 비교 분석한다. 그리고 실제교량에 대해 현장에서의 정적 및 동적 재하시험을 실시한 후 그 시험결과와 해석결과를 비교함으로써 격자모델의 타당성을 입증하고 합리적인 격자망을 제시한다. The aim of this paper is to present a resonable grillage model for approxmately analyzing actual behavior of a voided slab bridge and to compare two geometrical properties of isotropic and orthotropic in the bridge deck. In this study, three models were prepared and analyzed to form the grillage mesh relevant to the voided slab continuous bridge. The grillage mesh was consisted of the longitudinal beams and the transverse beams equivalent to the prototype slab stiffness . By applying the different section properites fo isotropic and orthotropic slab to each model, the difference of the resultant force was compared and studied. The loading tests in field were carried out to evaluate the static and dynamic behavior of a existing voided slab bridge. The results from the tests have been compared with it analyzed with the grillage model. Finally, it is concluded that the total number of logitudinal members should be les B(slab width)/1.5, spacing of transverse members should be about L(span length)/2.5.

문제중심학습(Problem Based Learning; PBL) 패키지 개발 : 지각·조정장애상황을 중심으로

김애리,김영경,송영선,신경림,안혜정,이지순,조계화 성인간호학회 2001 성인간호학회지 Vol.13 No.3

The Purpose of this study is to present an actual example for procedures for developing a PBL package based on philosophical backgrounds derived from Problem-based learning. To perform a systemic study on the operations of an intergrated curricula under multi-disciplines, a research team made up of several professors with different academic backgrounds was formed. Among the four situations for the patients with perception-adjustment disorder, especially a procedure for the development of PBL package which can be used in the emergency room situation has been proposed. The little(2000)'s PBL package model has been applied for this study. Tha package includes course objectives, learning objectives, concept map, situation scenario. tutor guide, and evaluation method. It is believed that learning objectives achievement procedures designed as a part of a problem-based learning package development procedures for the nursing of patients with perception-adjustment can be achieved at the same level as the learning objectives for the science of nursing founded by the Korean Nurses Association.

Culture and Identification of Bacteria from Marine Biofilms

Lee, Yoo-Kyung,Kwon, Kae-Kyung,Cho, Kyeung-Hee,Kim, Hyo-Won,Park, Jae-Hyun,Lee, Hong-Kum The Microbiological Society of Korea 2003 The journal of microbiology Vol.41 No.3

We isolated and cultured bacteria that inhabited marine biofilms, and identified them by phylogenetic analysis using 16S rDNA sequences. In the marine environment, biofilms cover most subtidal and intertidal solid surfaces such as rocks, ships, loops, marine animals, and algae. The bacteria in most biofilms are embedded in extracellular polymeric substances that comprise mainly of exopolysaccharides. The exopolysaccharides are excreted from multiple bacterial species; therefore, biofilms are a good source for screening exopolysaccharide-producing bacteria. Thirty-one strains were cultured, and a total of 17 unique strains were identified. Phylogenetic analysis using 16S rDNA sequences indicated that the 17 strains belonged to ${\alpha}$-Proteobacteria (Ochrobactrum anthropi, Paracoccus carotinifaciens); ${\gamma}$-Proteobacteria (Pseudoalteromonas agarovorans, P. piscicida, Pseudomonas aeruginosa, Shewanella baltica, Vibrio parahaemolyticus, V. pomeroyi); CFB group bacteria (Cytophaga latercula, Tenacibaculum mesophilum); high GC, Gram-positive bacteria (Arthrobacter nicotianae, Brevibacterium casei, B. epidermidis, Tsukamurella inchonensis); and low GC, Gram-positive bacteria (Bacillus macroides, Staphylococcus haemolyticus, S. warneri).

A Case of Reactive Systemic Amyloidosis Due to Rheumatiod Arthritis

김계영,이일준,홍경표,유지소,선덕재,이계숙,강신광 大韓血液學會 1988 大韓血液學會誌 Vol.23 No.2

Stepwise Involvement of Bacterial Strains During the Biofilm Formation

Kae Kyoung Kwon,Hong Kum Lee,Kyeung Hee Cho,Yoo Kyung Lee,Jae Hyun Park,Sun Jae Lee 한국생물공학회 2007 한국생물공학회 학술대회 Vol.2007 No.10

OFDM-Based ISAC Testbed Implementation

Kyung In Lee(이경인),Kae Won Choi(최계원) 한국통신학회 2023 한국통신학회 학술대회논문집 Vol.2023 No.11

균일한 FBG(Fiber Bragg Grating) Hydrophone 의 음향 : optic converter in the Uniform FBG hydrophone sensor 광변환기 설계 및 제작

곽계달,김경복 한국센서학회 2000 센서학회지 Vol.9 No.4

For the improvement of frequency characteristics of FBG(Fiber Bragg Grating) hydrophone sensor, we can detected the frequency ranging to 1.4KHz and acoustic directivity by the development of newly designed diaohragm and united tvoe of FBG.

장애 유아, 비장애 유아 어머니의 행복감에 영향을 미치는 요인

정계숙 ( Kae Sook Chung ),박재국 ( Jae Kook Park ),최은실 ( Eun Sil Choi ),서보순 ( Bo Soon Seo ),박희경 ( Hee Kyung Park ) 한국유아교육학회 2013 유아교육연구 Vol.33 No.1

본 연구는 장애 유아와 비장애 유아를 둔 어머니의 행복감에 영향을 미치는 요인이 사회인구학적 요인에 따라, 그리고 자녀의 장애유무에 따라 차이가 있는지를 알아보고자 하였다. 연구대상은 장애 유아와 비장애 유아를 둔 어머니 총 399명이었다. 연구 결과, 월수입은 모든 유아기 자녀를 둔 어머니의 행복에 영향을 미쳤으나, 직업유무는 장애유아 어머니의 행복에, 학력은 비장애 유아 어머니의 행복에만 영향을 미쳤다. 행복의 하위영역으로 나누어 살펴보았을 때, 소득수준은 장애유아를 둔 어머니의 생존, 관계 및 성장 영역의 행복에 영향을 미친 반면 비장애 유아를 둔 어머니의 생존과 관계 영역 행복에만 영향을 미치는 것으로 나타났다. 또한, 전반적으로 장애유아를 둔 어머니의 행복감이 비장애 유아기 자녀를 둔 어머니의 행복감에 비해 더 낮았다. 본 연구는 장애유아와 비장애 유아기 자녀를 둔 어머니의 행복을 비교해봄으로써 장애아 보육 및 통합교육 장면에서의 부모교육에 관한 시사점을 제공하였다. This study examines and compares the influence of demographic variables on the maternal happiness of mothers who have young children with disabilities and mothers whose young children have no disabilities. Subjects were 339 mothers divided into two groups: one group having young children with disabilities (Group I) and the other with children without disabilities (Group 2). The results reveal that family income influence maternal happiness for both groups of mothers whereas maternal education affects maternal happiness only for Group 2 mothers. When maternal happiness is separated into sub categories, family income is found to influence all aspects of maternal happiness such as everyday existence (ease or difficulty of everyday living), relationships, and growth for mothers in Group 1, whereas family income affects only the everyday existence for mothers in Group2. In addition, Group I mothers had lower scores in general maternal happiness than did mothers in Group 2. These findings have implications for the kind of parent education needed in integrated early childhood care and education settings.

Sub-THz 대역 채널 모델링을 위한 레이트레이싱 시뮬레이터

이경인(kyung In Lee),윤채원(Chae Won Yun),최계원(Kae Won Choi) 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.2

본 논문에서는 Sub – THz 대역 채널 특성이 반영된 레이트레이싱 시뮬레이터에 대해 설명한다. 먼저 가상의 통신 환경을 구현한 후, 레이 path를 구하고 전파의 세기와 위상 변화를 구한다. 그 후, radiative near field model, 빔포밍을 반영해 채널 계수를 구한다.