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An Economic and Environmental Impact Analysis of Renewable Electricity Generation Policy
Kyungwon Park(박경원),Sung Won Kang(강성원) 한국에너지기후변화학회 2021 에너지기후변화학회지 Vol.16 No.1
We analyzed the impact of increasing renewable electricity on Korea’s electricity policy: 8th Basic Plan for Long-term Electricity Supply and Demand; Renewable Energy 3020 Action Plan; and 3<SUP>rd</SUP> Korea Energy Master Plan. We used a single-country static computable general equilibrium model with internalizing CO₂ and air pollutants emissions. We assumed a ~22% reduction compared with the base year emissions due to the Korea Emissions Trading Scheme. We applied six scenarios, where each scenario depends on the increasing rate of the renewable electricity share and total factor productivity (TFP) improvement in the renewable electricity generation industry. As the renewable electricity share increases, the GDP loss increases, but TFP improvement reduces this loss. The share of electricity from fossil fuel and nuclear power decreases due to the increasing share of renewable electricity. However, the share of electricity decreases, and that of fossil fuels increases in national energy consumption with rising electricity prices. Moreover, the co-benefit of CO₂ reduction is the reduction of air pollutants. As the total production increases after the TFP improvement of the renewable electricity industry, the effect of reducing air pollutants is partially offset.
Immunosuppressive Effect of Silibinin in Experimental Autoimmune Encephalomyelitis
Kyungwon Min,Won-Kee Yoon,김상겸,Bong-Hee Kim 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.10
Silibinin is the major pharmacologically active compound of silymarin, the Silybum marianum fruit extract. Hepatoprotective activities of silibinin/silymarin are well-known, and recent studies demonstrated their anti-inflammatory and anti-carcinogenic effects which are due to inhibition of the transcription factor NF-κB. Based on this knowledge, we hypothesized that silibinin could be effective in the treatment of multiple sclerosis (MS) and so we tested its immunosuppressive effect in experimental autoimmune encephalomyelitis (EAE), the MS animal model. The process of spinal cord demyelination and inflammation were observed and T cell migration was determined by FACS analysis. The results showed that silibinin significantly reduced the histological signs of demyelination and inflammation in EAE. Since cytokines play an important role in inflammatory disease, the proliferative response and cytokine production were examined in lymphocytes from spleens and lymph nodes. We demonstrated that silibinin Agnonspecifically down-regulated the secretion of pro-inflammatory Th1 cytokines and up-regulated the anti-inflammatory Th2 cytokines in vitro. Silibinin also dose-dependently inhibited the production of Th1 cytokines ex vivo. These results indicate that silibinin is both immunosuppressive and immunomodulatory. Key words: EAE, Multiple sclerosis, Silibinin,
A Boy With Blau Syndrome Misdiagnosed as Refractory Kawasaki Disease
( Kyungwon Cho ),( Yoonsun Yoon ),( Joon-sik Choi ),( Sang Jin Kim ),( Hirokazu Kanegane ),( Yae-jean Kim ) 대한소아감염학회 2022 Pediatric Infection and Vaccine Vol.29 No.3
블라우 증후군(Blau syndrome)은 nucleotide-binding oligomerization domain protein 2 (NOD2) 유전자의 변이에 의해 발생하는 질환으로 육아종성 피부염 및 만성 포도막염, 관절염을 특징으로 한다. 증상이 비특이적이고 동시다발적으로 발생하지 않아 진단이 어려운 경우가 많다. 반복되는 피부 발진 및 발열에 대해 두 차례 가와사키병으로 오진되어 면역글로불린과 전신 스테로이드로 치료받은 바 있는 13개월 남자 환자에서 블라우 증후군을 진단한 증례를 보고하고자 한다. Blau syndrome is a systemic autoinflammatory disease presenting with non-caseating granulomatous dermatitis, chronic uveitis, and arthritis. It is caused by a gain-of-function variant of the nucleotide-binding oligomerization domain protein 2 gene, which leads to the overactivation of inflammatory cytokines and eventually causes autoinflammation. Since the symptoms of Blau syndrome are nonspecific and usually do not appear simultaneously, it is challenging to differentiate Blau syndrome from other inflammatory disorders. This is a case report of a 13-month-old boy who had suffered from recurrent skin rash and fever. The patient was previously misdiagnosed as refractory Kawasaki disease twice and was treated with intravenous immunoglobulin and systemic glucocorticoid, which only resulted in transient improvement of the symptoms. He was eventually diagnosed with Blau syndrome.
Kyungwon Min(민경원),Liu Bing(리우 빙),Sang-Ryong Lee(이상용),Rajeev Arora(라지브 아로라) 환경독성보건학회 2021 한국독성학회 심포지움 및 학술발표회 Vol.2021 No.5
Supplemental calcium (Ca2+)fertilization has been reported to enhance plant tolerance against various abiotic stresses, however, its effect on freezing tolerance has not been well studied. We investigated the effect of Ca2+supplementation on freezing tolerance of spinach (Spinacia oleracea L.) at whole-plant as well as excised-leaf level. Seedlings supplemented with 20 and 25 mM Ca2+ through sub-irrigation efficiently assimilated Ca2+, evident by higher leaf-Ca2+ content. Supplemental Ca2+ did not impede leaf-growth(leaf-area) but slightly increased dry weight / fresh weight ratio compared to the control. Supplemental Ca2+ significantly improved freezing tolerance as evident by reducing K+/Mg2+/total ion-leakage (i.e. indicative of less membrane damage), alleviating oxidative stress (less accumulation of O2 and H2O2), and enhancing PSII potential quantum yield /energy trapping efficiency (Fv/Fm) following a relatively moderate or severe freeze-thaw stress, i.e., -5.5 and -6.5 ˚C. Improved freezing tolerance by Ca2+ supplementation was paralleled by enhanced activities of antioxidant enzymes, super oxide dismutase (SOD), catalase(CAT), and ascorbate peroxidase (APX). Our data further suggests that, besides abolstered antioxidant status, improved freezing tolerance of Ca2+-fed seedlings may also be associated with reduced loss of Ca2+ from plasma membrane (due to lower abundance of leaked K+ in extra cellular spaces) as well as due to increased mechanical strength of cell wall as evident by cell wall augmentation.