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NEUTRON THREE-AXIS SPECTROMETRY AT THE ADVENT OF 21ST CENTURY
Kulda Jiri Korean Nuclear Society 2006 Nuclear Engineering and Technology Vol.38 No.5
The implementation of multiplexing techniques combined with advances in neutron optics make the neutron three-axis spectrometers (TAS) an efficient tool to map inelastic response from single crystals over momentum transfer ranges comparable to the size of a single Brillouin zone. Thanks to recent progress in polarization techniques such experiments can be combined relatively easily with neutron polarization analysis, which does not only provide unambiguous separation of response corresponding to structural and magnetic degrees of freedom, but permits a quantitative analysis of the magnetic response anisotropy, often of crucial importance to test theoretical predictions. In the forthcoming decade we therefore expect a further development of the complementary use, rather than competition, of the reactor-based TAS's with time-of-flight (TOF) instruments for single crystal spectroscopy at the existing (ISIS) as well as at the newly built (SNS, J-PARK) pulsed sources.
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NEUTRON THREE-AXIS SPECTROMETRY AT THEADVENT OF 21ST CENTURY
JIRI KULDA 한국원자력학회 2006 Nuclear Engineering and Technology Vol.38 No.5
The implementation of multiplexing techniques combined with advances in neutron optics make the neutron three-axisspectrometers (TAS) an efficient tool to map inelastic response from single crystals over momentum transfer ranges comparableto the size of a single Brillouin zone. Thanks to recent progress in polarization techniques such experiments can be combinedrelatively easily with neutron polarization analysis, which does not only provide unambiguous separation of responsecorresponding to structural and magnetic degrees of freedom, but permits a quantitative analysis of the magnetic responseanisotropy, often of crucial importance to test theoretical predictions. In the forthcoming decade we therefore expect a furtherdevelopment of the complementary use, rather than competition, of the reactor-based TAS’s with time-of-flight (TOF)instruments for single crystal spectroscopy at the existing (ISIS) as well as at the newly built (SNS, J-PARK) pulsed sources.
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Martin Pesta,Miroslava Cedikova,Pavel Dvorak,Jana Dvorakova,Vlastimil Kulda,Kristyna Srbecka,Ludek Muller,Vendula Bouchalova,Milena Kralickova,Vaclav Babuska,Jitka Kuncova,Dana Mullerova 대한독성 유전단백체 학회 2018 Molecular & cellular toxicology Vol.14 No.4
Backgrounds: Exposure to lipophilic environmental pollutants has been explored as a risk factor of development of diabetes mellitus in obese. Adipose tissue is a reservoir of bioaccumulative lipophilic contaminants including p,pʹ-dichlorodiphenyldichloroethylene (DDE). Our aim was to analyze the effect of DDE (in concentrations 0.1 μM, 1 μM, and 10 μM) on adipocyte differentiation and insulin signalling pathway on in vitro adipogenic model of human adipose derived mesenchymal stem cells (hADMSC). Methods: The effect of DDE was monitored by analysis of expression (RT qPCR, Western blotting) of genes involved in adipocyte differentiation and insulin signalling pathway including lipid metabolism on days 0, 4, 10, 21, 28 of differentiation. Results: The main observation was significant increase of INSR, LIPE, FASN, SREBP1, OCT4 and AKT2 expression under influence of DDE. We did not record any increase of the active form of Akt. Conclusion: Our findings suggest that DDE exposure changes the differentiation of adipocytes, enhances the lipid metabolism and so may play a role in the development of obesity and metabolic diseases by affecting the insulin signalling pathway. The influence of DDE seems to be similar to the effect of insulin itself. However, further studies to elucidate the mechanism of action of DDE are necessary.
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