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Performance Evaluation of Packet Radios with Finite Population under Multipath Interference
Jyh -Horng Wen,Di-Yar Han 에스케이텔레콤 (주) 1998 Telecommunications Review Vol.8 No.5
This paper proposes a three-dimensional Markov model to study the effect of multipath interference on packet radios with a finite population. With this Markov model and minislot approximation, the system performance in terms of throughput and delay is evaluated. Computer simulations are performed to verify the correctness of the analytical method. In addition, an extended-slot method is also proposed to reduce the multipath interference triggered by line-of-sight packets in the preceding slot. Numerical results show that the proposed method remarkably enhances system performance.
Bioactive Cadinane-type Compounds from the Soft Coral Sinularia scabra
Jyh-Horng Sheu,Jui-Hsin Su,Chiung-Yao Huang,Po-Ju Li,Yi Lu,Zhi-Hong Wen,Yao-Haur Kao 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.5
Two new cadinane-type sesquiterpenoids, scabralins A (1) and B (2) were obtained from the soft coral Sinularia scabra. Metabolite 1 was shown to exhibit moderate to weak cytotoxicity against MCF-7, WiDr, Daoy, and HEp 2 cancer cell lines. Also, incubation with 10 μM compound 1 significantly inhibited the accumulation of the pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells.
Application of Multiobjective Genetic Algorithms for Optimizing Aircraft Crew Pairing Problems
Tung-Kuan Liu,Chiu-Hung Chen,Jyh-Horng Chou,Shinn-Horng Chen,Ta-Yuan Chou 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This paper develops a method of inequalities-based multiobjective genetic algorithm (MMGA) to solve the crew pairing problems which mainly assign the crew members to each flight segment of a given time period, while complying with a variety of work regulations and collective agreements.There are various objectives to be addressed here and formulated into mathematical equations including legal turn-around time, dead-head, layover, flying time and flying duty period. Through the verification of the real-world study case, the proposed method can solve the crew pairing problems, and obtain feasible solutions which are more useful for practical use.
The assessment of host and bacterial proteins in sputum from active pulmonary tuberculosis
Hsin-Chih Lai,Yu-Tze Horng,Pen-Fang Yeh,Jann-Yuan Wang,Chin-Chung Shu,Chia-Chen Lu,Jang-Jih Lu,Jen-Jyh Lee,Po-Chi Soo 한국미생물학회 2016 The journal of microbiology Vol.54 No.11
Pulmonary tuberculosis (TB) is caused by Mycobacterium tuberculosis. The protein composition of sputum may reflect the immune status of the lung. This study aimed to evaluate the protein profiles in spontaneous sputum samples from patients with active pulmonary TB. Sputum samples were collected from patients with pulmonary TB and healthy controls. Western blotting was used to analyze the amount of interleukin 10 (IL-10), interferon-gamma (IFN-γ), IL-25, IL- 17, perforin-1, urease, albumin, transferrin, lactoferrin, adenosine deaminase (also known as adenosine aminohydrolase, or ADA), ADA-2, granzyme B, granulysin, and caspase- 1 in sputum. Results of detection of IL-10, IFN-γ, perforin- 1, urease, ADA2, and caspase-1, showed relatively high specificity in distinguishing patients with TB from healthy controls, although sensitivities varied from 13.3% to 66.1%. By defining a positive result as the detection of any two proteins in sputum samples, combined use of transferrin and urease as markers increased sensitivity to 73.2% and specificity to 71.1%. Furthermore, we observed that the concentration of transferrin was proportional to the number of acidfast bacilli detected in sputum specimens. Detection of sputum transferrin and urease was highly associated with pulmonary TB infection. In addition, a high concentration of transferrin detected in sputum might correlate with active TB infection. This data on sputum proteins in patients with TB may aid in the development of biomarkers to assess the severity of pulmonary TB.
A Cryptographic Key Assignment Scheme with Adaptable Time-token Constraint in a Hierarchy
Hsing-Chung Chen,Shiuh-Jeng Wang,Jyh-Horng Wen 보안공학연구지원센터 2008 International Journal of Multimedia and Ubiquitous Vol.3 No.4
A scheme, which uses flexible cryptographic key management upon adaptable time-token constraint for a user hierarchy access control (UHAC) scheme, is proposed in this paper. For adapting the changeability in a UHAC system, we propose a technique of assigning independent time-token which is distributed by a trusted agency server to reply an authorized user for once secure access request. The key feature of the technique is to adapt some secure parameters in distributed time-token for responding to each legal access request. Further, all class keys will be updated proactively by the concept of proactive key management, which makes the advantage that is proven and free from the scenario of the collusive attack example which proposed by Yi et al. in [18]. This cryptographic key assignment scheme based on the difficulty in solving a discrete logarithm, with adaptable time-token constraint, can achieve better security and more efficient management, than the conventional UHAC scheme. Besides, our scheme provides a flexible manner and dynamic key management to increase the availability of user access in UHAC structure.
Anti-inflammatory Cembranoids from the Formosan Soft Coral Sinularia discrepans
Yi Lu,Huey-Jen Su,Yung-Husan Chen,Zhi-Hong Wen,Jyh-Horng Sheu,Jui-Hsin Su 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.8
A new cembranoid, discrepanolide A (1), along with four known cembranoids 2-5 were isolated from the Formosan soft coral Sinularia discrepans. The structures of these compounds were determined by analysis of spectroscopic data and by comparison of NMR data with those of known compounds. None of these compounds were found to be cytotoxic towards a limited panel of cancer cell lines. Compounds 3-5 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 5 also significantly inhibited the accumulation of pro-inflammatory COX-2 protein.
Kok-Tong Tan,Yu-Hung Shih,Jiny Yin Gong,Xiang Zhang,Chiung-Yao Huang,Jui-Hsin Su,Jyh-Horng Sheu,Chi-Chen Lin The Korean Society of Pharmacology 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.4
Dihydroaustrasulfone alcohol (DA), the synthetic precursor of a natural compound (austrasulfone) isolated from the coral species Cladiella australis, has shown cytotoxic effects against cancer cells. However, it is unknown whether DA has antitumor effects on nasopharyngeal carcinoma (NPC). In this study, we determined the antitumor effects of DA and investigated its mechanism of action on human NPC cells. The MTT assay was used to determine the cytotoxic effect of DA. Subsequently, apoptosis and reactive oxygen species (ROS) analyses were performed by using flow cytometry. Apoptotic and PI3K/AKT pathway-related protein expression was determined using Western blotting. We found that DA significantly reduced the viability of NPC-39 cells and determined that apoptosis was involved in DA-induced cell death. The activity of caspase-9, caspase-8, caspase-3, and PARP induced by DA suggested caspase-mediated apoptosis in DA-treated NPC-39 cells. Apoptosis-associated proteins (DR4, DR5, FAS) in extrinsic pathways were also elevated by DA. The enhanced expression of proapoptotic Bax and decreased expression of antiapoptotic BCL-2 suggested that DA mediated mitochondrial apoptosis. DA reduced the expression of pPI3K and p-AKT in NPC-39 cells. DA also reduced apoptosis after introducing an active AKT cDNA, indicating that DA could block the PI3K/AKT pathway from being activated. DA increased intracellular ROS, but N-acetylcysteine (NAC), a ROS scavenger, reduced DA-induced cytotoxicity. NAC also reversed the chances in pPI3K/AKT expression and reduced DA-induced apoptosis. These findings suggest that ROS-mediates DA-induced apoptosis and PI3K/AKT signaling inactivation in human NPC cells.
User Identification Design by Fusion of Face Recognition and Speaker Recognition
Chao-Yu Lin,Kai-Tai Song,Yi-Wen Chen,Shuo-Cheng Chien,Sin-Horng Chen,Chen-Yu Chiang,Jyh-Her Yang,Yi-Chiao Wu,Tzu-Jui Liu 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10
Intelligent human-robot interface helps a mobile robot to extract external information and interact with a user. User identification information allows a robot to generate appropriate behaviors and make personalized human-robot interaction (PHRI) more natural and safe. Most of service robots move around in various application settings, and biometric features always change during relative movements. In this work, a fusion recognition system based on face and speaker classifiers is designed to achieve the user recognition in various environments. We propose a method to fuse face and speech recognition results based on the concept of confidence indices. Through the derived confidence indices, the system combines the two classifiers and gives improved recognition results. Experiments on a laboratory home service robot show that person recognition rates in 15 environmental situations all outperform those of using single modality.
Han-Chun Hung,Chien-Wei Feng,Yen-You Lin,Chun-Hong Chen,Kuan-Hao Tsui,Wu-Fu Chen,Chieh-Yu Pa,Jyh-Horng Sheu,Chun-Sung Sung,Zhi-Hong Wen 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Atopic dermatitis (AD) is a chronic inflammatory skin disease, and its prevalence is increasing. AD usually elicits skin barrier dysfunction, dry skin and itching. As the mechanisms of AD remain unknown, there is an urgent need to find effective therapies. Because of the diversity and complexity of marine environments, the discovery of drugs from marine organisms as novel therapeutic agents for human diseases has seen renewed interest. Dihydroaustrasulfone alcohol (WA-25), the synthetic precursor of austrasulfone, which is a natural product isolated from a Formosan soft coral, has been shown to possess many therapeutic effects in our previous studies. However, the detailed mechanisms and therapeutic effects of WA-25 on AD are incompletely understood. We performed in vitro and in vivo studies to examine the effects of WA-25 on AD. We showed that WA-25 blocks inflammation and oxidative stress. Simultaneously, we also found that WA-25 reduces the AD scores and AD-induced transepidermal water loss (TEWL), scratching behavior, and alloknesis. WA-25 is more effective in cases of AD than are the drugs that are currently used clinically. Importantly, we also found that when nucleophosmin (NPM) was inhibited or when its expression was reduced, the anti-inflammatory and anti-AD effects of WA-25 were blocked. These data suggest that NPM plays dual roles in inflammation and AD. Overall, these results suggest that WA-25 is a potential anti-inflammatory and AD therapeutic agent that is modulated by NPM.