패혈증의 경과에 따른 혈중 스테로이드와 Nitric Oxide의 연관성

이규성 ( Keu Sung Lee ),김영선 ( Young Sun Kim ),이형노 ( Hyoung No Lee ),박주헌 ( Joo Hun Park ),오윤정 ( Yoon Jung Oh ),신승수 ( Seung Soo Sheen ),최영화 ( Young Hwa Choi ),박광주 ( Kwang Joo Park ),황성철 ( Sung Chul Hwang ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.4

연구배경: 패혈증에서 Nitric oxide 스테로이드 호르몬은 혈역학적 변화와 염증반응에 관여하는데 이 두 인자는 서로 상관성이 있는 것으로 알려지고 있다. 하지만 실제 환자에서 서로의 상관성이나 임상적 의의는 연구가 부족한 실정이다. 방법: 패혈증 환자 26예와 대조군 14예를 대상으로 혈중 총 NO와 혈중 코티졸 농도를 측정하였고 이어서 제 3, 5, 7병일에도 연속적으로 측정을 하였다. 결과: 패혈증 환자군에서 초기 혈중 코티졸 및 총 NO 농도는 대조군에 비하여 유의하게 증가하였고 경증 패혈증에 비하여 중증 패혈증 환자군에서 유의하게 높았다. 초기 혈중 총 NO의 농도는 APACHE II 점수, 정맥혈 lactate 농도와 상관성이 있었다. 패혈증의 시간의 경과에 따라 혈중 NO 농도는 제 1병일, 제 5병일, 제 7병일에 혈중 코티졸의 농도와 유의한 상관성이 있었다. 결론: 패혈증 환자들에서 혈중 NO와 코티졸 농도는 증가되어 있었으며, 경과에 따라 서로 유의한 상관성이 지속되었다. 상호작용기전에 대하여는 추가적인 연구가 필요할 것이다. Background: The nitric oxide (NO) released by inducible NO synthase (iNOS) plays an important role in the pathophysiology of sepsis. Corticosteroids also play a role in the hemodynamic and inflammatory reactions in sepsis. Both have been shown to have a relationship theoretically, but their correlation and clinical impacts have rarely been evaluated. Methods: 26 patients with sepsis and 14 healthy controls were enrolled in this study. The initial random plasma total NO and the serum cortisol levels were measured. The same measurements were serially carried out on the 3rd, 5th, and 7th days. Results: The initial total plasma levels of NO and cortisol were higher in the patients with sepsis than in the healthy controls. The total NO levels were higher in patients with severe sepsis than in the those with mild sepsis. There was a correlation between the total NO and cortisol level throughout the study. Conclusion: In patients with sepsis, the levels of plasma NO and cortisol were well correlated during the first week of sepsis, which suggests an interrelationship. However, the clinical and pathogenetic implications await further evaluation. (Tuberc Respir Dis 2007; 62: 308-313)

수용액상 니트로스아민의 UV 광분해에서 pH 영향

심재구 ( Jae-goo Shim ),아프잘아킬 ( Afzal Aqeel ),최보미 ( Bo-mi Choi ),이정현 ( Jung-hyun Lee ),곽노상 ( No-sang Kwak ),임호진 ( Ho-jin Lim ) 한국물환경학회(구 한국수질보전학회) 2016 한국물환경학회지 Vol.32 No.4

N-nitrosamines are a class of carcinogenic chemicals that can pose significant hazards to the human life. Ultraviolet (UV) light irradiation is considered as one of the effective methods to reduce N-nitrosamines in the aqueous phase. This study aimed to investigate the pH influence on UV photodegradation of N-nitrosamines (i.e., N-nitrosodibutylamine (NDBA) and N-nitrosopyrrolidine (NPYR)) closely related to water treatment. Photodegradation rate constants of NDBA and NPYR remained between 3.26×10-2 L/W-min to 5.08×10-3 L/W-min and 1.14×10-2 L/W-min to 2.80×10-3 L/W-min at pH2-10, respectively. This study also focused on the formation of oxidized products (i.e., primarily NO2- and NO3-). Under slightly acidic and eutral conditions, NO2- formation was more prevalent than NO3- formation, while under strong acidic conditions, NO3- was more prevalent. There was no significant change in total organic carbon (TOC) and total nitrogen (TN), suggesting negligible loss of N-nitrosamines and degradation products from the system. NDBA was easily photodegraded than NPYR. This study also demonstrated that a lower pH is a favorable condition for photolytic degradation of N-nitrosamines in water.

축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

K-IFRS 적용 확정급여형 퇴직급여 회계정보의 가치관련성

노정희(Jung Hee No),최종서(Jong Seo Choi) 한국산업경제학회 2015 산업경제연구 Vol.28 No.6

본 연구에서는 K-IFRS 제1019호의 도입 이후 확정급여형 퇴직연금제도를 채택한 기업을 대상으로 퇴직연금요소의 가치관련성에 대해 조사하였다. 이를 위하여 K-IFRS를 전면 도입한 2011년부터 2013년까지 3년간 확정급여형 퇴직연금제도를 채택한 상장기업 중 제조업을 대상으로 기업-연도 관찰치를 수집하였다. 분석 결과, 퇴직급여와 관련된 회계정보는 가치관련성을 가짐을 확인하였다. 구체적으로 살펴보면 퇴직연금의 적립수준을 나타내는 순확정급여부채는 주가와 유의한 음의 관계를 보였으며, 순확정급여부채의 구성요소인 확정급여채무와 사외적립자산은 각각 주가와 유의한 음과 양의 관계를 가짐을 확인하였다. 또한 주석에 공시되는 퇴직급여원가의 주요구성항목들도 검증한 결과, 주가와 가치관련성을 가지나 일부 항목은 일관된 결과가 보이지 않았다. 추가분석에서는 이들 퇴직급여원가의 구성 항목들이 주가와 비선형관계를 가질 가능성이 있음을 확인하였다. 본 연구는 국내 연구에서 거의 다루지 않은 퇴직급여와 관련된 회계정보의 가치관련성에 대해 체계적으로 검증하였다는 점에서 공헌점을 갖는다. 또한 퇴직급여와 관련하여 주석에 공시되는 세부정보에 대한 가치관련성을 검증함으로써 퇴직급여와 관련하여 주석에 공시되는 정보들도 정보효과를 가짐을 확인하였다. In this paper, we examine value relevance of accounting numbers pertinent to post-employment benefits under K-IFRS No.1019. K-IFRS No.1019 requires companies to use the projected unit credit method to estimate pension costs and pension liabilities, and to disclose separately several components of pension costs. In order to find out whether pension accounting numbers are valued by the stock market, we use a sample of KOSPI-listed manufacturing firms with defined benefit pension plan from 2011 to 2013. The major findings are : (1) We find, as expected, that pension liability(the present value of the defined benefit obligation) and pension assets(plan assets) are value relevant. (2) Pension expenses(defined benefit cost) are value-relevant, that is, estimation for the regression coefficient turns out to be significantly negative. Additionally we disaggregate the pension expenses into current service cost, interest expense and expected return on plan assets and so on. Contrary to expectations, the coefficients on interest expense and expected return on plan assets are significantly positive and negative respectively. This puzzling result, that has also turned up in additional analysis, could be attributable to nonlinear relationship between the pension cost components and stock price. Another possibility is that information users may discount or ignore information disclosed on the footnote. Overall, the results suggest that information on the post-retirement benefits is value relevant. This study highlights the importance of considering information on post-employment benefits in the valuation.

소아 Mycoplasma Pneumoniae에 의한 폐렴의 임상적 고찰

김상갑,노상현,정은경,윤중근,김용태,박영봉 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

The author determined mycoplasma antibody titer in 127 cases of pneumonia who were admitted to the pediatric ward of Chosun University Hospital from December, 1989, to Novemver, 1990, and clinical investigation and statistical analysis were performed between mycoplasma antibody positive group and negative group. The following results were obtained: 1) In 127 cases of children with pneumonia, incidence of mycoplasma antibody positive cases was 22.8%(29/127). 2) Comparison of mean age between mycoplasma antibody positive group and negative group revealed significantly older in positive group than negative group (5.9±2.8 years, 2.7±3.5 years respectively), 3) The sex ratio was 1:1.23 in mycoplsma antibody positvie group and 1.6:1 in negative group. 4) There was no significant difference in the clinical symptoms and the physical signs betweem both groups. 5) There was no significant difference in total leukocyte count and ESR between both groups. 6) On radiological findings, the bronchopneumonia was significantly related to mycoplasma antibody positive group.

핑크 스트라이프 호접란 ‘SM 3337’ 육성

정민정(Min-Jung Jung),박노은(No Eun Park),김홍열(Hong-Yul Kim),임기병(Ki-Byung Lim) 한국육종학회 2019 한국육종학회지 Vol.51 No.4

A new Phalaenopsis cultivar SM 3337 was bred by Sangmiwon, Korea. The new cultivar SM 3337, with a pink color and striped characteristics, was derived by artificial crossing between Phal. Minho Princess (the female parent) and Phal. Minho Stripes (the male parent). From 2006 to 2007, 300 individuals were cultivated over 2 years. Among them, an elite individual, number ‘05-33-37’, with excellent growth and flowering characteristics was finally selected through an intensive selection process. The stability and uniformity of the cultivar were confirmed through the first and second characteristics tests in 2008 and 2009, and it was named ‘SM 3337’. SM 3337 produces bright clean pink (RHS#69C) flowers with incurved shape and striped characteristics, with a flower length and width of 9.8 cm and 10.8 cm, respectively. SM 3337 is regarded as a lightly striped flower type and is suitable for the new flowerpot market. The leaves of SM 3337 are arranged horizontally and are 22.2 cm in length and 10.7 cm in width. This cultivar also possesses no genetic variation, fast in vitro propagation, and easy growing due to vigorous growth habit. SM 3337 was registered to Korea Seed & Variety Service (KSVS) in September 30, 2013 and the plant breeder’s right (PBR) is currently controlled by Sangmiwon Orchid Company, Korea (Registration No. 4640).

Concrete의 龜裂發生 要因 및 龜裂對策에 관한 硏究

鄭魯益 釜山工業大學校 1994 論文集 Vol.36 No.-

The types and factors of concrete cracks are various, such as problems of material, structural and design, production of concrete, construction of building, deterioration of concrete, external forces after construction and environmental conditions etc. In this paper, the problems of materials and the construction conditions are focussed with concrete cracks. The counter-measure plan of concrete-cracks is studied. All this study was based on the literatures.

고온 석탄 가스정제를 위한 아연계 탈황제의 첨가제 영향

정용길,이종대,박노국,이태진 한국공업화학회 2003 응용화학 Vol.7 No.1

The effect of additives on zin-base desulfurization sorbents for hot coal gas clean-up at middle temperature was studied in this work. In roder to advance a regeneration and durability of ZnO/natural zeolite sorbents, it modification by adding Fe_2O_3 or ZrO_2 was studied. It were prepared that the ZnO/natural zeolite/Fe_2O_3 or ZrO_2 by physical mixture method : the amount of ZnO, natural zeolite and additives were repectively fixed as a wight percent of 65, 25 and 10. The reactivity of sorbents was determined for 5cycles of sulfidation and regeneration in fixed-bed. Result showed that regeneration and durability were improved. Further more, the sorbent, containing ZrO_2, an excellent attrition resistance. As mentioned above, the sorbents, were highly advanced for durability, regeneration and attrition resistance by additive.

건축물 용도별 분류에 따른 철근 콘크리트공사 소요수량 개산에 관한 연구

정노익 釜山工業大學校 1995 論文集 Vol.37 No.-

The purpose of this study is to survey for the approximate quantity of concrete, form-work, and reinforcing-bar for to excute on the various buildings of classified according to its use. The data of approximate quantity is useful to us when we estimate the building cost of to excute roughly without the time enough for it detaily. The researching data are the results of 110 buildings built up during '92∼94 in Pusan & Kyung-nam, and that are to be written in several architectural estimate offices in Pusan. The quantity data of concrete, form-work, and reinforcing-bar are expressed as the ratio of the total quantity to the building floor area of each. The results are following. 1) The quantity of concrete : average 0.713(range;0.426∼1.301)㎥/㎡ 2) The quantity of form-work :average 4.33(range;1.905∼8.235)㎡/㎡ 3) The quantity of reinforcing-bar : average 0.0754(range;0.034∼0.154)ton/㎡

금속담지 촉매를 이용한 아세틸렌의 삼합체 고리화 반응

정용화,박노국,김기석,이태진 한국공업화학회 2003 응용화학 Vol.7 No.2

Cyclotrimerization of acetylene to benzene was investigated on Pd/titania as a means to utilize acetylene as the feedstock for synthesis of valuable hydrocarbons. Literature indicated Pd and titania posses the activity for the reaction with relation to the density of Pd (111) plane and reduced titanium ions. Study of catalytic activity, product selectivity, and catalyst stability under varying catalyst specification and reaction condition has to be further conducted to develop a competitive process for the reaction. Our research investigated the effect of Pd loading, additional metal oxide, and reduction treatment upon the catalytic behavior of Pd/titania for the reaction in the laboratory scale.