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Jung-Wook Yang,Ju Hwan Kim,Kang-Lok Lee,Ki Jung Nam,Yun-Hee Kim 경상대학교 농업생명과학연구원 2022 농업생명과학연구 Vol.56 No.5
Expression changes of stress-induced peroxidase (swpa2 and swpa4) and storage root-specific sporamin (spo-A and spo-B) genes were examined using qRT-PCR after treatment with wounding and bacterial pathogens on leaves of sweetpotato (Ipomoea batatas) plants. As a result of examining the expression change in the wounding treatment condition for 48 hours after treatment, which is a representative physical stress, the expression of all genes increased after 12 hours of wounding treatment, but the expression pattern of each gene group showed distinct differences thereafter. Expression levels of swpa2 and swpa4 strongly increased up to 36 or 48 hours after wounding treatment, whereas spo-A and spo-B expression levels strongly decreased after 24 or 36 hours after wounding treatment. Peroxidase and sporamin genes are involved in the early response after wounding treatment and, in particular, the peroxidase swpa2 and swpa4 genes are also involved in the late response after wounding treatment. Gene expression analysis after infection with P. chrysanthemi, which causes softness in sweetpotato, showed that the swpa2 and swpa4 genes were weakly induced after 8 hours and then strongly induced after 20 hours during pathogen infection. Expression of the spo-A gene was weakly induced in the pathogen-treated group after 20 hours, whereas spo-B showed an expression pattern similar to that of the peroxidase genes. The above results indicate that expression of the stress-induced peroxidase gene used in this study is induced not only by abiotic stress but also by biological stress caused by bacterial pathogen invasion and that peroxidase plays an important function in the initial defense response.
( Jung Lok Lee ),( Jae Myung Cha ),( Hye Min Lee ),( Jung Won Jeon ),( Min Seob Kwak ),( Jin Young Yoon ),( Hyun Phil Shin ),( Kwang Ro Joo ),( Joung Il Lee ),( Dong Il Park ) 대한장연구학회 2017 Intestinal Research Vol.15 No.1
Background/Aims: Western surveillance strategies cannot be directly adapted to the Korean population. The aim of this study was to estimate the risk of metachronous neoplasia and the optimal surveillance interval in the Korean population. Methods: Clinical and pathological data from index colonoscopy performed between June 2006 and July 2008 and who had surveillance colonoscopies up to May 2015 were compared between low- and high-risk adenoma (LRA and HRA) groups. The 3- and 5-year cumulative risk of metachronous colorectal neoplasia in both groups were compared. Results: Among 895 eligible patients, surveillance colonoscopy was performed in 399 (44.6%). Most (83.3%) patients with LRA had a surveillance colonoscopy within 5 years and 70.2% of patients with HRA had a surveillance colonoscopy within 3 years. The cumulative risk of metachronous advanced adenoma was 3.2% within 5 years in the LRA group and only 1.7% within 3 years in the HRA group. The risk of metachronous neoplasia was similar between the surveillance interval of <5 and ≥5 years in the LRA group; however, it was slightly higher at surveillance interval of ≥3 than <3 years in the HRA group (9.4% vs. 2.4%). In multivariate analysis, age and the ≥3-year surveillance interval were significant independent risk factors for metachronous advanced adenoma (P =0.024 and P =0.030, respectively). Conclusions: Patients had a surveillance colonoscopy before the recommended guidelines despite a low risk of metachronous neoplasia. However, the risk of metachronous advanced adenoma was increased in elderly patients and those with a ≥3-year surveillance interval. (Intest Res 2017;15:109-117)
IceBreaker : An Efficient Simulation Management Framework for Web-based Supercomputing Services
Jung-Lok Yu,Hee-Jung Byun,Du-Seok Jin 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.10
With the recent advent of microprocessors and networks, supercomputing system has been increasingly adopted as a general-purpose simulation environment for a broad spectrum of applications. In particular, the simulation environment has allowed theoretical and/or experimental research in various fields of computational science and to be free of time and spatial limits, and maximized the use of cyber-infrastructure for next generation problem solving. However, traditional supercomputing services have only been handled through a simple form of command-line based console, which leads to the critical decrement of accessibility and usability of heterogeneous computing assets. To address this problem, this paper describes the design and implementation of heterogeneous computing resources/jobs management framework, named IceBreaker, to enable any web-based supercomputing services. The proposed framework has essential functions including user authentication, data management, physical/virtual computing resource management, job management, etc. to provide efficient supercomputing service environments. The framework follows highly extensible modula design principle to manage different kinds of simulations efficiently and allow heterogeneous computing resources, for example, computing clusters, clouds, grids, to be easily integrated with our framework. We also present the detailed specification of standard web-based RESTful endpoints for 3rd-party developers to configure and build a variety of supercomputing service gateways. We hope the attempt presented in this paper will encourage more researchers to join us in designing highly efficient and cost-effective supercomputing service platform.
Jung-Lok Yu,Hee-Jung Byun,Du-Seok Jin 한국정보통신학회 2015 2016 INTERNATIONAL CONFERENCE Vol.7 No.1
With the advent of microprocessors and networks, recently, supercomputing system has been increasingly adopted as a general-purpose computing environment for a broad spectrum of applications. However, traditional supercomputing services have only been handled through a simple form of command-line based console, which leads to the critical limit of accessibility and usability of heterogeneous computing assets. To address this problem, this paper describes the design and implementation of heterogeneous computing resources/jobs management framework, named IceBreaker, to enable any web-based supercomputing services. The proposed framework has essential functions including user authentication, data management, physical/virtual computing resource management, job management, etc. to provide efficient supercomputing service environments. We also present the detailed specification of standard web-based RESTful endpoints for 3rd-party developers to configure and build a variety of supercomputing service gateways.
A Case of Toxic Hepatitis by Weight-Loss Herbal Supplement Containing Garcinia cambogia
Jung Lok Lee,Hyun Phil Shin,Jung Won Jeon,Jae Myung Cha,Kwang Ro Joo,Joung Il Lee 순천향대학교 순천향의학연구소 2014 Journal of Soonchunhyang Medical Science Vol.20 No.2
We report a case of patient with acute toxic hepatitis induced by weight-loss herbal supplement. A patient took natural extract supplement containing Garcinia cambogia for only two days and visited Kyung Hee University Hospital at Gangdong complaining of abdominal discomfort and jaundice. Serum ceruloplasmin level was decreased and hepatic copper levels on liver biopsy specimen were increased. Although, those were mimicking Wilson’s disease, pathological findings and clinical manifestations were consistent with drug-induced acute hepatitis. Genetic test was negative for Wilson’s disease. After one month of hospitalization, the patient improved and was discharged home in good condition. She was followed up for four months and her symptoms and signs of hepatitis continued to improve steadily with normal liver function tests. Our case emphasizes the importance of taking a caution when taking herbal supplements for the purpose of weight loss. This case also demonstrates the importance of suspicion of medication- related adverse events, even though the duration of taking the materials seems to be too short to affect the patients.
Jung-Lok Yu,Du-Seok Jin,Il-Yeon Yeo,Hee-Jun Yoon 한국콘텐츠학회 2020 International Journal of Contents Vol.16 No.4
The size of observation data in astronomy has been increasing exponentially with the advents of wide-field optical telescopes. This means the needs of changes to the way used for large-scale astronomy data analysis. The complexity of analysis tools and the lack of extensibility of computing environments, however, lead to the difficulty and inefficiency of dealing with the huge observation data. To address this problem, this paper proposes a workflow execution system for analyzing large-scale astronomy data efficiently. The proposed system is composed of two parts: 1) a workflow execution manager and its RESTful endpoints that can automate and control data analysis tasks based on workflow templates and 2) an elastic resource manager as an underlying mechanism that can dynamically add/remove virtualized computing resources (i.e., virtual machines) according to the analysis requests. To realize our workflow execution system, we implement it on a testbed using OpenStack IaaS (Infrastructure as a Service) toolkit and HTCondor workload manager. We also exhaustively perform a broad range of experiments with different resource allocation patterns, system loads, etc. to show the effectiveness of the proposed system. The results show that the resource allocation mechanism works properly according to the number of queued and running tasks, resulting in improving resource utilization, and the workflow execution manager can handle more than 1,000 concurrent requests within a second with reasonable average response times. We finally describe a case study of data reduction system as an example application of our workflow execution system.