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Jung,,Eun-Jung,Won,,Jong-Ho,Lee,,Sang-Cheol,Kim,,Hyun-Jung,Bae,,Sang-Byung,Kim,,Chan-Kyu,Lee,,Nam-Su,Lee,,Kyu-Taeg,Park,,Sung-Kyu,Hong,,Dae-Sik,Park,,Hee-Sook 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2
조혈성장인자인 과립구 집락자극인가(G-CSF, granulocyte colony-stimulating factor)는 항암제 투여 후 발생하는 호중구감소증의 정도와 기간을 단축시켜 주어 항암제의 증량을 가능하게 하고, 감염의 위험을 줄여준다. G-CSF의 주입은 대개 안전하지만, 드물게 간질성폐렴같은 급성 폐손상을 일으킨다는 보고가 있다. 저자들은 급성 골수단핵구백혈병 환자에서 G-CSF 주입 후 발생한 초급성 간질성폐렴1예를 경험하였기에 보고하는 바이다.
Telomerase Activity In Human Placenta Tissues: Comparison Between Preeclampsia With and Without Fetal Growth Restriction Young Nae Jung, M.D., Sei Kwang Kim, M.D. Hyun Cheol Chung, M.D., Kyu Hyun Park, Ph.D. Chang Han Kim, Ph.D., Hyun Jung Cho, M.D. Jae Sung Cho, M.D., Yong Won Park, M.D., In Kyu Kim, M.D. Young Ho Yang, M.D., Jae Wook Kim, M.D. Department of Obstetrics and Gynecology, Department of Internal Medicine, Cancer REsearch Institute Yonsei University, College of Medicine, Animal Resources REsearch Center, Konkuk University Seoul, Korea Objectives: To analyze telomerase activity(TA) in human placenta tissues and to compare TA in preeclampsia with or without fetal growth restriction(FGR) Methods: Fourty-six placenta specimens were obtained from pregnant women between 29 and 41 weeks' gestation. TA of each specimen was analyzed including 21 specimens without either preeclampsia or FGR(Group 1), 9 specimens with preeclampsia but without FGR(Group 2), and 16 specimens with both preeclampsia and FGR(Group 3). TA was analysed by radioisotope PCR based telomeric repeat amplification protocol(TRAP) assay. Ta was calculated and translated into arbitrary units by computer-assisted densitometry with the control of TA in 293 cell lines. Results: TA was expressed in 16 of 21(76.1%) in group 1, and in 3 of 9(33.3%) in group 2. In contrast, only 4 patients(25%) in group 3 expressed TA. Thus, TA was expressed significantly more often in group 1 than in group 2 and group 3(p=0.003). However, compared with group 2, expression of telomerase activity in group 3 was not reduced significantly(p>0.05). Conclusion: TA was minimal in placenta from preeclamptic women with and without FGR, suggesting placental senescence and apoptosis may be associated with FGR and severe preeclampsia.
Purpose: To investigate the therapeutic effects of mineral oil (MO) and hyaluronic acid (HA) mixture eye drops on the tear film and ocular surface in a mouse model of experimental dry eye (EDE). Methods: Eye drops consisting of 0.1% HA alone or mixed with 0.1%, 0.5%, or 5.0% MO were applied to desiccating stress-induced murine dry eyes. Tear volume, corneal irregularity score, tear film break-up time (TBUT), and corneal fluorescein staining scores were measured at 5 and 10 days after treatment. Ten days after treatment, goblet cells in the conjunctiva were counted after Periodic acid-Schiff staining. Results: There was no significant difference in the tear volume between desiccating stress-induced groups. The corneal irregularity score was lower in the 0.5% MO group compared with the EDE and HA groups. The 0.5% and 5.0% MO groups showed a significant improvement in TBUT compared with the EDE group. Mice treated with 0.1% and 0.5% MO mixture eye drops showed a significant improvement in fluorescein staining scores compared with the EDE group and the HA group. The conjunctival goblet cell count was higher in the 0.5% MO group compared with the EDE group and HA group. Conclusions: The MO and HA mixture eye drops had a beneficial effect on the tear films and ocular surface of murine dry eye. The application of 0.5% MO and 0.1% HA mixture eye drops could improve corneal irregularity, the corneal fluorescein staining score, and conjunctival goblet cell count compared with 0.1% HA eye drops in the treatment of EDE.
Background: Psoriasis is a multifactorial disease associated with an increased risk for metabolic syndrome and cardiovascular diseases. Elevated levels of homocysteine (Hcy) are a marker of cardiovascular risk. Several studies have evaluated the associations between psoriasis and Hcy levels; however, the results remain inconclusive. Objective: We performed a systematic review of the literature and a meta-analysis to better understand the relationship between psoriasis and Hcy. Methods: Five scientific databases (MEDLINE, Embase, Cochrane Library, Scopus, and Web of Science) were searched to identify relevant studies. A review of 307 publications identified 16 studies that directly assessed plasma levels of Hcy in psoriasis patients. Results: A total of 16 studies including 2,091 subjects were included in the meta-analysis. Hcy levels were significantly higher in psoriasis patients relative to healthy controls (weighted mean difference [WMD], 3.30; 95% confidence interval [CI], 1.58∼ 5.02; I2=82.1%). Subgroup analyses revealed that patients with higher mean psoriasis area severity index (PASI) scores (PASI>10) had significantly higher Hcy levels compared to healthy controls (WMD, 4.17; 95% CI, 1.18∼7.16; I2=88.3%), whereas patients with lower mean PASI scores (PASI ≤10) had not (WMD, 0.76; 95% CI, -1.84∼3.35; I2=72.2%). Conclusion: This meta-analysis found that psoriasis patients, in particular those with PASI >10, had significantly higher Hcy levels compared to healthy controls. Further research is needed to determine the association between Hcy levels and psoriasis severity. (Ann Dermatol 31(4) 378∼386, 2019)
For Super-Cavitating Underwater Vehicles (SCUV), the numerical analyses and experiments in a large cavitation tunnel are carried out at relatively large Reynolds numbers. The numerical results agree well with experiments and the drag coefficient of SCUV is rarely changed by the Reynolds number. As the cavitation number is decreased, the cavity occurs and grows, the cavitator drag decreases and the body drag is affected by the degree of covering the body with the cavity. The tunnel effects, i.e. the blockage and the friction pressure drop of the tunnel, on the drag and the cavitation of SCUV are examined from the numerical results in between the tunnel and unbounded flows. In the tunnel, a minimum cavitation number exists and the drag of SCUV appears larger than that in unbounded flow. When the super-cavity covers the entire body, the friction drag almost disappears and the total drag of SCUV can be regarded as the pressure drag of cavitator.