연 착화제 효능에 관한 동물실험적 연구

김정만,김병권,김성환,서병성,김인식,김용규,정갑열,김준연 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.1

地中送電관의 최적 되메움재 선정을 위한 열특성 硏究

윤성중,류권일,고영헌,김팔규 忠南大學校 産業技術硏究所 2003 산업기술연구논문집 Vol.18 No.2

The purpose of this paper is development of the most suitable backfill material which increases thermal stability and decreases thermal resistances for increasing capacity of the transmission of electricity. In order to proceed this study, the sand which recently was used as backfill material and the stone dust as single material for most suitable backfill material was chosen and experiments on thermal character and basic soil properties were proceeded for appreciating stability and economical efficiency. As a result of this study, natural moisture content of stone dust was higher than that of sand and porosity of stone dust and thermal resistance of stone dust was lower than that of sand. Then the stone dust are expected to increase capacity of the transmission of electricity. In point of stability, because total strain of pipe was within allowed strain, two materials are expected to ensure against risks. Stone dust is considered as useful backfill materials by contributing great economical efficiency, because a price of stone dust is half to the sand.

당뇨병성 신증 환자 20예에서 복합한약전탕액이 신기능에 미치는 영향

최우정,김동웅,신선호,이언정,최진영,신학수,조권일,이광석 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.2

Diabetic Nephropathy is one of the major causes of chronic renal failure. It is a common microvascular complication and clinically defined as the presence of persistent Proteinuria. We studied the effects and change of the renal function of Complex Herbal medication of the 20Diabetic Nephropathy patients. We measured the initial levels of Total Protein, Creatinine Clearance Rate(Ccr), Serum Creatinine(Serum-Cr), Urine Creatinine(Urine-Cr) and HbA1C on admission and followed up the level changes of Total Protein, Ccr, Serum-Cr and Urine-Cr on discharge. The results are following : Complex Herbal Medication does not cause the renal toxicity. The longer hypertension period is, the higher Serum-Cr level and Urine-Cr level. In an older age group, Urine-Cr is lower. 4.From the "Deficiency in Origin and Excess in Superficiality(本虛表實)“points of view, Complex Herbal Medication improves the Serum-Cr in Diabetic Nephropathy patients. According to this results, it could be suggested that Complex Herbal Medication does not cause the renal toxicity in Diabetic Nephropathy patients and intensive controls of blood sugar, blood pressure and Complex Herbal Medication prevent the renal failure in Diabetic Nephropathy patients with early stage of Microalbumiuria.

리오캐스팅한 Al-Si 및 Mg-Al-Zn합금의 특성

이정일,양권승 조선대학교 생산기술연구소 2006 生産技術硏究 Vol.28 No.2

The effect of various thermomechanical treatments on the structure and rheological behaviour of Al-Si Al alloy and Mg-Al-Zn Mg alloy in its solidification range were investigated using a Searle type high temperature viscometer. During continuous cooling, the viscosity increases gradually with increasing fraction of solidified alloy, until a chtical fraction of solidified alloy is reached above which the viscosity sharply increases. The viscosity of the slurry, at a given volume fraction solid, decreased with increasing shear rate.

호장근 추출물의 Helicobacter pylori에 대한 생육억제 및 인간 위암세포주에 대한 유전적 손상 유도

박정현,김현정,이지원,임효권,이인선 대한암예방학회 2003 Journal of cancer prevention Vol.8 No.2

대퇴동맥을 통한 경피적 관동맥 중재시술 환자의 천자부위 지혈을 위한 Angioseal^(�) 사용과 고식적 용수 압박법의 비교 : 전향적 연구

김용훈,권현철,김필호,안석진,유철웅,최진호,이상철,김준수,김덕경,전은석,이상훈,홍경표,박정의,서정돈 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 경피적 관동맥 중재술은 최근 양적 및 질적으로 급격한 발전을 보였지만 시술 시 천자부위의 혈관 합병증은 아직 해결해야 할 문제점이다. 저자들은 대퇴동맥을 통한 경피적 관동맥 중재술을 환자에게 천자부위 지혈을 위한 혈관폐쇄기구인 안지오실의 안전성과 유용성을 고식적인 용수 압박법과 비교 연구하고자 하였다. 방법 : 2002년 4월부터 2003년 5월 사이에 삼성서울병원 심장혈관센터에서 대퇴동맥을 통한 경피적 관동맥 중재술을 성공적으로 시행한 200명의 환자(안지오실 사용군: A군, 100명, 고식적 용수압박법 사용군 B군, 100명)를 대상으로 시술 후 주요 합병증 및 경한 합병증, 지혈 후 환자가 자리에 앉기까지의 시간, 보행개시 가능시간, 총 재원 기간과 시술 1주 후의 합병증을 전향적으로 조사하여 비교 연구하였다. 결론 : 두 군에서 연령, 성별, 기저질환, 심혈관 질환의 위험요소, 시술의 종류, 시술 중 사용한 헤파린의 양, clopidogrel의 양, ticlopidine의 양, 지혈 시 수축기와 확장기혈압, ACT (activated clotting time)는 차이가 없었다. A군이 B군에 비해 시술 후 자리에 앉기까지의 시간 (A군: 4.3±0.3시간, B군: 13.7±0.8시간, p=0.004) 및 보행개시까지의 시간(A군: 6.8±0.5시간, B군: 18.8±2.1시간, p=0.013)이 유의하게 짧았다. 시술 후 주요 합병증은 두군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 A군에서 유의하게 적었다(A군: 28명, B군: 19명, p=0.003). 반상출혈의 경우는 A군에서 유의하게 낮았지만(A군: 3명, B군: 12명, p=0.01), 혈종, 출혈의 발생은 두군간에 차이가 없었다. 총 재원기간에는 두 군간에 차이가 없었다(p=0.239). 시술 1주 후 경과관찰에서 주요합병증은 역시 두 군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 두 군에서 차이가 없었다(A군: 15명, B군: 13명 p=0.418), 반상출혈의 빈도는 차이가 없었지만 혈종의 발생은 A군에서 더 낮았다(A군: 2명, B군:6명, p=0.004). 두 군 모두에서 출혈은 발생하지 않았다. 결론 : 대퇴동맥을 통한 경피적 관동맥 중재술을 시행한 환자에서 안지오실의 사용은 고식적 용수 압박법에 비해 환자의 침상 안정시간을 줄여 조기 활동개시가 가능하게 하였으며 국소합병증의 위험도를 일부 낮추어, 시술에 따른 환자의 불편을 현저하게 감소시킬 수 있다고 할 수 있을 것으로 기대된다. Background : Although the number and the quality of percutaneous coronary intervention have been recently increased dramatically, the vascular complication at puncture site is still the major cause of patients' morbidity. We evaluated the safety and efficacy of newly of newly-developed collagen-based arterial closure device, Angioseal after transfemoral percuatenous coronary intervention. Methods : This study was designed as a prospective single center non-randomized comparative study. A total 200 patients undergoing transfemoral percutaneous coronary intervention were enrolled between April 2002 and May 2003. They were divided into two groups; Angioseal group (group A, n=100) and manual compression group (group B, n=100). The baseline clinical and angiographic characteristics were reviewed. The time to sit up, the time to ambulation, the duration of hospital stay, major and minor vascular puncture site complications were monitored. The patients were followed-up for 1 week after procedure by telephone. Results : The baseline clinical characteriwtics, clinical diagnosis, cardiocascular risk factors, typesof procedure, doses and numbers of anticoagulants were similar between two groups. The blood pressure and activated clotting time were also similar. The time to sit up (group A: 4.3±0.3 hours, group B: 13.7±0.8 hours, p=0.004) and the time to ambulation (group A: 6.8±0.5 hours, group B: 18.8±2.1 hours, p=0.013) were shorter in group A. No major vascular complications were noted. The incidence of hematoma and bleeding were not significantly different between two groups. The incidence of ecchymosis, however, was significantly lower in group A (group A:12%, group B: 3%, p=0.001) The duration of gospital stay was similar between groups. During 7 days of follow-up period incidence of hematoma was significantly lower in group A (p=0.004). Although the incidence of ecchymosis was not significantly different between two groups. Conclusion : The angioseal may be associated with earlier ambulation and less patients' morbidity with low incidence of local complication rate compared to manual compression after transfemoral percutaneous coronary intervention.

벤처기업 해외진출시기의 결정요인

지용희,최순권,김정포 서강대학교 경영학연구원 2002 서강경영논총 Vol.13 No.2

근로자 건강증진 실천에 영향을 미치는 요인

김은경,김병권,박종태,김형렬,구정완 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1

목적: 본 연구에서는 사업장 근로자들의 건강증진 실천 현황을 알아보고, 실천에 있어서 장애요인이 되는 것이 무엇인지 파악하여 효율성과 실효성이 있는 사업장 건강 증진 사업의 발전방향을 모색하는데 그 목적을 두었다. 방법: 경기도 K대학병원, 서울시의 C대학병원에서 보건관리대행사업 또는 국고지원사업을 받고 있는 사업장 중 서울경기지역의 사업장 규모별 비율을 고려하여 사업장 규모별로 사업장 근로자수의 20%를 대상으로 사업장 건강증진사업 현황에 대한 설문조사를 시행하였다. 결과: 대상자 중 건강증진 활동을 하고 있는 비율은 51.3%로 나타났으며 건강증진을 실천하고 있는 경우, 금연을 하고 있다는 응답이 가장 많았고 실천의 계기로는 TV 또는 언론매체의 자극에 의한 경우가 33.4%, 건강진단에서 이상 소견 및 건강이상을 느껴서 시작한 경우가 22.1%였다. 근로자들이 가장 필요로 하는 사업장내 건강증진프로그램은 운동이 41.9%로 가장 높았고, 스트레스 관리가 그 뒤를 이었다. 건강증진사업에 대한 기대 정도는 상당히 효과가 있다고 응답하거나 어느 정도 효과가 있을 것이라고 응답한 경우가 84.8%로 건강증진사업에 대하여 근로자들이 긍정적으로 평가하고 있으며 기대도가 높은 것을 확인할 수 있었다. 건강증진 실천 여부에 영향을 주는 요인은 근로자의 건강상태, 직무자율성 등으로 나타났다. 결과: 개인의 의지 부족이나 시간, 비용 등이 건강증진 활동의 장애요인으로 작용하고, 근로자의 건강상태나 직무자율성 등이 건강증진 실천에 영향을 주고 있는 것으로 나타났다. 장애요인은 개인의 건강증진 실천 의지를 북돋아 주기 위한 사업장 단위의 근로자의 건강증진 활동의 유지 및 지지를 위한 프로그램 강화를 통해 극복할 수 있다. 또한 사업주의 시간적 배려, 사업주와 국가의 경제적 지원책, 지역사회 공공 체육시설 이용 개방 등을 고려할 필요가 있다. 건강증진 활동 실천집단과 비실천집단에 연령, 학력, 결혼여부, 연봉, 근무 일정 등의 차이가 있었는데 이를 통해 건강관리에 있어 시간, 경제, 개인의 생활환경이나 지식수준이 관여한다고 볼 수 있다. 결론: 이상의 결과를 통해 볼 때 건강증진 활동의 효과에 대해서 84.8%가 긍정적으로 평가하고 있다는 것을 알 수 있다. 현재 사업장 건강증진 활동은 금연이나 운동을 중심으로 이루어지고 있으나 본 연구 결과 운동이나 스트레스 관리에 대한 요구도가 높은 것을 확인할 수 있었다. 이에 따라 근로자들의 운동을 위해 사용이 용이한 운동 시설을 마련해야 하며 본 연구에서 긍정적으로 평가 되었던 바와 같이 사업장 밖에 공공 건강증진시설의 확대 방안을 강구하고, 스트레스 관리를 위한 구체적인 방안을 마련해야 할 것이다. Objective: The aim of this paper was to develop efficient and practical health promotion strategies in the workplace by investigating both the present status of health promotion and the barriers to its practice. Methods: A questionnaire was administered to 20% of industrial workers in the workplaces which receives the health care agency enterprise or are supported by a grant from the national treasury, K University Hospital in Gyeong-Gi province, and C University Hospital in Seoul. Results: According to the questionnaire survey, 51.3% workers were practicing health promotion activities and smoking cessation was the most common method among them. Regarding the factors that prompt workers to commence health promotion activities, TV or the mass media had a 33.4% effect, followed by a 22.1% effect for an abnormal finding at regular health screening. The most necessary health promotion activity in the workplace was exercise (41.9%), followed by stress management. When asked about their expectations of the health promotion program, 84.8% of the respondents answered that they expected it to be significantly or somewhat effective. Factors affecting the health promotion activities of workers were worker' s health status and job control. Conclusions: This study demonstrated that workers evaluate health promotion activities positively and that some workers are unable to participate in these activities despite their willingness to do so due to the barrier of circumstances. To encourage worker' s participation, the government and employers should remove barriers.

연 착화제 효능에 관한 동물실험적 연구

서병성,김준연,김정만,김용규,정갑열,김성환,김인식,김병권 동아대학교 부설 산업의학연구소 1997 산업의학연구소 논총 Vol.- No.3

This experiment was carried out to compare the efficacy of 2,3-dimercaptosuccinic acid(DMSA) and calcium ethylenediamine tetraacetate(CaEDTA) as chelating agents for lead poisoning. The rats had been fed water containing 0.5% lead acetate for 3 months and randomly divided into three groups. We administered DMSA only for group I(n=5), CaEDTA only for group II(n=5), and both DMSA and CaEDTA for group III(n=10), for 4 days. We evaluated urinary lead(PbU) level, blood lead(PbB) level and blood zinc protoporphyrin(ZPP) level before and after administration of the chelating agents. The results obtained were as follows; 1. After administration of chelating agents, the mean PbU levels, which were 248.2㎍/dl, 252.6㎍/dl and 270.0㎍/dl in group I, II and III before administration, were increased to 484.6㎍/dl, 479.9㎍/dl and 1,792.1㎍/dl in group I, II and III, respectively(p<0.05). 2. After administration of chelating agents, the mean PbB levels, which were 67.4㎍/dl, 59.9㎍/dl and 62.5㎍/dl in group I, II and III before administration, were decreased to 38.1㎍/dl, 36.3㎍/dl and 31.3㎍/dl in group I, II and III, respectively(p<0.05), but there were no different changes of ZPP level among groups. 3. The blood lead clearances, which were calculated by PbB level before and after administration of chelating agents, were 49.8%, 43.5% and 39.5% in group III, I and II, respectively.

한국형 출혈열 환자에서 분리한 한타 바이러스의 핵산 분석

조종태,윤성철,안규리,한진석,김성권,이정상 단국대학교 1998 論文集 Vol.33 No.-

Hemorrhagic fever with renal syndrome(HFRS)is an infectious disease showing diverse clinical manifestations according to different serotypes of hantavirus. On the assumption that the antigenicity, nucleotide and amino acid sequence diversity of hantaviruses, as well as immune response diversity of individual KHF patients may be present, this study was performed to analyse the genetic diversity of hantaviruses isolated from patients with KHF. In the 13 samples hantaviral RNAs were extracted, cDNAs of partial M segment were amplified by RT-PCR using genus-reactive primer, amplified cNNAs were analyzed by direct sequencing method, and then the nucleotide and deduced amino acid sequences were compared with previously known sequences of four serotypes of hantavirus isolated from rodent hosts and each other by the computer assistance. The results were as follows. The nucleotide and amino acid sequences of 11 samples among the 13 human isolates showed 90.3∼95.5%, 86.7∼97.9% the other 1 samples 82.7%, 71.9% homology respectively to those of Hantaan virus 76-118 strain, and another 1 sample showed 83.7%, 75.3% homology respectively to those of Seoul virus B1 strain isolated from rodent host. The nucleotide and amino acid sequences of 7 among 12 Hantaan samples showed differences within 5%, 10% respectively each other and high genetic similarities, but those of the oehr 5 among 12 Hantaan samples showed low genetic similarities each other. In conclusion, hantaviruese isolated from KHF patients showed genetic diversity compared with previously known hantaviruses isolated from rodent hosts.