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Flrt2 is involved in fine-tuning of osteoclast multinucleation
( Jumpei Shirakawa ),( Noriko Takegahara ),( Hyunsoo Kim ),( Seoung Hoon Lee ),( Kohji Sato ),( Satoru Yamagishi ),( Yongwon Choi ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.8
Osteoclasts are multinucleated giant cells derived from myeloid progenitors. Excessive bone resorption by osteoclasts can result in serious clinical outcomes for which better treatment options are needed. Here, we identified fibronectin leucine-rich transmembrane protein 2 (Flrt2), a ligand of the Unc5 receptor family for neurons, as a novel target associated with the late/maturation stage of osteoclast differentiation. Flrt2 expression is induced by stimulation with receptor activator of nuclear factor-kB ligand (RANKL). Flrt2 deficiency in osteoclasts results in reduced hyper-multinucleation, which could be restored by RNAi-mediated knockdown of Unc5b. Treatment with Netrin1, another ligand of Unc5b which negatively controls osteoclast multinucleation through down regulation of RANKL-induced Rac1 activation, showed no inhibitory effects on Flrt2-deficient cells. In addition, RANKLinduced Rac1 activation was attenuated in Flrt2-deficient cells. Taken together, these results suggest that Flrt2 regulates osteoclast multinucleation by interfering with Netrin 1-Unc5b interaction and may be a suitable therapeutic target for diseases associated with bone remodeling. [BMB Reports 2019; 52(8): 514-519]
社会とつながり、社会をつくる日本語教育実践 - 産学連携「にっぽん多文化共生発信プロジェクト」 -
三代純平 ( Miyo Jumpei ) 한국일어교육학회 2021 일본어교육연구 Vol.- No.54
本研究は、社会とつながる日本語教育実践として産学連携による日本語教育実践の意義と方法について論じた実践研究である。社会とつながる日本語教育実践とは、社会文化的アプローチに立脚し、学習を社会に埋め込まれたものとして捉え、社会参加を通じた日本語学習をデザインするプロジェクト型の日本語教育である。また、将来の社会とのつながり、つまりキャリア教育的側面も同時に含意される。そのような社会とつながる日本語教育実践に、産学が連携して取り組むことには、大きな可能性が開かれている。そこで、本稿では、産学連携による日本語教育の事例として武蔵野美術大学とカシオ計算機株式会社が取り組む「にっぽん多文化共生発信プロジェクト」を紹介し、その実践で得られた学びについて論じる。そして、最後に、社会とつながる日本語教育を実践する上で関係性レジリエンスと実践研究が重要であることを主張する。 The research is an action research that discusses the significance of and method for Japanese language education practice that connects with society through industry-academia collaboration. Japanese language education practice that connects with society is a project-based learning for Japanese language education that is based on a sociocultural approach, regards learning as embedded in society, and designs Japanese language learning through social participation. Moreover, it implies a connection with future society. In other words, it considers the aspect of career education. A great potential lies in industry-academia collaboration on such a project. Thus, the study introduces “Multicultural co-existence propmotion project” as a collaboration between Musashino Art University and Casio Computer Co., Ltd. and discusses the outcome of the project. And finally, I argues that relational resilience and action research are essential in practicing Japanese language education that connects with society.
New next-generation microwave thermosphere ablation for small hepatocellular carcinoma
( Hideyuki Tamai ),( Jumpei Okamura ) 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.4
Background/Aims: In July 2017, the Emprint™ next-generation microwave ablation system using thermosphere technology (Covidien, Boulder, CO, USA) was approved for use in Japan. This system can produce a predictable spherical ablation zone at higher temperatures than radiofrequency ablation (RFA). The aim of the present study was to elucidate whether this new microwave thermosphere ablation (MTA) could safely improve outcome compared to RFA, which is the standard of care for small hepatocellular carcinoma (HCC). Methods: This retrospective study analyzed 513 patients with 630 HCCs (≤3 cm) who were performed by percutaneous RFA (174 patients, 214 HCCs) or MTA (339 patients, 416 HCCs) between January 2016 and March 2020. Results: Median ablation time was significantly shorter for MTA (240 seconds) than for RFA (721 seconds; P<0.001). A significant difference in 3-year local tumor progression rate was evident between the RFA group (22%) and MTA group (8%; P<0.001). Multivariable analysis revealed ablation procedure and tumor diameter as independent factors contributing to local tumor progression (MTA; P<0.001; hazard ratio, 0.565; 95% confidence interval, 0.437-0.731). In patients with primary HCC, a significant difference in overall survival was evident (RFA vs. MTA, 3-year, 77% vs. 95%, P=0.029). Ablation procedure and Child-Pugh score were independent factors contributing to survival. The total complication rate was significantly lower for MTA (8%) than for RFA (14%, P<0.05), particularly for bile duct injury (3% vs. 9%, respectively; P<0.05). Conclusions: Next-generation MTA for small HCC could provide safer, more curative treatment in a shorter ablation time than RFA. (Clin Mol Hepatol 2021;27:564-574)
Katsumi Sakakibara,Jumpei Taketsugu 한국통신학회 2010 Journal of communications and networks Vol.12 No.1
IEEE 802.11 defines distributed coordination function (DCF), which is characterized by CSMA/CA and binary exponential backoff (BEB) algorithm. Most modifications on DCF so far have focused on updating of the contention window (CW) size depending on the outcome of own frame transmission without considering freezing periods experienced in the backoff interval. We propose two simple but novel schemes which effectively utilize the number of freezing periods sensed during the current backoff interval. The proposed schemes can be applied to DCF and its family,such as double increment double decrement (DIDD). Saturation throughput of the proposed schemes is analyzed by means of Bianchi’s Markovianmodel. Computer simulation validates the accuracy of the analysis. Numerical results based on IEEE 802.11b show that up to about 20% improvement of saturation throughput can be achieved by combining the proposed scheme with conventional schemes when applied to the basic access procedure.
Yu Wang,Jumpei Takata,Kwong Sang Cheng 한국우주과학회 2013 Journal of Astronomy and Space Sciences Vol.30 No.2
We use the outer gap model to explain the spectrum and the energy dependent light curves of the X-ray and soft γ-ray radiations of the spin-down powered pulsar PSR B1509-58. In the outer gap model, most pairs inside the gap are created around the null charge surface and the gap’s electric field separates the opposite charges to move in opposite directions. Consequently, the region from the null charge surface to the light cylinder is dominated by the outflow current and that from the null charge surface to the star is dominated by the inflow current. We suggest that the viewing angle of PSR B1509-58 only receives the inflow radiation. The incoming curvature photons are converted to pairs by the strong magnetic field of the star. The X-rays and soft γ-rays of PSR B1509-58 result from the synchrotron radiation of these pairs. The magnetic pair creation requires a large pitch angle, which makes the pulse profile of the synchrotron radiation distinct from that of the curvature radiation. We carefully trace the pulse profiles of the synchrotron radiation with different pitch angles. We find that the differences between the light curves of different energy bands are due to the different pitch angles of the secondary pairs, and the second peak appearing at E > 10 MeV comes from the region near the star, where the stronger magnetic field allows the pair creation to happen with a smaller pitch angle.
Kawachi, Shunsuke,Baba, Jumpei,Furukawa, Kei,Shimoda, Eisuke The Korean Institute of Electrical Engineers 2013 The Journal of International Council on Electrical Vol.3 No.1
In order to compensate power fluctuations caused by loads and renewable energy sources, the concept of controllable load has been proposed. In this paper, the use of heat pump air conditioning system (HPAC) as a controllable load is focused. To verify the advantage produced by control of HPAC's power consumption as a controllable load, experiments are conducted using model microgrid system with real machines. The results of the experiments showed that the control of HPAC's power consumption can contribute to power fluctuation compensation control in the microgrid. The energy capacity of energy storage system that is necessary to suppress the power fluctuation was analyzed and it has been clarified that the necessary energy capacity can be reduced by control of HPAC.