Different mr-proANP-release in High Volume High Intensity Interval Exercise and Continuous Exercise Regimens with Matched Mean Intensity: A Cross-over Design Study

Julian Eigendorf(Julian Eigendorf ) 사피엔시아 2020 Exercise Medicine Vol.4 No.-

Objectives: Prevalence and risk factors of arterial stiffness and diabetes can be improved through physical activity and exercise. Atrial natriuretic peptid (ANP) does impact vasodilation and lipid metabolism and thus is connected to both pathologies. To extend insights in ANP-release we measured mid regional-proANP (mr-proANP) in different exercise training protocols in rest and at cessation of exercise. We evaluated a high volume high intensity interval (HVHIT), high volume sprint interval training (HVSIT) and a continuous exercise (CE) regimen with matched mean intensity. Methods: Subjects completed HVHIT (30s interval/30s pause), HVSIT (6s interval /24s pause) and continuous exercise (CE) over 45 min, as well as an initial graded exercise test (GXT) to asses maximum power output (PmaxGXT). Intervals during HVHIT were set to 100% PmaxGXT, intervals during SIT were set to 250% PmaxGXT and load during CE was set to 50% PmaxGXT. HVHIT, HVSIT and CE sessions were initiated with a 10 min warm-up and concluded with a 10 min cool-down. Venous blood samples were drawn at rest and after cessation of exercise. Results: Δmr-proANP was significantly different (p=0.048; RM ANOVA) between the three different exercise regimens. Δmr-proANP during CE was 17.8 (±2.0) pmol*l-1, during HVHIT 22.5 (±4.5) pmol*l-1 and during SIT 24.5 (±7.8) pmol*l-1. [Δmr-proANP] was not correlated to absolute power during intervals, peak oxygen uptake or heartrate, but was significantly correlated to Δlactate. Conclusions: We conclude that high intensity exercise causes a higher ANP-release than CE. This can be caused by the recurrent shift from relaxing and stressing of the heart muscle, which is known to trigger ANP-release. Other factors are likely to contribute to ANP-release.

Protein Structure Prediction Based on Fragment Assembly and $\beta$-Strand Pairing Energy Function

Julian Lee,Jooyoung Lee,Seung-Yeon Kim 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.3

We develop an improved version of PROFESY, a novel method for ab-initio prediction of protein tertiary structures based on fragment assembly and global optimization. In contrast to the primitive version presented earlier, where the hydrogen bond was dened only in terms of inter-atom distance, the angle dependence is now correctly incorporated. This new feature allows us to obtain low-energy conformations with a reasonable number of beta strands, in contrast to the earlier version in which the fraction of alpha helices was excessively large on average. In order to enhance the performance of the prediction method, we optimize the linear parameters of the energy function so that nativelike conformations become energetically more favorable than non-native ones for proteins with known structures. We test the feasibility of the parameter optimization procedure by applying it to a training set consisting of two proteins of structural class + : 1FSD and 1PQS. We use the resulting parameter set for the jackknife test on several proteins from various structural classes. The results are quite promising. In particular, for protein 2GB1, the predictions improve dramatically with the optimized parameter set compared to the original parameters, despite the fact that 2GB1 was not included in the training set. This result suggests that parameters trained for a relatively small number of proteins are transferrable to other proteins to some extent.

Sustainable Industrial Value Creation in SMEs: A Comparison between Industry 4.0 and Made in China 2025

Julian M. Müller,Kai-Ingo Voigt 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.5 No.5

The Industrial Internet of Things (IIoT) confronts industrial manufactures with economic, ecological, as well as social benefits and challenges, referring to the Triple Bottom Line of sustainability. So far, research has mainly investigated its dimensions in isolation or economic aspects have not been compared with ecological and social perspectives. Further, research misses studies that are devoted to the special characteristics and requirements of Small and Medium-sized Enterprises (SMEs). This study aims to contribute to close this research gap, providing a research context that encompasses all three dimensions of sustainability. The results are based on data obtained from 329 SMEs, 222 in Germany and 107 in China, therefore allowing for a comparison of the concepts “Industrie 4.0” and “Made in China 2025” in the context of SMEs. In general, German SMEs expect a lower impact through “Industrie 4.0”, perceiving the concept as more beneficial for larger enterprises. We further find that Chinese SMEs foremost see social benefits. Challenges whilst introducing “Industrie 4.0”by German SMEs as well as several frame conditions are perceived more relevant than for “Made in China 2025”, as seen by Chinese SMEs. The paper closes with implications for research and practice based on these findings.

Musical Responses to Joyce: A Selection of Poetry and Prose Settings

( Julian Hall ) 한국제임스조이스학회 2010 제임스조이스저널 Vol.16 No.1

Setting Joyce`s poetry and prose to music is an activity which has occupied composers not only since his death, but also during Joyce`s lifetime. By selecting a representative sample of settings of Joyce`s poetry and prose for discussion, this paper attempts to show how a setting of a text addresses some of the difficulties a reader encounters concerning its composition and interpretation, as well as how a musical setting might enrich literary understanding. Chamber Music has been chosen as the most generally representative poetry text, and settings in which Joyce had an active role in assessing (mainly those by Palmer) have been considered, as well as later ones unknown to him. Settings from A Portrait of the Artist as a Young Man and Ulysses (those of Finnegans Wake are beyond the scope of this paper) provide an opportunity for showing how Joyce`s experiments in prose parallel, or even anticipate, some of the procedures used in a musical language, and begin to question the identity of the text itself as literature. Besides addressing these more abstract issues, the paper is also intended as a chance to expose musical settings which are worthwhile in themselves, and which the author feels both reflect Joyce`s achievements in each literary genre and demonstrate his wide-ranging musical knowledge and interests.

Conjugate Eye Deviation in Unilateral Lateral Medullary Infarction

Julian Teufel,Michael Strupp,Jennifer Linn,Roger Kalla,Katharina Feil 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.2

Background and Purpose The initial diagnosis of medullary infarction can be challenging since CT and even MRI results in the very acute phase are often negative. Methods A retrospective, observer-blinded study of horizontal conjugate eye deviation was performed in 1) 50 consecutive patients [age 58±15 years (mean±SD), 74% male, National Institutes of Health Stroke Scale 2±1] with acute unilateral lateral medullary infarction as seen in MRI (infarction group), 2) 54 patients with transient brainstem symptoms [transient ischemic attack of brainstem (TIA) group; age 69±16 years, 59% male], and 3) 53 patients (age 59±20 years, 49% male) with diagnoses other than stroke (control group). Results Conjugate eye deviation was found in all patients in the infarction group [n=47 (94%) with ipsilesional deviation and n=3 (6%) with contralesional deviation] compared to 41% (n=22) in the brainstem TIA group and 15% (n=8) in the control group (p<0.0001). Within all groups mean deviation and range were similar for both sides (to the right vs. to the left side 26.6°±12.3 vs. 26.1°±12.3 in the infarction group, 10.5°±5.8 vs. 8.4°±6.3 in the brainstem TIA group and 4.5°±3.2 vs. 7.5°±3.2 in the control group). The extent of eye deviation was significantly greater in the infarction group (p<0.05). Conclusions All patients with MRI-demonstrated unilateral medullary infarction showed conjugate eye deviation. Therefore, conjugate eye deviation in patients with suspected acute lateral medullary infarction is a helpful sensitive sign for supporting the diagnosis, particularly if the deviation is >20°.

Exact partition function zeros of two-dimensional lattice polymers

Julian Lee 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.44 No.32

We study the zeros of the exact partition function of lattice polymers on two-dimensional square lattices up to the chain length 28. We observe that the leading zeros tend to approach the real axis as the chain length increases. The results suggest that the locus of zeros may intersect the real axis in the limit of innite chain length, which is the necessary condition for the existence of the collapse transition.

Transfer Matrix Algorithm for Computing the Geometric Quantities of a Square Lattice Polymer

Julian Lee 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.12

I develop a transfer matrix algorithm for computing the geometric quantities of a square lattice polymer with nearest-neighbor interactions. The radius of gyration, the end-to-end distance, and the monomer-to-end distance were computed as functions of the temperature. The computation time scales as . 1:8N with a chain length N, in contrast to the explicit enumeration where the scaling is 2:7N. Various techniques for reducing memory requirements are implemented.

Adaptive bounding design for output feedback control using neural networks

Julian Stoev,Jin Young Choi 제어로봇시스템학회 2000 제어로봇시스템학회 국내학술대회 논문집 Vol.2 No.10

Engaging the Audience : Use of Classicization in Middle Byzantine Hagiography

Julian Hee Min YANG 한국서양중세사학회 2021 西洋中世史硏究 Vol.- No.48

이 논문은 성인전기의 문체를 고전화하는 작가적 기술에 대하여 연구하였다. 이것은 당시 성인전기 작가들이 독자들을 성공적으로 작품에 몰입 시키기 위해 사용한 기술들 중 하나였다. 이 역사적 현상은 비잔티움이 그리스-로마 세계의 후계자라는 문화적 정체성을 보여줌과 동시에 특히 중기 비잔티움 시기의 (9세 기-11세기 사이) 높은 교육수준을 가진 독자층이 유려하게 저술된 성인전기를 읽고 싶어했다는 사실을 우리로 하여금 깨닫게 한다. 이 논문은 비잔티움이 문 화적 절정기에 도달한 시기에 저술된 많은 작품들 중에 니케타스 마기스트로스 의 『레스보스의 테옥티스테』, 시메온 메타프라스테스의 『메놀로기온』, 저자미상 의 『카타니아의 레오』, 그리고 스스로가 주인공의 제자이자 그레고리라는 이름 을 가졌다고 주장한 작가의 작품 『소(小) 바실레이오스』 등을 중심으로 연구하 였다. 이러한 결정을 내리는데 두 가지 역사적 사유가 있었다. 첫 번째로는 이 성인전기들의 작가들이 작품을 통하여 주인공들이 성공적으로 개인적인 컬트를 만들 수 있도록 이바지하였고, 두 번째로는 유려하고 고전적인 문체로 저술된 이 작품들이 중기 비잔티움 독자층 사이에서 큰 성공을 거두었다는 점이다. 이 러한 점으로 볼 때 작가들은 자신의 뛰어난 교육수준을 작품을 통하여 드러내 는데 그치지 않고, 독자층에게 깊은 인상을 주고 싶어 했다는 것을 알 수 있다. 특히나 이점은 작품의 문체를 높은 수준의 그리스어와 상호텍스트성을 사용해 고전 그리스어 작품처럼 저술한 점에서 두드러진다. 따라서 독자들, 특히나 높 은 교육수준을 가진 이들은, 저자의 글을 읽어가면서 과거에 읽은 고전 작품과 기독교 작품을 떠올리며 더욱 몰입할 수 있었을 것이다. This study investigates the range of authorial techniques used to classicize the hagiographical narrative. This is directly related to Byzantium’s cultural identity as the heir to the classical Greco-Roman world and, especially during the middle Byzantine period (ninth to eleventh century), and the thirst by a highly educated audience to read an eloquently written story. Amongst numerous examples produced during this period, which was arguably the cultural Zenith of this medieval Empire, I have chosen to examine the Life of Theoktiste of Lesbos by Niketas Magistros, some selected stories from the redacted Menologion of Symeon Metaphrastes, the anonymously written Life of Leo of Catania , and the Life of Basil the Younger by his hypothetical disciple pseudo-Gregory. My decision is inclined by the following two historical issues: their protagonists successfully established the individual cult through their help and they were written specifically to appeal to the educated audience of Byzantium. These texts, which were very successful in the middle Byzantine society, are written in eloquent language. This reflects not only the author’s wish to establish his own educational background but also his desire to impress his intended audience. In particular this is demonstrated through embellishing the writing with a high register of Greek and intertextuality. The audience, especially an educated one, would become more engaged with the author’s narration as they found the clues that would lead them back to classical and Christian literature they have read in the past.

Japan's Mongolian Connection in North Korea

Julian Dierkes,Otgonbaatar Byambaa 제주평화연구원 2013 JPI Peace Net Vol.2013 No.29