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Julián David Salazar-Gutiérrez,Andrés Castelblanco,María Ximena Rodríguez-Bocanegrab,Wilson Teran,Adriana Sáenz-Aponte 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.4
Entomopathogenic nematodes are key players for insect pest control and constitute an environmentally friendly alternative for crop protection. The insecticidal activity of the family Heterorhabditidae relies on a tight symbiotic relationship with enterobacteria of the genus Photorhabdus, where the bacterial contribution towards the death of the host has been highlighted. In the present work, we report the identification and pathogenic characterization of Photorhabdus luminescens strain SL0708, which is the natural symbiont of Heterorhabditis indica SL0708. We evaluated the pathogenicity of whole bacterial cells and acellular extracts against both Spodoptera frugiperda larvae and Galleria mellonella. Phylogenetic analyses using a polygenic sequencing approach assigned the bacterial strain to Photorhabdus luminescens subsp. akhurstii and bioassays showed it is highly pathogenic for both insects. After 48 h of treatment with 1× 103 −1 × 104 CFU/larva, 100% mortality was attained. Furthermore, when intra- or extracellular bacterial extracts were injected into G. mellonella, a cumulative percent mortality of 63% and 100% was respectively obtained after 72 h. In contrast, a 10% and 93% mortality was achieved for S. frugiperda with intra and extracellular extracts, respectively highlighting the role of extracellular factors in pathogenicity. We detected extracellular activities potentially accounting for the high pathogenicity observed and these included; proteases, esterases, ureases, hemolysins and siderophores. Interestingly, S. frugiperda was more susceptible to P. luminescens SL0708 cells than G. mellonella, which contrasted to its higher resistance to H. indica SL0708 nematodes, which suggests that EPN biological control potential should also be evaluated based on bacterial symbiont pathogenicity
Refining drug administration in a murine model of acute infection with Trypanosoma cruzi
Julián Ernesto Nicolás Gulin,Margarita Bisio,Facundo García-Bournissen 한국실험동물학회 2020 Laboratory Animal Research Vol.36 No.4
Background: In animal research, “refinement” refers to modifications of husbandry or experimental procedures to enhance animal well-being and minimize or eliminate pain and distress. Evaluation of drug efficacy in mice models, such as those used to study Trypanosoma cruzi infection, require prolonged drug administration by the oral route (e.g. for 20 consecutive days). However, the orogastric gavage method can lead to significant discomfort, upper digestive or respiratory tract lesions, aspiration pneumonia and even accidental death. The aim of this work was to evaluate the effect of two administration methods (conventional oral gavage vs. a refined method using a disposable tip and automatic pipette) on the efficacy of benznidazole in a murine model of T. cruzi infection. Results: Both administration methods led to a rapid and persistent reduction in parasitaemia. Absence of T. cruzi DNA (evaluated by real-time PCR) in blood, cardiac and skeletal muscle confirmed that treatment efficacy was not influenced by the administration method used. Conclusions: The proposed refined method for long-term oral drug administration may be a suitable strategy for assessing drug efficacy in mice models of Chagas disease and can be applied to similar murine infection models to reduce animal discomfort.
David Price,Henry Chrystyn,Alan Kaplan,John Haughney,Miguel Román-Rodríguez,Annie Burden,Alison Chisholm,Elizabeth V. Hillyer,Julie von Ziegenweidt,Muzammil Ali,Thys van der Molen 대한천식알레르기학회 2012 Allergy, Asthma & Immunology Research Vol.4 No.4
Purpose: Correct use of inhaler devices is fundamental to effective asthma management but represents an important challenge for patients. The correct inhalation manoeuvre differs markedly for different inhaler types. The objective of this study was to compare outcomes for patients prescribed the same inhaler device versus mixed device types for asthma controller and reliever therapy. Methods: This retrospective observational study identified patients with asthma (ages 4-80 years) in a large primary care database who were prescribed an inhaled corticosteroid (ICS) for the first time. We compared outcomes for patients prescribed the same breath-actuated inhaler (BAI) for ICS controller and salbutamol reliever versus mixed devices (BAI for controller and pressurised metered-dose inhaler [pMDI] for reliever). The 2-year study included 1 baseline year before the ICS prescription (to identify and correct for confounding factors) and 1 outcome year. Endpoints were asthma control (defined as no hospital attendance for asthma,oral corticosteroids, or antibiotics for lower respiratory tract infection) and severe exacerbations (hospitalisation or oral corticosteroids for asthma). Results: Patients prescribed the same device (n=3,428) were significantly more likely to achieve asthma control (adjusted odds ratio, 1.15;95% confidence interval [CI], 1.02-1.28) and recorded significantly lower severe exacerbation rates (adjusted rate ratio, 0.79; 95% CI, 0.68-0.93) than those prescribed mixed devices (n=5,452). Conclusions: These findings suggest that, when possible, the same device should be prescribed for both ICS and reliever therapy when patients are initiating ICS.
Migisha Richard,Ario Alex Riolexus,Kadobera Daniel,Bulage Lilian,Katana Elizabeth,Ndyabakira Alex,Elyanu Peter,Kalamya Julius N.,Harris Julie R. 대한고혈압학회 2023 Clinical Hypertension Vol.29 No.-
Background: High blood pressure (HBP), including hypertension (HTN), is a predictor of cardiovascular events, and is an emerging challenge in young persons. The risk of cardiovascular events may be further amplifed among people living with HIV (PLHIV). We determined the prevalence of HBP and associated factors among PLHIV aged 13 to 25 years in Rwenzori region, western Uganda. Methods: We conducted a cross-sectional study among PLHIV aged 13 to 25 years at nine health facilities in Kabarole and Kasese districts during September 16 to October 15, 2021. We reviewed medical records to obtain clinical and demographic data. At a single clinic visit, we measured and classifed BP as normal (<120/<80 mmHg), elevated (120/<80 to 129/<80), stage 1 HTN (130/80 to 139/89), and stage 2 HTN (≥140/90). We categorized participants as having HBP if they had elevated BP or HTN. We performed multivariable analysis using modifed Poisson regression to identify factors associated with HBP. Results: Of the 1,045 PLHIV, most (68%) were female and the mean age was 20 (3.8) years. The prevalence of HBP was 49% (n=515; 95% confdence interval [CI], 46%–52%), the prevalence of elevated BP was 22% (n=229; 95% CI, 26%–31%), and the prevalence of HTN was 27% (n=286; 95% CI, 25%–30%), including 220 (21%) with stage 1 HTN and 66 (6%) with stage 2 HTN. Older age (adjusted prevalence ratio [aPR], 1.21; 95% CI, 1.01–1.44 for age group of 18–25 years vs. 13–17 years), history of tobacco smoking (aPR, 1.41; 95% CI, 1.08–1.83), and higher resting heart rate (aPR, 1.15; 95% CI, 1.01–1.32 for>76 beats/min vs.≤76 beats/min) were associated with HBP. Conclusions: Nearly half of the PLHIV evaluated had HBP, and one-quarter had HTN. These fndings highlight a previously unknown high burden of HBP in this setting’s young populations. HBP was associated with older age, elevated resting heart rate, and ever smoking; all of which are known traditional risk factors for HBP in HIV-negative persons. To prevent future cardiovascular disease epidemics among PLHIV, there is a need to integrate HBP/HIV management.
Angel Cuenca,Julián Salt,Vicente Casanova,Ricardo Pizá 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.2
This paper presents a control strategy to face time-varying delays induced in a Networked Control System (NCS). The delay is divided into two parts: the largest one (an integer multiple of the bus cycle) is compensated by means of an adaptive multi-rate Smith predictor, and the smallest one (whose value is strictly smaller than the bus cycle) via a gain scheduling approach based on root locus contour and linearization techniques. The gains to be scheduled belong to a multi-rate PID controller. Control system stability is studied by means of Lyapunov theory. Simulation results and the implementation on a test-bed Profibus-DP environment illustrate that this control structure can maintain NCS performance and stability, despite the considered delays.
Ricardo Gabriel Martínez,Julián Gabriel Leone,Juan Manuel Rodriguez Repeti 부산외국어대학교 중남미지역원 2021 이베로아메리카 Vol.23 No.2
The covid 19 pandemic led to an economic collapse and multiple impacts upon Argentina's labour dynamics. As well as in other parts of the region, falls in employment rates (both due to an increase in unemployment and significant withdrawals from the labour force) were combined with wage reductions for those who were able to keep their jobs. Thus, two important processes for the labour market complimented each other: a structural shock associated with a tasks automation as a reorganisation and substitution of factors, with a cyclical recession caused by the pandemic. The international experience shows the amplifying impact the latter has on the former, generating long-term consequences mainly in routine-intensive jobs. However, the knowledge-intensive services sector appears to be the most capable of cushioning the recessionary shock (both in terms of wages and labour absorption), even with nuances within the sector depending on the extent of the shutdown measures and its capability to switch to remote work. Finally, the task approach is decisive in capturing the ability to adapt both the cyclical and structural processes, absorbing a large part of the explanatory potential that sectoral classifications tend to bring about.
A Non-Uniform Predictor-Observer for a Networked Control System
Angel Cuenca,Pedro García,Pedro Albertos,Julián Salt 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.6
This paper presents a Non-Uniform Predictor-Observer (NUPO) based control approach in order to deal with two of the main problems related to Networked Control Systems (NCS) or Sensor Networks (SN): time-varying delays and packet loss. In addition, if these delays are longer than the sampling period, the packet disordering phenomenon can appear. Due to these issues, a (scarce) non-uniform, delayed measurement signal could be received by the controller. But including the NUPO proposal in the control system, the delay will be compensated by the prediction stage, and the non-available data will be reconstructed by the observer stage. So, a delay-free, uniformly sampled controller design can be adopted. To ensure stability, the predictor must satisfy a feasibility problem based on a time-varying delay-dependent condition expressed in terms of Linear Matrix Inequalities (LMI). Some aspects like the relation between network delay and robustness/performance trade-off are empirically studied. A simulation example shows the benefits (robustness and control performance improvement) of the NU-PO approach by comparison to another similar proposal.